Bioelectromagnetics最新文献_第5页

Expression levels of tam receptors and ligands in the testes of rats exposed to short and middle-term 2100 MHz radiofrequency radiation 短期和中期暴露于 2100 兆赫射频辐射的大鼠睾丸中 tam 受体和配体的表达水平。

IF 1.9 3区生物学

Bioelectromagnetics Pub Date : 2024-05-09 DOI: 10.1002/bem.22504

Ertan Katirci PhD, Esma Kirimlioglu PhD, Asli O. Oflamaz PhD, Enis Hidisoglu PhD, Alexandra Cernomorcenco MSc, Piraye Yargıcoğlu PhD, Sukru Ozen PhD, Necdet Demir PhD

{"title":"Expression levels of tam receptors and ligands in the testes of rats exposed to short and middle-term 2100 MHz radiofrequency radiation","authors":"Ertan Katirci PhD, Esma Kirimlioglu PhD, Asli O. Oflamaz PhD, Enis Hidisoglu PhD, Alexandra Cernomorcenco MSc, Piraye Yargıcoğlu PhD, Sukru Ozen PhD, Necdet Demir PhD","doi":"10.1002/bem.22504","DOIUrl":"10.1002/bem.22504","url":null,"abstract":"With advances in technology, the emission of radiofrequency radiation (RFR) into the environment, particularly from mobile devices, has become a growing concern. Tyro 3, Axl, and Mer (TAM) receptors and their ligands are essential for spermatogenesis and testosterone production. RFR has been shown to induce testicular cell apoptosis by causing inflammation and disrupting homeostasis. This study aimed to investigate the role of TAM receptors and ligands in the maintenance of homeostasis and elimination of apoptotic cells in the testes (weeks), short-term sham exposure (sham/1 week), and middle-term sham exposure (sham/10 weeks). Testicular morphology was assessed using hematoxylin-eosin staining, while immunohistochemical staining was performed to assess expression levels of TAM receptors and ligands in the testes of all groups. The results showed that testicular morphology was normal in the control, sham/1 week, and sham/10 weeks groups. However, abnormal processes of spermatogenesis and seminiferous tubule morphology were observed in RFR exposure groups. Cleaved Caspase 3 immunoreactivity showed statistically significant difference in 1 and 10 weeks exposure groups compared to control group. Moreover, there was no significant difference in the immunoreactivity of Tyro 3, Axl, Mer, Gas 6, and Pros 1 between groups. Moreover, Tyro 3 expression in Sertoli cells was statistically significantly increased in RFR exposure groups compared to the control. Taken together, the results suggest that RFR exposure negatively affects TAM signalling, preventing the clearance of apoptotic cells, and this process may lead to infection and inflammation. As a result, rat testicular morphology and function may be impaired.","PeriodicalId":8956,"journal":{"name":"Bioelectromagnetics","volume":"45 5","pages":"235-248"},"PeriodicalIF":1.9,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140897425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of the effectiveness of intermittent electromagnetic field stimulation for early internal cartilaginous ossification in prechondrocytic ATDC5 cells 间歇电磁场刺激对软骨前细胞 ATDC5 早期内部软骨骨化的有效性研究

IF 1.9 3区生物学

Bioelectromagnetics Pub Date : 2024-03-28 DOI: 10.1002/bem.22501

Takahiro Iwaki MD, Yasunobu Sawaji PhD, Toshinori Masaoka MD, PhD, Eiichi Fukada PhD, Munehiro Date PhD, Kengo Yamamoto MD, PhD

{"title":"Investigation of the effectiveness of intermittent electromagnetic field stimulation for early internal cartilaginous ossification in prechondrocytic ATDC5 cells","authors":"Takahiro Iwaki MD, Yasunobu Sawaji PhD, Toshinori Masaoka MD, PhD, Eiichi Fukada PhD, Munehiro Date PhD, Kengo Yamamoto MD, PhD","doi":"10.1002/bem.22501","DOIUrl":"10.1002/bem.22501","url":null,"abstract":"Pulsed electromagnetic field (PEMF) stimulation has been widely applied clinically to promote bone healing; however, its detailed mechanism of action, particularly in endochondral ossification, remains elusive, and long-term stimulation is required for its satisfactory effect. The aim of this study was to investigate the involvement of the mammalian target of rapamycin (mTOR) pathway in chondrocyte differentiation and proliferation using a mouse prechondroblast cell line (ATDC5), and establish an efficient PEMF stimulation strategy for endochondral ossification. The changes in cell differentiation (gene expression levels of aggrecan, type II collagen, and type X collagen) and proliferation (cellular uptake of bromodeoxyuridine [BrdU]) in ATDC5 cells in the presence or absence of rapamycin, an mTOR inhibitor, was measured. The effects of continuous and intermittent PEMF stimulation on changes in cell differentiation and proliferation were compared. Rapamycin significantly suppressed the induction of cell differentiation markers and the cell proliferation activity. Furthermore, only intermittent PEMF stimulation continuously activated the mTOR pathway in ATDC5 cells, significantly promoting cell proliferation. These results demonstrate the involvement of the mTOR pathway in chondrocyte differentiation and proliferation and suggest that intermittent PEMF stimulation could be effective as a stimulus for endochondral ossification during fracture healing process, thereby reducing stimulation time.","PeriodicalId":8956,"journal":{"name":"Bioelectromagnetics","volume":"45 5","pages":"226-234"},"PeriodicalIF":1.9,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bem.22501","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140304798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of electromagnetic pulses, exosomes inhibition and their coaction on A549 cells 电磁脉冲、外泌体抑制及其协同作用对 A549 细胞的影响

IF 1.9 3区生物学

Bioelectromagnetics Pub Date : 2024-03-27 DOI: 10.1002/bem.22500

Qian Zhang, Qingxia Hou, Guangzhou An

{"title":"Effects of electromagnetic pulses, exosomes inhibition and their coaction on A549 cells","authors":"Qian Zhang, Qingxia Hou, Guangzhou An","doi":"10.1002/bem.22500","DOIUrl":"10.1002/bem.22500","url":null,"abstract":"Mounting literature indicates that electromagnetic pulses (EMP) is the promising modality to treat cancers with advantages such as noninvasiveness and few side-effects, but its appropriate parameters and underlying mechanisms such as its influence on tumor-derived exosomes (TDEs) are largely unknown. This study aimed to elucidate effects of EMP, exosome inhibition and their coaction on A549 lung adenocarcinoma cells. A549 cells were randomly divided into control group, GW4869 group treated by 20 μM GW4869, vehicle group treated by dimethyl sulfoxide, EMP group treated by EMP exposure, and EMPG group treated by EMP exposure combined with 20 μM GW4869. After EMP exposure, cell proliferation was determined by CCK8 assay, cell cycle and apoptosis was detected by flow cytometry, and cell migration was determined by transwell assay. The results showed that EMP or exosomes inhibition did not affect cell proliferation, cell cycle, apoptosis and cell migration (p > 0.05), but cell migration in EMPG group was significantly decreased compared with vehicle group (p < 0.05). We concluded that under the experimental condition, EMP or GW4869 alone had no effects on behaviors of A549 cells, but their coaction could effectively inhibit the migration of A549 cells.","PeriodicalId":8956,"journal":{"name":"Bioelectromagnetics","volume":"45 5","pages":"218-225"},"PeriodicalIF":1.9,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140292683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New developments in cosmetic applications of electromagnetic fields: Client and occupational hazard assessment 电磁场美容应用的新发展：客户和职业危害评估。

IF 1.8 3区生物学

Bioelectromagnetics Pub Date : 2024-03-27 DOI: 10.1002/bem.22503

Rianne Stam PhD

{"title":"New developments in cosmetic applications of electromagnetic fields: Client and occupational hazard assessment","authors":"Rianne Stam PhD","doi":"10.1002/bem.22503","DOIUrl":"10.1002/bem.22503","url":null,"abstract":"Energy-based devices are used to improve features of appearance for aesthetic reasons while avoiding more invasive methods. Examples of treatment targets are the reduction of wrinkles, sagging, unwanted skin lesions, body hair and excess fatty tissue, and the enhancement of muscle tissue. One treatment modality is the use of electromagnetic fields (EMF, 0‒300 GHz). The present work aims to give an up-to-date survey of cosmetic applications of EMF for professional use with an assessment of client and worker exposure and possible adverse effects. A systematic search was conducted for peer-reviewed articles (2007–2022), patents, premarket notifications, manufacturer data, and adverse effects reports. Five categories of cosmetic EMF device with increasing frequency were identified: sinusoid low frequency magnetic fields for lipolysis; pulsed low frequency magnetic fields for skin rejuvenation; pulsed low frequency magnetic fields for muscle building; radiofrequency EMF for lipolysis or skin rejuvenation; microwaves for hair removal or hyperhidrosis. In the vicinity of the last four device categories, there is a potential for exceeding the occupational exposure limits in the European Union EMF Directive, which could lead to nerve or muscle stimulation, burns or overheating. There are also potential hazards for clients or workers wearing active or passive medical devices. The severity of reported adverse effects increases with EMF frequency.","PeriodicalId":8956,"journal":{"name":"Bioelectromagnetics","volume":"45 6","pages":"251-259"},"PeriodicalIF":1.8,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140292722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

5G NR launching in Greece: Preliminary in situ and monitoring network measurements of electromagnetic fields exposure levels at rooftops 希腊启动 5G NR：屋顶电磁场暴露水平的初步现场和监测网络测量。

IF 1.9 3区生物学

Bioelectromagnetics Pub Date : 2024-03-05 DOI: 10.1002/bem.22502

Maria I. Christopoulou PhD, Theodora Kyritsi MSc, Agamemnon Yalofas MSc, Dimitris Koutounidis MSc, Efthymios Karabetsos PhD

{"title":"5G NR launching in Greece: Preliminary in situ and monitoring network measurements of electromagnetic fields exposure levels at rooftops","authors":"Maria I. Christopoulou PhD, Theodora Kyritsi MSc, Agamemnon Yalofas MSc, Dimitris Koutounidis MSc, Efthymios Karabetsos PhD","doi":"10.1002/bem.22502","DOIUrl":"10.1002/bem.22502","url":null,"abstract":"In Greece, 5G New Radio (NR) has started launching in the end of 2020, at the 3400–3800 MHz (FR1) frequency band. Focusing on 117 Base Stations (BSs) which were already equipped with 5G NR antennas, in situ broadband and frequency selective measurements have been conducted at minimum three points of interest, at adjacent rooftops (when accessible). The points have been selected according to the sweeping method and the electric field strength (E) value has been stored on the selected worst-case scenario point. Spectrum analysis was conducted in the FR1, for the allocated spectrum that corresponds to each mobile communication provider, in order to get preliminary results concerning the contribution of the 5G NR emissions in the general public exposure levels. The vast majority of the in situ measurements has been conducted in urban environments from the beginning of 2021 until the mid of 2022, since in Greece 5G NR services launching started from the big cities. Additionally, a 5G NR BS, installed in a suburban environment (in the city of Kalamata) is thoroughly investigated during its pilot and regular operation, based on broadband and frequency selective measurements data derived by the National Observatory of Electromagnetic Fields (NOEF) monitoring sensor network. In situ measurement data within the 5G NR frequency range are verified via the NOEF's output. The 5G NR contribution to the total E-field levels is assessed in time, from pilot to regular operation of the BS. In all cases, compliance with the reference levels for general public exposure is affirmed.","PeriodicalId":8956,"journal":{"name":"Bioelectromagnetics","volume":"45 4","pages":"193-199"},"PeriodicalIF":1.9,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140038633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of 3.5-GHz radiofrequency radiation on energy-regulatory hormone levels in the blood and adipose tissue 3.5 GHz 射频辐射对血液和脂肪组织中能量调节激素水平的影响。

IF 1.9 3区生物学

Bioelectromagnetics Pub Date : 2024-02-18 DOI: 10.1002/bem.22498

Hava Bektas PhD, Suleyman Dasdag PhD, Fikret Altindag PhD, Mehmet Z. Akdag PhD, Korkut Yegin PhD, Sermin Algul PhD

{"title":"Effects of 3.5-GHz radiofrequency radiation on energy-regulatory hormone levels in the blood and adipose tissue","authors":"Hava Bektas PhD, Suleyman Dasdag PhD, Fikret Altindag PhD, Mehmet Z. Akdag PhD, Korkut Yegin PhD, Sermin Algul PhD","doi":"10.1002/bem.22498","DOIUrl":"10.1002/bem.22498","url":null,"abstract":"In recent years exposure of living beings to radiofrequency radiation (RFR) emitted from wireless equipment has increased. In this study, we investigated the effects of 3.5-GHz RFR on hormones that regulate energy metabolism in the body. Twenty-eight rats were divided into four groups: healthy sham (n = 7), healthy RFR (n = 7), diabetic sham (n = 7), and diabetic RFR (n = 7). Over a month, each group spent 2 h/day in a Plexiglas carousel. The rats in the experimental group were exposed to RFR, but the sham groups were not. At the end of the experiment, blood and adipose tissues were collected from euthanized rats. Total antioxidant, total oxidant, hydrogen peroxide, ghrelin, nesfatin-1, and irisin were determined. Insulin expression in pancreatic tissues was examined by immunohistochemical analysis. Whole body specific absorption rate was 37 mW/kg. For the parameters analyzed in blood and fat, the estimated effect size varied within the ranges of 0.215–0.929 and 0.503–0.839, respectively. The blood and adipose nesfatin-1 (p = 0.002), blood and pancreatic insulin are decreased, (p = 0.001), gherelin (p = 0.020), irisin (p = 0.020), and blood glucose (p = 0.040) are increased in healthy and diabetic rats exposed to RFR. While nesfatin-1 are negatively correlated with oxidative stress, hyperglycemia and insulin, ghrelin and irisin are positively correlated with oxidative stress and hyperglycemia. Thus, RFR may have deleterious effects on energy metabolism, particularly in the presence of diabetes.","PeriodicalId":8956,"journal":{"name":"Bioelectromagnetics","volume":"45 5","pages":"209-217"},"PeriodicalIF":1.9,"publicationDate":"2024-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139899290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is activation of the vestibular system by electromagnetic induction a possibility in an MRI context? 在核磁共振成像中，电磁感应激活前庭系统的可能性大吗？

IF 1.9 3区生物学

Bioelectromagnetics Pub Date : 2024-02-13 DOI: 10.1002/bem.22497

Nicolas Bouisset PhD, Janita Nissi MSc, Ilkka Laakso PhD, Raymond F. Reynolds PhD, Alexandre Legros

{"title":"Is activation of the vestibular system by electromagnetic induction a possibility in an MRI context?","authors":"Nicolas Bouisset PhD, Janita Nissi MSc, Ilkka Laakso PhD, Raymond F. Reynolds PhD, Alexandre Legros","doi":"10.1002/bem.22497","DOIUrl":"10.1002/bem.22497","url":null,"abstract":"In recent years, an increasing number of studies have discussed the mechanisms of vestibular activation in strong magnetic field settings such as occur in a magnetic resonance imaging scanner environment. Amid the different hypotheses, the Lorentz force explanation currently stands out as the most plausible mechanism, as evidenced by activation of the vestibulo-ocular reflex. Other hypotheses have largely been discarded. Nonetheless, both human data and computational modeling suggest that electromagnetic induction could be a valid mechanism which may coexist alongside the Lorentz force. To further investigate the induction hypothesis, we provide, herein, a first of its kind dosimetric analysis to estimate the induced electric fields at the vestibular system and compare them with what galvanic vestibular stimulation would generate. We found that electric fields strengths from induction match galvanic vestibular stimulation strengths generating vestibular responses. This review examines the evidence in support of electromagnetic induction of vestibular responses, and whether movement-induced time-varying magnetic fields should be further considered and investigated.","PeriodicalId":8956,"journal":{"name":"Bioelectromagnetics","volume":"45 4","pages":"171-183"},"PeriodicalIF":1.9,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bem.22497","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139721487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How to improve IARC's RF-EMF cancer hazard communication 如何改进国际癌症研究机构的射频-电磁场癌症危害通报。

IF 1.9 3区生物学

Bioelectromagnetics Pub Date : 2024-02-13 DOI: 10.1002/bem.22499

Peter M. Wiedemann PhD, Rodney J. Croft PhD

引用次数: 0

James C. Lin 詹姆斯-C-林

IF 1.9 3区生物学

Bioelectromagnetics Pub Date : 2023-12-20 DOI: 10.1002/bem.22496

引用次数: 0

Evaluation of mitochondrial stress following ultraviolet radiation and 5G radiofrequency field exposure in human skin cells 评估人体皮肤细胞暴露于紫外线辐射和 5G 射频场后的线粒体应激反应。

IF 1.9 3区生物学

Bioelectromagnetics Pub Date : 2023-12-19 DOI: 10.1002/bem.22495

Lorenza Patrignoni PhD, Annabelle Hurtier, Rosa Orlacchio, Alexandre Joushomme PhD, Florence Poulletier de Gannes, Philippe Lévêque RD, Delia Arnaud-Cormos, Hamid Reza Revzani RD, Walid Mahfouf, André Garenne, Yann Percherancier RD, Isabelle Lagroye

{"title":"Evaluation of mitochondrial stress following ultraviolet radiation and 5G radiofrequency field exposure in human skin cells","authors":"Lorenza Patrignoni PhD, Annabelle Hurtier, Rosa Orlacchio, Alexandre Joushomme PhD, Florence Poulletier de Gannes, Philippe Lévêque RD, Delia Arnaud-Cormos, Hamid Reza Revzani RD, Walid Mahfouf, André Garenne, Yann Percherancier RD, Isabelle Lagroye","doi":"10.1002/bem.22495","DOIUrl":"10.1002/bem.22495","url":null,"abstract":"Whether human cells are impacted by environmental electromagnetic fields (EMF) is still a matter of debate. With the deployment of the fifth generation (5G) of mobile communication technologies, the carrier frequency is increasing and the human skin becomes the main biological target. Here, we evaluated the impact of 5G-modulated 3.5 GHz radiofrequency (RF) EMF on mitochondrial stress in human fibroblasts and keratinocytes that were exposed for 24 h at specific absorption rate of 0.25, 1, and 4 W/kg. We assessed cell viability, mitochondrial reactive oxygen species (ROS) production, and membrane polarization. Knowing that human skin is the main target of environmental ultraviolet (UV), using the same read-out, we investigated whether subsequent exposure to 5G signal could alter the capacity of UV-B to damage skin cells. We found a statistically significant reduction in mitochondrial ROS concentration in fibroblasts exposed to 5G signal at 1 W/kg. On the contrary, the RF exposure slightly but statistically significantly enhanced the effects of UV-B radiation specifically in keratinocytes at 0.25 and 1 W/kg. No effect was found on mitochondrial membrane potential or apoptosis in any cell types or exposure conditions suggesting that the type and amplitude of the observed effects are very punctual.","PeriodicalId":8956,"journal":{"name":"Bioelectromagnetics","volume":"45 3","pages":"110-129"},"PeriodicalIF":1.9,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138797451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0