Bioelectromagnetics最新文献

{"title":"Issue Information - Page","authors":"","doi":"10.1002/bem.22488","DOIUrl":"https://doi.org/10.1002/bem.22488","url":null,"abstract":"","PeriodicalId":8956,"journal":{"name":"Bioelectromagnetics","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bem.22488","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138431733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the mechanisms for wireless nerve stimulation without active electrodes","authors":"Luke A. Smith MSc,&nbsp;Jaedon D. Bem MSc,&nbsp;Xiaojing Lv PhD,&nbsp;Antonio Lauto PhD,&nbsp;Ashour Sliow PhD,&nbsp;Zhiyuan Ma MD,&nbsp;David A. Mahns PhD,&nbsp;Carolyn Berryman PhD,&nbsp;Mark R. Hutchinson PhD,&nbsp;Christophe Fumeaux PhD,&nbsp;Giuseppe C. Tettamanzi PhD","doi":"10.1002/bem.22486","DOIUrl":"10.1002/bem.22486","url":null,"abstract":"<p>Electric-field stimulation of neuronal activity can be used to improve the speed of regeneration for severed and damaged nerves. Most techniques, however, require invasive electronic circuitry which can be uncomfortable for the patient and can damage surrounding tissue. A recently suggested technique uses a graft-antenna—a metal ring wrapped around the damaged nerve—powered by an external magnetic stimulation device. This technique requires no electrodes and internal circuitry with leads across the skin boundary or internal power, since all power is provided wirelessly. This paper examines the microscopic basic mechanisms that allow the magnetic stimulation device to cause neural activation via the graft-antenna. A computational model of the system was created and used to find that under magnetic stimulation, diverging electric fields appear at the metal ring's edges. If the magnetic stimulation is sufficient, the gradients of these fields can trigger neural activation in the nerve. In-vivo measurements were also performed on rat sciatic nerves to support the modeling finding that direct contact between the antenna and the nerve ensures neural activation given sufficient magnetic stimulation. Simulations also showed that the presence of a thin gap between the graft-antenna and the nerve does not preclude neural activation but does reduce its efficacy.</p>","PeriodicalId":8956,"journal":{"name":"Bioelectromagnetics","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bem.22486","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71420416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain-implanted conductors amplify radiofrequency fields in rodents: Advantages and risks","authors":"Mihály Vöröslakos MD, PhD,&nbsp;Omid Yaghmazadeh PhD,&nbsp;Leeor Alon PhD,&nbsp;Daniel K. Sodickson MD, PhD,&nbsp;György Buzsáki MD, PhD","doi":"10.1002/bem.22489","DOIUrl":"10.1002/bem.22489","url":null,"abstract":"<p>Over the past few decades, daily exposure to radiofrequency (RF) fields has been increasing due to the rapid development of wireless and medical imaging technologies. Under extreme circumstances, exposure to very strong RF energy can lead to heating of body tissue, even resulting in tissue injury. The presence of implanted devices, moreover, can amplify RF effects on surrounding tissue. Therefore, it is important to understand the interactions of RF fields with tissue in the presence of implants, in order to establish appropriate wireless safety protocols, and also to extend the benefits of medical imaging to increasing numbers of people with implanted medical devices. This study explored the neurological effects of RF exposure in rodents implanted with neuronal recording electrodes. We exposed freely moving and anesthetized rats and mice to 950 MHz RF energy while monitoring their brain activity, temperature, and behavior. We found that RF exposure could induce fast onset firing of single neurons without heat injury. In addition, brain implants enhanced the effect of RF stimulation resulting in reversible behavioral changes. Using an optical temperature measurement system, we found greater than tenfold increase in brain temperature in the vicinity of the implant. On the one hand, our results underline the importance of careful safety assessment for brain-implanted devices, but on the other hand, we also show that metal implants may be used for neurostimulation if brain temperature can be kept within safe limits.</p>","PeriodicalId":8956,"journal":{"name":"Bioelectromagnetics","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50156957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of direct voltage induction by low-frequency security systems on neurostimulator lead","authors":"Yasaman Ardeshirpour PhD,&nbsp;Ethan D. Cohen PhD,&nbsp;Seth J. Seidman MSc,&nbsp;Biniyam Taddese PhD,&nbsp;Tayeb Zaidi MSc,&nbsp;Howard Bassen MSc","doi":"10.1002/bem.22485","DOIUrl":"10.1002/bem.22485","url":null,"abstract":"<p>Low-frequency (LF) security systems, such as antitheft electronic article surveillance (EAS) gates emit strong magnetic fields that could potentially interfere with neurostimulator operation. Some patients reported pain and shocking sensations near EAS gates, even after they turned off their pulse generator. To investigate the direct voltage induction of EAS systems on neurostimulator leads, we evaluated voltages induced by two EAS systems (14 kHz continuous wave or 58 kHz pulsed) on a 40 cm sacral neurostimulator lead formed in a circular loop attached to a pulse generator that was turned off. The lead and neurostimulator were mounted in a saline-filled rectangular phantom placed within electromagnetic fields emitted by EAS systems. The measured voltage waveforms were applied to computational models of spinal nerve axons to predict whether these voltages may evoke action potentials. Additional in vitro testing was performed on the semicircular lead geometry, to study the effect of lead geometry on EAS induced voltages. While standard neurostimulator testing per ISO 14708-3:2017 recommends electromagnetic compatibility testing with LF magnetic fields for induction of malfunctions of the active electronic circuitry while generating intended stimulating pulses, our results show that close to the EAS antenna frames, the induced voltage on the lead could be strong enough to evoke action potentials, even with the pulse generator turned off. This work suggests that patient reports of pain and shocking sensations when near EAS systems could also be correlated with the direct EAS-induced voltage on neurostimulator lead.</p>","PeriodicalId":8956,"journal":{"name":"Bioelectromagnetics","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49688635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of exposure to alternating low-intensity, intermediate-frequency electric fields on the differentiation of human leukemic cell line U937","authors":"Rayehe Mamaghaniyeh MSc,&nbsp;Amirali Zandieh MSc,&nbsp;Bahram Goliaei PhD,&nbsp;Maryam S. Nezamtaheri PhD,&nbsp;Seyed P. Shariatpanahi PhD","doi":"10.1002/bem.22487","DOIUrl":"10.1002/bem.22487","url":null,"abstract":"<p>Studying the bioeffects of electric fields have been the subject of ongoing research which led to promising therapeutic effect, particularly in cancer treatment. Here, we investigated the impact of low-intensity, intermediate-frequency alternating electric fields on the differentiation of human myeloid leukemia cell line U937. The results showed a near twofold increase in differentiation of U937 cells treated for 24 h by alternating 600 kHz, 150 V/m electric fields, in comparison to their control groups. This measure was evaluated by latex bead phagocytosis assay, nitro blue tetrazolium test, and cell cycle analysis which revealed a significant shift in the number of cells from G₂+M to G₀+G₁ phases. The simulation result for the intracellular field intensity showed around 50% attenuation with respect to the applied external field for our setup which ruled out masking of the applied field by the internal electric noise of the cell. Based on previous studies we postulate a possible calcium-related effect for the observed differentiation, yet the exact underlying mechanism requires further investigation. Finally, our results may offer a potential therapeutic method for leukemia in the future.</p>","PeriodicalId":8956,"journal":{"name":"Bioelectromagnetics","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49688636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of the radiofrequency-induced heating inside the human head with dental implants at 7 T","authors":"Song Duan MEng,&nbsp;Xiuxiu Wu MEng,&nbsp;Juntian Shi MSc,&nbsp;Wenhui Li MMed,&nbsp;Qingshan Dong MD,&nbsp;Sherman Xuegang Xin PhD","doi":"10.1002/bem.22490","DOIUrl":"10.1002/bem.22490","url":null,"abstract":"<p>Conductive dental implants are commonly used in restorative therapy to replace missing teeth in patients. Ensuring the radiofrequency (RF) safety of these patients is crucial when performing 7 T magnetic resonance scans of their heads. This study aimed to investigate RF-induced heating inside the human head with dental implants at 7 T. Dental implants and their attachments were fabricated and integrated into an anatomical head model, creating different measurement configurations (MCs). Numerical simulations were conducted using a 7 T transmit coil loaded with the anatomical head model, both with and without dental implants. The maximum temperatures inside the head for various MCs were computed using the maximum permissible input powers (MPIPs) obtained without dental implants and compared with published limits. Additionally, the MPIPs with dental implants were calculated for scenarios where the temperature limits were exceeded. The maximum temperatures observed inside the head ranged from 38.4°C to 39.6°C. The MPIPs in the presence of dental implants were 81.9%–97.3% of the MPIPs in the absence of dental implants for scenarios that exceeded the regulatory limit. RF-induced heating effect of the dental implants was not significant. The safe scanning condition in terms of RF exposure was achievable for patients with dental implants. For patients with conductive dental implants of unknown configuration, it is recommended to reduce the input power by 18.1% of MPIP without dental implants to ensure RF safety.</p>","PeriodicalId":8956,"journal":{"name":"Bioelectromagnetics","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49673963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review on cellular responses of Escherichia coli to nonthermal electromagnetic irradiation","authors":"Khadijeh Askaripour PhD,&nbsp;Arkadiusz Żak PhD","doi":"10.1002/bem.22484","DOIUrl":"10.1002/bem.22484","url":null,"abstract":"<p>Investigation of <i>Escherichia coli</i> under electromagnetic fields is of significance in human studies owing to its short doubling time and human-like DNA mechanisms. The present review aims to systematically evaluate the literature to conclude causality between 0 and 300 GHz electromagnetic fields and biological effects in <i>E. coli</i>. To that end, the OHAT methodology and risk of bias tool were employed. Exponentially growing cells exposed for over 30 min at temperatures up to <math>\u0000 <semantics>\u0000 <mrow>\u0000 <mn>3</mn>\u0000 \u0000 <msup>\u0000 <mn>7</mn>\u0000 \u0000 <mo>∘</mo>\u0000 </msup>\u0000 \u0000 <mi>C</mi>\u0000 </mrow>\u0000 <annotation> $3{7}^{circ },{rm{C}}$</annotation>\u0000 </semantics></math> with fluctuations below <math>\u0000 <semantics>\u0000 <mrow>\u0000 <msup>\u0000 <mn>1</mn>\u0000 \u0000 <mo>∘</mo>\u0000 </msup>\u0000 \u0000 <mi>C</mi>\u0000 </mrow>\u0000 <annotation> ${1}^{circ },{rm{C}}$</annotation>\u0000 </semantics></math> were included from the Web-of-Knowledge, PubMed, or EMF-Portal databases. Out of 904 records identified, 25 articles satisfied the selection criteria, with four excluded during internal validation. These articles examined cell growth (11 studies), morphology (three studies), and gene regulation (11 studies). Most experiments (85%) in the included studies focused on the extremely low-frequency (ELF) range, with 60% specifically at 50 Hz. Changes in growth rate were observed in 74% of ELF experiments and 71% of radio frequency (RF) experiments. Additionally, 80% of ELF experiments showed morphology changes, while gene expression changes were seen in 33% (ELF) and 50% (RF) experiments. Due to the limited number of studies, especially in the intermediate frequency and RF ranges, establishing correlations between EMF exposure and biological effects on <i>E. coli</i> is not possible.</p>","PeriodicalId":8956,"journal":{"name":"Bioelectromagnetics","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41149075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EMEMI: An interference-free mini-incubator with integrated electric and magnetic field exposure for real-time microscopic imaging of field effects","authors":"Farhad Alizadeh MSc,&nbsp;Mehrdad Saviz PhD,&nbsp;Farbod Khoraminia MSc,&nbsp;Ali Talebipour MSc,&nbsp;Rana Imani PhD,&nbsp;Iman Shabani PhD","doi":"10.1002/bem.22483","DOIUrl":"10.1002/bem.22483","url":null,"abstract":"<p>Uninterrupted microscopic observation and real-time imaging of cell behavior during exposure to the stimulus, for example, electric and/or magnetic fields, especially for periods of several days, has been a challenge in experimental bioelectromagnetics due to a lack of proper gas/temperature conditions outside the incubator. Conventional mini-incubators might suffer from stray fields produced by heating elements. We report an in vitro electric and magnetic fields (EMF) exposure system embedded inside a novel under-the-microscope mini-CO₂-incubator with a unique design to avoid electromagnetic interference from the heating and circulation functions while ensuring the requisite temperature. A unique, reconfigurable array of electrodes and/or coils excited by calculated current distributions among array elements is designed to provide excellent field uniformity and controllable linear or circular polarization (even at very low frequencies) of the EMF within the cell culture. Using standard biochemical assays, long-term cell viability has been verified and compared with a conventional incubator. Cell orientation/migration in three-dimensional culture made of collagen-hydrogels has been successfully observed in vitro, in long-term, and in real-time under the influence of DC electric fields with the device.</p>","PeriodicalId":8956,"journal":{"name":"Bioelectromagnetics","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41117934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel nonsurgical therapy for peri-implantitis using focused pulsed electromagnetic field: A pilot randomized double-blind controlled clinical trial","authors":"Yaniv Mayer DMD,&nbsp;Juan Khoury DMD,&nbsp;Jacob Horwitz,&nbsp;Ofir Ginesin MSc,&nbsp;Luigi Canullo PhD,&nbsp;Eran Gabay PhD,&nbsp;Hadar Z. Giladi PhD","doi":"10.1002/bem.22481","DOIUrl":"10.1002/bem.22481","url":null,"abstract":"<p>Pulsed electromagnetic field (PEMF) therapy modulates the immune response and is successfully used in orthopedics to treat osteoarthritis and improve bone regeneration. This may suggest that this treatment may consequently reduce peri-implant soft tissue inflammation and marginal bone loss. To compare clinical, radiographic, and immunological results following nonsurgical treatment for peri-implantitis with or without PEMF therapy. Patients with peri-implantitis were included: pocket probing depth (PPD) between 6 and 8 mm with bleeding on probing (BOP); crestal bone loss between 3 and 5 mm. A novel healing abutment that contained active (test) or inactive (control) PEMF was connected. PEMF was administered via the abutment at exposure ratio of 1/500–1/5000, intensity: 0.05–0.5 mT, frequency: 10–50 kHz for 30 days. Nonsurgical mechanical implant surface debridement was performed. Patients were examined at baseline, 1 and 3 months. Clinical assessment included: plaque index, BOP, PPD, recession, and bone crest level which was radiography measured. Samples of peri-implant crevicular fluid were taken to analyze interleukin-1β (IL-1β). Twenty-three patients (34 implants; 19 control, 15 test) were included. At the follow-up, mean crestal bone loss was lower in the test group at 1 and 3 months (2.48 mm vs. 3.73 mm, <i>p</i> &lt; 0.05 and 2.39 vs. 3.37, <i>p</i> &lt; 0.01). IL-1β levels were also lower in the test group at 2 weeks (72.86 pg/mL vs. 111.7, <i>p</i> &lt; 0.05). Within all the limitation of this preliminary study, the test group improved clinical parameters after a short-term period compared to the control group.</p>","PeriodicalId":8956,"journal":{"name":"Bioelectromagnetics","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bem.22481","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10185802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of ultra-strong static magnetic field on the gut microbiota of humans and mice","authors":"Wen Zhao PhD,&nbsp;Yijuan Han PhD,&nbsp;Dongyan Shao PhD,&nbsp;Cuicui Han PhD,&nbsp;Yixiao Tian PhD,&nbsp;Qingsheng Huang PhD","doi":"10.1002/bem.22482","DOIUrl":"10.1002/bem.22482","url":null,"abstract":"<p>To explore the effect of ultra-strong static magnetic field on gut microbiota, 16 T static magnetic field was used to study the changes in the structure and composition of human and mouse gut microbiota in this environment. In the mouse gut microbiota, at the genus level, the magnetic field significantly decreased the relative abundances of <i>Escherichia-Shigella, Lactobacillus, Enterococcus, Burkholderia-Caballeronia-Paraburkholderia, Parasutterella</i>, and <i>Ralstonia</i> and significantly increased those of <i>Parabacteroides, Alloprevotella, Alistipes, Odoribacter, Bacteroides, Mucispirillum, Sutterella</i>, and <i>Prevotellaceae_UCG-001</i>. Similarly, at the genus level, the relative abundances of <i>Bacteroides</i>, <i>Parabacteroides, Romboutsia, and Streptococcus</i> significantly decreased in the human gut microbiota. Contrary to the changing trend of the abundance in the mouse gut, the abundances of <i>Bacteroides</i> and <i>Parabacteroides</i> in the human gut were significantly reduced under magnetic field. The BugBase phenotypic prediction analysis showed that the relative abundances of five phenotypes, including anaerobism, mobile elements, potential pathogenicity, stress-tolerant, and biofilm formation, changed significantly in the mouse gut microbiota, while the relative abundances of two phenotypes, including Gram-positive and Gram-negative phenotypes, changed significantly in the human gut microbiota. The 16 T magnetic field could differently affect the composition, structure, and phenotypes of gut microbiota in human and mice, suggesting the importance of model selection in studying the biological effects of magnetic field.</p>","PeriodicalId":8956,"journal":{"name":"Bioelectromagnetics","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10129956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}