Association of functional disability with cardiometabolic disease status in a national cohort study

IF 3.9

Experimental gerontology Pub Date : 2025-05-01 DOI:10.1016/j.exger.2025.112771

Ping Ni , Fang Wang , Li Liu , Meiling Ge , Xiuying Hu

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Abstract

Background

Cardiometabolic disease (CMD) status increases the risk of functional disability; however, the reverse relationship remains unclear. This study aimed to examine the impact of different patterns of functional disability on CMD status among Chinese middle-aged and older adults.

Methods

We used data from two waves of the China Health and Retirement Longitudinal Study. Functional disability was assessed based on activities of daily living (ADL) and instrumental activities of daily living (IADL), while CMD status was evaluated based on the incidence of diabetes, heart disease, and stroke. Generalized ordinal logistic regression analysis was employed to investigate the impact of functional disability on CMD status.

Results

In the longitudinal study, 509 individuals (20.0 %) developed CMD, and 102 individuals (4.0 %) developed cardiometabolic multimorbidity. After adjusting for confounders, Model 1 showed an odds ratio of 1.64 (95 % CI: 1.17, 2.29) for increased CMD status in individuals with ADL and IADL disability compared to those without functional disability. Model 2 and Model 3 produced similar results.

Conclusions

Functional disability, particularly ADL and IADL disability, increases the risk of CMD status in Chinese middle-aged and older adults. Measures should be implemented to maintain functional status in middle-aged and older adults.

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一项国家队列研究中功能障碍与心脏代谢疾病状态的关系

背景：心脏代谢疾病（CMD）状态增加功能性残疾的风险；然而，反向关系仍不清楚。本研究旨在探讨不同功能障碍模式对中国中老年人群CMD状态的影响。方法：采用中国健康与退休纵向研究的两波数据。根据日常生活活动（ADL）和日常生活工具活动（IADL）评估功能性残疾，根据糖尿病、心脏病和中风的患病率评估CMD状态。采用广义有序logistic回归分析探讨功能障碍对CMD状态的影响。结果：在纵向研究中，509人（20.0 %）发展为CMD， 102人（4.0 %）发展为心脏代谢多发病。在调整混杂因素后，模型1显示，与没有功能障碍的个体相比，ADL和IADL残疾个体的CMD状态增加的优势比为1.64（95 % CI: 1.17, 2.29）。模型2和模型3得出了类似的结果。结论：功能障碍，尤其是ADL和IADL功能障碍，增加了中国中老年人群发生CMD的风险。应采取措施维持中老年人的功能状态。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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