Bioactive Materials最新文献

{"title":"Shape memory hydrogels in tissue engineering: Recent advances and challenges","authors":"Abid Naeem ,&nbsp;Chengqun Yu ,&nbsp;Lili Zhou ,&nbsp;Yingqiu Xie ,&nbsp;Yuhua Weng ,&nbsp;Yuanyu Huang ,&nbsp;Mengjie Zhang ,&nbsp;Qi Yang","doi":"10.1016/j.bioactmat.2025.08.009","DOIUrl":"10.1016/j.bioactmat.2025.08.009","url":null,"abstract":"<div><div>Shape memory hydrogels (SMHs) have emerged as transformative materials in tissue engineering, owing to their unique ability to recover their original shape after deformation. These hydrogels combine hydrophilicity and elasticity with shape memory capabilities, making them ideal candidates for various biomedical applications. This review examines their innovative design and synthesis, highlighting the physical and biological characteristics that make them well-suited for tissue engineering, such as mechanical properties, biocompatibility, and biodegradability. SMHs have diverse applications in tissue engineering, including bone regeneration, soft tissue reconstruction, and the engineering of vascular and neural tissues. Additionally, they are utilized in smart drug delivery systems and the fabrication of 3D-printed customized implants. Despite these advancements, challenges such as production scalability, optimization of mechanical properties, shape recovery and fixation, controlled degradation, and long-term stability persist. Interdisciplinary approaches are crucial for overcoming these challenges and enhancing their clinical potential. In conclusion, SMHs offer innovative solutions to complex biomedical problems, making them valuable tools for advancing regenerative medicine and improving patient outcomes.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"54 ","pages":"Pages 215-247"},"PeriodicalIF":18.0,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144864916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lithium fine-tunes biodegradation of Zn-based implant to promote osseointegration through immunomodulation","authors":"Danni Shen ,&nbsp;Wei Qiao ,&nbsp;Xiaoxue Xu ,&nbsp;Shery L.Y. Chang ,&nbsp;Thomas E. Lockwood ,&nbsp;Wenting Li ,&nbsp;Parkarsh Kumar ,&nbsp;Jie Shen ,&nbsp;Jun Wu ,&nbsp;Feihong Liu ,&nbsp;Kelvin W.K. Yeung ,&nbsp;Yufeng Zheng","doi":"10.1016/j.bioactmat.2025.08.011","DOIUrl":"10.1016/j.bioactmat.2025.08.011","url":null,"abstract":"<div><div>The intricate degradation dynamics exhibited by biodegradable alloys significantly influence host responses during the implantation process, posing challenges in achieving stable osseointegration. It is thus critical to tailor the biodegradation profiles of these implants to establish a conductive tissue microenvironment for bone tissue regeneration. In this study, we demonstrate that Zn-Li alloy forms a layer of Li-containing degradation products at the bone-implant interface to accommodate the bone regeneration process. During the early inflammatory phase, the controlled release of lithium ions (Li⁺) and zinc ions (Zn²⁺) from the alloy induces chemokine (C-C motif) ligand 5 (CCL5) production from macrophages, which promotes the recruitment and differentiation of osteoblastic lineage cells. As a protective bone-implant interface is formed subsequently, the active Zn²⁺ release from Zn-Li alloy is suppressed while Li⁺ continues to exhibit anti-inflammatory effects and inhibit osteoclastogenesis. Therefore, the presence of Li in Zn-based alloy prevents the prolonged inflammation and fibrous capsulation typically seen in pure Zn implants. Our findings offer valuable insights into the development of novel biodegradable implants aimed at achieving osseointegration through bioadaption.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"54 ","pages":"Pages 201-214"},"PeriodicalIF":18.0,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144860793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-assembled hybrid hydrogel microspheres create a bone marrow-mimicking niche for bone regeneration","authors":"Zhi He ,&nbsp;Peilun Hu ,&nbsp;Zifan Li ,&nbsp;Kaige Mao ,&nbsp;Jingchuan Zheng ,&nbsp;Chun-Yi Yang ,&nbsp;Yuyang Luo ,&nbsp;Jia Yang ,&nbsp;Zheng Cao ,&nbsp;Jingsong Lu ,&nbsp;Xiaobin Luo ,&nbsp;Sengpav Tong ,&nbsp;Zhijun He ,&nbsp;Kunkoo Kim ,&nbsp;Yaosai Liu ,&nbsp;Xiaodan Sun ,&nbsp;Lingyun Zhao ,&nbsp;Yongwei Pan ,&nbsp;Yongping Cao ,&nbsp;Yu Wang ,&nbsp;Xiumei Wang","doi":"10.1016/j.bioactmat.2025.08.003","DOIUrl":"10.1016/j.bioactmat.2025.08.003","url":null,"abstract":"<div><div>Bone marrow (BM), a natural niche rich in growth factors and bone marrow mesenchymal stem cells (BMSCs), provides an optimal regenerative microenvironment and is widely used in clinical applications. However, the limited proliferative capacity of BMSCs and the mismatch between bone regeneration and growth factors release constrain their effectiveness in treating critical bone defects. Drawing inspiration from the regenerative properties of BM, we developed self-assembled hybrid microspheres to replicate its function and address these challenges through a tissue engineering approach. This BM-mimicking niche enriched BMSCs via fast-degrading gelatin methacryloyl (GelMA) microspheres, which were loaded with exogenous BMSCs and conjugated with stem cell homing peptides (SKP) to recruit endogenous BMSCs. SKP further enhanced the stemness of BMSCs, thereby promoting angiogenesis and resolving inflammation. Slow-degrading chitosan methacryloyl (ChitoMA) microspheres facilitated sustained release of angiogenic (KLT) and osteogenic (OGP) peptides, supporting blood vessel maturation and osteogenesis. The early release of BMSCs and SKP, followed by the subsequent release of OGP and KLT, aligned with the dynamic process of bone regeneration. In a rat critical femoral condyle defect model, the BM-mimicking niche formed an in-situ ossification center, significantly enhancing bone regeneration. This study introduces a novel BM-mimicking niche characterized by a BMSC-enriched environment and the sequential release of therapeutic factors, offering a promising strategy for treating critical bone defects.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"54 ","pages":"Pages 179-200"},"PeriodicalIF":18.0,"publicationDate":"2025-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144860794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Injectable sustained-release danshensu sodium-loaded nanoparticle hydrogel targets macrophages to improve myocardial microenvironment for myocardial infarction treatment","authors":"Jianqiu Yang ,&nbsp;Jing Wang ,&nbsp;Zhihua Zeng ,&nbsp;Zhenyu Chen ,&nbsp;Dingguo Wang ,&nbsp;Yongbing Wu","doi":"10.1016/j.bioactmat.2025.08.014","DOIUrl":"10.1016/j.bioactmat.2025.08.014","url":null,"abstract":"<div><div>Myocardial infarction (MI) induces cardiomyocyte necrosis, inflammation, fibrosis, and ventricular remodeling, leading to heart failure. To address this, we developed an intelligent cardiac patch, SMM@Gel, composed of a reactive oxygen species (ROS)-responsive PVA-TSPBA hydrogel matrix reinforced via solvent exchange and salting-out technology, loaded with mannose-functionalized, danshensu sodium-loaded hollow mesoporous polydopamine nanoparticles (Sa@mPDA-Man). This design makes sustained drug release and ROS scavenging come true. In vitro, studies demonstrated SMM@Gel promoted endothelial tube formation (24 ± 3 nodes vs. 6 ± 2 in controls) and M2 macrophage polarization (CD206+ cells) while reducing inflammation (iNOS downregulation). In vivo, experiments in MI rats revealed SMM@Gel preserved left ventricular ejection fraction (LVEF: 52.3 % ± 4.1 % vs. 38.5 % ± 3.2 % in the saline group), normalized ventricular dimensions (EDV/ESV) and enhanced wall thickness. Histological analysis showed reduced infarct size (18.7 % ± 2.5 % vs. 32.1 % ± 3.8 %), decreased inflammation, and improved neovascularization. RNA-seq identified pathways linked to angiogenesis, inflammation resolution, and extracellular matrix remodeling. These findings highlight SMM@Gel's potential as a dual-action therapy for MI, combining ROS scavenging, anti-inflammatory effects, and angiogenic promotion to mitigate post-MI remodeling and preserve cardiac function.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"54 ","pages":"Pages 159-178"},"PeriodicalIF":18.0,"publicationDate":"2025-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144858062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lactobacillus extracellular vesicle-driven oxygen-releasing photothermal hydrogel reprograms macrophages and promotes angiogenesis to accelerate diabetic wound healing","authors":"Pingyun Yuan ,&nbsp;Meng Deng ,&nbsp;Xueru Li ,&nbsp;Xiaotong Lu ,&nbsp;Hui Yang ,&nbsp;Ronghua Jin ,&nbsp;Lan Wang ,&nbsp;Mi Chen ,&nbsp;Tian Bai ,&nbsp;Tao Liu ,&nbsp;Wenhao Zhou ,&nbsp;Xiangdong Wang","doi":"10.1016/j.bioactmat.2025.08.010","DOIUrl":"10.1016/j.bioactmat.2025.08.010","url":null,"abstract":"<div><div>Chronic wound healing remains clinically challenging due to insufficient angiogenesis coupled with persistent inflammatory microenvironments. Macrophage M2 polarization plays a pivotal role in resolving inflammation and promoting angiogenesis. Capitalizing on scalability and translational advantages, extracellular vesicles derived from <em>Lactobacillus bulgaricus</em> (<em>Lac</em>-EVs) were employed to activate this mechanism. The anti-inflammatory and pro-angiogenic efficacy of <em>Lac</em>-EVs was initially confirmed through in vitro experiments. To support their delivery and function within the hostile diabetic wound microenvironment, a chitosan (CS)-based hydrogel incorporating haemoglobin (Hb)-polydopamine (PDA) complexes was engineered via Schiff base crosslinking with aldehyde-functionalised polyethylene glycol (CHO-PEG-CHO). This platform enabled stable delivery of <em>Lac</em>-EVs, supplemental oxygen release, and NIR-triggered photothermal functionality. In vitro studies demonstrated that the <em>Lac</em>-EVs-laden hydrogel (PCPH@<em>Lac</em>-EVs) effectively induced M2 macrophage polarization, enhanced endothelial cell migration, and promoted angiogenesis. In murine full-thickness diabetic wounds, PCPH@<em>Lac</em>-EVs combined with NIR irradiation achieved 99.3 % wound closure within 13 days, significantly outperforming untreated controls (72.3 %). Mechanistic analysis indicated that the accelerated healing resulted from synergistic enhancement of <em>Lac</em>-EV-mediated inflammation modulation and functional angiogenesis via oxygen release and mild photothermal stimulation. This study highlights the potential of <em>Lac</em>-EVs, delivered via a functional hydrogel, as a promising therapeutic strategy for diabetic wound treatment.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"54 ","pages":"Pages 144-158"},"PeriodicalIF":18.0,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144827765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CRCs-CAFs crosstalk-targeted nano-delivery system reprograms tumor microenvironment for oxaliplatin resistance reversing and liver metastasis inhibition in colorectal cancer","authors":"Heshi Liu ,&nbsp;Caina Xu ,&nbsp;Pai Wang ,&nbsp;Lei Guo ,&nbsp;Xiuzhang Yan ,&nbsp;Rui Zhou ,&nbsp;Yixin Tang ,&nbsp;Siyuan Wang ,&nbsp;Jie Chen ,&nbsp;Quan Wang ,&nbsp;Huayu Tian","doi":"10.1016/j.bioactmat.2025.08.002","DOIUrl":"10.1016/j.bioactmat.2025.08.002","url":null,"abstract":"<div><div>The five-year survival rate of patients with colorectal cancer (CRC) liver metastasis is less than 30 %, and chemotherapy resistance and metastatic microenvironment remodeling are the current treatment bottlenecks. Cancer-associated fibroblasts (CAFs) in the tumor microenvironment (TME) form a “CRCs-CAFs crosstalk” with colorectal cancer cells (CRCs) by secreting dense extracellular matrix (ECM), free fatty acids (FFA), and pro-metastatic factors, driving a vicious cycle of drug resistance and metastasis. During liver metastasis, hepatic stellate cells (HSCs)-derived CAFs (HSC-CAFs) promote tumor metastasis by remodeling the pre-metastatic microenvironment. Based on clinical sample RNA sequencing and mouse single-cell sequencing to reveal ECM signal enrichment and CAFs activation characteristics, we innovatively constructed a nano-delivery system using hyaluronic acid-modified MIL-100 nanoparticles (OEMH NPs) co-loaded with oxaliplatin (OXA) and epigallocatechin gallate (EGCG). This system can target the CRCs-CAFs crosstalk through CD44 receptor: on the one hand, OEMH NPs can inhibit CAFs activation and reduce ECM deposition, improve drug penetration and down-regulate FFA metabolic reprogramming, reverse OXA resistance; on the other hand, OEMH NPs can block the transformation of HSCs to CAFs, down-regulate pro-metastatic factors such as VEGF/IL-11/ANG, induce vascular normalization, and reprogram the pre-metastatic microenvironment. This strategy can simultaneously achieve primary lesion drug sensitization and liver metastasis inhibition, providing a new paradigm for the treatment of advanced colorectal cancer to break through the traditional treatment dilemma through dual reprogramming of metabolism and microenvironment, and has significant clinical translation potential.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"54 ","pages":"Pages 126-143"},"PeriodicalIF":18.0,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144827764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stable, bioactive hydrogel coating on silicone surfaces for non-invasive decontamination via photochemical treatment","authors":"Romina Berger ,&nbsp;Alina Rahtz ,&nbsp;Alexander Schweigerdt ,&nbsp;Daniel D. Stöbener ,&nbsp;Andrea Cosimi ,&nbsp;Wibke Dempwolf ,&nbsp;Henning Menzel ,&nbsp;Sonja Johannsmeier ,&nbsp;Marie Weinhart","doi":"10.1016/j.bioactmat.2025.07.052","DOIUrl":"10.1016/j.bioactmat.2025.07.052","url":null,"abstract":"<div><div>Polydimethylsiloxane (PDMS) is widely used in biomedical applications due to its biocompatibility, chemical stability, flexibility, and resistance to degradation in physiological environments. However, its intrinsic inertness limits further (bio)functionalization, and its hydrophobic recovery compromises the longevity of conventional surface modifications. To address these challenges, we developed a nanoprecipitation method for the straightforward colloidal deposition, covalent thermal crosslinking, and surface anchoring of a chemically tunable, biocompatible polyacrylamide with reactive hydroxyl groups, enabling further surface modifications. This polymer incorporates ∼6 % bioinspired catechol units, introduced via an elegant one-pot Kabachnik-Fields reaction, to facilitate thermally induced network formation and enhance adhesion to plasma-activated PDMS. The resulting uniform coatings exhibited tunable dry layer thicknesses up to 44 ± 7 nm and effectively suppressed PDMS chain rearrangement even after steam autoclaving, ensuring long-term stability in aqueous and ambient environments for at least 90 days.</div><div>The bioactive post-modification potential was demonstrated in a proof-of-concept study by immobilizing the photosensitizer <em>rose bengal</em> at surface concentrations of 20 or 40 μg cm⁻². The coating exhibited antimicrobial activity against <em>S. aureus</em>, achieving a 4-log reduction (99.99 %) in colony-forming units after 30 min of irradiation at 554 nm (342 J cm⁻²), even when bacteria were suspended in liquid, without direct surface contact. In contrast, antimicrobial activity against <em>E. coli</em> was only observed with minimized liquid volume, bringing the motile bacteria into close contact with the surface.</div><div>This work established a straightforward and versatile strategy for the stable and bioactive functionalization of PDMS surfaces for application in non-invasive surface decontamination.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"54 ","pages":"Pages 86-102"},"PeriodicalIF":18.0,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144827821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioinspired porous core-shell microspheres with spatiotemporal delivery coordinate immunomodulatory-osteogenic coupling via NF-κB/P-STAT6 and Rho/MAPK signaling for enhanced calvarial regeneration","authors":"Jiahe Zheng ,&nbsp;Chengrun Li ,&nbsp;Qingxia Zhang ,&nbsp;Tao Ou ,&nbsp;Linlong Li ,&nbsp;Pengfei Yu ,&nbsp;Shujuan Wei ,&nbsp;Guige Hou ,&nbsp;Huanhuan Yan","doi":"10.1016/j.bioactmat.2025.08.005","DOIUrl":"10.1016/j.bioactmat.2025.08.005","url":null,"abstract":"<div><div>Critical-sized calvarial defects remain a formidable clinical challenge due to dyssynchronous immunomodulation-osteogenesis coupling and unregulated growth factor release. Here, a bioinspired porous core-shell microsphere system (GCI@HPPS) is developed, integrating hydroxyapatite (HA)-loaded shell, surface-immobilized SDF-1α, and IGF-1-encapsulated cores to immunomodulate osteoimmune microenvironment and osteogenesis promotion. The hierarchical architecture achieved spatiotemporally programmed release: HA degradation-dependent mineralization, SDF-1α-mediated BMSC chemotaxis, and sustained IGF-1 delivery, mimicking natural bone repair cascades. Dual covalent/guest-host crosslinking (GelMA/Ac-β-CD) enhanced compressive strength, while polydopamine functionalization of microspheres conferred electroactivity, hydrophilicity, ROS/RNS scavenging (97.29 % ABTS•+ elimination), antibacterial efficacy (&gt;99.8 %) and hemostasis. <em>In vitro</em>, GCI@HPPS mitigates oxidative stress, induces M2 macrophage polarization, and suppresses inflammatory cascades while concomitantly enhancing endogenous BMSC recruitment, proliferation, and osteogenic differentiation. Proteomics revealed a tetradic anti-inflammatory mechanisms of GCI@HPPS: NF-κB/P-JNK suppression, pro-inflammatory cytokines downregulation, mitochondrial oxidative modulation, and STAT6-driven M2 polarization. <em>In vivo</em>, GCI@HPPS achieved calvarial defect closure at 8 weeks through porous matrix-guided cellular infiltration, and SDF-1α/IGF-1-mediated chemotaxis, Rho/MAPK signaling pathway activation balancing osteoclast-osteoblast dynamics, stage-specific osteogenic induction and AGE-RAGE/VEGF-coupled angiogenesis-osteogenesis. This work pioneers a spatiotemporal delivery paradigm that coordinates inflammation modulation, stem cell recruitment, osteogenic differentiation, and mineralization phases, offering a promising approach for complex cranial reconstruction.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"54 ","pages":"Pages 103-125"},"PeriodicalIF":18.0,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144827763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tannic acid-loaded zinc- and copper-doped mesoporous bioactive glass nanoparticles: Potential antioxidant nanocarriers for wound healing","authors":"Sara Pourshahrestani ,&nbsp;Irem Unalan ,&nbsp;Ehsan Zeimaran ,&nbsp;Zhiyan Xu ,&nbsp;Judith A. Roether ,&nbsp;Andrea Kerpes ,&nbsp;Christina Janko ,&nbsp;Christoph Alexiou ,&nbsp;Aldo R. Boccaccini","doi":"10.1016/j.bioactmat.2025.07.046","DOIUrl":"10.1016/j.bioactmat.2025.07.046","url":null,"abstract":"<div><div>Polyphenols such as tannic acid (TA) with antibacterial and antioxidant activities have recently attracted significant attention for wound healing applications. Mesoporous bioactive glass nanoparticles (MBGNs) have also garnered considerable interest to be employed as nanocarriers of therapeutic biomolecules. This study focuses on the fabrication of TA-loaded MBGNs which were doped with two well-known biologically active elements, copper (Cu) and zinc (Zn). The effect of TA loading on the antioxidant and biological properties of the nanoparticles was investigated in the context of potential wound healing applications. As proven with various techniques, TA was successfully loaded on CuMBGNs and ZnMBGNs. With increasing TA concentration, the phenolic content in the nanoparticles was found to increase and CuMBGNs-TA and ZnMBGNs-TA were found to possess 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity. The nanoparticles not only showed biocompatibility towards normal human dermal fibroblast (NHDF) cells, but they were also found to be hemocompatible. In comparison to CuMBGNs-TA leachates resulting in <em>in vitro</em> wound closure rate of ∼66 %–∼83 %, the dissolution products of ZnMBGNs-TA led to higher wound closure rate (&gt;90 %). Our results demonstrate that CuMBGNs or ZnMBGNs are suitable nanocarriers for antioxidant TA and are candidates to promote wound healing.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"54 ","pages":"Pages 71-85"},"PeriodicalIF":18.0,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144827820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photocatalytic CO-releasing spray hydrogel for in situ postoperative cancer treatment","authors":"Zaiyan Wang ,&nbsp;Jianxiang Zhu ,&nbsp;Bobin Mi ,&nbsp;Ming Ni ,&nbsp;Yuming Xue ,&nbsp;Yiling Deng ,&nbsp;Lu Chen ,&nbsp;Xiangyang Xu ,&nbsp;Xiaoyan Li ,&nbsp;Guohui Liu ,&nbsp;Tao Yu","doi":"10.1016/j.bioactmat.2025.07.024","DOIUrl":"10.1016/j.bioactmat.2025.07.024","url":null,"abstract":"<div><div>The high invasiveness and metastatic potential of breast cancer increase the risk of postoperative recurrence. To address this issue, a composite hydrogel drug delivery system based on sodium alginate (SA) has been developed for the in situ release of carbon monoxide (CO) at the tumor resection site. This system aims to enhance the effectiveness of chemotherapy and improve the clearance of residual tumor cells after surgery, thereby preventing tumor recurrence and metastasis. A gold nanoparticle-modified g-C₃N₄ nanophotocatalyst (C₃N₄/Au) has been designed to convert CO₂ within the tumor into CO under visible light irradiation. The C₃N₄/Au is loaded into an SA hydrogel and applied to the postoperative incision in a spray form. The rapid crosslinking reaction between SA and Ca²⁺ forms a network structure, enabling precise drug delivery. CO is generated in situ in the postoperative tumor tissue under light stimulation and is combined with folic acid (FA) modified doxorubicin (DOX) micelles (FA@DM) to achieve effective synergy between CO therapy and chemotherapy. The composite hydrogel drug delivery system not only increases the concentration of CO within the tumor and reduces systemic toxicity but also enhances the effectiveness of chemotherapy by increasing oxidative stress within tumor cells. It provides a new and safe strategy for efficient and precise postoperative tumor treatment, reducing the risk of tumor recurrence and metastasis.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"53 ","pages":"Pages 893-907"},"PeriodicalIF":18.0,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144826873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}