Bioactive Materials最新文献

{"title":"End-tail soaking strategy toward robust and biomimetic sandwich-layered hydrogels for full-thickness bone regeneration","authors":"Jianyang Shan ,&nbsp;Liang Cheng ,&nbsp;Xiang Li ,&nbsp;Wenhao Liu ,&nbsp;Zhihua Liu ,&nbsp;Yimin Chai ,&nbsp;Yaling Yu ,&nbsp;Xing Wang ,&nbsp;Gen Wen","doi":"10.1016/j.bioactmat.2025.02.045","DOIUrl":"10.1016/j.bioactmat.2025.02.045","url":null,"abstract":"<div><div>Despite an increasing number of tissue-engineered scaffolds have been developing for bone regeneration, simple and universal fabrication of biomimetic bone microstructure to repair full-thickness bone defects remains a challenge and an acute clinical demand due to the negligence of microstructural differences within the cortex of cancellous bone. In this work, a biomimetic sandwich-layered PACG-CS@Mn(III) hydrogel (SL hydrogel) was facilely fabricated in an end-tail soaking strategy by simply post-crosslinking of poly(acryloyl 2-glycine)-chitosan (PACG-CS) composite hydrogel using trivalent manganese solutions. Taking the merits of <em>in-situ</em> formation and flexible adjustment of chain entanglements, hydrogen bonds and metal chelate interactions, SL hydrogel with sandwich-like three-layered structures and anisotropic mechanical performance was easily customized through control of the manganese concentration and soaking time in fore-and-aft sides, simulating the structurally and mechanically biomimetic characteristics of cortical and cancellous bone. Furthermore, the produced SL hydrogel also demonstrated favorable biocompatibility and enhanced MnSOD activity via a peroxidase-like reaction, which enabled the excellent radical scavenging efficiency and anti-inflammatory regulation for facilitating the activity, proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). <em>In vivo</em> studies further revealed that these SL hydrogels achieved restrictive pro-vascular regeneration through their stratified structure, thereby promoting the differentiation of osteoblasts. Simultaneously, the mechanical cues of stratified structure could mediate macrophage phenotype transitions in accordance with stem cell-osteoblast differentiation process via the PI3K-AKT pathway, resulting in robust osteogenesis and high-quality bone reconstruction. This facile yet efficient strategy of turning anisotropic hydrogel offers a promising alternative for full-thickness repair of bone defects, which is also significantly imperative to achieve high-performance scaffolds with specific usage requirements and expand their clinic applicability in more complex anisotropic tissues.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"49 ","pages":"Pages 486-501"},"PeriodicalIF":18.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The revolutionary role of placental derivatives in biomedical research","authors":"Saeid Moghassemi ,&nbsp;Saba Nikanfar ,&nbsp;Arezoo Dadashzadeh ,&nbsp;Maria João Sousa ,&nbsp;Yuting Wan ,&nbsp;Fengxuan Sun ,&nbsp;Arthur Colson ,&nbsp;Sven De Windt ,&nbsp;Lena Kwaspen ,&nbsp;Marc Kanbar ,&nbsp;Keyvan Sobhani ,&nbsp;Jie Yang ,&nbsp;Hanne Vlieghe ,&nbsp;Yongqian Li ,&nbsp;Frédéric Debiève ,&nbsp;Christine Wyns ,&nbsp;Christiani A. Amorim","doi":"10.1016/j.bioactmat.2025.03.011","DOIUrl":"10.1016/j.bioactmat.2025.03.011","url":null,"abstract":"<div><div>The human placenta is a transient yet crucial organ that plays a key role in sustaining the relationship between the maternal and fetal organisms. Despite its historical classification as “biowaste,\" placental tissues have garnered increasing attention since the early 1900s for their significant medical potential, particularly in wound repair and surgical application. As ethical considerations regarding human placental derivatives have largely been assuaged in many countries, they have gained significant attention due to their versatile applications in various biomedical fields, such as biomedical engineering, regenerative medicine, and pharmacology. Moreover, there is a substantial trend toward various animal product substitutions in laboratory research with human placental derivatives, reflecting a broader commitment to advancing ethical and sustainable research methodologies. This review provides a comprehensive examination of the current applications of human placental derivatives, explores the mechanisms behind their therapeutic effects, and outlines the future potential and directions of this rapidly advancing field.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"49 ","pages":"Pages 456-485"},"PeriodicalIF":18.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143643307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protein to biomaterials: Unraveling the antiviral and proangiogenic activities of Ac-Tβ1-17 peptide, a thymosin β4 metabolite, and its implications in peptide-scaffold preparation","authors":"Khandoker Asiqur Rahaman ,&nbsp;Md Sofequl Islam Mukim ,&nbsp;Md Lemon Hasan ,&nbsp;Hyeok Kim ,&nbsp;Cheol-Ho Pan ,&nbsp;Oh-Seung Kwon ,&nbsp;Dae-Geun Song ,&nbsp;Hyung-Seop Han","doi":"10.1016/j.bioactmat.2025.02.008","DOIUrl":"10.1016/j.bioactmat.2025.02.008","url":null,"abstract":"<div><div>Peptide metabolites are emerging biomolecules with numerous possibilities in biomaterial-based regenerative medicine due to their inherent bioactivities. These small, naturally occurring compounds are intermediates or byproducts of larger proteins and peptides, and they can have profound effects, such as antiviral therapeutics, proangiogenic agents, and regenerative medicinal applications. This study is among the first to focus on using thymosin β4 protein-derived metabolites to pioneer novel applications for peptide metabolites in biomaterials. This study found that the novel peptide metabolite acetyl-thymosin β4 (amino acid 1–17) (Ac-Tβ_1-17) exhibited significant protease inhibition activity against SARS-CoV-2, surpassing its precursor protein. Additionally, Ac-Tβ_1-17 demonstrated beneficial effects, such as cell proliferation, wound healing, and scavenging of reactive oxygen species (ROS) in human umbilical vein endothelial cells (HUVEC). Integrating Ac-Tβ_1-17 into a peptide-based scaffold facilitated cell growth and angiogenesis inside the scaffold and through gradual release into the surrounding environment. The Ac-Tβ_1-17 peptide treatment induced significant biochemical responses in HUVEC, increasing Akt, ERK, PI3K, MEK, and Bcl-2 gene expression and proangiogenic proteins. Ac-Tβ_1-17 peptide treatment showed similar results in ex vivo by enhancing mouse fetal metatarsal growth and angiogenesis. These findings highlight the potential of natural protein metabolites to generate biologically active peptides, offering a novel strategy for enhancing biomaterial compatibility. This approach holds promise for developing therapeutic biomaterials using peptide metabolites, presenting exciting prospects for future research and applications.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"49 ","pages":"Pages 437-455"},"PeriodicalIF":18.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143643238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The paradigm shifts of periodontal regeneration strategy: From reparative manipulation to developmental engineering","authors":"Guanqi Liu ,&nbsp;Junlong Xue ,&nbsp;Xuan Zhou ,&nbsp;Mixiao Gui ,&nbsp;Ruidi Xia ,&nbsp;Yanshu Zhang ,&nbsp;Yihua Cai ,&nbsp;Shuhua Li ,&nbsp;Songtao Shi ,&nbsp;Xueli Mao ,&nbsp;Zetao Chen","doi":"10.1016/j.bioactmat.2025.03.009","DOIUrl":"10.1016/j.bioactmat.2025.03.009","url":null,"abstract":"<div><div>Ideal periodontal regeneration requires the integration of alveolar bone, periodontal ligament, and cementum, along with Sharpey's fibers for occlusal force resistance. However, physiological regeneration remains rare due to its intricate structure, making clinical regeneration a challenge. Periodontal ligament stem cells (PDLSCs), first isolated in 2004, hold the key to multi-directional differentiation into cementoblasts, fibroblasts, and osteoblasts. While traditional therapies like guided tissue regeneration (GTR) aim to activate PDLSCs, clinical outcomes are inconsistent, suggesting the need for additional strategies to enhance PDLSCs' functions. Advancements in molecular biotechnology have introduced the use of recombinant growth factors for tissue regeneration. However, maintaining their efficacy requires high doses, posing cost and safety issues. Multi-layered scaffolds combined with cell sheet technology offer new insights, but face production, ethical, and survival challenges. Immune regulation plays a crucial role in PDLSC-mediated regeneration. The concept of “coagulo-immunomodulation” has emerged, emphasizing the coupling of blood coagulation and immune responses for periodontal regeneration. Despite its potential, the clinical translation of immune-based strategies remains elusive. The “developmental engineering” approach, which mimics developmental events using embryonic-stage cells and microenvironments, shows promise. Our research group has made initial strides, indicating its potential as a viable solution for periodontal complex regeneration. However, further clinical trials and considerations are needed for successful clinical application. This review aims to summarize the strategic transitions in the development of periodontal regenerative materials and to propose prospective avenues for future development.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"49 ","pages":"Pages 418-436"},"PeriodicalIF":18.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143642216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulating macrophage glucose metabolism homeostasis via mitochondrial rheostats by short fiber-microsphere scaffolds for bone repair","authors":"Pengzhen Zhuang ,&nbsp;Yu Chen ,&nbsp;Yu Zhang ,&nbsp;Wu Yang ,&nbsp;Guilai Zuo ,&nbsp;Jessica M. Rosenholm ,&nbsp;Zhongmin Wang ,&nbsp;Juan Wang ,&nbsp;Wenguo Cui ,&nbsp;Hongbo Zhang","doi":"10.1016/j.bioactmat.2025.03.008","DOIUrl":"10.1016/j.bioactmat.2025.03.008","url":null,"abstract":"<div><div>The alterations in glucose metabolism flux induced by mitochondrial function changes are crucial for regulating bone immune homeostasis. The restoration of mitochondrial homeostasis, serving as a pivotal rheostat for balancing glucose metabolism in immune cells, can effectively mitigate inflammation and initiate osteogenesis. Herein, an ion-activated mitochondrial rheostat fiber-microsphere polymerization system (FM@CeZnHA) was innovatively constructed. Physical-chemical and molecular biological methods confirmed that CeZnHA, characterized by a rapid degradation rate, releases Ce/Zn ions that restore mitochondrial metabolic homeostasis and M1/M2 balance of macrophages through swift redox reactions. This process reduces the glycolysis level of macrophages by down-regulating the NF-κB p65 signaling pathway, enhances their mitochondrial metabolic dependence, alleviates excessive early inflammatory responses, and promptly initiates osteogenesis. The FM network provided a stable platform for macrophage glycolytic transformation and simulated extracellular matrix microenvironment, continuously restoring mitochondrial homeostasis and accelerating ossification center formation through the release of metal ions from the internal CeZnHA for efficient bone immune cascade reactions. This strategy of bone immunity mediated by the restoration of macrophage mitochondrial metabolic function and glucose metabolic flux homeostasis opens up a new approach to treating bone defects.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"49 ","pages":"Pages 399-417"},"PeriodicalIF":18.0,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143629112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Silicified curcumin microspheres Combats cardiovascular diseases via Nrf2/HO-1 pathway","authors":"Tianwang Guan ,&nbsp;Zhenxing Lu ,&nbsp;Rundong Tai ,&nbsp;Shuai Guo ,&nbsp;Zhaowenbin Zhang ,&nbsp;Shaohui Deng ,&nbsp;Jujian Ye ,&nbsp;Kaiyi Chi ,&nbsp;Binghua Zhang ,&nbsp;Huiwan Chen ,&nbsp;Zhilin Deng ,&nbsp;Yushen Ke ,&nbsp;Andong Huang ,&nbsp;Peier Chen ,&nbsp;Chunming Wang ,&nbsp;Caiwen Ou","doi":"10.1016/j.bioactmat.2025.03.007","DOIUrl":"10.1016/j.bioactmat.2025.03.007","url":null,"abstract":"<div><div>Diabetes and chemotherapy frequently give rise to severe cardiovascular complications, including chemotherapy-induced cardiotoxicity and diabetes-associated vascular remodeling. Nevertheless, the precise epidemiological features of these cardiovascular ailments remain incompletely elucidated, resulting in a dearth of effective therapeutic strategies in clinical settings. To tackle this intricate challenge, we have delved extensively into database resources, conducted comprehensive analyses of pertinent epidemiological data, and designed silicified curcumin (Si/Cur) microspheres as a novel therapeutic approach for cardiovascular diseases. By harnessing the alkaline microenvironment generated by silicon (Si), Si/Cur markedly elevates the bioavailability of curcumin (Cur). Further investigations have elucidated that Si/Cur exerts its therapeutic actions primarily via the Nrf2/HO-1 signaling pathway, effectively suppressing vascular remodeling and mitigating myocardial injury, thus disrupting the vicious cycle of persistent cardiovascular damage. In conclusion, this study integrates clinical cohort research to dissect epidemiological characteristics, directs the design and application of biomaterials, and paves the way for a novel and efficacious therapeutic avenue for the management of cardiovascular diseases.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"49 ","pages":"Pages 378-398"},"PeriodicalIF":18.0,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143629111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Noninvasive method for achieving the regeneration of damaged nerves via ultrasonic nasal drops","authors":"Ning Zhu ,&nbsp;Fan Wang ,&nbsp;Zeyu Han ,&nbsp;Shifeng Ling ,&nbsp;Duo Wai-Chi Wong ,&nbsp;Shenglin Ye ,&nbsp;Mingyue Liu ,&nbsp;Yanyang Chen ,&nbsp;Gracie Shen ,&nbsp;Ming Ni ,&nbsp;Huitong Ruan ,&nbsp;Yan Qiu ,&nbsp;Wenguo Cui","doi":"10.1016/j.bioactmat.2025.02.022","DOIUrl":"10.1016/j.bioactmat.2025.02.022","url":null,"abstract":"<div><div>Repair and regeneration of damaged neurons is a promising therapeutic strategy for central nervous system (CNS) diseases such as ischemic stroke (IS). However, achieving efficient neuronal repair and regeneration after CNS injury through noninvasive methods remains a significant challenge. Therefore, this study proposes, for the first time, an ultrasonic nasal drop formulation that induces efficient regeneration of damaged neurons through electropharmacological coupling in an noninvasive manner. Liposomes containing the natural anti-inflammatory drug Timosaponin B-II (TB) were coated onto barium titanate nanoparticles (BTO) to form LTO@TB. Using microfluidic technology and a Schiff base reaction, LTO@TB was encapsulated into aldehyde-based and methacrylate-modified microspheres (MS) to create the ultrasonic nasal drop MS@LTO@TB. The aldehyde groups of MS@LTO@TB spontaneously formed amide bonds with the numerous amino groups in the nasal mucosa, facilitating specific adhesion. Due to its enhanced bioadhesion and efficient transmembrane transport, LTO@TB was continuously and noninvasively delivered to the brain when administered nasally. Additionally, under ultrasonic stimulation, LTO@TB in the brain exerted an electropharmacological coupling effect, achieving noninvasive electrical stimulation of damaged neurons. MS@LTO@TB modulated microglial phenotypes, restored electrical signal conduction among damaged neurons, reshaped the inflammatory microenvironment, reduced neuronal apoptosis, activated the PI3K/AKT signaling pathway, and promoted axonal regeneration. MS@LTO@TB also showed the unique ability to alleviate inflammation and promote neuronal remodeling in a mouse model of middle cerebral artery occlusion/reperfusion (MCAO/R). This study presents a promising strategy involving the nasal administration of ultrasonic nasal drops as a noninvasive and efficient treatment for CNS injuries.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"49 ","pages":"Pages 342-361"},"PeriodicalIF":18.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143621368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sequential construction of vascularized and mineralized bone organoids using engineered ECM-DNA-CPO-based bionic matrix for efficient bone regeneration","authors":"Tingting Gai ,&nbsp;Hao Zhang ,&nbsp;Yan Hu ,&nbsp;Ruiyang Li ,&nbsp;Jian Wang ,&nbsp;Xiao Chen ,&nbsp;Jianhua Wang ,&nbsp;Zhenhua Chen ,&nbsp;Yingying Jing ,&nbsp;Chenglong Wang ,&nbsp;Long Bai ,&nbsp;Xiuhui Wang ,&nbsp;Jiacan Su","doi":"10.1016/j.bioactmat.2025.02.033","DOIUrl":"10.1016/j.bioactmat.2025.02.033","url":null,"abstract":"<div><div>Given the limitations of allogeneic and artificial bone grafts, bone organoids have attracted extensive attention for their physiological properties that closely resemble natural bone, offering great potential to bone reconstruction for critical-sized bone defects. Although early-stage bone organoids such as osteo-callus organoids and woven bone organoids have been reported, functional bone organoids with vascularization and mineralization are currently unavailable due to the lack of bone-mimicking matrix and dynamic culture systems suitable for the long-term cultivation of mature bone organoids. Herein, a novel engineered bionic matrix hydrogels with multifunctional components and double network structure are developed by incorporating calcium phosphate oligomers (CPO) into a combination of bone-derived decellularized extracellular matrix (ECM) and salmon-derived deoxyribonucleic acid (DNA) via photo-crosslinking and dynamic self-assembly strategies. This kind of bionic matrix hydrogels facilitate recruitment, proliferation, osteogenesis and angiogenesis of bone marrow mesenchymal stromal cells (BMSCs). More importantly, vascularized and mineralized bone organoids are sequentially constructed using BMSCs-loaded engineered bionic matrix hydrogels via <em>in vitro</em> dynamic culture and <em>in vivo</em> heterotopic ossification. Meanwhile, this kind of engineered bionic matrix are capable of achieving efficient bone repair for cranial defect. These findings suggest that engineered bionic matrix hydrogels combined with such dynamic culture system, providing a promising strategy for functional bone organoids construction.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"49 ","pages":"Pages 362-377"},"PeriodicalIF":18.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143621315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Cyanobacteria-based self-oxygenated photodynamic therapy for anaerobic infection treatment and tissue repair\" [Bioactive Materials 12 (2022) 314–326]","authors":"Bailiang Wang ,&nbsp;Liyang Zhou ,&nbsp;Yishun Guo ,&nbsp;Hanwen Guo ,&nbsp;Yiming Zhong ,&nbsp;Xiaomin Huang ,&nbsp;Yifan Ge ,&nbsp;Qingying Wang ,&nbsp;Xiaoying Chu ,&nbsp;Yingying Jin ,&nbsp;Kaiyue Lan ,&nbsp;Mei Yang ,&nbsp;Jia Qu","doi":"10.1016/j.bioactmat.2025.02.027","DOIUrl":"10.1016/j.bioactmat.2025.02.027","url":null,"abstract":"","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"49 ","pages":"Pages 340-341"},"PeriodicalIF":18.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143611649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Organelle-oriented nanomedicines in tumor therapy: Targeting, escaping, or collaborating?","authors":"Kexin Tan ,&nbsp;Haiyang Zhang ,&nbsp;Jianyuan Yang ,&nbsp;Hang Wang ,&nbsp;Yongqiang Li ,&nbsp;Guqiao Ding ,&nbsp;Ping Gu ,&nbsp;Siwei Yang ,&nbsp;Jipeng Li ,&nbsp;Xianqun Fan","doi":"10.1016/j.bioactmat.2025.02.040","DOIUrl":"10.1016/j.bioactmat.2025.02.040","url":null,"abstract":"<div><div>Precise tumor therapy is essential for improving treatment specificity, enhancing efficacy, and minimizing side effects. Targeting organelles is a key strategy for achieving this goal and is a frontier research area attracting a considerable amount of attention. The concept of organelle targeting has a significant effect on the structural design of the nanodrugs employed. Most notably, the intricate interactions among different organelles in a tumor cell essentially create a unified system. Unfortunately, this aspect might have been somewhat overlooked when existing organelle-targeting nanodrugs were designed. In this review, we underscore the synergistic relationship among the various organelles and advocate for a holistic view of organelle-targeting design. Through the integration of biology and material science, recent advancements in organelle targeting, escaping, and collaborating are consolidated to offer fresh perspectives for the development of antitumor nanomedicines.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"49 ","pages":"Pages 291-339"},"PeriodicalIF":18.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143611648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}