Bioactive Materials最新文献_第5页

A self-hygroscopic, rapidly self-gelling polysaccharide-based sponge with robust wet adhesion for non-compressible hemorrhage control and infected wounds healing 一种自吸湿、快速自胶的多糖基海绵，具有强大的湿粘附性，用于不可压缩出血控制和感染伤口愈合。

IF 18 1区医学

Bioactive Materials Pub Date : 2024-12-25 DOI: 10.1016/j.bioactmat.2024.12.016

Xiong-Xin Lei , Meng-Long Liu , Chao-Feng Lu , Li-Li Han , Jie-Zhi Jia , Zheng Li , Na Xu , Jiang-Feng Li , Xuan-Jian Fu , Ya-Bin Jin , Ri-Kuan Tong , Yun-Long Yu , Gao-Xing Luo , Yang Chen

{"title":"A self-hygroscopic, rapidly self-gelling polysaccharide-based sponge with robust wet adhesion for non-compressible hemorrhage control and infected wounds healing","authors":"Xiong-Xin Lei , Meng-Long Liu , Chao-Feng Lu , Li-Li Han , Jie-Zhi Jia , Zheng Li , Na Xu , Jiang-Feng Li , Xuan-Jian Fu , Ya-Bin Jin , Ri-Kuan Tong , Yun-Long Yu , Gao-Xing Luo , Yang Chen","doi":"10.1016/j.bioactmat.2024.12.016","DOIUrl":"10.1016/j.bioactmat.2024.12.016","url":null,"abstract":"<div><div>Uncontrollable non-compressible hemorrhage and traumatic infection have been major causes of mortality and disability in both civilian and military populations. A dressing designed for point-of-care control of non-compressible hemorrhage and prevention of traumatic infections represents an urgent medical need. Here, a novel self-gelling sponge OHN@ε-pL is developed, integrating N-succinimidyl ester oxidized hyaluronic acid (OHN) and ε-poly-L-lysine (ε-pL). Upon application to the wound site, the sponge can rapidly absorb interfacial fluids and undergo a phase transition from sponge to gel. The transformed gel facilitates robust tissue adhesion and achieves synergistic hemostasis by enriching coagulation factors within the sponge phase and providing a barrier effect in the gel phase. The in vitro and in vivo studies revealed that the optimized OHN@ε-pL<sub>3</sub> sponge possesses self-gelling capability, tissue adhesion, enhanced coagulation ability, and exhibits excellent biocompatibility and antibacterial efficacy. In hemostasis, OHN@ε-pL<sub>3</sub> sponges exhibited reduced blood loss and decreased hemostatic time compared to commercial hemostatic agents, as demonstrated in rat liver, femoral vein, and tail truncation bleeding models. Furthermore, the OHN@ε-pL<sub>3</sub> sponge exhibited superior performance in accelerating wound closure and healing of <em>S. aureus</em>-infected wounds. Collectively, OHN@ε-pL sponges represent a promising candidate for medical dressings, specifically for managing uncontrollable non-compressible hemorrhage and traumatic infections.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"46 ","pages":"Pages 311-330"},"PeriodicalIF":18.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11732608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MSAB limits osteoarthritis development and progression through inhibition of β-catenin-DDR2 signaling MSAB通过抑制β-catenin-DDR2信号传导来限制骨关节炎的发展和进展。

IF 18 1区医学

Bioactive Materials Pub Date : 2024-12-24 DOI: 10.1016/j.bioactmat.2024.10.023

Ke Lu , Zhidong Liao , Jingwen Li , Yuhan Wang , Yuting Zhang , Lintao Cai , William W. Lu , Fan Yang , Hong Pan , Di Chen

{"title":"MSAB limits osteoarthritis development and progression through inhibition of β-catenin-DDR2 signaling","authors":"Ke Lu , Zhidong Liao , Jingwen Li , Yuhan Wang , Yuting Zhang , Lintao Cai , William W. Lu , Fan Yang , Hong Pan , Di Chen","doi":"10.1016/j.bioactmat.2024.10.023","DOIUrl":"10.1016/j.bioactmat.2024.10.023","url":null,"abstract":"<div><div>The aberrant activation of the canonical Wnt/β-catenin signaling has been identified as a significant contributor to the pathogenesis of osteoarthritis (OA), exacerbating OA symptoms and driving OA progression. Despite its potential as a therapeutic target, clinical translation is impeded by the lack of a targeting delivery system and effective drug candidate that can modulate steady-state protein levels of β-catenin at post-translational level. Our study addresses these challenges by offering a new approach for OA treatment. To overcome these challenges, we introduced a novel delivery system using human serum albumin (HSA) to deliver a small molecule β-catenin inhibitor, Methyl-Sulfonyl AB (MSAB). This system is designed to enhance the bioavailability of MSAB, ensuring its accumulation inside the joint space, and facilitating the degradation of β-catenin protein. We have demonstrated that MSAB, when delivered via HSA, not only effectively inhibits cartilage damage but also ameliorates OA-related pain in an OA mouse model. We then performed proteomic analysis and biochemical studies to determine the molecular mechanisms underlying the therapeutic effects of MSAB. We identified that discoidin domain receptor 2 (DDR2), a critical mediator in OA pathology, is a downstream molecule of β-catenin signaling and β-catenin/TCF7 directly controls DDR2 gene transcription. MSAB suppressed the DDR2 expression in chondrocytes. MSAB ameliorated OA progression and OA-associated pain through inhibition of β-catenin-DDR2 signaling. This study underscores the efficacy of MSAB/HSA in OA treatment, providing new insights into its molecular mechanism of OA. It suggests that targeted therapies with MSAB/HSA could be a new OA management strategy.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"46 ","pages":"Pages 259-272"},"PeriodicalIF":18.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11732246/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Injection of ROS-Responsive Hydrogel Loaded with IL-1β-targeted nanobody for ameliorating myocardial infarction 负载il -1β靶向纳米体的ros反应水凝胶对心肌梗死的改善作用。

IF 18 1区医学

Bioactive Materials Pub Date : 2024-12-24 DOI: 10.1016/j.bioactmat.2024.12.013

Lu Wang , Changjiang Yu , Ting You , Xinkui Zhang , Haotao Su , Bihui Cao , Sainiwaer Anwaier , Hongmo Xiang , Chengming Dai , Xiang Long , Linjiang Han , Dengfeng Zhang , Junwei Wang , Peng Zhu , Xinjian Yan , Jialiang Liang , Zerui Chen , Huanlei Huang , Shuoji Zhu , Tucheng Sun , Ping Zhu

{"title":"Injection of ROS-Responsive Hydrogel Loaded with IL-1β-targeted nanobody for ameliorating myocardial infarction","authors":"Lu Wang , Changjiang Yu , Ting You , Xinkui Zhang , Haotao Su , Bihui Cao , Sainiwaer Anwaier , Hongmo Xiang , Chengming Dai , Xiang Long , Linjiang Han , Dengfeng Zhang , Junwei Wang , Peng Zhu , Xinjian Yan , Jialiang Liang , Zerui Chen , Huanlei Huang , Shuoji Zhu , Tucheng Sun , Ping Zhu","doi":"10.1016/j.bioactmat.2024.12.013","DOIUrl":"10.1016/j.bioactmat.2024.12.013","url":null,"abstract":"<div><div>The cardiac microenvironment profoundly restricts the efficacy of myocardial regeneration tactics for the treatment of myocardial infarction (MI). A prospective approach for MI therapeutics encompasses the combined strategy of scavenging reactive oxygen species (ROS) to alleviate oxidative stress injury and facilitating macrophage polarization towards the regenerative M2 phenotype. In this investigation, we fabricated a ROS-sensitive hydrogel engineered to deliver our previously engineered IL-1β-VHH for myocardial restoration. In mouse and rat models of myocardial infarction, the therapeutic gel was injected into the pericardial cavity, effectively disseminated over the heart surface, forming an in situ epicardial patch. The IL-1β-VHH released from the hydrogel exhibited penetrative potential into the myocardium. Our results imply that this infarct-targeting gel can adhere to the damaged cardiac tissue and augment the quantity of anti-IL-1β antibodies. Moreover, the anti-IL-1β hydrogel safeguards cardiomyocytes from apoptosis by neutralizing IL-1β and inducing M2-type polarization within the myocardial infarction regions, thereby facilitating therapeutic cardiac repair. Our results emphasize the effectiveness of this synergistic comprehensive treatment modality in the management of MI and showcase its considerable potential for promoting recovery in infarcted hearts.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"46 ","pages":"Pages 273-284"},"PeriodicalIF":18.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11732248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergizing adaptive immunity and regenerative signals to enhance osteochondral defects repair

IF 18 1区医学

Bioactive Materials Pub Date : 2024-12-21 DOI: 10.1016/j.bioactmat.2024.12.011

Changjian Lin , Chenting Ying , Yibo Xu , Yuxuan Zou , Ruihan Chen , Kaicheng Xu , Xiaoxiao Ji , Qihua Cao , Jiahui Weng , Lifeng Jiang , Chenyi Ye , Kai Xu , Yuzhe He , Weijun Li , Lidong Wu , Jisheng Ran , Yan Xiong , Xiaohua Yu , Jiapeng Bao

{"title":"Synergizing adaptive immunity and regenerative signals to enhance osteochondral defects repair","authors":"Changjian Lin , Chenting Ying , Yibo Xu , Yuxuan Zou , Ruihan Chen , Kaicheng Xu , Xiaoxiao Ji , Qihua Cao , Jiahui Weng , Lifeng Jiang , Chenyi Ye , Kai Xu , Yuzhe He , Weijun Li , Lidong Wu , Jisheng Ran , Yan Xiong , Xiaohua Yu , Jiapeng Bao","doi":"10.1016/j.bioactmat.2024.12.011","DOIUrl":"10.1016/j.bioactmat.2024.12.011","url":null,"abstract":"<div><div>In clinical practice, repairing osteochondral defects (OCDs) is challenging because of the complex cartilage/subchondral bone structure and intricate immunological microenvironment. Here, we identify the crucial role of adaptive immunity dysfunction by revealing that an increase of T helper 17 (Th17) cells exacerbated osteochondral tissue degradation via its pro-inflammatory cytokine interleukin-17 (IL-17) in the early-stage OCDs. Next, we leveraged this adaptive immunity mechanism and combined it with regenerative signals to develop a multifunctional hydrogel system capable of simultaneously tackling immune dysfunction and regenerative deficiency. Rapid IL-4 release from the methacrylated hyaluronic acid (HAMA) hydrogel exerts a potent immunomodulatory effect by inhibiting the differentiation and function of Th17 cells. Moreover, transforming growth factor-beta1 anchored on methacrylated hyaluronic acid and heparin (HAMA@HepMA) microparticles provides sustained regenerative signals, which synergistically transform the pro-inflammatory microenvironment into a pro-regenerative niche for enhanced OCDs healing. Our study suggests that targeting specific immune pathways can significantly enhance the efficacy of regenerative strategies, paving the way for innovative treatments in orthopedic medicine.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"46 ","pages":"Pages 242-258"},"PeriodicalIF":18.0,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143156804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Compensatory effect-based oxidative stress management microneedle for psoriasis treatment 基于补偿效应的氧化应激管理微针治疗银屑病。

IF 18 1区医学

Bioactive Materials Pub Date : 2024-12-20 DOI: 10.1016/j.bioactmat.2024.12.015

Chaoxiong Wu, Xinyu Yang, Kaiyue Yang, Qingyu Yu, Chenlu Huang, Fangzhou Li, Linhua Zhang, Dunwan Zhu

{"title":"Compensatory effect-based oxidative stress management microneedle for psoriasis treatment","authors":"Chaoxiong Wu, Xinyu Yang, Kaiyue Yang, Qingyu Yu, Chenlu Huang, Fangzhou Li, Linhua Zhang, Dunwan Zhu","doi":"10.1016/j.bioactmat.2024.12.015","DOIUrl":"10.1016/j.bioactmat.2024.12.015","url":null,"abstract":"<div><div>Reactive oxygen species (ROS) at elevated levels trigger oxidative DNA damage, which is a significant factor in psoriasis exacerbation. However, normal ROS levels are essential for cell signaling, cell growth regulation, differentiation, and immune responses. To address this, we developed ROS control strategies inspired by compensatory effects. DNA nanostructures with the advantage of being more stable than linear nucleic acid molecules in physiological environments were exquisitely fabricated and incorporated into microneedles (MN). These nanostructures regulate ROS levels and facilitate the delivery of IL-17A siRNA to psoriatic lesions. Our findings demonstrate that this transdermal drug delivery system effectively manages ROS levels in the psoriatic microenvironment, inhibiting pyroptosis and abnormal immune activation. Moreover, modulating ROS levels enhances the therapeutic impact of IL-17A siRNA, offering a promising <em>in situ</em> treatment approach for psoriasis.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"46 ","pages":"Pages 229-241"},"PeriodicalIF":18.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11732109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual-layer microneedles with NO/O2 releasing for diabetic wound healing via neurogenesis, angiogenesis, and immune modulation 具有NO/O2释放的双层微针通过神经发生、血管生成和免疫调节促进糖尿病伤口愈合。

IF 18 1区医学

Bioactive Materials Pub Date : 2024-12-16 DOI: 10.1016/j.bioactmat.2024.12.012

Changjiang Liu , Kun Liu , Dong Zhang , Yuting Liu , Yifeng Yu , Haifei Kang , Xianzhen Dong , Honglian Dai , Aixi Yu

{"title":"Dual-layer microneedles with NO/O2 releasing for diabetic wound healing via neurogenesis, angiogenesis, and immune modulation","authors":"Changjiang Liu , Kun Liu , Dong Zhang , Yuting Liu , Yifeng Yu , Haifei Kang , Xianzhen Dong , Honglian Dai , Aixi Yu","doi":"10.1016/j.bioactmat.2024.12.012","DOIUrl":"10.1016/j.bioactmat.2024.12.012","url":null,"abstract":"<div><div>Diabetic wounds present multiple functional impairments, including neurovascular dysregulation, oxidative imbalance, and immune dysfunction, making wound healing particularly challenging, while traditional therapeutical strategies fail to address these complex issues effectively. Herein, we propose a strategy utilizing dual-layer microneedles to deliver therapeutic gases by modulating neurovascular coupling and immune functions for diabetic wound treatment. The microneedle can respond to reactive oxygen species (ROS) in the diabetic microenvironment and subsequently generate oxygen (O<sub>2</sub>) and nitric oxide (NO). These gases comprehensively promote neuro-vascular regeneration, reduce oxidative stress levels, and attenuate inflammation. <em>In vivo</em> studies demonstrate that the microneedle can accelerate diabetic wound healing by modulating neurovascular regeneration and inflammatory processes. Transcriptomic analyses further validate the involvement of related advantageous signaling pathways. The potential mechanism involves the activation of the PI3K-AKT-mTOR pathway to facilitate autophagy, ultimately accelerating the healing process. Thus, our multifunctional dual-layer microneedles provide an effective strategy for treating diabetic wounds.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"46 ","pages":"Pages 213-228"},"PeriodicalIF":18.0,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11719290/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Copper doped bioactive glass promotes matrix vesicles-mediated biomineralization via osteoblast mitophagy and mitochondrial dynamics during bone regeneration 铜掺杂生物活性玻璃通过成骨细胞自噬和骨再生过程中的线粒体动力学促进基质囊泡介导的生物矿化。

IF 18 1区医学

Bioactive Materials Pub Date : 2024-12-14 DOI: 10.1016/j.bioactmat.2024.12.010

Ziji Ling , Xiao Ge , Chengyu Jin , Zesheng Song , Hang Zhang , Yu Fu , Kai Zheng , Rongyao Xu , Hongbing Jiang

{"title":"Copper doped bioactive glass promotes matrix vesicles-mediated biomineralization via osteoblast mitophagy and mitochondrial dynamics during bone regeneration","authors":"Ziji Ling , Xiao Ge , Chengyu Jin , Zesheng Song , Hang Zhang , Yu Fu , Kai Zheng , Rongyao Xu , Hongbing Jiang","doi":"10.1016/j.bioactmat.2024.12.010","DOIUrl":"10.1016/j.bioactmat.2024.12.010","url":null,"abstract":"<div><div>Bone defect repair remains a great challenge in the field of orthopedics. Human body essential trace element such as copper is essential for bone regeneration, but how to use it in bone defects and the underlying its mechanisms of promoting bone formation need to be further explored. In this study, by doping copper into mesoporous bioactive glass nanoparticles (Cu-MBGNs), we unveil a previously unidentified role of copper in facilitating osteoblast mitophagy and mitochondrial dynamics, which enhance amorphous calcium phosphate (ACP) release and subsequent biomineralization, ultimately accelerating the process of bone regeneration. Specifically, by constructing conditional knockout mice lacking the autophagy gene <em>Atg5</em> in osteogenic lineage cells, we first confirmed the role of Cu-MBGNs-promoted bone formation via mediating osteoblast autophagy pathway. Then, the <em>in vitro</em> studies revealed that Cu-MBGNs strengthened mitophagy by inducing ROS production and recruiting PINK1/Parkin, thereby facilitating the efficient release of ACP from mitochondria into matrix vesicles for biomineralization during bone regeneration. Moreover, we found that Cu-MBGNs promoted mitochondrion fission via activating dynamin related protein 1 (Drp1) to reinforce mitophagy pathway. Together, this study highlights the potential of Cu-MBGNs‐mediated mitophagy and biomineralization for augmenting bone regeneration, offering a promising avenue for the development of advanced bioactive materials in orthopedic applications.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"46 ","pages":"Pages 195-212"},"PeriodicalIF":18.0,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11699476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in biomaterial-based tissue engineering for peripheral nerve injury repair 基于生物材料的周围神经损伤修复组织工程研究进展。

IF 18 1区医学

Bioactive Materials Pub Date : 2024-12-13 DOI: 10.1016/j.bioactmat.2024.12.005

Xinlei Yao , Tong Xue , Bingqian Chen , Xinyang Zhou , Yanan Ji , Zihui Gao , Boya Liu , Jiawen Yang , Yuntian Shen , Hualin Sun , Xiaosong Gu , Bin Dai

{"title":"Advances in biomaterial-based tissue engineering for peripheral nerve injury repair","authors":"Xinlei Yao , Tong Xue , Bingqian Chen , Xinyang Zhou , Yanan Ji , Zihui Gao , Boya Liu , Jiawen Yang , Yuntian Shen , Hualin Sun , Xiaosong Gu , Bin Dai","doi":"10.1016/j.bioactmat.2024.12.005","DOIUrl":"10.1016/j.bioactmat.2024.12.005","url":null,"abstract":"<div><div>Peripheral nerve injury is a common clinical disease. Effective post-injury nerve repair remains a challenge in neurosurgery, and clinical outcomes are often unsatisfactory, resulting in social and economic burden. Particularly, the repair of long-distance nerve defects remains a challenge. The existing nerve transplantation strategies show limitations, including donor site morbidity and immune rejection issues. The multiple studies have revealed the potential of tissue engineering strategies based on biomaterials in the repair of peripheral nerve injuries. We review the events of regeneration after peripheral nerve injury, evaluates the efficacy of existing nerve grafting strategies, and delves into the progress in the construction and application strategies of different nerve guidance conduits. A spotlight is cast on the materials, technologies, seed cells, and microenvironment within these conduits to facilitate optimal nerve regeneration. Further discussion was conducted on the approve of nerve guidance conduits and potential future research directions. This study anticipates and proposes potential avenues for future research, aiming to refine existing strategies and uncover innovative approaches in biomaterial-based nerve repair. This study endeavors to synthesize the collective insights from the fields of neuroscience, materials science, and regenerative medicine, offering a multifaceted perspective on the role of biomaterials in advancing the frontiers of peripheral nerve injury treatment.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"46 ","pages":"Pages 150-172"},"PeriodicalIF":18.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11699443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioinspired conductive oriented nanofiber felt with efficient ROS clearance and anti-inflammation for inducing M2 macrophage polarization and accelerating spinal cord injury repair 生物启发导电定向纳米纤维毡具有有效的ROS清除和抗炎症诱导M2巨噬细胞极化和加速脊髓损伤修复。

IF 18 1区医学

Bioactive Materials Pub Date : 2024-12-13 DOI: 10.1016/j.bioactmat.2024.12.009

Qingxia Zhang , Jiahe Zheng , Linlong Li , Jui-Ming Yeh , Xianrui Xie , Yuqing Zhao , Chengbo Li , Guige Hou , Huanhuan Yan

{"title":"Bioinspired conductive oriented nanofiber felt with efficient ROS clearance and anti-inflammation for inducing M2 macrophage polarization and accelerating spinal cord injury repair","authors":"Qingxia Zhang , Jiahe Zheng , Linlong Li , Jui-Ming Yeh , Xianrui Xie , Yuqing Zhao , Chengbo Li , Guige Hou , Huanhuan Yan","doi":"10.1016/j.bioactmat.2024.12.009","DOIUrl":"10.1016/j.bioactmat.2024.12.009","url":null,"abstract":"<div><div>Complete spinal cord injury (SCI) causes permanent locomotor, sensory and neurological dysfunctions. Targeting complex immunopathological microenvironment at SCI sites comprising inflammatory cytokines infiltration, oxidative stress and massive neuronal apoptosis, the conductive oriented nanofiber felt with efficient ROS clearance, anti-inflammatory effect and accelerating neural regeneration is constructed by step-growth addition polymerization and electrostatic spinning technique for SCI repair. The formation of innovative Fe<sup>3+</sup>-PDA-PAT chelate in nanofiber felt enhances hydrophilic, antioxidant, antibacterial, hemostatic and binding factor capacities, thereby regulating immune microenvironment of SCI. With the capabilities of up-regulating COX5A and STAT6 expressions, down-regulating the expressions of IL1β, CD36, p-ERK, NFκB2 and NFκB signaling pathway proteins, the nanofiber felt attenuates oxidative stress injury, promotes M2 macrophage polarization and down-regulates inflammatory response. After implantation into complete transection SCI rats, the nanofiber felt is revealed to recruit endogenous NSCs, induce the differentiation of NSCs into neurons while inhibit astrocytes formation and inflammation, reduces glia scar, and promotes angiogenesis, remyelination and neurological functional recovery. Overall, this innovative strategy provides a facile immune regulatory system to inhibit inflammatory response and accelerate nerve regeneration after SCI, and its targeted proteins and mechanisms are first elucidated, which holds great application promise in clinical treatment of complete SCI.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"46 ","pages":"Pages 173-194"},"PeriodicalIF":18.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11699466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TClC effectively suppresses the growth and metastasis of NSCLC via polypharmacology TClC通过多种药理作用有效抑制非小细胞肺癌的生长和转移。

IF 18 1区医学

Bioactive Materials Pub Date : 2024-12-13 DOI: 10.1016/j.bioactmat.2024.11.019

Jing Lu , Ying Zhang , Chunyan Yan , Jingwen Liu , Dan Qi , Yue Zhou , Qinwen Wang , Juechen Yang , Jing Jiang , Benhao Wu , Meiling Yang , Weiwei Zhang , Xin Zhang , Xiaoyu Shi , Yan Zhang , Kun Liu , Yongcai Liang , Chaoyang Wang , Hanyu Yang , Yuqing Gao , Guoying Zhang

{"title":"TClC effectively suppresses the growth and metastasis of NSCLC via polypharmacology","authors":"Jing Lu , Ying Zhang , Chunyan Yan , Jingwen Liu , Dan Qi , Yue Zhou , Qinwen Wang , Juechen Yang , Jing Jiang , Benhao Wu , Meiling Yang , Weiwei Zhang , Xin Zhang , Xiaoyu Shi , Yan Zhang , Kun Liu , Yongcai Liang , Chaoyang Wang , Hanyu Yang , Yuqing Gao , Guoying Zhang","doi":"10.1016/j.bioactmat.2024.11.019","DOIUrl":"10.1016/j.bioactmat.2024.11.019","url":null,"abstract":"<div><div>Despite significant advances in targeted therapies and immunotherapies, non-small cell lung cancer (NSCLC) continues to present a global health challenge, with a modest five-year survival rate of 28 %, largely due to the emergence of treatment-resistant and metastatic tumors. In response, we synthesized a novel bioactive compound, ethyl 6-chlorocoumarin-3-carboxylyl L-theanine (TClC), which significantly inhibited NSCLC growth, epithelial mesenchymal transition (EMT), migration, and invasion <em>in vitro</em> and tumor growth and metastasis <em>in vivo</em> without inducing toxicity. TClC disrupts autocrine loops that promote tumor progression, particularly in stem-like CD133-positive NSCLC (CD133+ LC) cells, which are pivotal in tumor metastasis. Through targeted molecular assays, we identified direct binding targets of TClC, including Akt, NF-κB, β-catenin, EZH2, and PD-L1. This interaction not only suppresses the expression of oncogenic factors and cancer stem cell markers but also downregulates the expression of a multidrug resistance transporter, underscoring the compound's polypharmacological potential. These results position TClC as a promising candidate for NSCLC treatment, signaling a new era in the development of cancer therapies that directly target multiple critical cancer pathways.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"45 ","pages":"Pages 567-583"},"PeriodicalIF":18.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11700266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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