Bioactive Materials最新文献_第6页

From hard tissues to beyond: Progress and challenges of strontium-containing biomaterials in regenerative medicine applications

IF 18 1区医学

Bioactive Materials Pub Date : 2025-03-06 DOI: 10.1016/j.bioactmat.2025.02.039

Liyun Wang , Shengjie Jiang , Jialiang Zhou , Mazaher Gholipourmalekabadi , Yuan Cao , Kaili Lin , Yu Zhuang , Changyong Yuan

{"title":"From hard tissues to beyond: Progress and challenges of strontium-containing biomaterials in regenerative medicine applications","authors":"Liyun Wang , Shengjie Jiang , Jialiang Zhou , Mazaher Gholipourmalekabadi , Yuan Cao , Kaili Lin , Yu Zhuang , Changyong Yuan","doi":"10.1016/j.bioactmat.2025.02.039","DOIUrl":"10.1016/j.bioactmat.2025.02.039","url":null,"abstract":"<div><div>Tissue engineering and regenerative medicine have emerged as crucial disciplines focused on the development of new tissues and organs to overcome the limitations of traditional treatments for tissue damage caused by accidents, diseases, or aging. Strontium ion (Sr<sup>2+</sup>) has garnered significant attention for its multifaceted role in promoting regeneration medicine and therapy, especially in bone tissue regeneration. Recently, numerous studies further confirm that Sr<sup>2+</sup> also plays a critical in soft tissue regeneration. This review firstly summarizes the influence of Sr<sup>2+</sup> on critical biological processes such as osteogenesis, angiogenesis, immune modulation, matrix synthesis, mineralization, and antioxidative defence mechanisms. Then details the classification, properties, advantages, and limitations of Sr-containing biomaterials (SrBMs). Additionally, this review extends to the current applications of SrBMs in regenerative medicine for diverse tissues, including bone, cartilage, skeletal muscle, dental pulp, cardiac tissue, skin, hair follicles, etc. Moreover, the review addresses the challenges associated with current SrBMs and provides insights for their future designing and applications in regenerative medicine.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"49 ","pages":"Pages 85-120"},"PeriodicalIF":18.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143548692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review: Carrier-based hydrogels containing bioactive molecules and stem cells for ischemic stroke therapy

IF 18 1区医学

Bioactive Materials Pub Date : 2025-03-05 DOI: 10.1016/j.bioactmat.2025.01.014

Wenqi Yin , Yuchi Jiang , Guangrui Ma , Bricard Mbituyimana , Jia Xu , Zhijun Shi , Guang Yang , Hong Chen

{"title":"A review: Carrier-based hydrogels containing bioactive molecules and stem cells for ischemic stroke therapy","authors":"Wenqi Yin , Yuchi Jiang , Guangrui Ma , Bricard Mbituyimana , Jia Xu , Zhijun Shi , Guang Yang , Hong Chen","doi":"10.1016/j.bioactmat.2025.01.014","DOIUrl":"10.1016/j.bioactmat.2025.01.014","url":null,"abstract":"<div><div>Ischemic stroke (IS), a cerebrovascular disease, is the leading cause of physical disability and death worldwide. Tissue plasminogen activator (tPA) and thrombectomy are limited by a narrow therapeutic time window. Although strategies such as drug therapies and cellular therapies have been used in preclinical trials, some important issues in clinical translation have not been addressed: low stem cell survival and drug delivery limited by the blood-brain barrier (BBB). Among the therapeutic options currently sought, carrier-based hydrogels hold great promise for the repair and regeneration of neural tissue in the treatment of ischemic stroke. The advantage lies in the ability to deliver drugs and cells to designated parts of the brain in an injectable manner to enhance therapeutic efficacy. Here, this article provides an overview of the use of carrier-based hydrogels in ischemic stroke therapy and focuses on the use of hydrogel scaffolds containing bioactive molecules and stem cells. In addition to this, we provide a more in-depth summary of the composition, physicochemical properties and physiological functions of the materials themselves. Finally, we also outline the prospects and challenges for clinical translation of hydrogel therapy for IS.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"49 ","pages":"Pages 39-62"},"PeriodicalIF":18.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143548681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Topological cues of microparticles train stem cells for tissue repair via mechanotransduction

IF 18 1区医学

Bioactive Materials Pub Date : 2025-03-03 DOI: 10.1016/j.bioactmat.2025.02.032

Jiannan Mao , Yichang Xu , Wenbo Wang , Xiongwei Deng , Yujian Hui , Min Rui , Jincheng Tang , Wei Wang , Yiyang Huang , Liang Wu , Kun Xi , Yunrong Zhu , Yong Gu , Liang Chen

{"title":"Topological cues of microparticles train stem cells for tissue repair via mechanotransduction","authors":"Jiannan Mao , Yichang Xu , Wenbo Wang , Xiongwei Deng , Yujian Hui , Min Rui , Jincheng Tang , Wei Wang , Yiyang Huang , Liang Wu , Kun Xi , Yunrong Zhu , Yong Gu , Liang Chen","doi":"10.1016/j.bioactmat.2025.02.032","DOIUrl":"10.1016/j.bioactmat.2025.02.032","url":null,"abstract":"<div><div>Microspheres (MPs) and porous microspheres (PMPs) are the two most widely used microparticles in tissue engineering and stem cell therapy. However, how stem cells perceive the topological differences between them to regulate cell function remains to be unclear. Here, we systematically studied the changes in stem cell function under the action of MPs and PMPs and elucidated the related mechanisms. Our findings show that the porous structure of PMPs can be sensed by focal adhesions (FAs), which triggers the synthesis of F-actin to inhibit the phosphorylation and degradation of Yes-associated protein (YAP), while also transmitting stress to the nucleus through the contraction of F-actin, thereby enhancing the nuclear translocation of YAP protein. The activation of YAP significantly enhances the proliferation, osteogenesis, paracrine and glucose metabolism of BMSCs, making them exhibit stronger bone repair ability in both in vivo and in vitro experiments. In summary, this study provides a comprehensive and reliable understanding of the behavior of BMSCs in response to MPs and PMPs. It also deepens our understanding of the association between microparticles’ topological cues and biological functions, which will provide valuable guidance for the construction of bone tissue engineering (BTE) scaffolds.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"48 ","pages":"Pages 531-549"},"PeriodicalIF":18.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143529444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MXenes as emerging materials to repair electroactive tissues and organs

IF 18 1区医学

Bioactive Materials Pub Date : 2025-03-03 DOI: 10.1016/j.bioactmat.2025.01.035

Keshav Narayan Alagarsamy , Leena Regi Saleth , Saravanan Sekaran , Laura Fusco , Lucia Gemma Delogu , Maksym Pogorielov , Açelya Yilmazer , Sanjiv Dhingra

{"title":"MXenes as emerging materials to repair electroactive tissues and organs","authors":"Keshav Narayan Alagarsamy , Leena Regi Saleth , Saravanan Sekaran , Laura Fusco , Lucia Gemma Delogu , Maksym Pogorielov , Açelya Yilmazer , Sanjiv Dhingra","doi":"10.1016/j.bioactmat.2025.01.035","DOIUrl":"10.1016/j.bioactmat.2025.01.035","url":null,"abstract":"<div><div>Nanomaterials with electroactive properties have taken a big leap for tissue repair and regeneration due to their unique physiochemical properties and biocompatibility. MXenes, an emerging class of electroactive materials have generated considerable interest for their biomedical applications from bench to bedside. Recently, the application of these two-dimensional wonder materials have been extensively investigated in the areas of biosensors, bioimaging and repair of electroactive organs, owing to their outstanding electromechanical properties, photothermal capabilities, hydrophilicity, and flexibility. The currently available data reports that there is significant potential to employ MXene nanomaterials for repair, regeneration and functioning of electroactive tissues and organs such as brain, spinal cord, heart, bone, skeletal muscle and skin. The current review is the first report that compiles the most recent advances in the application of MXenes in bioelectronics and the development of biomimetic scaffolds for repair, regeneration and functioning of electroactive tissues and organs including heart, nervous system, skin, bone and skeletal muscle. The content in this article focuses on unique features of MXenes, synthesis process, with emphasis on MXene-based electroactive tissue engineering constructs, biosensors and wearable biointerfaces. Additionally, a section on the future of MXenes is presented with a focus on the clinical applications of MXenes.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"48 ","pages":"Pages 583-608"},"PeriodicalIF":18.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143534989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Piezoelectric nanofilms fabricated by coaxial electrospun polycaprolactone/Barium titanate promote Achilles tendon regeneration by reducing IL-17A/NF-κB-mediated inflammation

IF 18 1区医学

Bioactive Materials Pub Date : 2025-03-01 DOI: 10.1016/j.bioactmat.2025.02.038

Wufei Dai , Qi Xu , Qinglin Li , Xiansong Wang , Wenjie Zhang , Guangdong Zhou , Xu Chen , Wei Liu , Wenbo Wang

{"title":"Piezoelectric nanofilms fabricated by coaxial electrospun polycaprolactone/Barium titanate promote Achilles tendon regeneration by reducing IL-17A/NF-κB-mediated inflammation","authors":"Wufei Dai , Qi Xu , Qinglin Li , Xiansong Wang , Wenjie Zhang , Guangdong Zhou , Xu Chen , Wei Liu , Wenbo Wang","doi":"10.1016/j.bioactmat.2025.02.038","DOIUrl":"10.1016/j.bioactmat.2025.02.038","url":null,"abstract":"<div><div>Tendon injuries are often exacerbated by persistent inflammation, which hampers tissue regeneration. In this study, we developed a noninvasive, wirelessly controlled, and self-powered piezoelectric nanofilm fabricated by coaxial electrospinning of polycaprolactone (PCL) and tetragonal barium titanate nanoparticles (BTO), and investigated its roles in modulating inflammation and repairing Achilles tendon defects as well as the mechanism in a rat model. <em>In vitro</em> study and <em>in vivo</em> study upon subcutaneous implantation showed that the piezoelectric PCL/BTO nanofilms could inhibit M1 macrophage polarization and reduce the secretion of inflammatory factors. Moreover, when bridging an Achilles tendon defect, the nanofilms could promote tenogenic gene expression including collagen deposition, and collagen remodeling, facilitate functional tendon recovery and significantly reduce tissue inflammation by suppressing M1 macrophage polarization and promoting M2 polarization. Moreover, the piezoelectric stimulation could also enhance tendon regeneration by inhibiting angiogenesis, reducing lipid deposition, and decreasing ectopic ossification. Mechanistically, the piezoelectric nanofilms reduced tissue inflammation mainly via inhibiting the nuclear factor (NF)-κB signaling pathway that is mediated by interleukin (IL)-17A secreted from CD3<sup>+</sup> T cells, and thus to reduce proinflammatory factors, such as IL-1β and IL-6, inducible nitric oxide synthase, monocyte chemoattractant protein-1, and tumor necrosis factor-α. These findings indicate the potential of piezoelectric stimulation in immunomodulation, and in promoting tendon regeneration via IL-17A/NF-κB-mediated pathway.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"49 ","pages":"Pages 1-22"},"PeriodicalIF":18.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143519114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immune-modulated adhesive hydrogel for enhancing osteochondral graft adhesion and cartilage repair

IF 18 1区医学

Bioactive Materials Pub Date : 2025-03-01 DOI: 10.1016/j.bioactmat.2025.02.035

Jiaqi Zhou , Xiongfa Ji , Yu Xue , Wenjie Yang , Guoqing Zhong , Zhiyang Zhou , Xingmei Chen , Zehua Lei , Teliang Lu , Yu Zhang , Ji Liu , Limin Ma

{"title":"Immune-modulated adhesive hydrogel for enhancing osteochondral graft adhesion and cartilage repair","authors":"Jiaqi Zhou , Xiongfa Ji , Yu Xue , Wenjie Yang , Guoqing Zhong , Zhiyang Zhou , Xingmei Chen , Zehua Lei , Teliang Lu , Yu Zhang , Ji Liu , Limin Ma","doi":"10.1016/j.bioactmat.2025.02.035","DOIUrl":"10.1016/j.bioactmat.2025.02.035","url":null,"abstract":"<div><div>Osteochondral autograft transfer system (OATS) can effectively improve cartilage injuries by obtaining bone-cartilage grafts from healthy sites and implanting them into the defective areas. However, in up to 40 % of patients, the lack of a stable adhesive interface between the osteochondral graft and the normal tissue surface reduces the repair efficiency. In this work, we report an injectable and biocompatible poly (N-hydroxyethyl acrylamide-N-hydroxy succinimide)/Gelatin (PHE-Gel) hydrogel, featuring the instant formation of a tough bio-interface, which allows for robust adhesion with osteochondral grafts. Through physicochemical characterization, we found that a system composed of 10%PHE-Gel possesses superior interfacial toughness and excellent biocompatibility. In vitro, mechanistic studies and RNA-seq analysis had shown that 10%PHE-Gel promotes the expression of cartilage anabolic metabolism genes by upregulating the hypoxia-inducible factor alpha (HIF-α) signaling pathway and downregulating the tumor necrosis factor (TNF) signaling pathway. Dimethyloxalylglycine (DMOG) loaded liposome (DMOG-Lip) promotes the transition of M1 macrophages to M2 macrophages, shifting the microenvironment towards a pro-repair direction. Studies on a rabbit OATS model indicated that DMOG-Lip loaded 10%PHE-Gel (10%PHE-Gel@DMOG-Lip) effectively modulated the immune microenvironment, facilitated the repair of the hyaline cartilage, and inhibited further degeneration of cartilage. This composite hydrogel offers a promising solution for enhancing OATS repair in tissue engineering and has the potential to improve outcomes in cartilage restoration procedures.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"49 ","pages":"Pages 23-38"},"PeriodicalIF":18.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143519115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single-cell RNA sequencing-guided engineering of mitochondrial therapies for intervertebral disc degeneration by regulating mtDNA/SPARC-STING signaling

IF 18 1区医学

Bioactive Materials Pub Date : 2025-03-01 DOI: 10.1016/j.bioactmat.2025.02.036

Guoyu Yang , Chenpeng Dong , Zhaoxi Wu , Peng Wu , Cao Yang , Lanlan Li , Jianxiang Zhang , Xinghuo Wu

{"title":"Single-cell RNA sequencing-guided engineering of mitochondrial therapies for intervertebral disc degeneration by regulating mtDNA/SPARC-STING signaling","authors":"Guoyu Yang , Chenpeng Dong , Zhaoxi Wu , Peng Wu , Cao Yang , Lanlan Li , Jianxiang Zhang , Xinghuo Wu","doi":"10.1016/j.bioactmat.2025.02.036","DOIUrl":"10.1016/j.bioactmat.2025.02.036","url":null,"abstract":"<div><div>Intervertebral disc degeneration (IVDD) is a leading cause of discogenic low back pain, contributing significantly to global disability and economic burden. Current treatments provide only short-term pain relief without addressing the underlying pathogenesis. Herein we report engineering of biomimetic therapies for IVDD guided by single-cell RNA-sequencing data from human nucleus pulposus tissues, along with validation using animal models. In-depth analyses revealed the critical role of mitochondrial dysfunction in fibrotic phenotype polarization of nucleus pulposus cells (NPCs) during IVDD progression. Consequently, mitochondrial transplantation was proposed as a novel therapeutic strategy. Transplanted exogeneous mitochondria improved mitochondrial quality control in NPCs under pathological conditions, following endocytosis, separate distribution or fusion with endogenous mitochondria, and transfer to neighboring cells by tunneling nanotubes. Correspondingly, intradiscal mitochondrial transplantation significantly delayed puncture-induced IVDD progression in rats, demonstrating efficacy in maintaining mitochondrial homeostasis and alleviating pathological abnormalities. Furthermore, exogenous mitochondria were engineered with a bioactive, mitochondrial-targeting macromolecule to impart anti-oxidative and anti-inflammatory activities. The obtained multi-bioactive biotherapy exhibited significantly enhanced benefits in IVDD treatment, in terms of reversing IVDD progression and restoring structural integrity through the mtDNA/SPARC-STING signaling pathways. Overall, our engineered mitochondrial therapies hold great promise for treating IVDD and other musculoskeletal diseases linked to mitochondrial dysfunction.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"48 ","pages":"Pages 564-582"},"PeriodicalIF":18.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143520967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifunctional magneto-electric and exosome-loaded hydrogel enhances neuronal differentiation and immunoregulation through remote non-invasive electrical stimulation for neurological recovery after spinal cord injury

IF 18 1区医学

Bioactive Materials Pub Date : 2025-02-28 DOI: 10.1016/j.bioactmat.2025.02.034

Wubo Liu , Qiang Liu , Zeqin Li , Chunjia Zhang , Zehui Li , Han Ke , Xin Xu , Xiaoxin Wang , Huayong Du , Zuliyaer Talifu , Yunzhu Pan , Xiaoxiong Wang , Jingyun Mao , Feng Gao , Degang Yang , Yan Yu , Xinyu Liu , Jianjun Li

{"title":"Multifunctional magneto-electric and exosome-loaded hydrogel enhances neuronal differentiation and immunoregulation through remote non-invasive electrical stimulation for neurological recovery after spinal cord injury","authors":"Wubo Liu , Qiang Liu , Zeqin Li , Chunjia Zhang , Zehui Li , Han Ke , Xin Xu , Xiaoxin Wang , Huayong Du , Zuliyaer Talifu , Yunzhu Pan , Xiaoxiong Wang , Jingyun Mao , Feng Gao , Degang Yang , Yan Yu , Xinyu Liu , Jianjun Li","doi":"10.1016/j.bioactmat.2025.02.034","DOIUrl":"10.1016/j.bioactmat.2025.02.034","url":null,"abstract":"<div><div>Intervention in the differentiation of neural stem cells (NSCs) is emerging as a highly promising approach for the treatment of spinal cord injury (SCI). However, NSCs at the injury site often suffer from low survival and uncontrolled differentiation. Whereas electrical stimulation has proven effective in regulating the fate of NSCs and promoting tissue repair, however, conventional electrical stimulation therapy has failed to be widely applied due to challenges such as invasiveness and technical complexity. To overcome these limitations, we developed a biomimetic magneto-electric hydrogel incorporating Fe<sub>3</sub>O<sub>4</sub>@BaTiO<sub>3</sub> core-shell nanoparticles and human umbilical mesenchymal stem cell exosomes (HUMSC-Exos) around the concept of constructing remote noninvasive electrical stimulation for the synergistic treatment of SCI. The Fe<sub>3</sub>O<sub>4</sub>@BaTiO<sub>3</sub> is activated by the peripheral magnetic field to generate electrical stimulation, which, in conjunction with the synergistic effects of HUMSC-Exos, significantly alleviates the early inflammatory response associated with SCI and enhances the regeneration of newborn neurons and axons, thereby creating favorable conditions for functional recovery post-SCI. Our findings indicate that applying this magneto-exosome hydrogel in a rat model of SCI leads to substantial functional recovery. This innovative combination represents a promising therapeutic strategy for SCI repair.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"48 ","pages":"Pages 510-528"},"PeriodicalIF":18.0,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143511368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Special issue: Recent advances in immunotherapy and immunoengineering

IF 18 1区医学

Bioactive Materials Pub Date : 2025-02-28 DOI: 10.1016/j.bioactmat.2025.01.038

Gloria B. Kim , Quanyin Hu , Philipp C. Rommel

引用次数: 0

Innovative liquid embolic agents based on deep eutectic solvent: Rapid gelation in situ via solvent exchange with water for endovascular embolization

IF 18 1区医学

Bioactive Materials Pub Date : 2025-02-28 DOI: 10.1016/j.bioactmat.2025.02.037

Yitong Zhou , Menghui Liu , Chuandong He , Jiayuan Lin , Yanlv Chen , Mingyu Yu , Yuhan Jiang , Xin Peng

{"title":"Innovative liquid embolic agents based on deep eutectic solvent: Rapid gelation in situ via solvent exchange with water for endovascular embolization","authors":"Yitong Zhou , Menghui Liu , Chuandong He , Jiayuan Lin , Yanlv Chen , Mingyu Yu , Yuhan Jiang , Xin Peng","doi":"10.1016/j.bioactmat.2025.02.037","DOIUrl":"10.1016/j.bioactmat.2025.02.037","url":null,"abstract":"<div><div>Current liquid embolic agents face several challenges, including poor biocompatibility and vascular recanalization. Herein, we propose an innovative liquid embolic agent composed of a coenzyme-based polymer (poly lipoic acid, PLA) and a biocompatible solvent (deep eutectic solvent, DES). The agent undergoes phase transformation to form a stable hydrogel in situ through solvent exchange with water, thereby enabling safe and effective embolization. First, DES is obtained by heating a mixture of choline chloride (ChCl) and glycerol (Gly). Subsequently, lipoic acid (LA) is incorporated into the DES and heated to produce the PLA/DES complex. Owing to the strong hydrogen bonding between the DES and PLA, the DES acts as a solvent while also inhibiting PLA depolymerization. Upon contact with blood, most of the DES exchange with water, whereas some amount of ChCl integrates within the PLA via strong hydrogen bonding. This hydrogen bonding not only prevents PLA depolymerization but also reinforces the PLA network, resulting in a stable PLA hydrogel rather than depolymerized LA monomers. Furthermore, liquid-metal (LM) nanoparticles are incorporated to fabricate radiopaque PLA/LM/DES. PLA/LM/DES shows better in vitro hemocompatibility and cytocompatibility, milder inflammatory response in a rat model, and more effective and safer embolization in a rabbit model than a commercial embolic agent (Onyx). Thus, this work provides an innovative liquid embolic agent and broadens the biomedical applications of DES.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"48 ","pages":"Pages 550-563"},"PeriodicalIF":18.0,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143520966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0