Bioactive Materials最新文献_第5页

Molybdenum-bridged endo-exogenous antioxidant synergy reverses acute kidney injury via mitochondrial homeostasis reconstruction 钼桥内外抗氧化协同作用通过线粒体稳态重建逆转急性肾损伤

IF 18 1区医学

Bioactive Materials Pub Date : 2025-09-10 DOI: 10.1016/j.bioactmat.2025.09.006

Qiaohui Chen , Zuoxiu Xiao , Xiaohong Ying , Yongqi Yang , Jianlin Chen , Ziyu Wu , Wan Zeng , Chenxi Miao , Yayun Nan , Qiong Huang , Kelong Ai

{"title":"Molybdenum-bridged endo-exogenous antioxidant synergy reverses acute kidney injury via mitochondrial homeostasis reconstruction","authors":"Qiaohui Chen , Zuoxiu Xiao , Xiaohong Ying , Yongqi Yang , Jianlin Chen , Ziyu Wu , Wan Zeng , Chenxi Miao , Yayun Nan , Qiong Huang , Kelong Ai","doi":"10.1016/j.bioactmat.2025.09.006","DOIUrl":"10.1016/j.bioactmat.2025.09.006","url":null,"abstract":"<div><div>Acute kidney injury (AKI) progression is driven by mitochondrial redox collapse in proximal tubular epithelial cells (PTECs), where reactive oxygen species (ROS) surge and molybdenum (Mo) metabolic dysregulation create an “oxidative storm-defense collapse” cycle. Conventional antioxidant therapies fail to halt AKI chronicity due to their inability to restore Mo-dependent detoxification enzymes (e.g., Mo-containing Amidoxime Reducing Component, mARC). To address this dual pathology, we developed N-acetylcysteine (NAC)-modified molybdenum disulfide quantum dots (NMDs) that implement an endo-exogenous antioxidant collaborative strategy, synergizing exogenous ROS elimination with endogenous Mo enzyme restoration. NMDs achieve triple-tiered targeting: 1) Organ-selective accumulation leveraging NMDs' hydrophilicity and ultrasmall size; 2) Cell-specific internalization through Organic Anion Transporter 1 (OAT1)-mediated active uptake into PTECs; 3) Mitochondrial precision delivery guided by NAC's intrinsic mitochondrial affinity. Within pathological microenvironments, NMDs exhibit multidimensional therapeutic superiority: exposed Mo(Ⅳ) directly quenches mitochondrial ROS via electron transfer (external clearance), while released Mo ions reactivate mARC and NAC supplies glutathione precursors, synergistically rebuilding endogenous antioxidant defenses (internal reinforcement). <em>In vivo</em> validation demonstrated NMDs’ superior therapeutic efficacy, outperforming clinical antioxidant NAC. This work pioneers a “scavenging-fortification” strategy through Mo-centric metabolic regulation and nanotechnology integration, validating Mo-based materials' therapeutic potential and establishing a paradigm for mitochondrial-targeted AKI treatment.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"54 ","pages":"Pages 777-796"},"PeriodicalIF":18.0,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145026998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydrodynamic-derived centrifugal blood pump design for stable-low-flow-rate rate performance: from surface to structure 流体动力学衍生离心血泵设计，稳定低流量的流量性能：从表面到结构

IF 18 1区医学

Bioactive Materials Pub Date : 2025-09-09 DOI: 10.1016/j.bioactmat.2025.09.009

Miaowen Jiang , Chunhao Yu , Yiming Huang , Xing Zhao , Shiyi Xu , Hongkang Zhang , Yunong Shen , Xiaofei Han , Duo Chen , Kun Wang , Xunming Ji , Ming Li

{"title":"Hydrodynamic-derived centrifugal blood pump design for stable-low-flow-rate rate performance: from surface to structure","authors":"Miaowen Jiang , Chunhao Yu , Yiming Huang , Xing Zhao , Shiyi Xu , Hongkang Zhang , Yunong Shen , Xiaofei Han , Duo Chen , Kun Wang , Xunming Ji , Ming Li","doi":"10.1016/j.bioactmat.2025.09.009","DOIUrl":"10.1016/j.bioactmat.2025.09.009","url":null,"abstract":"<div><div>Long-lasting stability of the anticoagulant coating on centrifugal blood pumps (CBPs) is of vital importance to ensure the hemocompatibility of the blood circulation system therein. Heparin coatings are often prepared using static wet chemical technique, but these face risks of delamination or deactivation induced by blood flow. Inspired by the flow-shear-stress mediated conformation changes of von Willebrand factor, a novel fluid-driven deposition technique was employed to apply polydopamine-heparin coatings within CBPs. Moreover, most FDA-approved CBPs are designed for high-flow-rate CBPs of major organs like the heart and lungs (1000∼8000 ml/min). Few are tailored for low-flow-rate perfusion of other organs such as the liver, kidney and brain (<50–300 mL/min). Our approach addresses this gap by developing low-flow-rate CBPs through anti-thrombogenic coatings and anti-hemolytic structural optimizations. In this study, we introduced an axial magnetic direct drive motor with our optimized low-flow-rate CBPs, achieving a stable-low-flow-rate rate ranging from 16.3 mL/min (300 rpm) to 121.0 mL/min (2000 rpm). The resulting CBPs system exhibited enhanced flow stability and hemocompatibility in rabbit model experiments, demonstrating significantly lower hemolysis rates and lower thrombus formation risks. These results indicate that the polydopamine-assisted heparin coating provides short-term stability under dynamic flow, offering a promising strategy for low-flow-rate CBPs, though its long-term durability and clinical translation potential require further validation.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"54 ","pages":"Pages 730-743"},"PeriodicalIF":18.0,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145019737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Core-shell engineered Col/Cs@ECM microspheres for macrophage-targeted intracellular drug release in RA therapy 核壳工程Col/Cs@ECM微球用于RA治疗中巨噬细胞靶向细胞内药物释放

IF 18 1区医学

Bioactive Materials Pub Date : 2025-09-08 DOI: 10.1016/j.bioactmat.2025.08.043

Xiyue Duan , Kepeng Hu , Jiawei Wang , Xiaozhao Wang , Xiaojun Long , Weiming Lin , Chengwei Wu , Wenjian Weng , Zhangfa Song , Kui Cheng

{"title":"Core-shell engineered Col/Cs@ECM microspheres for macrophage-targeted intracellular drug release in RA therapy","authors":"Xiyue Duan , Kepeng Hu , Jiawei Wang , Xiaozhao Wang , Xiaojun Long , Weiming Lin , Chengwei Wu , Wenjian Weng , Zhangfa Song , Kui Cheng","doi":"10.1016/j.bioactmat.2025.08.043","DOIUrl":"10.1016/j.bioactmat.2025.08.043","url":null,"abstract":"<div><div>The imbalance of macrophage polarization between M1 and M2 phenotypes in rheumatoid arthritis (RA) results in a persistent inflammatory cascade. Activating M2 anti-inflammatory polarization, which remove excess extracellular matrix (ECM) via phagocytosis, represents a potential therapeutic target for RA. This study introduces Col/Cs@ECM microspheres, a novel drug delivery system designed for macrophage recognition via a tailored ECM surface, enhancing phagocytic efficiency and accumulation. Moreover, the Col/Cs@ECM microspheres are composed of biocompatible and fully degradable materials, ensuring their safety profile within the physiological environment. Following cell phagocytosis, the collagen/chitosan (Col/Cs) core release the drug (Dexamethasone, Dex) intracellularly to inhibit M1 polarization by inhibiting the NF-κB signaling pathway and to facilitate M2 polarization. This macrophage targeted and intracellular release approach offers a significant advantage over traditional medications by reducing systemic side effects and improving the therapeutic index. The strategy prompts macrophages to express anti-inflammatory cytokines like IL-10 while suppressing pro-inflammatory cytokines such as TNF-α, thereby remodeling the immune microenvironment. Additionally, the specially engineered ECM shell of the microspheres extends the anti-inflammatory response by prolonging macrophage lifespan, a feature that is not present in conventional treatments. This results in improved treatment outcomes in an in vivo RA animal model. This research presents a possible intracellular anti-inflammatory treatment approach for rheumatoid arthritis injection therapy with the potential to outperform existing treatments in terms of efficacy and safety.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"54 ","pages":"Pages 715-729"},"PeriodicalIF":18.0,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145019738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomaterials targeting senescent cells for bone regeneration: State-of-the-art and future perspectives 针对衰老细胞的骨再生生物材料：最新的和未来的观点

IF 18 1区医学

Bioactive Materials Pub Date : 2025-09-08 DOI: 10.1016/j.bioactmat.2025.09.002

Haitong Wu , Qing Zhang , Jinhao Zhu , Lihong Wu , Yin Xiao , Xuechao Yang

{"title":"Biomaterials targeting senescent cells for bone regeneration: State-of-the-art and future perspectives","authors":"Haitong Wu , Qing Zhang , Jinhao Zhu , Lihong Wu , Yin Xiao , Xuechao Yang","doi":"10.1016/j.bioactmat.2025.09.002","DOIUrl":"10.1016/j.bioactmat.2025.09.002","url":null,"abstract":"<div><div>Bone defect treatment remains a significant clinical challenge, further exacerbated by the demographic transition toward an aging society. In elderly populations, the increased proportion of senescent cells emerges as a fundamental determinant that substantially compromises regenerative outcomes. In senescent bone tissues, the progressive accumulation of senescent cells compromises bone regenerative capacity through multifaceted mechanisms, encompassing both intrinsic functional impairment of senescent cells and the far-reaching impact of the senescence-associated secretory phenotype (SASP) on the surrounding cellular and tissue microenvironment. Advanced biomaterials provide a platform for targeted anti-senescence interventions. One strategy is the selective elimination of senescent cells, achieved by engineering materials as delivery systems for senolytics or as platforms that modulate immune clearance. A more nuanced approach seeks functional rejuvenation, using biomaterials to restore cellular homeostasis by mitigating inflammation, correcting metabolic dysfunction, and reprogramming gene expression. A holistic strategy remodels the senescent microenvironment itself, accomplished through materials designed to restore biochemical homeostasis, provide physical guidance, and reprogram biological communication. This review delineates these material-based strategies, from direct cellular targeting to comprehensive niche remodeling. We also evaluate the significant hurdles to clinical translation, including challenges in biological specificity, preclinical model fidelity, and regulatory pathways. Ultimately, this work provides a conceptual framework for designing next-generation biomaterials to regenerate aging bone tissues.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"54 ","pages":"Pages 686-714"},"PeriodicalIF":18.0,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145019736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adaptive bioactivable nanosystems for synergistic myocardial infarction therapy using traditional pharmaceutics 应用传统药物协同治疗心肌梗死的适应性生物活性纳米系统

IF 18 1区医学

Bioactive Materials Pub Date : 2025-09-07 DOI: 10.1016/j.bioactmat.2025.08.041

Shuai Mao , Yubin Liang , Zikang Chen , Lei Wang , Quanfu Chen , Zhuting Fang , Qifan Zheng , Wen Ma , Hanping Zhang , Zhiqiang Yu , Ling Yu

{"title":"Adaptive bioactivable nanosystems for synergistic myocardial infarction therapy using traditional pharmaceutics","authors":"Shuai Mao , Yubin Liang , Zikang Chen , Lei Wang , Quanfu Chen , Zhuting Fang , Qifan Zheng , Wen Ma , Hanping Zhang , Zhiqiang Yu , Ling Yu","doi":"10.1016/j.bioactmat.2025.08.041","DOIUrl":"10.1016/j.bioactmat.2025.08.041","url":null,"abstract":"<div><div>Heart failure resulting from myocardial infarction (MI) is a leading global health concern. Current revascularization therapies cannot fully restore the infarcted myocardium or prevent maladaptive ventricular remodeling. Traditional Chinese medicine with its multitarget regulation and favorable biosafety shows a promising therapeutic potential. Tanshinone IIA (TIIA) and formononetin (FM), two bioactive compounds derived from <em>Salvia miltiorrhiza</em> and <em>Astragalus membranaceus</em>, respectively, exhibit antioxidant, anti-inflammatory, and proangiogenic effects. Herein, a neutrophil-targeted nanomedicine (TF-5NP) was developed to deliver TIIA and FM to the infarcted myocardium for mitigating oxidative damage and promoting angiogenesis. TF-5NP was synthesized by coassembling <em>bis</em>-5-hydroxytryptamine-modified 1,2-distearoyl-sn-glycero-3-phosphoethanolamine–polyethylene glycol–carboxylic acid with cholesterol and lipid 1,2-distearoyl-sn-glycero-3-phosphoglycerol, which binds to troponin in the infarcted myocardium. This nanomedicine reduces inflammation and cardiomyocyte damage and improves cardiac function in porcine MI models, with therapeutic effects lasting for ∼28 d. These findings suggest that TF-5NP use is a promising approach for treating post-MI maladaptive remodeling and heart failure.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"54 ","pages":"Pages 648-665"},"PeriodicalIF":18.0,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145007560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modulation of bone homeostasis by dual drug-loaded premixed magnesium tri-magnesium phosphate bone cement for the treatment of osteoporotic vertebral compression fractures 双重载药预混磷酸镁三镁骨水泥对骨质疏松性椎体压缩性骨折骨平衡的调节作用

IF 18 1区医学

Bioactive Materials Pub Date : 2025-09-07 DOI: 10.1016/j.bioactmat.2025.08.022

Jiawei Liu , Jinjin Zhu , Takashi Goto , Shuhui Yang , Honglei Kang , Xiumei Wang , Honglian Dai

{"title":"Modulation of bone homeostasis by dual drug-loaded premixed magnesium tri-magnesium phosphate bone cement for the treatment of osteoporotic vertebral compression fractures","authors":"Jiawei Liu , Jinjin Zhu , Takashi Goto , Shuhui Yang , Honglei Kang , Xiumei Wang , Honglian Dai","doi":"10.1016/j.bioactmat.2025.08.022","DOIUrl":"10.1016/j.bioactmat.2025.08.022","url":null,"abstract":"<div><div>Osteoporotic vertebral compression fractures (OVCF) have emerged as a significant public health concern. Traditionally, poly(methyl methacrylate) (PMMA) has been utilized in clinical to treat OVCF. Nevertheless, its poor degradability, uncontrollable setting time, high curing temperatures, and the potential for cement leakage have limited their application. In addition, these bone cements required clinical handling, bringing inconvenience to surgery.This study developed a premixed magnesium phosphate bone cement loaded with strontium ranelate and bioglass microspheres grafted with alendronate sodium (pTMPC-SMA), to achieve regulation between osteogenesis and osteoclastogenesis on osteoporosis. The premixed cement offered storage stability, easy of use, anti-washout behavior, and sustained drug release properties. The in vivo osteoporotic rabbit vertebroplasty model demonstrated that pTMPC-SMA exhibited excellent cavity-filling adaptability, significantly enhanced new bone formation, and achieved superior osseointegration compared to the PMMA group. These findings demonstrate that pTMPC-SMA provides both excellent handling properties and osteogenic therapeutic advantages for treating osteoporosis-related bone defects.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"54 ","pages":"Pages 631-647"},"PeriodicalIF":18.0,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145007493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A long-term quasi-equivalent in vitro study of high-strength Zn alloy interference screws for anterior cruciate ligament reconstruction 高强度锌合金干涉螺钉用于前交叉韧带重建的长期准等效体外研究

IF 18 1区医学

Bioactive Materials Pub Date : 2025-09-07 DOI: 10.1016/j.bioactmat.2025.07.036

Bo-Yao Li , Zhang-Zhi Shi , Xiang-Min Li , Xiao-Long Liu , Yu Yan , Lu-Ning Wang

{"title":"A long-term quasi-equivalent in vitro study of high-strength Zn alloy interference screws for anterior cruciate ligament reconstruction","authors":"Bo-Yao Li , Zhang-Zhi Shi , Xiang-Min Li , Xiao-Long Liu , Yu Yan , Lu-Ning Wang","doi":"10.1016/j.bioactmat.2025.07.036","DOIUrl":"10.1016/j.bioactmat.2025.07.036","url":null,"abstract":"<div><div>Biodegradable Zn alloy interference screws are promising for anterior cruciate ligament reconstruction. However, previous <em>in vitro</em> studies not only predominantly focus on short-term (≤30 days) immersion, but also neglect influence of crevice corrosion in bone tunnel. This study develops a Zn-0.45Mn-0.2 Mg alloy with yield strength of 288.3 MPa, ultimate tensile strength of 325.4 MPa and elongation of 26.3 %. The alloy is fabricated into screws, inserted into polyurethane bone blocks and immersed in Hank's balanced salt solution for 180 days. The alloy degraded at a corrosion rate of 0.07 mm/y, with its yield strength and elongation eventually decreasing to 229 MPa and 4.3 %, respectively. Second phase detachment during long-term corrosion reduces alloy's surface fracture toughness (<em>K</em><sub>IC</sub>) and increases stress intensity (<em>K</em><sub>I</sub>) at corrosion pits. This causes premature fracture of the alloy (<em>K</em><sub>I</sub> > <em>K</em><sub>IC</sub>) and a larger decrease in the alloy's ductility (70 %) than that in strength (30 %). Crevice corrosion of the screws originates deep within the bone tunnel and spreads outward over time. Accumulation of Cl<sup>−</sup> ions exacerbates corrosion severity in the narrow thread tops of the screws. This study provides a foundation for quasi-equivalent <em>in vitro</em> studies of Zn alloy implants, and highlights the necessity of developing ductility-attenuation-resistant Zn alloys.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"54 ","pages":"Pages 666-685"},"PeriodicalIF":18.0,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145007713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toxoplasma gondii-derived nanocarriers: leveraging protozoan membrane biology for scalable immune modulation and therapeutic delivery 刚地弓形虫衍生的纳米载体：利用原生动物膜生物学进行可扩展的免疫调节和治疗递送

IF 18 1区医学

Bioactive Materials Pub Date : 2025-09-04 DOI: 10.1016/j.bioactmat.2025.08.037

Jiating Chen , Pengfei Zhang , Hongjuan Peng , Jihong Chen

{"title":"Toxoplasma gondii-derived nanocarriers: leveraging protozoan membrane biology for scalable immune modulation and therapeutic delivery","authors":"Jiating Chen , Pengfei Zhang , Hongjuan Peng , Jihong Chen","doi":"10.1016/j.bioactmat.2025.08.037","DOIUrl":"10.1016/j.bioactmat.2025.08.037","url":null,"abstract":"<div><div>Cell membrane-derived nanovesicles (CMNVs) are nanoscale lipid bilayer structures obtained from cellular membranes that serve as biomimetic drug delivery platforms, offering immune evasion, targeting, and surface functionalization capabilities. While most CMNVs originate from mammalian cells, <em>Toxoplasma gondii</em> (<em>T. gondii</em>), a genetically tractable protozoan with a structurally distinct membrane, offers a high-yield and underexplored source for producing <em>T. gondii</em>-derived CMNVs (<em>Tg</em>CMNVs). These vesicles are obtained from the parasite's plasma membrane and inner membrane complex and retain unique features including abundant GPI-anchored SRS proteins, phosphatidylthreonine-rich lipids, and an editable genome, enabling versatile engineering via genetic and chemical strategies. We review methods for <em>Tg</em>CMNV fabrication, purification, and functionalization, and evaluate their potential in immunomodulation, attenuation of tissue injury, cancer immunotherapy, and self-adjuvanting vaccine design. By combining intrinsic immune engagement with programmable surface architecture, <em>Tg</em>CMNVs could serve as a complementary and adaptable platform alongside established CMNV systems. Finally, we discuss key translational considerations, including scalable production, immunogenicity control, regulatory compliance, and stability testing, which will be essential for assessing the feasibility of <em>Tg</em>CMNVs in clinical applications.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"54 ","pages":"Pages 602-613"},"PeriodicalIF":18.0,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144988188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Activatable companion theranostics for dual-modality imaging-escorted pyroptosis-propelled synergistic cancer therapy 双模成像伴热推动的协同癌症治疗的可激活伴治疗

IF 18 1区医学

Bioactive Materials Pub Date : 2025-09-04 DOI: 10.1016/j.bioactmat.2025.08.036

Yilin Wan , Yurong Liu , Weihua Wen , Ting He , Chunying Li , Guohua Wang , Lijun Jin , Meng Li , Yumeng Wu , Rong Wen , Yifan Zhang , Lian-Hua Fu , Jing Lin , Peng Huang , Daxiang Cui

{"title":"Activatable companion theranostics for dual-modality imaging-escorted pyroptosis-propelled synergistic cancer therapy","authors":"Yilin Wan , Yurong Liu , Weihua Wen , Ting He , Chunying Li , Guohua Wang , Lijun Jin , Meng Li , Yumeng Wu , Rong Wen , Yifan Zhang , Lian-Hua Fu , Jing Lin , Peng Huang , Daxiang Cui","doi":"10.1016/j.bioactmat.2025.08.036","DOIUrl":"10.1016/j.bioactmat.2025.08.036","url":null,"abstract":"<div><div>Companion diagnostics (CDx) plays a pivotal role in precision medicine for cancer treatment. However, conventional CDx are often limited by their inability to provide real-time monitoring of cancer progression and therapeutic responses. Herein, we develop a dual-modality imaging-based companion theranostic (CTx) nanoplatform (LET-Cl@GOx), which integrates activatable photoacoustic (PA) and fluorescence (FL) imaging to enable the enhanced diagnostic accuracy and real-time therapeutic feedback, while demonstrating cascade-amplified photothermal/starvation synergistic therapy. The LET-Cl@GOx is designed by the assembly of glucose oxidase (GOx) with a pH-activatable near-infrared (NIR) dye (LET-Cl), enabling the turn-on of PA/FL imaging within the acidic tumor microenvironment (TME). The dynamic alterations of PA/FL imaging signals provide real-time feedback on TME acidification, enabling accurate monitoring of GOx catalysis progression and precision timing of photothermal therapy (PTT) intervention. Furthermore, the GOx-mediated tumor starvation reduces adenosine triphosphate (ATP) levels, leading to the diminished heat shock protein expression and consequently enhanced the sensitivity to PTT. Concurrently, the photothermal effect reciprocally enhances the catalytic activity of GOx, establishing a triple closed-loop system with positive feedback amplification. This multiscale-augmented synergistic therapy triggers robust pyroptosis via the Caspase-3/gasdermin E signaling pathway, demonstrating remarkable therapeutic efficacy of tumors <em>in vivo</em>.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"54 ","pages":"Pages 614-630"},"PeriodicalIF":18.0,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144988189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cascade-targeted delivery platform enhances antigen cross-presentation and STING activation for durable cellular immunity 级联靶向递送平台增强抗原交叉呈递和STING激活，实现持久的细胞免疫

IF 18 1区医学

Bioactive Materials Pub Date : 2025-09-03 DOI: 10.1016/j.bioactmat.2025.08.033

Yuan Xue , Shuting Bai , Yating Wang , Jiaxing Feng , Kun Xiong , Xue Tang , Chunting He , Yanhua Xu , Hongling Yu , Tianyi Luo , Qing Lin , Xun Sun , Ling Zhang , Zhirong Zhang , Tao Gong

{"title":"Cascade-targeted delivery platform enhances antigen cross-presentation and STING activation for durable cellular immunity","authors":"Yuan Xue , Shuting Bai , Yating Wang , Jiaxing Feng , Kun Xiong , Xue Tang , Chunting He , Yanhua Xu , Hongling Yu , Tianyi Luo , Qing Lin , Xun Sun , Ling Zhang , Zhirong Zhang , Tao Gong","doi":"10.1016/j.bioactmat.2025.08.033","DOIUrl":"10.1016/j.bioactmat.2025.08.033","url":null,"abstract":"<div><div>Achieving robust and durable cellular immunity remains a key challenge in the development of subunit vaccines, primarily due to inefficient antigen cross-presentation and inadequate immune activation. Here, we engineered a series of nano-emulsions by conjugating human serum albumin (HSA) with fatty acids of varying chain lengths. Through systematic screening, the palmitic acid–modified nano-emulsion was identified as the most effective carrier, exhibiting intrinsic self-adjuvant properties and a strong capacity to elicit cellular immune responses. Notably, this formulation enables cascade-targeted delivery, trafficking sequentially from lymph nodes to antigen-presenting cells (APCs), and ultimately to the endoplasmic reticulum (ER). Upon co-delivery of the model antigen ovalbumin (OVA) and a stimulator of interferon genes (STING) agonist, the nano-emulsion facilitates both efficient antigen cross-presentation and precise intracellular activation of the STING pathway. This synergistic mechanism significantly enhances CD8<sup>+</sup> T cell responses and promotes durable memory formation, resulting in potent antitumor efficacy in murine models. Collectively, this study presents a safe and versatile nano-emulsion platform that overcomes key barriers in subunit vaccine delivery, offering a promising strategy for next-generation vaccine design.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"54 ","pages":"Pages 584-601"},"PeriodicalIF":18.0,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144932949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0