Enhancing remanent magnetization of injectable hydrogels improves realtime transluminal localization of tumor in hollow soft viscera

IF 18 1区医学 Q1 ENGINEERING, BIOMEDICAL

Bioactive Materials Pub Date : 2025-09-26 DOI:10.1016/j.bioactmat.2025.08.025

Junnan Gu , Yuxuan Sun , Tianyi Zhang , Zhenxing Jiang , Falong Zou , Denglong Cheng , Wentai Cai , Hao Wen , Shenghe Deng , Jun Wang , Shuang Zhao , Quanliang Cao , Yinghao Cao , Zichun Yang , Liang Li , Jun Ouyang , Kailin Cai

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引用次数: 0

Abstract

The accuracy of intraoperative localization of tumors undetectable under optical visualization determines surgical quality and survival outcomes in gastrointestinal cancers. Current approaches, however, remain constrained by suboptimal spatial resolution and low procedural efficiency. Additionally, conventional electromagnetic localization techniques based on image registration face challenges in soft tissue deformation scenarios. Here, we developed an electromagnetic localization technology for intraluminal tumor localization based on injectable magnetic hydrogel with sustained magnetization properties (MagLabel-IH). Following endoscopic injection into the gastrointestinal tract and in situ realignment, MagLabel-IH enables continuous intraluminal magnetic signal tracing. Intraoperatively, a dynamic registration framework synchronizes the magnetic coordinate system with real-time anatomical positions under visual guidance, achieving precise localization of optically invisible intraluminal tumors. The system demonstrated exceptional surgical instrument maneuverability (e.g., tissue grasping, resection path selection) during MagLabel-IH detection. In vivo animal evaluations demonstrated significantly enhanced localization accuracy compared to conventional biological dyes tattooing (3.8 ± 0.8 mm vs. 16.8 ± 8.6 mm, P < 0.05). Furthermore, the magnetic labels-based localization system exhibited promising utility for tumor margin demarcation and planning of gastrointestinal functional reconstruction.

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增强可注射水凝胶的剩余磁化，可改善空心软脏器内肿瘤的实时腔内定位

在光学显像下无法检测的肿瘤术中定位的准确性决定了胃肠道肿瘤的手术质量和生存结果。然而，目前的方法仍然受到次优空间分辨率和低程序效率的限制。此外，传统的基于图像配准的电磁定位技术在软组织变形场景下面临挑战。在这里，我们开发了一种基于具有持续磁化特性的可注射磁性水凝胶（MagLabel-IH）的腔内肿瘤电磁定位技术。在内镜下注入胃肠道并原位调整后，MagLabel-IH可以连续跟踪腔内磁信号。术中，动态配准框架在视觉引导下将磁坐标系与实时解剖位置同步，实现光学不可见腔内肿瘤的精确定位。在MagLabel-IH检测过程中，该系统展示了卓越的手术器械可操作性（例如，组织抓取、切除路径选择）。与传统生物染料纹身相比，体内动物评估显示，定位精度显著提高（3.8±0.8 mm vs. 16.8±8.6 mm, P < 0.05）。此外，基于磁标记的定位系统在肿瘤边缘划分和胃肠功能重建规划方面具有广阔的应用前景。

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来源期刊

Bioactive Materials Biochemistry, Genetics and Molecular Biology-Biotechnology

CiteScore

28.00

自引率

6.30%

发文量

436

审稿时长

20 days

期刊介绍： Bioactive Materials is a peer-reviewed research publication that focuses on advancements in bioactive materials. The journal accepts research papers, reviews, and rapid communications in the field of next-generation biomaterials that interact with cells, tissues, and organs in various living organisms. The primary goal of Bioactive Materials is to promote the science and engineering of biomaterials that exhibit adaptiveness to the biological environment. These materials are specifically designed to stimulate or direct appropriate cell and tissue responses or regulate interactions with microorganisms. The journal covers a wide range of bioactive materials, including those that are engineered or designed in terms of their physical form (e.g. particulate, fiber), topology (e.g. porosity, surface roughness), or dimensions (ranging from macro to nano-scales). Contributions are sought from the following categories of bioactive materials: Bioactive metals and alloys Bioactive inorganics: ceramics, glasses, and carbon-based materials Bioactive polymers and gels Bioactive materials derived from natural sources Bioactive composites These materials find applications in human and veterinary medicine, such as implants, tissue engineering scaffolds, cell/drug/gene carriers, as well as imaging and sensing devices.