Bioactive Materials最新文献

{"title":"Artificial multienzyme nanoflower composite hydrogel for efficiently promoting MRSA-infected diabetic wound healing via glucose-activated NO releasing and microenvironment regulation","authors":"Hui Ma ,&nbsp;Yuanhao Luo ,&nbsp;Yifu Wang ,&nbsp;Yi Hao ,&nbsp;Jinjin Li ,&nbsp;Xiaolan Gao ,&nbsp;Yamin Xiong ,&nbsp;Leiliang He","doi":"10.1016/j.bioactmat.2025.03.014","DOIUrl":"10.1016/j.bioactmat.2025.03.014","url":null,"abstract":"<div><div>Diabetic wound repair is a global challenge due to bacterial infection and the typical microenvironments of hyperglycemia, high pH value, hypoxia, persistent inflammation and insufficient angiogenesis. Herein, a glucose-activated nitric oxide (NO) releasing and microenvironment regulation hydrogel dressing (COH-GB) has been developed for efficiently promoting infectious diabetic wound healing. Specifically, an artificial multienzyme nanoflower (GB nanoflower) composed of glucose oxidase (GOx) and hemoglobin (Hb) was synthesized and incorporated into the hydrogel formed by carboxymethyl chitosan (CMCS), oxidized sodium alginate (OSA) and hydroxyurea (HU). In which, the hyperglycemia-triggered cascade reaction could consume glucose, while providing hydrogen peroxide (H₂O₂) for the generation of NO by HU in the presence of Hb with peroxidase-mimicking activity. The COH-GB hydrogel with essential wound dressing characteristics could remodel the microenvironment of diabetic wounds by reducing local glucose and pH levels, alleviating hypoxia, and scavenging excessive ROS; and releasing NO under different blood glucose levels for antibacterial or angiogenesis. Importantly, the prepared COH-GB hydrogel significantly accelerated the MRSA-infected diabetic wound healing by effectively reducing wound infection, inhibiting inflammation, and promoting collagen deposition, angiogenesis and the migration and differentiation of fibroblasts and keratinocytes. Notably, the formation of GB nanoflowers could enhance the activity and stability of enzymes, and improve the cascade reaction efficiency, thereby inducing a more efficient performance in microenvironment regulation, antibacterial and angiogenesis, as well as wound healing. Hence, the prepared artificial multienzyme nanoflower composite hydrogel provides an efficient and secure dressing for promoting infectious diabetic wound healing via glucose-activated NO releasing and microenvironment regulation.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"49 ","pages":"Pages 531-548"},"PeriodicalIF":18.0,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive vascular buds promote collateral vessel formation by grafting on the artificial vessel walls","authors":"Yulian Yang ,&nbsp;Yonghao Qiu ,&nbsp;Shijing Xu ,&nbsp;Huichang Gao ,&nbsp;Chunhui Wang ,&nbsp;Haohui Huang ,&nbsp;Zhengyu Yang ,&nbsp;Xiaofeng Chen ,&nbsp;Fujian Zhao","doi":"10.1016/j.bioactmat.2025.03.015","DOIUrl":"10.1016/j.bioactmat.2025.03.015","url":null,"abstract":"<div><div>Vascular injury and some chronic ischemic lesions usually lead to insufficient blood supply to tissues, which will lead to tissue ischemia or even necrosis in severe cases. Current artificial blood vessels lack effective collateral vascularization capabilities to provide adequate blood supply in areas with restricted blood flow. Herein, inspired by the grafting of tree buds to form lateral branches, the vascular buds model was successfully constructed by inoculating HUVECs into bioactive hydrogel microspheres. Under the influence of ions dissolved from bioactive glass and three-dimensional culture environment, the cytoskeleton was remodeled, the cells showed obvious outward migration and budding trend, which significantly enhanced the angiogenesis ability. After grafted vascular buds to the lateral wall of the artificial blood vessel, a large number of collateral vessels are formed, which effectively alleviates the tissue ischemia in the region through which blood vessels pass. This study confirms the impact of bioactive ions on angiogenesis in a three-dimensional environment and offers novel insights for the development of lateral branches in artificial blood vessels.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"49 ","pages":"Pages 564-575"},"PeriodicalIF":18.0,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exosomes from young plasma stimulate the osteogenic differentiation and prevent osteoporosis via miR-142-5p","authors":"Zhikun Li ,&nbsp;Qifeng Yu ,&nbsp;Xiang Cui ,&nbsp;Yi Wang ,&nbsp;Ruijun Xu ,&nbsp;Renjie Lu ,&nbsp;Jiahao Chen ,&nbsp;Xiaohan Zhou ,&nbsp;Chi Zhang ,&nbsp;Lanya Li ,&nbsp;Wei Xu","doi":"10.1016/j.bioactmat.2025.03.012","DOIUrl":"10.1016/j.bioactmat.2025.03.012","url":null,"abstract":"<div><div>Osteoporosis (OP) is a multifactorial metabolic bone disorder commonly observed in the elderly, particularly prevalent in postmenopausal women. However, many conventional anti-osteoporosis drugs have undesirable side effects, limiting their long-term use. Here, we demonstrated that exosomes derived from both young and old healthy human plasma, which exhibited similar morphology, could significantly enhance the proliferation and migration of mesenchymal stem cells (MSCs). Furthermore, treatment with these exosomes increased alkaline phosphatase (ALP) activity, enhanced the mineralization of MSCs, and decreased the number of osteoclasts in vitro. When intravenously injected into rats, these exosomes accumulated in bone tissue. In vivo experiments demonstrated that both types of exosomes had a beneficial effect on osteoporosis by facilitating bone formation and suppressing osteoclast differentiation in an ovariectomized (OVX)-induced osteoporotic rat model. Strikingly, exosomes derived from young healthy human plasma exhibited stronger anti-osteoporosis effect. The miRNA sequencing analysis showed that miR-142-5p expression was significantly higher in the exosomes from young healthy adult plasma compared to in exosomes from older controls. Importantly, miR-142-5p overexpression exerted similar pro-osteogenic effects to those of exosomes from young healthy human plasma, while miR-142-5p downregulation had the opposite effect on osteogenic differentiation of MSCs. The anti-osteoporosis effect of exosomes from young healthy adult plasma were reversed upon miR-142-5p inhibition. In addition, ZFPM2 was a potential target of miR-142-5p involved in osteoporosis. Therefore, our study reveals the potential anti-osteoporosis effects of plasma exosomes and their underlying mechanisms, thereby providing an effective therapeutic strategy for clinical treatment of osteoporosis.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"49 ","pages":"Pages 502-514"},"PeriodicalIF":18.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exosomes derived from MSCs exposed to hypoxic and inflammatory environments slow intervertebral disc degeneration by alleviating the senescence of nucleus pulposus cells through epigenetic modifications","authors":"Yongzhao Zhao ,&nbsp;Longting Chen ,&nbsp;Shuai Jiang ,&nbsp;Zhenquan Wu ,&nbsp;Qian Xiang ,&nbsp;Jialiang Lin ,&nbsp;Shuo Tian ,&nbsp;Zhuoran Sun ,&nbsp;Chuiguo Sun ,&nbsp;Weishi Li","doi":"10.1016/j.bioactmat.2025.02.046","DOIUrl":"10.1016/j.bioactmat.2025.02.046","url":null,"abstract":"<div><div>Intervertebral disc degeneration (IDD) is the leading cause of low back pain, which places heavy burdens on society and individuals. Surgical intervention is the conventional therapy for IDD, but patients who undergo surgery face relatively high risks of recurrence and complications. Therefore, a relatively less invasive and efficient treatment for IDD is urgently needed. In this study, we constructed a novel nanobiomaterial, named Hi-Exos, to slow IDD. Hi-Exos are exosomes derived from mesenchymal stem cells exposed to hypoxic and inflammatory environments. Hi-Exos could relieve the senescence of nucleus pulposus cells and slow IDD through an epigenetic modification mechanism by introducing the epigenetic factor miR-221-3p into senescent nucleus pulposus cells to reduce DDIT4 expression and inhibit the activation of NF-κB signalling pathway. This study provided a novel strategy for IDD treatment involving the use of Hi-Exos to deliver miR-221-3p to reduce the senescence of nucleus pulposus cells and repair IDD via epigenetic modifications.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"49 ","pages":"Pages 515-530"},"PeriodicalIF":18.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"End-tail soaking strategy toward robust and biomimetic sandwich-layered hydrogels for full-thickness bone regeneration","authors":"Jianyang Shan ,&nbsp;Liang Cheng ,&nbsp;Xiang Li ,&nbsp;Wenhao Liu ,&nbsp;Zhihua Liu ,&nbsp;Yimin Chai ,&nbsp;Yaling Yu ,&nbsp;Xing Wang ,&nbsp;Gen Wen","doi":"10.1016/j.bioactmat.2025.02.045","DOIUrl":"10.1016/j.bioactmat.2025.02.045","url":null,"abstract":"<div><div>Despite an increasing number of tissue-engineered scaffolds have been developing for bone regeneration, simple and universal fabrication of biomimetic bone microstructure to repair full-thickness bone defects remains a challenge and an acute clinical demand due to the negligence of microstructural differences within the cortex of cancellous bone. In this work, a biomimetic sandwich-layered PACG-CS@Mn(III) hydrogel (SL hydrogel) was facilely fabricated in an end-tail soaking strategy by simply post-crosslinking of poly(acryloyl 2-glycine)-chitosan (PACG-CS) composite hydrogel using trivalent manganese solutions. Taking the merits of <em>in-situ</em> formation and flexible adjustment of chain entanglements, hydrogen bonds and metal chelate interactions, SL hydrogel with sandwich-like three-layered structures and anisotropic mechanical performance was easily customized through control of the manganese concentration and soaking time in fore-and-aft sides, simulating the structurally and mechanically biomimetic characteristics of cortical and cancellous bone. Furthermore, the produced SL hydrogel also demonstrated favorable biocompatibility and enhanced MnSOD activity via a peroxidase-like reaction, which enabled the excellent radical scavenging efficiency and anti-inflammatory regulation for facilitating the activity, proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). <em>In vivo</em> studies further revealed that these SL hydrogels achieved restrictive pro-vascular regeneration through their stratified structure, thereby promoting the differentiation of osteoblasts. Simultaneously, the mechanical cues of stratified structure could mediate macrophage phenotype transitions in accordance with stem cell-osteoblast differentiation process via the PI3K-AKT pathway, resulting in robust osteogenesis and high-quality bone reconstruction. This facile yet efficient strategy of turning anisotropic hydrogel offers a promising alternative for full-thickness repair of bone defects, which is also significantly imperative to achieve high-performance scaffolds with specific usage requirements and expand their clinic applicability in more complex anisotropic tissues.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"49 ","pages":"Pages 486-501"},"PeriodicalIF":18.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The revolutionary role of placental derivatives in biomedical research","authors":"Saeid Moghassemi ,&nbsp;Saba Nikanfar ,&nbsp;Arezoo Dadashzadeh ,&nbsp;Maria João Sousa ,&nbsp;Yuting Wan ,&nbsp;Fengxuan Sun ,&nbsp;Arthur Colson ,&nbsp;Sven De Windt ,&nbsp;Lena Kwaspen ,&nbsp;Marc Kanbar ,&nbsp;Keyvan Sobhani ,&nbsp;Jie Yang ,&nbsp;Hanne Vlieghe ,&nbsp;Yongqian Li ,&nbsp;Frédéric Debiève ,&nbsp;Christine Wyns ,&nbsp;Christiani A. Amorim","doi":"10.1016/j.bioactmat.2025.03.011","DOIUrl":"10.1016/j.bioactmat.2025.03.011","url":null,"abstract":"<div><div>The human placenta is a transient yet crucial organ that plays a key role in sustaining the relationship between the maternal and fetal organisms. Despite its historical classification as “biowaste,\" placental tissues have garnered increasing attention since the early 1900s for their significant medical potential, particularly in wound repair and surgical application. As ethical considerations regarding human placental derivatives have largely been assuaged in many countries, they have gained significant attention due to their versatile applications in various biomedical fields, such as biomedical engineering, regenerative medicine, and pharmacology. Moreover, there is a substantial trend toward various animal product substitutions in laboratory research with human placental derivatives, reflecting a broader commitment to advancing ethical and sustainable research methodologies. This review provides a comprehensive examination of the current applications of human placental derivatives, explores the mechanisms behind their therapeutic effects, and outlines the future potential and directions of this rapidly advancing field.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"49 ","pages":"Pages 456-485"},"PeriodicalIF":18.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143643307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protein to biomaterials: Unraveling the antiviral and proangiogenic activities of Ac-Tβ1-17 peptide, a thymosin β4 metabolite, and its implications in peptide-scaffold preparation","authors":"Khandoker Asiqur Rahaman ,&nbsp;Md Sofequl Islam Mukim ,&nbsp;Md Lemon Hasan ,&nbsp;Hyeok Kim ,&nbsp;Cheol-Ho Pan ,&nbsp;Oh-Seung Kwon ,&nbsp;Dae-Geun Song ,&nbsp;Hyung-Seop Han","doi":"10.1016/j.bioactmat.2025.02.008","DOIUrl":"10.1016/j.bioactmat.2025.02.008","url":null,"abstract":"<div><div>Peptide metabolites are emerging biomolecules with numerous possibilities in biomaterial-based regenerative medicine due to their inherent bioactivities. These small, naturally occurring compounds are intermediates or byproducts of larger proteins and peptides, and they can have profound effects, such as antiviral therapeutics, proangiogenic agents, and regenerative medicinal applications. This study is among the first to focus on using thymosin β4 protein-derived metabolites to pioneer novel applications for peptide metabolites in biomaterials. This study found that the novel peptide metabolite acetyl-thymosin β4 (amino acid 1–17) (Ac-Tβ_1-17) exhibited significant protease inhibition activity against SARS-CoV-2, surpassing its precursor protein. Additionally, Ac-Tβ_1-17 demonstrated beneficial effects, such as cell proliferation, wound healing, and scavenging of reactive oxygen species (ROS) in human umbilical vein endothelial cells (HUVEC). Integrating Ac-Tβ_1-17 into a peptide-based scaffold facilitated cell growth and angiogenesis inside the scaffold and through gradual release into the surrounding environment. The Ac-Tβ_1-17 peptide treatment induced significant biochemical responses in HUVEC, increasing Akt, ERK, PI3K, MEK, and Bcl-2 gene expression and proangiogenic proteins. Ac-Tβ_1-17 peptide treatment showed similar results in ex vivo by enhancing mouse fetal metatarsal growth and angiogenesis. These findings highlight the potential of natural protein metabolites to generate biologically active peptides, offering a novel strategy for enhancing biomaterial compatibility. This approach holds promise for developing therapeutic biomaterials using peptide metabolites, presenting exciting prospects for future research and applications.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"49 ","pages":"Pages 437-455"},"PeriodicalIF":18.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143643238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The paradigm shifts of periodontal regeneration strategy: From reparative manipulation to developmental engineering","authors":"Guanqi Liu ,&nbsp;Junlong Xue ,&nbsp;Xuan Zhou ,&nbsp;Mixiao Gui ,&nbsp;Ruidi Xia ,&nbsp;Yanshu Zhang ,&nbsp;Yihua Cai ,&nbsp;Shuhua Li ,&nbsp;Songtao Shi ,&nbsp;Xueli Mao ,&nbsp;Zetao Chen","doi":"10.1016/j.bioactmat.2025.03.009","DOIUrl":"10.1016/j.bioactmat.2025.03.009","url":null,"abstract":"<div><div>Ideal periodontal regeneration requires the integration of alveolar bone, periodontal ligament, and cementum, along with Sharpey's fibers for occlusal force resistance. However, physiological regeneration remains rare due to its intricate structure, making clinical regeneration a challenge. Periodontal ligament stem cells (PDLSCs), first isolated in 2004, hold the key to multi-directional differentiation into cementoblasts, fibroblasts, and osteoblasts. While traditional therapies like guided tissue regeneration (GTR) aim to activate PDLSCs, clinical outcomes are inconsistent, suggesting the need for additional strategies to enhance PDLSCs' functions. Advancements in molecular biotechnology have introduced the use of recombinant growth factors for tissue regeneration. However, maintaining their efficacy requires high doses, posing cost and safety issues. Multi-layered scaffolds combined with cell sheet technology offer new insights, but face production, ethical, and survival challenges. Immune regulation plays a crucial role in PDLSC-mediated regeneration. The concept of “coagulo-immunomodulation” has emerged, emphasizing the coupling of blood coagulation and immune responses for periodontal regeneration. Despite its potential, the clinical translation of immune-based strategies remains elusive. The “developmental engineering” approach, which mimics developmental events using embryonic-stage cells and microenvironments, shows promise. Our research group has made initial strides, indicating its potential as a viable solution for periodontal complex regeneration. However, further clinical trials and considerations are needed for successful clinical application. This review aims to summarize the strategic transitions in the development of periodontal regenerative materials and to propose prospective avenues for future development.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"49 ","pages":"Pages 418-436"},"PeriodicalIF":18.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143642216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulating macrophage glucose metabolism homeostasis via mitochondrial rheostats by short fiber-microsphere scaffolds for bone repair","authors":"Pengzhen Zhuang ,&nbsp;Yu Chen ,&nbsp;Yu Zhang ,&nbsp;Wu Yang ,&nbsp;Guilai Zuo ,&nbsp;Jessica M. Rosenholm ,&nbsp;Zhongmin Wang ,&nbsp;Juan Wang ,&nbsp;Wenguo Cui ,&nbsp;Hongbo Zhang","doi":"10.1016/j.bioactmat.2025.03.008","DOIUrl":"10.1016/j.bioactmat.2025.03.008","url":null,"abstract":"<div><div>The alterations in glucose metabolism flux induced by mitochondrial function changes are crucial for regulating bone immune homeostasis. The restoration of mitochondrial homeostasis, serving as a pivotal rheostat for balancing glucose metabolism in immune cells, can effectively mitigate inflammation and initiate osteogenesis. Herein, an ion-activated mitochondrial rheostat fiber-microsphere polymerization system (FM@CeZnHA) was innovatively constructed. Physical-chemical and molecular biological methods confirmed that CeZnHA, characterized by a rapid degradation rate, releases Ce/Zn ions that restore mitochondrial metabolic homeostasis and M1/M2 balance of macrophages through swift redox reactions. This process reduces the glycolysis level of macrophages by down-regulating the NF-κB p65 signaling pathway, enhances their mitochondrial metabolic dependence, alleviates excessive early inflammatory responses, and promptly initiates osteogenesis. The FM network provided a stable platform for macrophage glycolytic transformation and simulated extracellular matrix microenvironment, continuously restoring mitochondrial homeostasis and accelerating ossification center formation through the release of metal ions from the internal CeZnHA for efficient bone immune cascade reactions. This strategy of bone immunity mediated by the restoration of macrophage mitochondrial metabolic function and glucose metabolic flux homeostasis opens up a new approach to treating bone defects.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"49 ","pages":"Pages 399-417"},"PeriodicalIF":18.0,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143629112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Silicified curcumin microspheres Combats cardiovascular diseases via Nrf2/HO-1 pathway","authors":"Tianwang Guan ,&nbsp;Zhenxing Lu ,&nbsp;Rundong Tai ,&nbsp;Shuai Guo ,&nbsp;Zhaowenbin Zhang ,&nbsp;Shaohui Deng ,&nbsp;Jujian Ye ,&nbsp;Kaiyi Chi ,&nbsp;Binghua Zhang ,&nbsp;Huiwan Chen ,&nbsp;Zhilin Deng ,&nbsp;Yushen Ke ,&nbsp;Andong Huang ,&nbsp;Peier Chen ,&nbsp;Chunming Wang ,&nbsp;Caiwen Ou","doi":"10.1016/j.bioactmat.2025.03.007","DOIUrl":"10.1016/j.bioactmat.2025.03.007","url":null,"abstract":"<div><div>Diabetes and chemotherapy frequently give rise to severe cardiovascular complications, including chemotherapy-induced cardiotoxicity and diabetes-associated vascular remodeling. Nevertheless, the precise epidemiological features of these cardiovascular ailments remain incompletely elucidated, resulting in a dearth of effective therapeutic strategies in clinical settings. To tackle this intricate challenge, we have delved extensively into database resources, conducted comprehensive analyses of pertinent epidemiological data, and designed silicified curcumin (Si/Cur) microspheres as a novel therapeutic approach for cardiovascular diseases. By harnessing the alkaline microenvironment generated by silicon (Si), Si/Cur markedly elevates the bioavailability of curcumin (Cur). Further investigations have elucidated that Si/Cur exerts its therapeutic actions primarily via the Nrf2/HO-1 signaling pathway, effectively suppressing vascular remodeling and mitigating myocardial injury, thus disrupting the vicious cycle of persistent cardiovascular damage. In conclusion, this study integrates clinical cohort research to dissect epidemiological characteristics, directs the design and application of biomaterials, and paves the way for a novel and efficacious therapeutic avenue for the management of cardiovascular diseases.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"49 ","pages":"Pages 378-398"},"PeriodicalIF":18.0,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143629111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}