Bioactive Materials最新文献_第6页

Liver-bone organoids reveal senescence-driven interorgan crosstalk 肝-骨类器官揭示衰老驱动的器官间串扰

IF 18 1区医学

Bioactive Materials Pub Date : 2025-09-03 DOI: 10.1016/j.bioactmat.2025.08.039

Yingting Zhang , Yue Li , Fuxiao Wang , Zhenglin Dong , Jian Wang , Yi Chen , Yinkun Fu , Yuheng Lu , Xinyu Bao , Yuxiao Lai , Yingying Jing , Jianhua Wang , Jianping Peng , Chao-Po Lin , Jiacan Su , Ming He

{"title":"Liver-bone organoids reveal senescence-driven interorgan crosstalk","authors":"Yingting Zhang , Yue Li , Fuxiao Wang , Zhenglin Dong , Jian Wang , Yi Chen , Yinkun Fu , Yuheng Lu , Xinyu Bao , Yuxiao Lai , Yingying Jing , Jianhua Wang , Jianping Peng , Chao-Po Lin , Jiacan Su , Ming He","doi":"10.1016/j.bioactmat.2025.08.039","DOIUrl":"10.1016/j.bioactmat.2025.08.039","url":null,"abstract":"<div><div>The liver-bone axis plays a critical role in age-related diseases. However, current models inadequately capture its complex inter-organ communication. Here, we established novel, physiologically relevant senescent liver and bone organoid models using engineered bionic hydrogels combined with doxorubicin (DOX)-induced senescence. These models successfully recapitulated hallmark aging characteristics: bone organoids exhibited reduced mineralization accompanied by elevated senescence markers, and liver organoids demonstrated DNA damage along with structural deterioration. Notably, aged mouse serum effectively induced senescence in both organoid types, confirming the existence of systemic aging regulators. The platform demonstrated robust bidirectional crosstalk, with senescent liver organoid-conditioned medium potently driving degradation in bone organoids and senescent bone organoid-conditioned medium aggravating dysfunction in liver organoids. Mechanistically, we identified 27-hydroxycholesterol (27-OHC) as a novel hepatocyte-derived factor mediating liver-to-bone communication. 27-OHC not only induced bone organoids senescence but also synergized with DOX treatment to exacerbate bone loss, a finding corroborated by <em>in vivo</em> mouse studies that validated the relevance of our platform in the context of pathological damage. This study pioneers the first organoid-based platform that elucidates multi-organ aging mechanisms, uncovering 27-OHC as a pivotal regulator of liver-bone axis dysfunction and proposing novel treatment strategies for age-related systemic disorders.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"54 ","pages":"Pages 570-583"},"PeriodicalIF":18.0,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144932856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microfluidic chip-integrated vascularized endometrial complexes: Mitochondrial function and paracrine crosstalk enhance regenerative potential 微流控芯片集成血管化子宫内膜复合物：线粒体功能和旁分泌串扰增强再生潜能

IF 18 1区医学

Bioactive Materials Pub Date : 2025-09-02 DOI: 10.1016/j.bioactmat.2025.08.035

Yongdong Dai , Fanxuan Zhao , Qiuli Chen , Biya Zeng , Weijia Gu , Yi Zhang , Fangying Sun , Xinyu Wang , Xiang Lin , Na Liu , Yulu Wang , Feng Zhou , Jianhua Yang , Shangjing Xin , Ye Feng , Songying Zhang

{"title":"Microfluidic chip-integrated vascularized endometrial complexes: Mitochondrial function and paracrine crosstalk enhance regenerative potential","authors":"Yongdong Dai , Fanxuan Zhao , Qiuli Chen , Biya Zeng , Weijia Gu , Yi Zhang , Fangying Sun , Xinyu Wang , Xiang Lin , Na Liu , Yulu Wang , Feng Zhou , Jianhua Yang , Shangjing Xin , Ye Feng , Songying Zhang","doi":"10.1016/j.bioactmat.2025.08.035","DOIUrl":"10.1016/j.bioactmat.2025.08.035","url":null,"abstract":"<div><div>Endometrial injury is a prevalent gynecological condition that poses a significant threat to fertility and women's health. While the current reported endometrial organoids demonstrate potential in remodeling endometrial functions, they often lack the complexity and physiological relevance of <em>in vivo</em> tissue. Here, we introduce a vascularized triple-cellular endometrial complex integrating endometrial epithelial organoids, stromal cells, and endothelial cells within a microfluidic chip with a composite hydrogel comprising Matrigel and fibrin. This novel endometrial complex exhibits robust growth and endometrial repair capabilities in an immunodeficient mouse model of endometrial damage, significantly improving pregnancy rates. Single-cell RNA sequencing revealed bidirectional cellular paracrine crosstalk between epithelial, stromal, and endothelial cells in the vascularized endometrial complex. Endothelial cells secrete BMP6 and Galectin-9, which enhance mitochondrial function and promote epithelial cell proliferation. Conversely, epithelial and stromal cells secrete WNT7A and WNT5A, respectively, to stimulate angiogenesis and vascular network formation of endothelial cells. These findings reveal the paracrine interactions that underpin the superior regenerative properties of the vascularized triple-cellular endometrial complex, offering a potential therapeutic strategy for endometrial repair and a valuable <em>in vitro</em> model for endometrial pathophysiological studies.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"54 ","pages":"Pages 551-569"},"PeriodicalIF":18.0,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144932855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A hierarchical MgF2/polyurethane/pitavastatin coating alleviates degradation and enhances endothelialization of bioresorbable magnesium alloy stents 多层MgF2/聚氨酯/匹伐他汀涂层减轻了生物可吸收镁合金支架的降解并增强了内皮化

IF 18 1区医学

Bioactive Materials Pub Date : 2025-09-02 DOI: 10.1016/j.bioactmat.2025.08.038

Zhenglong Dou , Yan Fu , Shuiling Chen , Manfred F. Maitz , Wengtai Zhang , Keyun Li , Jingcheng Zheng , Zhen Zhang , Nan Huang , Zhilu Yang

{"title":"A hierarchical MgF2/polyurethane/pitavastatin coating alleviates degradation and enhances endothelialization of bioresorbable magnesium alloy stents","authors":"Zhenglong Dou , Yan Fu , Shuiling Chen , Manfred F. Maitz , Wengtai Zhang , Keyun Li , Jingcheng Zheng , Zhen Zhang , Nan Huang , Zhilu Yang","doi":"10.1016/j.bioactmat.2025.08.038","DOIUrl":"10.1016/j.bioactmat.2025.08.038","url":null,"abstract":"<div><div>Rare-earth-free magnesium (Mg) alloy bioresorbable stent (BRS) exhibits significant potential in vascular intervention due to its exceptional biosafety. However, its susceptibility to corrosion complicates surface functionalization and renders existing coating strategies ineffective for degradation-remodeling kinetics, resulting in delayed re-endothelialization and excessive lumen loss. Herein, a hierarchical MgF<sub>2</sub>/polyurethane (PU)/pitavastatin (PTV) coating system is constructed on Mg-Zn-Mn BRS using elastomeric PU as an intermediate layer. Studies confirm the PU layer effectively accommodates stent deformation, alleviates stress concentrations, and confines corrosion propagation triggered by deformation-induced MgF<sub>2</sub> microcracks. The <em>in situ</em> formed MgF<sub>2</sub> layer concurrently decreases substrate reactivity, establishes stable interfaces with PU, and synergistically enhances the corrosion resistance. The surface PTV-loaded poly-L-lactic acid layer maintains sustained drug release through PU-mediated interfacial stability while serving as an initial corrosion barrier. <em>In vivo</em> evaluations demonstrate the MgF<sub>2</sub>/PU/PTV-functionalized stent significantly suppresses neointimal hyperplasia in rabbit models while achieving synchronized degradation-remodeling kinetics. This hierarchical coating architecture, which synergistically integrates controlled drug elution with degradation modulation, provides a viable solution to clinical challenges of post-implant restenosis and vascular remodeling mismatch.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"54 ","pages":"Pages 509-530"},"PeriodicalIF":18.0,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144932915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “Treatment of hemophilic arthropathy by immunomodulatory extracellular vesicle delivered by liposome hybrid nanoparticles” [Bioact. Mater. 40 (2024) 47–63] “由脂质体混合纳米颗粒递送的免疫调节细胞外囊泡治疗血友病关节病”的勘误表[Bioact]。Mater. 40 (2024) 47-63]

IF 18 1区医学

Bioactive Materials Pub Date : 2025-09-02 DOI: 10.1016/j.bioactmat.2025.07.041

Dong Wang , Wenzhe Chen , Jiali Chen , Du He , Yanli Pan , Pinger Wang , Qinghe Zeng , Mancang Gu , Peijian Tong , Di Chen , Hongting Jin

引用次数: 0

KNC nanozyme repairs hypoxia ischemia brain damage through ALOX12 mediated lipid peroxidation inhibition KNC纳米酶通过ALOX12介导的脂质过氧化抑制修复缺氧缺血脑损伤

IF 18 1区医学

Bioactive Materials Pub Date : 2025-09-02 DOI: 10.1016/j.bioactmat.2025.08.032

Xiaohua Dong , Dongya Jiang , Shuhan Chen , Ji Tan , Jing Zhao , Xingdan Liu , Ziyi Lu , Kelvin W.K. Yeung , Yun Liao , Xuanyong Liu , Liping Ouyang

{"title":"KNC nanozyme repairs hypoxia ischemia brain damage through ALOX12 mediated lipid peroxidation inhibition","authors":"Xiaohua Dong , Dongya Jiang , Shuhan Chen , Ji Tan , Jing Zhao , Xingdan Liu , Ziyi Lu , Kelvin W.K. Yeung , Yun Liao , Xuanyong Liu , Liping Ouyang","doi":"10.1016/j.bioactmat.2025.08.032","DOIUrl":"10.1016/j.bioactmat.2025.08.032","url":null,"abstract":"<div><div>Hypoxia-Ischemia Brain Damage (HIBD) results in a widespread neuronal damage and permanent brain tissue injury due to the severe reactive oxygen species (ROS) boost induced neuroinflammation. In this work, a K doped N-C based nanozyme was fabricated for scavenging ROS. KNC could impair ROS production and M1 polarization in microglia. Beneficial from these contents, the brain damage was mitigated in HIBD rats, which was proved by the increased regional blood flow, decreased pro-inflammatory microglia and astrocyte activation. The learning and memory capabilities were restored after applying with KNC post HIBD, which was ascribed to the diminished HI-induced dendritic spine loss in hippocampal regions. RNA-seq revealed that decreased ALOX12 expression is one of the clues of neuronal protection. KNC could combine with ALOX12 and further inhibit the lipid peroxidation. These two clues obtain KNC with superior ability of inhibition of ROS boost induced brain damage post HIBD. This nanozyme provided a potential strategies and new idea of HIBD therapy.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"54 ","pages":"Pages 531-548"},"PeriodicalIF":18.0,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144932916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outside Back Cover 外封底

IF 18 1区医学

Bioactive Materials Pub Date : 2025-09-01 DOI: 10.1016/S2452-199X(25)00345-7

引用次数: 0

Inherently bioactive iron-chelating Poly (N-acryloyl 2-glycine)/chitosan hydrogel scaffolds orchestrating dual hypoxic-immune microenvironment for functional meniscus regeneration 天然生物活性铁螯合聚（n-丙烯酰2-甘氨酸）/壳聚糖水凝胶支架协调双缺氧免疫微环境功能半月板再生

IF 18 1区医学

Bioactive Materials Pub Date : 2025-09-01 DOI: 10.1016/j.bioactmat.2025.08.028

Bingbing Xu , Jing Ye , Shitang Song , Xueyu Dou , Chao Li , Xing Wang , Jia-Kuo Yu

{"title":"Inherently bioactive iron-chelating Poly (N-acryloyl 2-glycine)/chitosan hydrogel scaffolds orchestrating dual hypoxic-immune microenvironment for functional meniscus regeneration","authors":"Bingbing Xu , Jing Ye , Shitang Song , Xueyu Dou , Chao Li , Xing Wang , Jia-Kuo Yu","doi":"10.1016/j.bioactmat.2025.08.028","DOIUrl":"10.1016/j.bioactmat.2025.08.028","url":null,"abstract":"<div><div>Despite progress in tissue-engineered meniscus (TEM) as alternatives to meniscectomy, challenges remain in inflammatory regulation, oxidative resistance, and mechanical stability under pathological microenvironments. Innovatively, we combined personalized meniscus scaffold, hydrogel ion crosslinking network technology, and microenvironment regulation function to prepare a multifunctional poly (N-acryloyl 2-glycine)/chitosan (PACG/CS) composite hydrogel meniscus scaffold featuring heterogeneous bionic structure, high strength and toughness, hypoxic inducing activity, and anti-inflammatory and antioxidant effects. Crucially, the inherently bioactive hydrogel networks crucially leveraged their carboxyl groups to orchestrate iron ion chelation, establishing a hypoxia-mediated microenvironment that dynamically modulated pro-/anti-inflammatory equilibrium, which in turn supported the chondrocyte survival, facilitated the development of a cartilage matrix, and ultimately promoted the meniscus regeneration. Notably, peripheral blood mesenchymal stem cells (PBMSCs) exhibited superior meniscus regeneration efficiency in low-oxygen conditions compared to bone marrow mesenchymal stem cells (BMSCs). After evaluating the effects of hypoxia environment induced by highly efficient iron chelation of PACG/CS hydrogel scaffolds on the activation of HIF-1α signaling pathway, anti-inflammatory and antioxidant regulation, the regulatory mechanism of immune microenvironment on the growth and cultivation quality of TEM were elucidated <em>in vivo</em> and <em>in vitro</em>. Overall, our have important implications for comprehending the biological impacts of biomaterials and developing novel approaches for meniscus regeneration.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"54 ","pages":"Pages 492-508"},"PeriodicalIF":18.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144922110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bifunctional adECM bioscaffold with STIM1-ASCs and IGF-2 promotes functional masseter VML repair via myogenesis and fibrosis suppression 含有STIM1-ASCs和IGF-2的双功能adECM生物支架通过肌肉发生和纤维化抑制促进功能性咬肌VML修复

IF 18 1区医学

Bioactive Materials Pub Date : 2025-08-29 DOI: 10.1016/j.bioactmat.2025.08.019

Wei Liang , Rigele Ao , Mengli Xu , Mengying Jin , Meng Han , Zimo Wang , Wanwen Dang , Hongxu Wu , Weibo Lin , Yonghuan Zhen , Tao Xu , Yang An

{"title":"Bifunctional adECM bioscaffold with STIM1-ASCs and IGF-2 promotes functional masseter VML repair via myogenesis and fibrosis suppression","authors":"Wei Liang , Rigele Ao , Mengli Xu , Mengying Jin , Meng Han , Zimo Wang , Wanwen Dang , Hongxu Wu , Weibo Lin , Yonghuan Zhen , Tao Xu , Yang An","doi":"10.1016/j.bioactmat.2025.08.019","DOIUrl":"10.1016/j.bioactmat.2025.08.019","url":null,"abstract":"<div><div>Craniofacial muscles are essential for a variety of functions, including fine facial expressions. Severe injuries to these muscles often lead to more devastating consequences than limb muscle injuries, resulting in the loss of critical functions such as mastication and eyelid closure, as well as facial aesthetic impairment. Therefore, the development of targeted repair strategies for craniofacial muscle injuries is crucial. In this study, we engineered an adipose-derived decellularized extracellular matrix (adECM) bioscaffold co-loaded with seed cells and bioactive factors. The seed cells were STIM1-overexpressing adipose-derived stem cells (STIM1-ASCs), which exhibit directed and highly efficient myogenic differentiation, addressing the low differentiation efficiency of conventional ASCs that limits muscle regeneration. The bioactive factor used was insulin-like growth factor-2 (IGF-2), which modulates the immune microenvironment by reprogramming mitochondrial energy metabolism to promote M2 macrophage polarization. These M2 macrophages further suppress fibroblast collagen deposition, alleviating muscle fibrosis, while simultaneously enhancing the myogenic differentiation of STIM1-ASCs and myotube formation. Together, the recellularized adECM bioscaffold harnesses these dual mechanisms (promoting functional muscle regeneration and anti-fibrotic repair) to significantly improve the recovery of volumetric muscle loss (VML) in the masseter. The development of this bifunctional bioscaffold offers a novel therapeutic strategy and theoretical foundation for treating severe craniofacial muscle injuries.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"54 ","pages":"Pages 466-491"},"PeriodicalIF":18.0,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144913861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondria-targeted MXene@MnO2-TPP nanoheterostructures for synergistic enhancement of sonodynamic therapy and immunotherapy in osteosarcoma 线粒体靶向MXene@MnO2-TPP纳米异质结构对骨肉瘤声动力治疗和免疫治疗的协同增强作用

IF 18 1区医学

Bioactive Materials Pub Date : 2025-08-28 DOI: 10.1016/j.bioactmat.2025.08.029

Jin Zeng , Zuyun Yan , Dong Wang , Tao He , Zhaochen Tong , Jinglei Miao , Jinsong Li , Wei Tan , Shijie Chen , Youwen Deng

{"title":"Mitochondria-targeted MXene@MnO2-TPP nanoheterostructures for synergistic enhancement of sonodynamic therapy and immunotherapy in osteosarcoma","authors":"Jin Zeng , Zuyun Yan , Dong Wang , Tao He , Zhaochen Tong , Jinglei Miao , Jinsong Li , Wei Tan , Shijie Chen , Youwen Deng","doi":"10.1016/j.bioactmat.2025.08.029","DOIUrl":"10.1016/j.bioactmat.2025.08.029","url":null,"abstract":"<div><div>Mitochondrial DNA (mtDNA) functions as an endogenous danger-associated molecular pattern that broadly activates the cGAS–STING pathway to potentiate antitumor immunotherapy. However, inefficient mtDNA release severely limits its ability to robustly activate downstream immune responses. Recent studies reveal that ferroptosis can trigger mtDNA release from damaged mitochondria into the cytosol, thereby stimulating antitumor immunity. Thus, precisely modulating mitochondria-associated ferroptosis to promote mtDNA-dependent cGAS–STING activation represents a promising strategy for enhancing immunotherapy. Here, we engineered a mitochondria-targeted MXene@MnO<sub>2</sub>-TPP Schottky heterojunction that integrates sonosensitization, ferroptosis induction, and immune activation for synergistic therapy. This nanoplatform not only directly generates ROS to trigger tumor cell ferroptosis but also amplifies ferroptosis via an MCU-dependent Ca<sup>2+</sup> influx pathway. Furthermore, it dual-activates the cGAS–STING pathway through released mtDNA and Mn<sup>2+</sup>, stimulating type I interferon production and eliciting systemic antitumor immunity. In vitro and in vivo studies demonstrate robust tumor suppression and prolonged survival in osteosarcoma-bearing mice. Our work proposes an innovative “ferroptosis–mtDNA–immunotherapy” paradigm, offering a promising strategy for osteosarcoma treatment.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"54 ","pages":"Pages 450-465"},"PeriodicalIF":18.0,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144908986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanotechnology strategies for endometrium health: Are we on the right track? 子宫内膜健康的纳米技术策略：我们在正确的轨道上吗？

IF 18 1区医学

Bioactive Materials Pub Date : 2025-08-27 DOI: 10.1016/j.bioactmat.2025.08.016

Victoria Herrara , Dana Tarab-Ravski , Subhash C. Chauhan , Nikesh Narang , Mohammad Mirazul Islam , Dan Peer , Rajendra Prasad , Murali M. Yallapu

{"title":"Nanotechnology strategies for endometrium health: Are we on the right track?","authors":"Victoria Herrara , Dana Tarab-Ravski , Subhash C. Chauhan , Nikesh Narang , Mohammad Mirazul Islam , Dan Peer , Rajendra Prasad , Murali M. Yallapu","doi":"10.1016/j.bioactmat.2025.08.016","DOIUrl":"10.1016/j.bioactmat.2025.08.016","url":null,"abstract":"<div><div>The endometrium is a vital mucosal tissue which undergoes cyclical regeneration, differentiation, and remodeling upon hormonal, cellular, and molecular signaling networks. Dysregulation of these processes can trigger a range of pathological conditions including chronic inflammatory disorders, hyperplastic lesions, malignancies, and infertility, necessitating the need for effective therapeutic interventions. Furthermore, we are still dependent on conventional treatment modalities which are often constrained by inefficient drug biodistribution, systemic toxicity, and emergence of therapeutic resistance. Recently, nanomedicines have gained tremendous attention in human healthcare, because they not only diagnose the disease but also deliver therapeutic agents to the targeted site without affecting healthy organs. There are numerous nanotechnology-based approaches that have been applied for clinical usage(s). In addition, recent advances in nanoparticle-based photothermal therapy, immunomodulatory approaches, and molecular imaging techniques have demonstrated considerable potential in refining both therapeutic and diagnostic strategies for endometrial pathologies. Herein, we reviewed a comprehensive analysis of nanotechnology-driven innovations in endometrial disease management, elucidating their mechanistic foundations, translational prospects, and future trajectories in endometrium and gynecological nanomedicine.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"54 ","pages":"Pages 423-449"},"PeriodicalIF":18.0,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144908985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0