Bioactive Materials最新文献_第2页

Enhancing remanent magnetization of injectable hydrogels improves realtime transluminal localization of tumor in hollow soft viscera 增强可注射水凝胶的剩余磁化，可改善空心软脏器内肿瘤的实时腔内定位

IF 18 1区医学

Bioactive Materials Pub Date : 2025-09-26 DOI: 10.1016/j.bioactmat.2025.08.025

Junnan Gu , Yuxuan Sun , Tianyi Zhang , Zhenxing Jiang , Falong Zou , Denglong Cheng , Wentai Cai , Hao Wen , Shenghe Deng , Jun Wang , Shuang Zhao , Quanliang Cao , Yinghao Cao , Zichun Yang , Liang Li , Jun Ouyang , Kailin Cai

{"title":"Enhancing remanent magnetization of injectable hydrogels improves realtime transluminal localization of tumor in hollow soft viscera","authors":"Junnan Gu , Yuxuan Sun , Tianyi Zhang , Zhenxing Jiang , Falong Zou , Denglong Cheng , Wentai Cai , Hao Wen , Shenghe Deng , Jun Wang , Shuang Zhao , Quanliang Cao , Yinghao Cao , Zichun Yang , Liang Li , Jun Ouyang , Kailin Cai","doi":"10.1016/j.bioactmat.2025.08.025","DOIUrl":"10.1016/j.bioactmat.2025.08.025","url":null,"abstract":"<div><div>The accuracy of intraoperative localization of tumors undetectable under optical visualization determines surgical quality and survival outcomes in gastrointestinal cancers. Current approaches, however, remain constrained by suboptimal spatial resolution and low procedural efficiency. Additionally, conventional electromagnetic localization techniques based on image registration face challenges in soft tissue deformation scenarios. Here, we developed an electromagnetic localization technology for intraluminal tumor localization based on injectable magnetic hydrogel with sustained magnetization properties (MagLabel-IH). Following endoscopic injection into the gastrointestinal tract and <em>in situ</em> realignment, MagLabel-IH enables continuous intraluminal magnetic signal tracing. Intraoperatively, a dynamic registration framework synchronizes the magnetic coordinate system with real-time anatomical positions under visual guidance, achieving precise localization of optically invisible intraluminal tumors. The system demonstrated exceptional surgical instrument maneuverability (e.g., tissue grasping, resection path selection) during MagLabel-IH detection. <em>In vivo</em> animal evaluations demonstrated significantly enhanced localization accuracy compared to conventional biological dyes tattooing (3.8 ± 0.8 mm vs. 16.8 ± 8.6 mm, <em>P</em> < 0.05). Furthermore, the magnetic labels-based localization system exhibited promising utility for tumor margin demarcation and planning of gastrointestinal functional reconstruction.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"55 ","pages":"Pages 410-425"},"PeriodicalIF":18.0,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145156075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Responsive nanomedicine strategies achieve pancreatic cancer precise theranostics 反应性纳米医学策略实现胰腺癌精确治疗

IF 18 1区医学

Bioactive Materials Pub Date : 2025-09-25 DOI: 10.1016/j.bioactmat.2025.08.012

Fangjian Li , Zixiang Tang , Yating Zheng , Tao Jiang , Lin Deng , Wenjie Dai , Yuxing Zhao , Nan Zheng , Siman Liu , Yuxuan Fan , Sihan Lu , Yanxi Chen , Gang Liu , Yang Zhang , Yongfu Xiong

{"title":"Responsive nanomedicine strategies achieve pancreatic cancer precise theranostics","authors":"Fangjian Li , Zixiang Tang , Yating Zheng , Tao Jiang , Lin Deng , Wenjie Dai , Yuxing Zhao , Nan Zheng , Siman Liu , Yuxuan Fan , Sihan Lu , Yanxi Chen , Gang Liu , Yang Zhang , Yongfu Xiong","doi":"10.1016/j.bioactmat.2025.08.012","DOIUrl":"10.1016/j.bioactmat.2025.08.012","url":null,"abstract":"<div><div>Pancreatic ductal adenocarcinoma (PDAC), the predominant subtype of pancreatic cancer, ranks among the deadliest malignancies worldwide, with a 5-year survival rate remaining below 13 %. Its poor prognosis stems from complex anatomical barriers, a dense and heterogeneous tumor microenvironment (TME), and intricate molecular regulatory networks that collectively hinder early detection and limit therapeutic efficacy. Nanomedicine offers promising solutions by enhancing drug loading, improving delivery, counteracting drug resistance, and enabling stimuli-responsive control. Notably, stimuli-responsive nanotherapeutics have emerged as a transformative strategy, achieving precise drug release through activation by endogenous TME cues (e.g., acidic pH, redox gradients, hypoxia, enzyme overexpression) or exogenous triggers (e.g., ultrasound, light, magnetic fields). Endogenous-responsive systems autonomously activate at tumor sites, enhancing intratumoral drug accumulation and reducing off-target effects, while exogenous-responsive platforms enable spatiotemporal control through external modulation. Multi-responsive systems integrate both mechanisms to achieve dynamic and synergistic therapeutic effects, holding significant promise for PDAC theranostics. This review summarizes recent advances in stimuli-responsive nanotherapeutics for PDAC, detailing their activation mechanisms, biomedical applications, and theranostic potential across endogenous, exogenous, and multi-responsive modalities. It further discusses current challenges and future directions for translating these technologies into clinical practice.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"55 ","pages":"Pages 334-375"},"PeriodicalIF":18.0,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145156072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mn3O4-potentiated bifunctional hydrogel for mild temperature-controlled tumor ablation and osteogenesis mn3o4增强双功能水凝胶用于轻度温控肿瘤消融和成骨

IF 18 1区医学

Bioactive Materials Pub Date : 2025-09-25 DOI: 10.1016/j.bioactmat.2025.09.037

Yao Zhao , Wenkai Wang , Mingyi Liu , Yunfan Cai , Yan Wang , Yan Dong , Yong-kang Bai , Juanfang Zhu , Franklin R. Tay , Lina Niu

{"title":"Mn3O4-potentiated bifunctional hydrogel for mild temperature-controlled tumor ablation and osteogenesis","authors":"Yao Zhao , Wenkai Wang , Mingyi Liu , Yunfan Cai , Yan Wang , Yan Dong , Yong-kang Bai , Juanfang Zhu , Franklin R. Tay , Lina Niu","doi":"10.1016/j.bioactmat.2025.09.037","DOIUrl":"10.1016/j.bioactmat.2025.09.037","url":null,"abstract":"<div><div>Postoperative bone reconstruction after tumor resection remains challenging due to tumor recurrence and poor osteogenesis. Although photothermal scaffolds can ablate tumors (via high heat) and stimulate bone formation (via mild heat), balancing these effects is difficult—excessive heat damages tissue, while insufficient heat fails to eliminate tumors. Here, we develop an injectable Mn<sub>3</sub>O<sub>4</sub>-enhanced hydrogel (GM/OD/Mn<sub>3</sub>O<sub>4</sub>) to address this. Mn<sub>3</sub>O<sub>4</sub> nanosheets, firstly synthesized via biomineralization, exhibit high photothermal efficiency and enzyme-mimetic activity (glucose oxidase/peroxidase-like). The hydrogel adapts to irregular defects and releases Mn<sub>3</sub>O<sub>4</sub> in acidic tumor microenvironments. Through catalytic cascades, it depletes ATP and inhibits heat shock proteins, overcoming tumor thermoresistance and enabling effective ablation at mild temperatures (43 °C). Lower NIR power (40 °C) further enhances osteogenesis. In vivo, the hydrogel suppresses tumor recurrence while promoting bone regeneration, offering a dual-functional strategy for postoperative bone repair.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"55 ","pages":"Pages 391-409"},"PeriodicalIF":18.0,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145156074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thermosensitive antibacterial nanocomposite hydrogel guiding macrophage polarization and bone regeneration for periodontitis treatment 热敏抗菌纳米复合水凝胶诱导巨噬细胞极化和骨再生治疗牙周炎

IF 18 1区医学

Bioactive Materials Pub Date : 2025-09-25 DOI: 10.1016/j.bioactmat.2025.09.030

Xiang Yu , Huiling Liu , Lingdi Chen , Xiaohui Cheng , Gang Wu , Tim Forouzanfar , Longbao Feng , Rui Guo , Miao Zhou , Ting Sun

{"title":"Thermosensitive antibacterial nanocomposite hydrogel guiding macrophage polarization and bone regeneration for periodontitis treatment","authors":"Xiang Yu , Huiling Liu , Lingdi Chen , Xiaohui Cheng , Gang Wu , Tim Forouzanfar , Longbao Feng , Rui Guo , Miao Zhou , Ting Sun","doi":"10.1016/j.bioactmat.2025.09.030","DOIUrl":"10.1016/j.bioactmat.2025.09.030","url":null,"abstract":"<div><div>Periodontitis is a chronic inflammatory disease caused by bacterial infection that leads to the destruction of periodontal tissues. Traditional treatment involves scaling and root planing combined with antibiotics, but systemic antibiotic therapy often results in insufficient drug concentration at the treatment site and unwanted side effects. Here, we developed a nanocomposite thermosensitive hydrogel (CFMD) designed for localized drug delivery. The chitosan-grafted Pluronic® F127 hydrogel (CP) had natural antibacterial activity. After the thermosensitive material flows into the periodontal pocket, it transforms into a gel phase at body temperature, filling the periodontal pocket and preserving the nanomedicine. As the hydrogel retained in the periodontal pocket is degraded, folic acid-modified MBG nanoparticles loaded with doxycycline (FA-MBG@Dox) nanoparticles deliver doxycycline hydrochloride (Dox) to below the gum line, where instruments and hydrogel drug carriers cannot reach, enabling deeper antibacterial, anti-inflammatory, and osteogenesis-promoting effects. <em>In vitro</em>, CFMD hydrogel exhibited potent antibacterial activity, promoted human periodontal ligament stem cells (hPDLSCs) differentiation, and induced macrophage polarization toward the anti-inflammatory (M2) phenotype. <em>In vivo</em>, it effectively inhibited alveolar bone loss, promoted bone regeneration, and reshaped the inflammatory microenvironment. This study showed that CFMD hydrogel with targeted polarization regulation, oxidative stress regulation and osteogenesis regeneration capabilities may provide a simpler and more effective way for the treatment of periodontitis.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"55 ","pages":"Pages 376-390"},"PeriodicalIF":18.0,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145156073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D-printed functionalized strontium-silk fibroin-hydroxyapatite scaffolds facilitate bone regeneration via immunomodulatory and sequential angiogenic-osteogenic coupling 3d打印功能化锶-丝素-羟基磷灰石支架通过免疫调节和顺序血管生成-成骨耦合促进骨再生

IF 18 1区医学

Bioactive Materials Pub Date : 2025-09-24 DOI: 10.1016/j.bioactmat.2025.09.033

Kui Huang , Qilin Li , Yunfei Liu , Piaoye Ming , Long Bo , Qiumei Li , Rui Cai , Gang Tao , Xiaoxiao Cai , Jingang Xiao

{"title":"3D-printed functionalized strontium-silk fibroin-hydroxyapatite scaffolds facilitate bone regeneration via immunomodulatory and sequential angiogenic-osteogenic coupling","authors":"Kui Huang , Qilin Li , Yunfei Liu , Piaoye Ming , Long Bo , Qiumei Li , Rui Cai , Gang Tao , Xiaoxiao Cai , Jingang Xiao","doi":"10.1016/j.bioactmat.2025.09.033","DOIUrl":"10.1016/j.bioactmat.2025.09.033","url":null,"abstract":"<div><div>The repair of large bone defects remains a significant clinical challenge. The development of bioactive materials for bone tissue engineering offers promising solutions to address these problems. However, the lack of vascularization and the risk of endogenous immune rejection severely hinder the application of implantable biomaterials in bone regeneration. Therefore, in this study, we synthesized a multifunctional 3D-printed biological scaffold (EP@PCL/Sr) for achieving staged vascularized bone regeneration in the immune microenvironment to promote bone defect repair. Firstly, the rough surface morphology of the EP@PCL/Sr scaffolds enhanced cell proliferation and adhesion. Furthermore, epigallocatechin-3-gallate, a surface-coating component, contributed to immune regulation. Finally, strontium-silk fibroin (Sr-SF)-modified hydroxyapatite, embedded within the PCL scaffold, released Sr and Ca ions to improve both angiogenesis and osteogenesis. Both <em>in vivo</em> and <em>ex vivo</em> experimental results demonstrated that EP@PCL/Sr scaffolds exhibited excellent multifunctional properties, including good tissue compatibility, effective scavenging of reactive oxygen species, strong balancing of the immune microenvironment and regulation of macrophage polarization, perfect enhancement of angiogenesis and promotion of osteogenesis for promoting bone regeneration. Furthermore, the underlying mechanism were revealed that EP@PCL/Sr scaffolds promoted osteogenesis of BMSCs by activating the ITGA10/PI3K/AKT pathway. This study presents a comprehensive and innovative strategy for bone regeneration and bone defect repair, providing a new possibility for its clinical application.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"55 ","pages":"Pages 271-289"},"PeriodicalIF":18.0,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145118896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancements in dual-targeting nanoparticle strategies for enhanced atherosclerosis therapy: Overcoming limitations of single-targeting approaches 增强动脉粥样硬化治疗的双靶向纳米颗粒策略的进展：克服单靶向方法的局限性

IF 18 1区医学

Bioactive Materials Pub Date : 2025-09-24 DOI: 10.1016/j.bioactmat.2025.09.023

Can Yang , Liqing Mo , Guizhi Zhang , Yingxuan Dai , Binxiang Li , Zihan Tan , Yujie Guo , Shan Lu , Yi Hong , Hongliang He , Hu Yang , Jianhua He

{"title":"Advancements in dual-targeting nanoparticle strategies for enhanced atherosclerosis therapy: Overcoming limitations of single-targeting approaches","authors":"Can Yang , Liqing Mo , Guizhi Zhang , Yingxuan Dai , Binxiang Li , Zihan Tan , Yujie Guo , Shan Lu , Yi Hong , Hongliang He , Hu Yang , Jianhua He","doi":"10.1016/j.bioactmat.2025.09.023","DOIUrl":"10.1016/j.bioactmat.2025.09.023","url":null,"abstract":"<div><div>Atherosclerosis treatment remains challenging, particularly in terms of developing effective targeted drug delivery strategies to enhance therapeutic efficacy. As research advances, considerable attention has been paid to identifying specific cell types and subcellular organelles—based on molecular mechanisms, damage progression, and drug action—to design next-generation nanoformulations with greater precision. Dual-targeting nanoparticles, which integrate numerous targeting modalities, offer a promising approach to precise drug delivery to pathological plaque sites. By enabling sequential and synchronous navigation of the targeting moieties, these strategies offer greater control over drug delivery than conventional methods. In this review, we discuss the pathological process of atherosclerosis and examine the progress made in its treatment using rationally designed nanoparticles over recent decades. We critically evaluate the limitations of single-targeting strategies and explore potential areas for improvement. Further, we provide a comprehensive overview of the classification and core principles of dual-targeting methods, thereby evaluating their efficiency. Finally, we discuss the design and application of strategies that integrate targeting ligands with stimulus-responsive moieties or nanobiomimetic techniques, thereby demonstrating their potential to address ligand-based dual-targeting nanotechnology limitations.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"55 ","pages":"Pages 302-333"},"PeriodicalIF":18.0,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145156071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cocklebur-inspired magnetic nanomotors for targeted thrombus therapy 针对血栓治疗的cockleber启发的磁性纳米马达

IF 18 1区医学

Bioactive Materials Pub Date : 2025-09-24 DOI: 10.1016/j.bioactmat.2025.09.029

Shuyin Zhou , Lijun Cai , Yi Cheng , Yepeng Zhang , Yuanjin Zhao , Min Zhou

{"title":"Cocklebur-inspired magnetic nanomotors for targeted thrombus therapy","authors":"Shuyin Zhou , Lijun Cai , Yi Cheng , Yepeng Zhang , Yuanjin Zhao , Min Zhou","doi":"10.1016/j.bioactmat.2025.09.029","DOIUrl":"10.1016/j.bioactmat.2025.09.029","url":null,"abstract":"<div><div>Nanomotors have come to the forefront as a powerful tool for thrombolysis. Attempts in this field tend to improve the structure and function of nanomotors for safe and efficient treatment. To address the problem of low utilization and high bleeding risk, herein, we present a magnetically-driven cocklebur-like nanomotor for efficient delivery of recombinant tissue plasminogen activator (rt-PA) to treat thrombus. Composed of Fe<sub>3</sub>O<sub>4</sub> cores and spiked silicate shells, these nanomotors can rapidly respond to magnetic fields and adhere to the thrombus regardless of the blood flow impact. Besides, we use an H<sub>2</sub>O<sub>2</sub>-responsive ester to conjugate rt-PA to the nanomotors, releasing the medication only around the thrombus with abundant reactive oxygen species, thereby ensuring effective potency preservation. <em>In vivo</em> study proves that these cocklebur-like nanomotors can successfully treat a mouse model with a reduced thrombus area of 3.3-fold compared with direct-injection of rt-PA. Also, the coagulation system exhibits no obvious changes. All the results confirm the synergistic effect of magnetic control, adherence, and targeted drug release. These features suggest that the efficient thrombolysis ability of these nanomotors could offer new therapeutic strategies and practical value for cardiac, cerebral, and peripheral thrombotic diseases.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"55 ","pages":"Pages 290-301"},"PeriodicalIF":18.0,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145119476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic fusion of CD47, VE-cadherin and mussel adhesion protein promotes endothelialization and suppresses inflammation in vascular stents CD47、VE-cadherin和贻贝粘附蛋白的协同融合促进血管支架内皮化并抑制炎症

IF 18 1区医学

Bioactive Materials Pub Date : 2025-09-23 DOI: 10.1016/j.bioactmat.2025.09.015

Wenhua Yan , Shuyu Li , Tian Zhang , Junli Huang , Chengchen Deng , Kunshan Yuan , Nan Huang , Haijun Zhang , Guixue Wang

{"title":"Synergistic fusion of CD47, VE-cadherin and mussel adhesion protein promotes endothelialization and suppresses inflammation in vascular stents","authors":"Wenhua Yan , Shuyu Li , Tian Zhang , Junli Huang , Chengchen Deng , Kunshan Yuan , Nan Huang , Haijun Zhang , Guixue Wang","doi":"10.1016/j.bioactmat.2025.09.015","DOIUrl":"10.1016/j.bioactmat.2025.09.015","url":null,"abstract":"<div><div>Endothelial cell (EC)-specific coatings for vascular stents are crucial for enhancing their biocompatibility and preventing complications such as restenosis and thrombosis. This study developed an innovative CD47-VE-cadherin-Mfp5 (CD47-VE-M) fusion protein coating for cardiovascular stents that integrates three distinct functional domains: endothelial adhesion enhancement (VE-cadherin EC1-2), macrophage inhibitory signaling (CD47), and substrate adhesion reinforcement (Mfp5). <em>In vitro</em>, CD47-VE-M coatings significantly promoted EC adhesion (3.4-fold increase vs. bare-metal stent (BMS) (p < 0.001)), directional migration (accelerated 62 % compared to BMS at 24 h) and proliferation (2.3-fold increase vs. BMS (p < 0.01)), with increased VE-cadherin expression and improved tight junction formation (1.5-fold higher than BMS (p < 0.001)). Additionally, the CD47-VE-M coating reduced macrophage phagocytosis by 59 % (p < 0.01). Compared with BMS, synergistic CD47-VE-M fusion protein-coated stents showed accelerated endothelialization and reduced neointimal hyperplasia and restenosis by 64.4 % (p < 0.001) <em>in vivo</em>. Besides, the coating also decreased the presence of M1 pro-inflammatory macrophages (64.74 % decrease vs. BMS (p < 0.01)), which mitigated the inflammatory response. This novel coating strategy overcomes the limitations of current drug-eluting stent (DES) by simultaneously enhancing endothelial regeneration and suppressing pathological inflammation.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"55 ","pages":"Pages 257-270"},"PeriodicalIF":18.0,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145119477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sonotheranostic nanosideromycin eradicates bacterial biofilm infections via ultrasound-detonated ROS generation and ferroptosis-like death 超声治疗纳米铁霉素通过超声引爆ROS产生和铁中毒样死亡根除细菌生物膜感染

IF 18 1区医学

Bioactive Materials Pub Date : 2025-09-20 DOI: 10.1016/j.bioactmat.2025.09.020

Xin Pang , Chang Zhang , Qicai Xiao , Yi Cheng , Qixuan Dai , Hu Chen , Sijia Tan , Gang Liu , Yun Zeng

{"title":"Sonotheranostic nanosideromycin eradicates bacterial biofilm infections via ultrasound-detonated ROS generation and ferroptosis-like death","authors":"Xin Pang , Chang Zhang , Qicai Xiao , Yi Cheng , Qixuan Dai , Hu Chen , Sijia Tan , Gang Liu , Yun Zeng","doi":"10.1016/j.bioactmat.2025.09.020","DOIUrl":"10.1016/j.bioactmat.2025.09.020","url":null,"abstract":"<div><div>Biofilm formation poses a severe challenge to antibacterial stewardship. While siderophore-antibiotic conjugates (termed as sideromycins) offer a promising solution, their efficacy is inherently limited by antibiotic resistance. To transcend this barrier, we pioneer a transformative siderophore-sonosensitizer conjugate through covalent linkage of a catechol siderophore to purpurin 18 (a sonosensitizer). This novel conjugate further self-assembles with iron(III) ions, forming the first-reported carrier-free nanosideromycin—an all-in-on iron-siderophore-sonosensitizer nanoplatform. This design enables ultrasound-denotated reactive oxygen species (ROS) generation and ferroptosis-like amplication. Capitalizing on bacteria-specific siderophore uptake and pH-responsive assembly/disassembly, the nanosideromycin enables precision delivery and active internalization of sonosensitizers into bacteria. This strategy permits real-time localization of infections via concurrent fluorescence/photoacoustic and magnetic resonance imaging. Upon ultrasound irradiation, dual antimicrobial mechanisms of sonosensitizer-mediated sonodynamic therapy and siderophore/iron-augmented sono-Fenton catalysis are stimuonously unleashed, synergistically tirggering an explosive ROS burst and potent ferroptosis-like bacterial death. As a result, mice with multidrug-resistant biofilm-induced pyomyositis were completely cured. Collectively, this first-in-class theranostic nanosideromycin integrates highly-targeted imaging diagnostics, cost-effective yet ultra-efficient ROS generation, and ferroptosis-like bacterial killing, establishing a paradigm-shifting strategy for biofilm therapy with spatiotemporal controllability.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"55 ","pages":"Pages 241-256"},"PeriodicalIF":18.0,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145107345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coenzyme-based elastomeric adhesive patch as iron ion capturer to regulate iron metabolism for diabetic oral ulcer repair 辅酶基弹性贴片作为铁离子捕获剂调节糖尿病口腔溃疡修复中的铁代谢

IF 18 1区医学

Bioactive Materials Pub Date : 2025-09-20 DOI: 10.1016/j.bioactmat.2025.09.019

Rong Yang, Jiaxing Shao, Qian Zhang, Yage Sun, Xinrui Zhao, Chunyan Cui, Wenguang Liu

{"title":"Coenzyme-based elastomeric adhesive patch as iron ion capturer to regulate iron metabolism for diabetic oral ulcer repair","authors":"Rong Yang, Jiaxing Shao, Qian Zhang, Yage Sun, Xinrui Zhao, Chunyan Cui, Wenguang Liu","doi":"10.1016/j.bioactmat.2025.09.019","DOIUrl":"10.1016/j.bioactmat.2025.09.019","url":null,"abstract":"<div><div>Iron metabolism imbalance under high-glucose and nutrient-rich conditions is a key factor inhibiting the healing of diabetic oral ulcers. This study confirms the extensive iron accumulation and ferroptosis occurrence in diabetic oral ulcers. To address this, an oral patch (PLTP) is designed by combining two natural bioactive molecules of lipoic acid (LA) and tea polyphenols (TP). The abundant carboxyl and hydroxyl groups in PLTP act as iron ion capturers, adsorbing extracellular iron, reducing iron transport into cells, and effectively cutting off the iron source for intracellular ferroptosis. The in-situ release of LA and <span>TP</span> at wound site not only aids in restoring intercellular iron homeostasis via regulating the intracellular Xc<sup>−</sup>/GPX4 axis, enhancing antioxidant capacity, upregulating the expression of SLC40A1, and downregulating the expression of DMT1, but also modulates the immune microenvironment, further supporting wound healing. In addition, PLTP exhibits a robust adhesion strength of 14.32 kPa to oral mucosa even after 24 h of vigorous stirring in an iron-rich solution <em>in vitro</em>, and maintains prolonged adhesion in the moist and dynamic oral cavity for over 24 h <em>in vivo</em>. This effectively protects ulcer sites from bacterial invasion and food debris contamination. <em>In vivo</em> experiments show that PLTP significantly accelerates diabetic oral ulcer healing, achieving 92.4 % wound closure by day 8, outperforming both commercial chitosan patches (53.7 %) and the anti-ferroptosis drug Deferasirox (60.0 %). The underlying mechanisms and therapeutic effects of PLTP are further systematically validated <em>in vivo</em>, hoping to provide new insights into iron metabolism regulation for tissue repair in diabetes.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"55 ","pages":"Pages 224-240"},"PeriodicalIF":18.0,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145107344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0