Bioactive Materials最新文献_第2页

Corrigendum to “Surface modification of electrospun fibers with mechano-growth factor for mitigating the foreign-body reaction” [Bioact. Mater. 6 (9) (2021) 2983–2998]

IF 18 1区医学

Bioactive Materials Pub Date : 2025-05-12 DOI: 10.1016/j.bioactmat.2025.04.035

Yang Song , Linhao Li , Weikang Zhao , Yuna Qian , Lili Dong , Yunnan Fang , Li Yang , Yubo Fan

引用次数: 0

Antibacterial MXenes: An emerging non-antibiotic paradigm for surface engineering of orthopedic and dental implants

IF 18 1区医学

Bioactive Materials Pub Date : 2025-05-12 DOI: 10.1016/j.bioactmat.2025.05.002

Sathishkumar Gnanasekar , Xiaodong He , Bruna E. Nagay , Kun Xu , Xi Rao , Shun Duan , Selvakumar Murugesan , Valentim A.R. Barão , En-Tang Kang , Liqun Xu

{"title":"Antibacterial MXenes: An emerging non-antibiotic paradigm for surface engineering of orthopedic and dental implants","authors":"Sathishkumar Gnanasekar , Xiaodong He , Bruna E. Nagay , Kun Xu , Xi Rao , Shun Duan , Selvakumar Murugesan , Valentim A.R. Barão , En-Tang Kang , Liqun Xu","doi":"10.1016/j.bioactmat.2025.05.002","DOIUrl":"10.1016/j.bioactmat.2025.05.002","url":null,"abstract":"<div><div>The colonization of planktonic bacteria onto implant surfaces is a serious concern in the medical field due to increasing infection-related mortality and fiscal difficulties worldwide. Various static, dynamic, and active coating techniques were established to tackle implant-associated infections (IAIs). However, the existing implant coating methods often confront issues with poor universality for different substrates, adaptability, stability, and the emergence of multi-drug resistance (MDR). The miraculous two-dimensional (2D) MXenes with outstanding multimodal bactericidal effects have been spotted as promising non-antibiotic implant surface coating additives for superior antibiofilm and osseointegration properties. This review systematically assesses the recent progress of antibacterial MXenes and their revolutionary usage to prevent peri-implantitis. We specifically sought to disclose the various forms of MXenes, such as composites, heterojunctions (HJs), and functional biomaterials used in combatting MDR and non-MDR bacterial pathogens by adopting therapeutic ventures such as photothermal therapy (PTT), photodynamic therapy (PDT), chemodynamic therapy (CDT), and sonodynamic therapy (SDT). In addition, we outlined the extension of MXene antibacterial systems for orthopedic and dental implant surface engineering to improve their longevity and safety. A thorough understanding of antibacterial MXenes synthesis, surface modification strategies, and biocompatible functional properties was deliberated to facilitate the construction of innovative coatings. Lastly, some viewpoints on the current limitations and key considerations for the future concept design of MXenes-coated implants were contemplated constructively to promote clinical outcomes.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"51 ","pages":"Pages 150-176"},"PeriodicalIF":18.0,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143943243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dental follicle stem cell-derived small extracellular vesicles ameliorate pulpitis by reprogramming macrophage metabolism

IF 18 1区医学

Bioactive Materials Pub Date : 2025-05-12 DOI: 10.1016/j.bioactmat.2025.04.034

Jun Tian , Yaxin Lou , Mengjie Li , Yihong Duan , He Liu , Chanchan Chen , Yu Qiu , Weiyang Chen , Chunfeng Pang , Yuhua Xiong , Ya Shen , Xi Wei

{"title":"Dental follicle stem cell-derived small extracellular vesicles ameliorate pulpitis by reprogramming macrophage metabolism","authors":"Jun Tian , Yaxin Lou , Mengjie Li , Yihong Duan , He Liu , Chanchan Chen , Yu Qiu , Weiyang Chen , Chunfeng Pang , Yuhua Xiong , Ya Shen , Xi Wei","doi":"10.1016/j.bioactmat.2025.04.034","DOIUrl":"10.1016/j.bioactmat.2025.04.034","url":null,"abstract":"<div><div>Vital pulp therapy (VPT) is considered a conservative means of preserving the vitality and function of the dental pulp after injury. However, current VPT has unfavorable effects on inflamed pulp. Mesenchymal stem cell (MSC)-derived small extracellular vesicles (MSC-sEVs) show powerful immunomodulatory capacities and exert therapeutic effects on a variety of inflammatory diseases. However, whether MSC-sEVs ameliorate the inflammatory response and promote inflammatory pulp repair in pulpitis is largely unknown. In this study, we show that sEVs derived from dental follicle stem cells (typical dental MSCs, DFSC-sEVs) alleviate lipopolysaccharide-induced pulpitis in rats and enhance pulp repair by inducing M2 macrophage polarization. Mechanistically, heat shock protein 70 (HSP70) within DFSC-sEVs can be supplemented into lysosomes to directly protect lysosomal function and induce mitophagy to promote the degradation of depolarized mitochondria, thereby preprogramming inflammatory macrophages to commit to oxidative phosphorylation, which fuels M2 polarization. Furthermore, DFSC-sEVs also transfer antioxidant miRNAs, including <em>miR-24-3p</em> and <em>let-7c-5p</em>, to inhibit mitochondrial reactive oxygen species production, thereby indirectly stabilizing lysosomes to induce M2 macrophage generation. Our study reveals a promising immunotherapeutic potential of DFSC-sEVs for VPT in inflamed pulp and a novel role for DFSC-sEVs in inhibiting the macrophage inflammatory response by protecting lysosomes and inducing mitophagy-mediated metabolic shifts toward oxidative phosphorylation.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"51 ","pages":"Pages 179-196"},"PeriodicalIF":18.0,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143943238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Progress in visible-light-activated photocatalytic coatings to combat implant-related infections: From mechanistic to translational roadmap

IF 18 1区医学

Bioactive Materials Pub Date : 2025-05-11 DOI: 10.1016/j.bioactmat.2025.04.037

Bruna E. Nagay , Samuel S. Malheiros , Maria H.R. Borges , Conrado Aparicio , Jeroen J.J.P. van den Beucken , Valentim A.R. Barão

{"title":"Progress in visible-light-activated photocatalytic coatings to combat implant-related infections: From mechanistic to translational roadmap","authors":"Bruna E. Nagay , Samuel S. Malheiros , Maria H.R. Borges , Conrado Aparicio , Jeroen J.J.P. van den Beucken , Valentim A.R. Barão","doi":"10.1016/j.bioactmat.2025.04.037","DOIUrl":"10.1016/j.bioactmat.2025.04.037","url":null,"abstract":"<div><div>Biomedical and dental implants have enhanced healthcare but concurrently increased the risk of infections. Innovations in smart biomaterials, especially those responding to light stimuli through photocatalytic mechanisms, are emerging as promising solutions for activating targeted antimicrobial responses. While extensive reviews have provided insight into photocatalysis and its medical and environmental applications, limited focus has been given to solutions specifically tailored for implant contexts. The recent introduction of photocatalysis in the implant field, particularly visible-light-triggered photocatalytic coatings, represents a versatile approach to managing infections. These coatings offer on-demand reactive oxygen species generation, delivering antibacterial effects against a range of pathogens. Hence, this comprehensive review aims to summarize the latest advancements in design principles, physicochemical modifications, and surface optimizations, along with novel research concepts towards the achievement of visible-light-triggered photocatalytic antibacterial activity. Moreover, through a systematic search, this review discusses the current state-of-the-art regarding the antimicrobial efficacy of these biomaterials and the key factors influencing their performance, including microorganism type, photocatalyst properties, light source and intensity, and exposure time. Finally, it provides an in-depth discussion of current challenges, future directions, and regulatory considerations targeting biofilm-related implant treatments, offering guidance for future clinical adoption of multifunctional photocatalytic coatings in implant therapy.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"51 ","pages":"Pages 83-137"},"PeriodicalIF":18.0,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143943240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radiation cross-linked collagen scaffolds facilitate root coverage and keratinized gingival regeneration

IF 18 1区医学

Bioactive Materials Pub Date : 2025-05-11 DOI: 10.1016/j.bioactmat.2025.04.023

Hongwei Li , Xin Chen , Bozhao Wang , Caiming Wu , Jian Li , Ling Xu

{"title":"Radiation cross-linked collagen scaffolds facilitate root coverage and keratinized gingival regeneration","authors":"Hongwei Li , Xin Chen , Bozhao Wang , Caiming Wu , Jian Li , Ling Xu","doi":"10.1016/j.bioactmat.2025.04.023","DOIUrl":"10.1016/j.bioactmat.2025.04.023","url":null,"abstract":"<div><div>The study aimed to develop a radiation cross-linked collagen scaffold (RCS) and assess its potential for root coverage and keratinized gingival regeneration, addressing the prevalent issue of gingival recession and limitations of traditional treatments. RCS was prepared through electron beam irradiation and cross-linking followed by freeze-drying. Its properties were evaluated, including Fourier transform infrared analysis, swelling behavior, microscopic observation, porosity measurement, compression modulus and structural stability. In a rat gingival recession model with 96 rats divided into four groups, the root coverage index and gingival health indices were measured, and histological analyses were conducted. The cross-linked network structure of RCS provided excellent mechanical properties and stability. In the rat model, RCS effectively promoted gingival regeneration, with the RCS group achieving a root coverage index of 87.7 ± 2.7 %, which was 54.13 %, 42.83 % and 8.41 % higher than that of the sham operation group, non-crosslinked group and chemical crosslinked group respectively. Histological analysis showed that RCS promoted anti-inflammatory macrophage polarization, enhanced collagen deposition and gingival lamina propria fiber density and increased angiogenesis. Additionally, RCS exhibited good biosafety, as blood indices and organ coefficients remained normal. In conclusion, RCS effectively promotes gingival regeneration and is a promising keratinized gingiva substitute for gingival recession, offering a new option for oral tissue repair.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"51 ","pages":"Pages 138-149"},"PeriodicalIF":18.0,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143943241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of bioactive materials primary cilia as a novel delivery vehicle 生物活性材料原毛作为新型传递载体的应用

IF 18 1区医学

Bioactive Materials Pub Date : 2025-05-08 DOI: 10.1016/j.bioactmat.2025.04.015

Ayan K. Barui , Farideh Amirrad , Vansh Goel , Sharareh Ohadi , Rajasekharreddy Pala , Ashraf M. Mohieldin , Andromeda M. Nauli , Surya M. Nauli

{"title":"Application of bioactive materials primary cilia as a novel delivery vehicle","authors":"Ayan K. Barui , Farideh Amirrad , Vansh Goel , Sharareh Ohadi , Rajasekharreddy Pala , Ashraf M. Mohieldin , Andromeda M. Nauli , Surya M. Nauli","doi":"10.1016/j.bioactmat.2025.04.015","DOIUrl":"10.1016/j.bioactmat.2025.04.015","url":null,"abstract":"<div><div>Primary cilia are hair-like structured cell organelles functioning as cellular antennae with chemosensory and mechanosensory roles. Dysfunction of cilia results in ciliopathies, including renovascular diseases (polycystic kidneys, hypertension, aneurysm), mental impedances (Alzheimer's disease, Parkinson's disease, dementia), metabolic diseases (obesity, developmental skeleton defects), blindness, and so on. With a diameter of 150 nm, cilia can be cleaved, released and circulated in the body as injury biomarkers. We here assessed the potential use of isolated cilia as a novel delivery vehicle. Cilia were isolated from renal epithelial cells, and a specific-targeting chemotherapeutic was designed on the cilia. The data show a remarkable property of cilia to significantly inhibit disease progression with reduced toxicity. These findings emphasize the prospective biomedical applications of primary cilia in generating novel drug, gene, protein, and other delivery systems to treat diverse pathological conditions. While there are many synthetic drug delivery vehicles, our studies demonstrate for the first time that physiologically produced primary cilia can be adapted as a unique carrier system.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"51 ","pages":"Pages 70-82"},"PeriodicalIF":18.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143916246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineered nerve guide conduit enhances peripheral nerve regeneration by modulating the microenvironment through macrophage-triggered cascade reactions 工程神经导管通过巨噬细胞触发级联反应调节微环境，促进周围神经再生

IF 18 1区医学

Bioactive Materials Pub Date : 2025-05-07 DOI: 10.1016/j.bioactmat.2025.04.033

Xindi Yang , Xiao Liang , Binyi Wang , Xing Gao , Wenqiang Yang , Jiajun Li , Huaan Cai , Zan Tong , Yun Chen

{"title":"Engineered nerve guide conduit enhances peripheral nerve regeneration by modulating the microenvironment through macrophage-triggered cascade reactions","authors":"Xindi Yang , Xiao Liang , Binyi Wang , Xing Gao , Wenqiang Yang , Jiajun Li , Huaan Cai , Zan Tong , Yun Chen","doi":"10.1016/j.bioactmat.2025.04.033","DOIUrl":"10.1016/j.bioactmat.2025.04.033","url":null,"abstract":"<div><div>Nerve regeneration after peripheral nerve injury (PNI) depends on exogenous and endogenous pro-healing signals in the microenvironment. Maintaining immune system homeostasis and remodeling the regenerative microenvironment are crucial prerequisites for promoting nerve regeneration. Here, a double-layer PSM/Gel-SC(IL-4) nerve guide conduit was fabricated by photocrosslinking poly (ethylene glycol) diacrylate (PEGDA) and methacrylic acid-sodium alginate (SAMA) hydrogel as the outer layer, with GelMA encapsulating IL-4 overexpressing Schwann cells as the inner layer. PSM/Gel-SC(IL-4) conduit enabled the sustained release of IL-4, inducing pro-healing macrophages polarization through JAK1/STAT6 pathway <em>in vitro</em>. The polarized macrophages further triggered the cellular cascade reactions, enhancing the pro-healing characteristics of endothelial cells and Schwann cells. In addition, PSM/Gel-SC(IL-4) conduit significantly promoted functional recovery and nerve regeneration in 12-mm rat sciatic nerve defect model, induced pro-healing macrophage polarization at the early stage and accelerated angiogenesis and myelination at the nerve regeneration stage. This study developed a novel immunomodulatory strategy to remodel the regenerative microenvironment, and explored the underlying cellular and molecular mechanism, demonstrating considerable therapeutic potential for long-distance nerve defect.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"51 ","pages":"Pages 46-69"},"PeriodicalIF":18.0,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143912394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From mechanism to applications: Advanced microneedles for clinical medicine 从机理到应用：用于临床医学的先进微针

IF 18 1区医学

Bioactive Materials Pub Date : 2025-05-05 DOI: 10.1016/j.bioactmat.2025.04.025

Yuqing Yang , Haifu Sun , Xiao Sun , Yu Wang , Fan Xu , Wenyu Xia , Liang Chen , Manyi Li , Tianke Yang , Yusen Qiao , Dechun Geng

{"title":"From mechanism to applications: Advanced microneedles for clinical medicine","authors":"Yuqing Yang , Haifu Sun , Xiao Sun , Yu Wang , Fan Xu , Wenyu Xia , Liang Chen , Manyi Li , Tianke Yang , Yusen Qiao , Dechun Geng","doi":"10.1016/j.bioactmat.2025.04.025","DOIUrl":"10.1016/j.bioactmat.2025.04.025","url":null,"abstract":"<div><div>Advanced microneedles (MNs) are a series of complex and multifunctional MNs designed for a variety of clinical applications that are not only efficacious but also cost-effective, acceptable, and safe. In light of the potential limitations of conventional drug delivery, including low drug bioavailability and insufficient therapeutic efficiency, as well as the financial burden and discomfort associated with conventional detection, there is a thirst for alternatives. As a novel form of cargo delivery capable of penetrating tissue surface barriers easily, MNs avoid the various risks associated with traditional testing tools, and can achieve precise, on-demand, or continuous drug delivery. It has great potential to become an ideal clinical tool. Herein, an exhaustive review is proposed to summarize the designs and research progress of MNs. First, the designs and fabrication of it are introduced. Next, recent advances of applications in detection and therapy of MNs are systematically classified and discussed. Second, clinical trials of MNs in recent five years and commercial MNs are provided. Furthermore, this review discusses the limitations and challenges of MNs and speculates on their prospective evolution and applications in biomedicine. This review focuses on the future effective utilization of MNs and novel designs of innovative and effective clinical MNs devices.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"51 ","pages":"Pages 1-45"},"PeriodicalIF":18.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143906094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human induced pluripotent stem cell derived nanovesicles for cardiomyocyte protection and proliferation 人诱导多能干细胞衍生的纳米囊泡对心肌细胞的保护和增殖

IF 18 1区医学

Bioactive Materials Pub Date : 2025-05-02 DOI: 10.1016/j.bioactmat.2025.04.017

Yuhua Wei , Xiaoxiao Geng , Qing You , Yu Zhang , Fangfang Cao , Gunaseelan Narayanan , Thanh Nguyen , Xiaoyuan Chen , Jianyi Zhang , Lei Ye

{"title":"Human induced pluripotent stem cell derived nanovesicles for cardiomyocyte protection and proliferation","authors":"Yuhua Wei , Xiaoxiao Geng , Qing You , Yu Zhang , Fangfang Cao , Gunaseelan Narayanan , Thanh Nguyen , Xiaoyuan Chen , Jianyi Zhang , Lei Ye","doi":"10.1016/j.bioactmat.2025.04.017","DOIUrl":"10.1016/j.bioactmat.2025.04.017","url":null,"abstract":"<div><div>It remains a significant challenge to reactivate the cell cycle activity of adult mammalian cardiomyocytes (CMs). This study created a hypo-immunogenic human induced pluripotent stem cell (hiPSC) line using clustered regularly interspaced palindromic repeats (CRISPR)/Cas9 gene editing to knockout β2-microglobulin in hiPSCs (<sup>B2MKO</sup>hiPSCs) for manufacturing nanovesicles (<sup>B2MKO</sup>hiPSC-NVs). Approximately 9500 <sup>B2MKO</sup>hiPSC-NVs were produced from a single <sup>B2MKO</sup>hiPSC. Proteomic analyses indicated that, compared to <sup>B2MKO</sup>hiPSCs, the cargos of <sup>B2MKO</sup>hiPSC-NVs were enriched in spindle and chromosomal proteins, as well as proteins that regulate the cell cycle and scavenge reactive oxygen species (ROS). When administrated to hiPSCs derived CMs (hiPSC-CMs), <sup>B2MKO</sup>hiPSC-NVs reduced lactate dehydrogenase leakage and apoptosis in hypoxia-cultured hiPSC-CMs through activating the AKT pathway, protected hiPSC-CMs from H<sub>2</sub>O<sub>2</sub>-induced damage by ROS scavengers in the NV cargo, increased hiPSC-CM proliferation via the YAP pathway, and were hypoimmunogenic when co-cultured with human CD8<sup>+</sup> T cells or delivered to mice. Furthermore, when <sup>B2MKO</sup>hiPSC-NVs or 0.9 % NaCl were intramyocardially injected into mice after cardiac ischemia/reperfusion injury, cardiac function and infarct size, assessed 4 weeks later, were significantly improved in the <sup>B2MKO</sup>hiPSC-NV group, with increased mouse CM survival and cell cycle activity. Thus, the proteins in the <sup>B2MKO</sup>hiPSC-NV cargos convergently activated the AKT pathway, scavenged ROS to protect CMs, and upregulated YAP signaling to induce CM cell cycle activity. Thus, <sup>B2MKO</sup>hiPSC-NVs hold great potential for cardiac protection and regeneration.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"50 ","pages":"Pages 585-602"},"PeriodicalIF":18.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143899938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrasound-activated carrier-free nanoprodrugs enhanced universality and efficiency of solid tumor-targeting chemotherapy 超声激活的无载体纳米药物提高了实体肿瘤靶向化疗的普遍性和有效性

IF 18 1区医学

Bioactive Materials Pub Date : 2025-05-02 DOI: 10.1016/j.bioactmat.2025.04.038

Xiaodan Xu , Guowei Wang , Yijie Chen , Peile Jin , Jifan Chen , Xia Fang , Dequan Ye , Pintong Huang

{"title":"Ultrasound-activated carrier-free nanoprodrugs enhanced universality and efficiency of solid tumor-targeting chemotherapy","authors":"Xiaodan Xu , Guowei Wang , Yijie Chen , Peile Jin , Jifan Chen , Xia Fang , Dequan Ye , Pintong Huang","doi":"10.1016/j.bioactmat.2025.04.038","DOIUrl":"10.1016/j.bioactmat.2025.04.038","url":null,"abstract":"<div><div>The clinical outcome of chemotherapy for solid tumors is significantly restricted by adverse off-target side effects and heterogeneous microenvironments. Herein, we developed a series of ultrasound (US)-activated carrier-free self-assembled nanoprodrugs (PBSN38-OSs) to enhance universality and efficiency of tumor-targeting chemotherapy. The nanoprodrugs integrated reactive oxygen species (ROS)-responsive pinacol boronic ester-conjugated SN38 (PBSN38) and organic sonosensitizers (OSs). By screening the OSs library, six small molecules with strong binding ability with PBSN38 and high sonodynamic generation efficiency were identified. Then, various PBSN38-OSs nanoprodrugs with high drug-loading content and aqueous stability were fabricated using a facile nano-precipitation method. When exposed to US irradiation, PBSN38-OSs produced extensive ROS <em>in situ</em>, strongly disturbing the endogenous redox balance to overcome the heterogeneity of tumoral ROS content. They subsequently triggered the release of active SN38, thereby resulting in severe oxidative damage and microenvironment-independent cell apoptosis. The antitumor activity and biocompatibility of PBSN38-OSs were thoroughly examined <em>in vitro</em> and <em>in vivo</em>, and two optimal nanoprodrugs were screened, which exhibited potent therapeutical effects toward solid tumor models of colon adenocarcinoma, hepatocellular carcinoma, and pancreatic carcinoma. Overall, the versatile US-activated carrier-free nanoprodrugs could significantly minimize the side effects of chemo-drugs and improve the tumor-targeting chemotherapy efficacy in a spatial-controlled and microenvironment-independent manner, holding great prospects in further clinical translation.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"50 ","pages":"Pages 571-584"},"PeriodicalIF":18.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143895243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0