Characterising core body temperature response of free-moving C57BL/6 mice to 1.95 GHz whole-body radiofrequency-electromagnetic fields

IF 1.8 3区 生物学 Q3 BIOLOGY
Emma Sylvester BMedHlthSc (Hons), Chao Deng PhD, Robert McIntosh PhD, Steve Iskra PhD, John Frankland BComp (Hons), Raymond McKenzie BAppSc (Phys) (Hons), Rodney J. Croft PhD
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Abstract

The present study investigated the core body temperature (CBT) response of free-moving adult male and female C57BL/6 mice, during and following a 2-h exposure to 1.95 GHz RF-EMF within custom-built reverberation chambers, using temperature capsules implanted within the intraperitoneal cavity and data continuously logged and transmitted via radiotelemetry postexposure. Comparing RF-EMF exposures (WBA-SAR of 1.25, 2.5, 3.75, and 5 W/kg) to the sham-exposed condition, we identified a peak in CBT within the first 16 min of RF-EMF exposure (+0.15, +0.31, +0.24, +0.37°C at 1.25, 2.5, 3.75, and 5 W/kg respectively; statistically significant at WBA-SAR ≥ 2.5 W/kg only), which largely dissipated for the remainder of the exposure period. Immediately before the end of exposure, only the CBT of the 5 W/kg condition was statistically differentiable from sham. Based on our findings, it is apparent that mice are able to effectively compensate for the increased thermal load at RF-EMF strengths up to 5 W/kg. In addition, the elevated CBT at the end of the exposure period in the 5 W/kg condition was statistically significantly reduced compared to the sham condition immediately after RF-EMF exposure ceased. This would indicate that measures of CBT following the end of an RF-EMF exposure period may not reflect the actual change in the CBT of mice caused by RF-EMF exposure in mice.

Abstract Image

自由移动的 C57BL/6 小鼠对 1.95 GHz 全身射频电磁场的核心体温反应特征。
本研究调查了自由活动的成年雄性和雌性 C57BL/6 小鼠在定制混响室中暴露于 1.95 GHz 射频-电磁场 2 小时期间和之后的核心体温(CBT)反应,采用的方法是在腹腔内植入温度囊,暴露后通过无线电遥测连续记录和传输数据。将射频-电磁场暴露(WBA-SAR 为 1.25、2.5、3.75 和 5 W/kg)与假暴露条件进行比较,我们发现在射频-电磁场暴露的前 16 分钟内 CBT 达到峰值(在 1.25、2.5、3.75 和 5 W/kg 条件下分别为 +0.15、+0.31、+0.24、+0.37°C;仅在 WBA-SAR ≥ 2.5 W/kg 条件下具有统计学意义),并在暴露的剩余时间内基本消散。在暴露结束前,只有 5 W/kg 条件下的 CBT 与假体有统计学差异。根据我们的研究结果,小鼠显然能够在射频-电磁场强度达到 5 W/kg 时有效补偿增加的热负荷。此外,在 5 W/kg 条件下,暴露期结束时升高的 CBT 与射频-电磁场暴露停止后的假体条件相比在统计学上明显降低。这表明,射频-电磁场暴露期结束后的CBT测量值可能无法反映射频-电磁场暴露对小鼠CBT造成的实际变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Bioelectromagnetics
Bioelectromagnetics 生物-生物物理
CiteScore
4.60
自引率
0.00%
发文量
44
审稿时长
6-12 weeks
期刊介绍: Bioelectromagnetics is published by Wiley-Liss, Inc., for the Bioelectromagnetics Society and is the official journal of the Bioelectromagnetics Society and the European Bioelectromagnetics Association. It is a peer-reviewed, internationally circulated scientific journal that specializes in reporting original data on biological effects and applications of electromagnetic fields that range in frequency from zero hertz (static fields) to the terahertz undulations and visible light. Both experimental and clinical data are of interest to the journal''s readers as are theoretical papers or reviews that offer novel insights into or criticism of contemporary concepts and theories of field-body interactions. The Bioelectromagnetics Society, which sponsors the journal, also welcomes experimental or clinical papers on the domains of sonic and ultrasonic radiation.
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