Dietary inflammatory index and Alzheimer's disease mortality in a prospective cohort

IF 4.3

Experimental gerontology Pub Date : 2025-05-02 DOI:10.1016/j.exger.2025.112770

Ruitong Liao , Jinzhao Yang , Xiaoping Huang , Yue Xu , Qianqian Ji , Qi Liu , Shan Xu , Peiyi Liu , Yiqiang Zhan

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引用次数: 0

Abstract

Objective

This study examined the relationship between the Dietary Inflammatory Index (DII) and Alzheimer's disease (AD) mortality in US adults.

Methods

Data from 45,093 participants in the 1988–2014 National Health and Nutrition Examination Survey (NHANES) were analyzed, with mortality follow-up through December 2019. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95 % confidence intervals (CIs) for AD mortality. Restricted cubic spline analysis explored the non-linear association of DII with AD mortality, and stratified analyses identified higher-risk subgroups.

Results

Over a median follow-up of 14.3 years, 455 AD-related deaths occurred. Participants in the highest DII quartile (>2.41) had a 1.50-fold increased risk of AD mortality (95 % CI: 1.12–2.01) compared to the lowest quartile (≤−0.44). Pro-inflammatory diets (DII > 0) were associated with a 44 % higher risk of AD mortality (HR: 1.44, 95 % CI: 1.14–1.81). A dose-response relationship was observed, with increased risks across quartiles, and findings were consistent across demographic and clinical subgroups.

Conclusions

Higher DII levels were significantly associated with elevated AD mortality risk, highlighting the potential role of pro-inflammatory diets in AD-related outcomes.

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前瞻性队列中的饮食炎症指数与阿尔茨海默病死亡率

目的研究美国成人饮食炎症指数（DII）与阿尔茨海默病（AD）死亡率之间的关系。方法分析1988-2014年全国健康与营养调查（NHANES） 45,093名参与者的数据，并对死亡率进行随访至2019年12月。Cox比例风险模型用于估计AD死亡率的风险比（hr）和95%置信区间（ci）。限制性三次样条分析探讨了DII与AD死亡率的非线性关联，分层分析确定了高风险亚组。结果在14.3年的中位随访中，发生了455例ad相关死亡。与最低四分位数（≤- 0.44）相比，最高DII四分位数（>2.41）的参与者AD死亡风险增加1.50倍（95% CI: 1.12-2.01）。促炎饮食(DII >；0)与阿尔茨海默病死亡率增高44%相关（HR: 1.44, 95% CI: 1.14-1.81）。观察到剂量-反应关系，四分位数的风险增加，并且在人口统计学和临床亚组中发现是一致的。结论较高的DII水平与AD死亡风险升高显著相关，强调了促炎饮食在AD相关结局中的潜在作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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