Bioactive Materials最新文献

{"title":"AntagomiR-192-5p-engineered exosomes encapsulated in MXene-modified GelMA hydrogel facilitated epithelization of burn wounds by targeting OLFM4","authors":"Wenzhang Liu ,&nbsp;Hongchao Huang ,&nbsp;Futing Shu ,&nbsp;Yingying Liu ,&nbsp;Jiezhi Lin ,&nbsp;Lu Yang ,&nbsp;Wei Zhang ,&nbsp;Luofeng Jiang ,&nbsp;Tianyi Liu ,&nbsp;Chaoran Xie ,&nbsp;Lei Li ,&nbsp;Yin He ,&nbsp;Shichu Xiao ,&nbsp;Yongjun Zheng ,&nbsp;Zhaofan Xia","doi":"10.1016/j.bioactmat.2025.06.013","DOIUrl":"10.1016/j.bioactmat.2025.06.013","url":null,"abstract":"<div><div>Burn wound healing is a multifaceted process often complicated by excessive inflammation and impaired keratinocyte function, both of which are key factors contributing to delayed healing. In this study we screened the key miRNA regulating the epithelialization process under oxidative stress conditions through high-throughput sequencing. We identified that miR-192-5p was significantly upregulated in both oxidative stress models of keratinocytes and burn wound tissues, with detrimental effects on keratinocyte proliferation, migration, and apoptosis. Inhibition of miR-192-5p enhanced epidermal cell function by upregulating olfactomedin-4 (OLFM4), a key gene associated with cell proliferation, adhesion and migration. To optimize delivery and therapeutic efficacy, we engineered MSC-derived exosomes loaded with antagomiR-192-5p (ant-192; Final content: 2 nmol per wound; Loading efficiency: 35.22 ± 0.34 %) and then encapsulated into a composite hydrogel composed of GelMA and MXene (Ti₃C₂Tx) nanosheets, forming a multifunctional dressing (Exo-ant-192@M-Gel). It achieved sustained release of ant-192, delay its degradation, and exert anti-inflammatory properties, thus promoting epithelization and burn wound healing. This study offered a novel therapeutic approach for burn wound closure.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"52 ","pages":"Pages 318-337"},"PeriodicalIF":18.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144253557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic mastery: Advancing mechanical and electrical harmony in conducting polymer hydrogel bioelectronics","authors":"Ting Wang ,&nbsp;Jiajun Liu ,&nbsp;Yuli Zhao ,&nbsp;Yuan Lu","doi":"10.1016/j.bioactmat.2025.06.015","DOIUrl":"10.1016/j.bioactmat.2025.06.015","url":null,"abstract":"<div><div>Conducting polymer hydrogels offer promising electrical interfaces with biological tissues for electrophysiological signal recording, sensing, and stimulation due to their favorable electrical properties, biocompatibility, and stability. Among them, Poly (3,4-ethylenedioxythiophene): Polystyrene sulfonate (PEDOT:PSS) is widely used as a conductive filler, forming a network of conjugated nanofibers within the hydrogel matrix. This structure enables robust electronic conductivity while preserving ionic transport and biocompatibility in physiological environments. However, the mechanical integrity of these hydrogels is often compromised by micellar microstructures in aqueous colloidal dispersions. The absence of interconnected conducting polymer nanofibers to maintain mechanical integrity during swelling hinders the mechanical properties of hydrogels. Here, three modification strategies were explored to enhance the flexibility and stretchability: constructing an interpenetrating network, phase separation induced by ionic compounds, and pure conductive hydrogels formed through polar solvent additives and dry-annealing. These strategies synergistically enhance conductivity and flexibility by controlling interchain entanglement and redesigning the distribution of conjugated crystal regions and soft regions. The resulting hydrogels exhibit excellent conductivity (1.99–5.25 S/m), softness (elastic modulus as low as 280 Pa), and elasticity (tensile properties up to 800 %). When used as epidermal or implantable bioelectrodes, they provided a soft interface, ensuring longer-lasting and more stable electromyogram, electrocardiogram, and electroencephalogram signals compared to commercial gel electrodes, with a signal-to-noise ratio of up to 20.0 dB. Therefore, the conducting polymer hydrogels developed in this study leverage the synergy between conductivity and flexibility, paving the way for further transformative applications in bioelectronics.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"52 ","pages":"Pages 300-317"},"PeriodicalIF":18.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144253555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic therapy for pancreatic cancer by deactivating cancer-associated fibroblasts and driving T-cell migration into tumor microenvironment using nanochaperone delivery system","authors":"Jiajing Chen ,&nbsp;Feihe Ma ,&nbsp;Yujie Chen ,&nbsp;Mengchen Xu ,&nbsp;Yongxin Zhang ,&nbsp;Shuyu Wang ,&nbsp;Hongyun Liu ,&nbsp;Linlin Xu ,&nbsp;Yang Liu ,&nbsp;Rujiang Ma ,&nbsp;Jinpu Yu ,&nbsp;Linqi Shi","doi":"10.1016/j.bioactmat.2025.06.010","DOIUrl":"10.1016/j.bioactmat.2025.06.010","url":null,"abstract":"<div><div>The success of immunotherapy in pancreatic ductal adenocarcinoma (PDAC) is greatly limited by the scarcity of cytotoxic T lymphocytes (CTLs) in tumor microenvironment, which is mainly due to the physical barrier formed by a dense extracellular matrix (ECM). Here we reported a potent strategy to rectify the CTLs infiltration in PDAC by synergistically deactivating cancer-associated fibroblasts (CAFs) and driving T-Cell migration into tumor microenvironment. This combination therapy is achieved by co-delivery of vitamin D receptor ligand (calcipotriol, Cal) and chemokine (CXCL9) using nanochaperone (nChap) delivery platform. We demonstrate that Cal reverses the activated CAFs to quiescence for resulting in a loosened ECM, while the CXCL9 gradient increases the recruitment signal of CD8⁺ T cells, synergistically enhancing the intratumoral infiltration of CD8⁺ T cells. Noteworthily, this system (Cal@nChap-CXCL9) promotes both the penetration of immunotherapeutic (anti-PD-1) and chemotherapeutic (gemcitabine), significantly enhancing the efficacy of chemo-immunotherapy for advanced large Panc02 tumors. This study provides a promising strategy for enhanced PDAC immunotherapy.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"52 ","pages":"Pages 287-299"},"PeriodicalIF":18.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144253556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Near-infrared light-induced photothermal and immunotherapy system for lung cancer bone metastasis treatment with simultaneous bone repair","authors":"Guoqing Zhong ,&nbsp;Yali Miao ,&nbsp;Jielong Zhou ,&nbsp;Yijie He ,&nbsp;Wenjie Yang ,&nbsp;Chongquan Huang ,&nbsp;Yunhui Zhang ,&nbsp;Jin Xiao ,&nbsp;Bingqing Bai ,&nbsp;Jiaqi Zhou ,&nbsp;Renshan Li ,&nbsp;Tiantian Wei ,&nbsp;Yu Zhang ,&nbsp;Shi Cheng","doi":"10.1016/j.bioactmat.2025.06.008","DOIUrl":"10.1016/j.bioactmat.2025.06.008","url":null,"abstract":"<div><div>Approximately half of lung cancer patients experience bone metastasis, leading to bone loss, fracture, and other skeletal-related events. Although immunotherapies have significantly advanced the therapeutic landscape for lung cancer, bone metastases have an immunologically \"cold\" microenvironment, representing a challenging obstacle when treating lung cancer. The combination of immunotherapy and photothermal therapy (PTT) for treating tumor-induced bone defects holds promise for enhancing the efficacy of local tumor ablation and inhibiting tumor recurrence and metastasis through activating systemic immune responses. Herein, we developed an injectable hydrogel-based photothermal immunotherapy system (BP@Gel-CD[SA] hydrogel) incorporating STING agonists (SA) and black phosphorus nanosheets (BPNSs) for high-efficiency tumor elimination, immune activation, and bone regeneration. The photothermal and photodynamic activities of BPNSs induce hyperthermia and ROS-mediated apoptosis of tumor cells. Meanwhile, SA loaded into the nano-boxes in BP@Gel-CD[SA] hydrogel by host-guest interaction significantly activates the cGas-STING pathway. It stimulates immunogenic cell death (ICD), synergistically promoting immune cell infiltration. Single-cell RNA sequence analysis confirms the modulation of the tumor microenvironment (TME) through the PTT-mediated ICD effect and the transactivation of the cGAS-STING pathway in immune cells of the TME. More importantly, the system can significantly inhibit the growth of distant tumors via systemic immune activation and elicit long-term immune memory in addition to tumor eradication. In the long term, this hydrogel system can promote the formation of new bone at sites of tumor-induced bone destruction, improving bone strength in the affected area. Collectively, this strategy provides an effective and safe option for treating lung cancer bone metastases.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"52 ","pages":"Pages 182-199"},"PeriodicalIF":18.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144243088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One-step strategy for fabricating icariin-encapsulated biomimetic Scaffold: Orchestrating immune, angiogenic, and osteogenic cascade for enhanced bone regeneration","authors":"Fengxin Zhao ,&nbsp;Fuying Chen ,&nbsp;Tao Song ,&nbsp;Luoqiang Tian ,&nbsp;Hang Guo ,&nbsp;Dongxiao Li ,&nbsp;Jirong Yang ,&nbsp;Kai Zhang ,&nbsp;Yumei Xiao ,&nbsp;Xingdong Zhang","doi":"10.1016/j.bioactmat.2025.06.001","DOIUrl":"10.1016/j.bioactmat.2025.06.001","url":null,"abstract":"<div><div>The repair of bone defects relies on the intricate coordination of inflammation, angiogenesis, and osteogenesis. However, scaffolds capable of integrating osteo-immunomodulation and vascular-bone coupling to cascade-activate these processes remain a challenge. Here, a biomimetic scaffold (CHP@IC) with <em>in situ</em> PLGA@icariin (PLGA@IC) microspheres encapsulation was successfully fabricated using a one-step emulsification and polymerization strategy. This approach not only simplifies the fabrication process but also ensures high encapsulation efficiency and sustained release of IC through PLGA@IC microspheres. The findings from subcutaneous implantation, network pharmacology-predicted molecular targets, and <em>in vitro</em> studies collectively reveal that the CHP@IC-induced M2 polarization of macrophages via STAT3 signaling pathway triggers the sequential activation of inflammation, angiogenesis, and osteogenesis to enhance bone regeneration. The CHP@IC scaffold exhibited a significant osteogenic advantage in cranial defect repair, yielding new bone volumes approximately 3-fold and 10-fold greater than those in the CHP group and blank control group, respectively. This study not only elucidates the mechanism of IC in promoting regeneration of bone but also provides a novel method for designing scaffolds aimed at the efficient repair of bone defects.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"52 ","pages":"Pages 271-286"},"PeriodicalIF":18.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144243492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smart coacervate microdroplets: biomimetic design, material innovations, and emerging applications in biomacromolecule delivery","authors":"Bingyu Ding ,&nbsp;Wenzhuo Jiang ,&nbsp;Ting Ouyang ,&nbsp;Helin Xu","doi":"10.1016/j.bioactmat.2025.06.016","DOIUrl":"10.1016/j.bioactmat.2025.06.016","url":null,"abstract":"<div><div>Coacervate microdroplets, formed via liquid-liquid phase separation, represent a transformative platform in biomacromolecule delivery due to their unique physicochemical properties, such as ultralow interfacial tension, high cargo capacity, and biomimetic cellular condensate-like behavior. This review systematically explored the design principles, driving forces (electrostatic, hydrophobic, and hydrogen-bond interactions) and physicochemical properties of coacervates droplets (microstructure, ultralow interfacial tension, coalescence). We highlighted diverse coacervate materials, including natural polysaccharides, synthetic polymers, polyphenols, nucleotides, proteins/peptides and inorganic polyphosphates, alongside functionalization strategies for controlled release (<em>e.g.,</em> enzymatic/magnetic triggers). The advance in coacervate-derived systems, <em>e.g.,</em> nanoparticles, microdroplets, interface-coated microdroplets, hydrogel, and biomedical devices have been discussed, emphasizing their advantages over conventional carriers. Breakthrough applications of coacervate systems in biomacromolecule or live cells delivery are further summarized in terms of sustained growth factor release for tissue regeneration, achieving cytosolic delivery with minimal toxicity, delivering probiotics to enhance gastrointestinal survival, and mimicking native extracellular matrices to deliver stem cells. Alternatively, pitfalls of coacervate systems for drug delivery, <em>e.g.,</em> thermodynamic instability, cargo leakage, and immunogenicity were analyzed and some potential strategies like surface lipid coating or PEGylation, have been put forward. Bridging fundamental insights with translational needs, this work outlined a roadmap for developing next-generation coacervates, emphasizing multicompartmental architectures for synthetic biology and precision therapeutics. Future directions include adaptive coacervates for personalized medicine, positioning coacervates as versatile tools for advancing regenerative medicine and targeted therapy.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"52 ","pages":"Pages 244-270"},"PeriodicalIF":18.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144243027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrically conductive biopolymer-based hydrogels and fibrous materials fabricated using 3D printing and electrospinning for cardiac tissue engineering","authors":"Arnaud Kamdem Tamo ,&nbsp;Ingo Doench ,&nbsp;Kaveh Roshanbinfar ,&nbsp;Alexandra Montembault ,&nbsp;Anatoli Serghei ,&nbsp;Felix B. Engel ,&nbsp;Anayancy Osorio-Madrazo","doi":"10.1016/j.bioactmat.2025.05.014","DOIUrl":"10.1016/j.bioactmat.2025.05.014","url":null,"abstract":"<div><div>Cardiovascular diseases pose a significant global health challenge, driving ongoing efforts to develop effective treatments. Various biofabrication technologies utilizing numerous materials have been employed to design functional cardiac tissues. Choosing the right material is crucial to support cardiac cell growth, proliferation, tissue maturation and functionality. 3D printing enables the fabrication of structures that mimic the hierarchical organization of native cardiac tissue, further enhancing its function. Electrospinning produces nanofibrous scaffolds with a high surface area and porosity, mimicking the extracellular matrix and promoting the cell behaviors required for tissue formation. Although typically employed independently, combining these technologies can enable the fabrication of patches with properties closely resembling those of native cardiac tissues. Recent research focuses on the use of electroconductive materials, which enhance cell-to-cell communication and promote the maturation of cardiomyocytes, thereby preventing arrhythmic contractions and improving the functionality of engineered cardiac tissues. In this review, recent studies showcasing the applications of electroconductive biopolymer-based fibrous materials and hydrogels designed using 3D printing and/or electrospinning for cardiac tissue engineering are discussed. Furthermore, the review evaluates the synergistic effects of biopolymer-based materials and electrical components in 3D printed electroconductive hydrogels. It also discusses the challenges faced in fabricating these hydrogels and explores their future prospects for biomedical applications.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"51 ","pages":"Pages 650-719"},"PeriodicalIF":18.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144241535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efferocytosis in tissue engineering: A comprehensive review of emerging therapeutic strategies for enhanced tissue repair and regeneration","authors":"Yue-Qi Zhang ,&nbsp;Rong Nie ,&nbsp;Zi-Yuan Feng ,&nbsp;Ming-Hui Fan ,&nbsp;Zhi-Xue Shen ,&nbsp;Xiu-Zhen Zhang ,&nbsp;Qing-Yi Zhang ,&nbsp;Chen-Yu Zou ,&nbsp;Ji-Ye Zhang ,&nbsp;Kai Huang ,&nbsp;Li-Ping Mou ,&nbsp;Hui-Qi Xie","doi":"10.1016/j.bioactmat.2025.05.026","DOIUrl":"10.1016/j.bioactmat.2025.05.026","url":null,"abstract":"<div><div>This comprehensive review elucidates the critical role of efferocytosis in tissue repair and regeneration processes, while systematically exploring innovative approaches through which tissue engineering strategies can modulate efferocytosis to optimize these biological processes. The manuscript is structured to first establish a fundamental understanding of efferocytosis, encompassing its core concepts, molecular mechanisms, and physiological functions within tissue repair. Subsequently, it provides an in-depth analysis of the regulatory role of efferocytosis in inflammatory response modulation during tissue repair cascades. The review culminates in a detailed investigation of cutting-edge tissue engineering applications specifically designed to manipulate efferocytosis pathways. Substantial evidence from recent studies has unequivocally demonstrated that efferocytosis serves as a crucial biological process in maintaining tissue homeostasis and orchestrating injury repair mechanisms. In this context, tissue engineering has emerged as a transformative approach, offering precise control over efferocytosis enhancement, inflammation resolution, and tissue regeneration processes. Through sophisticated integration of bioactive factor regulation, advanced scaffolding materials, and targeted cellular interactions, tissue engineering platforms have established novel therapeutic paradigms, providing unprecedented insights and innovative strategies for the treatment of diverse pathological conditions.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"52 ","pages":"Pages 155-181"},"PeriodicalIF":18.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144243087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomimetic extracellular vesicles derived from chimeric antigen receptor monocytes to treat glioblastoma: An efficient and safe intranasal drug delivery nanoplatform","authors":"Qihong Cheng ,&nbsp;Minjie Wang ,&nbsp;Zijie Zhou ,&nbsp;Huitang Xia ,&nbsp;Shaojie Yu ,&nbsp;Jianglin Zheng ,&nbsp;Kai Zhu ,&nbsp;Xudong Li ,&nbsp;Xuan Wang ,&nbsp;Tao Xin ,&nbsp;Xiaobing Jiang ,&nbsp;Junjun Li","doi":"10.1016/j.bioactmat.2025.05.032","DOIUrl":"10.1016/j.bioactmat.2025.05.032","url":null,"abstract":"<div><h3>Background</h3><div>Extracellular vesicles (EVs) have emerged as a promising pharmacotherapeutic modality for glioblastoma (GBM) drug delivery. However, the clinical translation of EVs remains restricted due to their low yield and demanding extraction steps. Therefore, extracellular vesicle mimetics (EVMs), as alternatives to EVs, have received much attention.</div></div><div><h3>Results</h3><div>Herein, inspired by the inherent GBM tropism of monocytes and the editable target recognition ability of chimeric antigen receptors (CARs), we present the synthesis and systemic evaluation of a doxorubicin (DOX)-loaded nanoplatform (termed CAR-EVMs@DOX) generated by loading DOX into EVMs derived from CAR-modified monocytes (CAR-EVMs) via a modified extrusion method. Due to insufficient GBM drug delivery efficacy and great systemic toxicity caused by the resistance of the blood−brain barrier (BBB), CAR-EVMs@DOX can be administered intranasally to bypass the BBB, resulting in dramatic GBM-targeted migration and accumulation in the GBM site. Moreover, compared with intravenous administration, intranasal delivery of CAR-EVMs@DOX increases tumor inhibition efficacy while protecting against DOX-induced cardiotoxicity.</div></div><div><h3>Conclusions</h3><div>The findings of our study demonstrate that the intranasal administration of the facile and well-designed nanoplatform CAR-EVMs@DOX is an advanced drug delivery tactic for GBM therapy, with the potential for future clinical translation.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"52 ","pages":"Pages 228-243"},"PeriodicalIF":18.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144243026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Near-field electrospun 3D anisotropic fiber-hydrogel scaffold integrated with photothermal effect for skin wound healing","authors":"Ruinan Hao ,&nbsp;Hongtao Hu ,&nbsp;Xilin Ye ,&nbsp;Xiaofeng Chen ,&nbsp;Jinzhi Du ,&nbsp;Shuolei Li ,&nbsp;Chenglin Song ,&nbsp;Feng Tian ,&nbsp;Nana Zhao ,&nbsp;Fujian Xu ,&nbsp;Tao Zhang ,&nbsp;Feng Rao ,&nbsp;Jiajia Xue","doi":"10.1016/j.bioactmat.2025.05.034","DOIUrl":"10.1016/j.bioactmat.2025.05.034","url":null,"abstract":"<div><div>Wound healing remains a critical clinical challenge due to inflammatory responses, oxidative stress in the wound microenvironment, and impaired tissue remodeling. In this study, an anisotropic scaffold was developed by integrating photothermal stimulation with topographical cues to modulate wound healing. The scaffold consisted of gelatin methacryloyl (GM) hydrogel and radially aligned poly (ε-caprolactone) (PCL) fibers integrated with polydopamine (PDA). The anisotropic scaffold not only exhibited anti-inflammatory effects but also enabled localized thermal stimulation under near-infrared (NIR) light to promote wound healing. It guided cell migration and proliferation from the wound edge toward the center, while the GM hydrogel maintained a moist environment and mitigated uncontrolled thermal damage. In a full-thickness skin wound model in rats, the anisotropic scaffold accelerated wound healing, epidermal regeneration, angiogenesis, and collagen deposition. This approach offers a safe, efficient, and bioactive-factor-free therapeutic strategy for wound repair, showing great potential for clinical translation.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"52 ","pages":"Pages 200-212"},"PeriodicalIF":18.0,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144231123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}