Bioactive Materials最新文献_第10页

Bridging immune-neurovascular crosstalk via the immunomodulatory microspheres for promoting neural repair 通过免疫调节微球架起免疫-神经血管串扰的桥梁，促进神经修复

IF 18 1区医学

Bioactive Materials Pub Date : 2024-11-08 DOI: 10.1016/j.bioactmat.2024.10.031

Tongtong Xu , Lin Gan , Wei Chen , Dandan Zheng , Hanlai Li , Shiyu Deng , Dongliang Qian , Tingting Gu , Qianyuan Lian , Gracie Shen , Qingzhu An , Wanlu Li , Zhijun Zhang , Guo-Yuan Yang , Huitong Ruan , Wenguo Cui , Yaohui Tang

{"title":"Bridging immune-neurovascular crosstalk via the immunomodulatory microspheres for promoting neural repair","authors":"Tongtong Xu , Lin Gan , Wei Chen , Dandan Zheng , Hanlai Li , Shiyu Deng , Dongliang Qian , Tingting Gu , Qianyuan Lian , Gracie Shen , Qingzhu An , Wanlu Li , Zhijun Zhang , Guo-Yuan Yang , Huitong Ruan , Wenguo Cui , Yaohui Tang","doi":"10.1016/j.bioactmat.2024.10.031","DOIUrl":"10.1016/j.bioactmat.2024.10.031","url":null,"abstract":"<div><div>The crosstalk between immune cells and the neurovascular unit plays a pivotal role in neural regeneration following central nervous system (CNS) injury. Maintaining brain immune homeostasis is crucial for restoring neurovascular function. In this study, an interactive bridge was developed via an immunomodulatory hydrogel microsphere to link the interaction network between microglia and the neurovascular unit, thereby precisely regulating immune-neurovascular crosstalk and achieving neural function recovery. This immunomodulatory crosstalk microsphere (MP/RIL4) was composed of microglia-targeted RAP12 peptide-modified interleukin-4 (IL-4) nanoparticles and boronic ester-functionalized hydrogel using biotin-avidin reaction and air-microfluidic techniques. We confirmed that the immunomodulatory microspheres reduced the expression of pro-inflammatory factors including IL-1β, iNOS, and CD86, while upregulating levels of anti-inflammatory factors such as IL-10, Arg-1, and CD206 in microglia. In addition, injection of the MP/RIL4 significantly mitigated brain atrophy volume in a mouse model of ischemic stroke, promoted neurobehavioral recovery, and enhanced the crosstalk between immune cells and the neurovascular unit, thus increasing angiogenesis and neurogenesis of stroke mice. In summary, the immunomodulatory microspheres, capable of orchestrating the interaction between immune cells and neurovascular unit, hold considerable therapeutic potential for ischemic stroke and other CNS diseases.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"44 ","pages":"Pages 558-571"},"PeriodicalIF":18.0,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142661030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging biotechnologies for engineering liver organoids 用于肝脏器官组织工程的新兴生物技术

IF 18 1区医学

Bioactive Materials Pub Date : 2024-11-08 DOI: 10.1016/j.bioactmat.2024.11.002

Junqi Zhao , Yue Zhi , Haozhen Ren , Jinglin Wang , Yuanjin Zhao

{"title":"Emerging biotechnologies for engineering liver organoids","authors":"Junqi Zhao , Yue Zhi , Haozhen Ren , Jinglin Wang , Yuanjin Zhao","doi":"10.1016/j.bioactmat.2024.11.002","DOIUrl":"10.1016/j.bioactmat.2024.11.002","url":null,"abstract":"<div><div>The engineering construction of the liver has attracted enormous attention. Organoids, as emerging miniature three-dimensional cultivation units, hold significant potential in the biomimetic simulation of liver structure and function. Despite notable successes, organoids still face limitations such as high variability and low maturity. To overcome these challenges, engineering strategies have been established to maintain organoid stability and enhance their efficacy, laying the groundwork for the development of advanced liver organoids. The present review comprehensively summarizes the construction of engineered liver organoids and their prospective applications in biomedicine. Initially, we briefly present the latest research progress on matrix materials that maintain the three-dimensional morphology of organoids. Next, we discuss the manipulative role of engineering technologies in organoid assembly. Additionally, we outline the impact of gene-level regulation on organoid growth and development. Further, we introduce the applications of liver organoids in disease modeling, drug screening and regenerative medicine. Lastly, we overview the current obstacles and forward-looking perspectives on the future of engineered liver organoids. We anticipate that ongoing innovations in engineered liver organoids will lead to significant advancements in medical applications.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"45 ","pages":"Pages 1-18"},"PeriodicalIF":18.0,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142652913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

β-Ketoenamine covalent organic framework nanoplatform combined with immune checkpoint blockade via photodynamic immunotherapy inhibit glioblastoma progression β-酮胺共价有机框架纳米平台结合光动力免疫疗法的免疫检查点阻断抑制胶质母细胞瘤进展

IF 18 1区医学

Bioactive Materials Pub Date : 2024-11-07 DOI: 10.1016/j.bioactmat.2024.10.029

Tengfeng Yan , Qiuye Liao , Zhihao Chen , Yang Xu , Wenping Zhu , Ping Hu , Si Zhang , Yanze Wu , Lei Shu , Junzhe Liu , Min Luo , Hongxin Shu , Yilei Sheng , Li Wang , Chun Xu , Chang Lei , Hongming Wang , Qingsong Ye , Li Yang , Xingen Zhu

{"title":"β-Ketoenamine covalent organic framework nanoplatform combined with immune checkpoint blockade via photodynamic immunotherapy inhibit glioblastoma progression","authors":"Tengfeng Yan , Qiuye Liao , Zhihao Chen , Yang Xu , Wenping Zhu , Ping Hu , Si Zhang , Yanze Wu , Lei Shu , Junzhe Liu , Min Luo , Hongxin Shu , Yilei Sheng , Li Wang , Chun Xu , Chang Lei , Hongming Wang , Qingsong Ye , Li Yang , Xingen Zhu","doi":"10.1016/j.bioactmat.2024.10.029","DOIUrl":"10.1016/j.bioactmat.2024.10.029","url":null,"abstract":"<div><div>The synergistic approach of combining photodynamic immunotherapy with endogenous clearance of PD-L1 immune checkpoint blockade therapy holds promise for enhancing survival outcomes in glioblastoma (GBM) patients. The observed upregulation of O-GlcNAc glycolysis in tumors may contribute to the stabilization of endogenous PD-L1 protein, facilitating tumor immune evasion. This study presents a pH-adapted excited state intramolecular proton transfer (ESIPT)-isomerized β-ketoamide-based covalent organic framework (COF) nanoplatform (denoted as OT@COF-RVG). Temozolomide (TMZ) and OSMI-4 (O-GlcNAc transferase inhibitor) were integrated into COF cavities, then modified on the surface with polyethylene glycol and the rabies virus peptide RVG-29, showing potential for sensitizing TMZ chemotherapy and initiating photodynamic therapy (PDT). By inhibiting O-GlcNAc and promoting lysosomal degradation of PD-L1, OT@COF-RVG enhanced the effectiveness of immune checkpoint blockade (ICB) therapy. Additionally, treatment with OT@COF-RVG led to a notable elevation in reactive oxygen species (ROS) levels, thereby re-establishing an immunostimulatory state, inducing immunogenic cell death (ICD). In summary, our research unveiled a correlation between O-GlcNAc in GBM and the evasion of immune responses by tumors, while showcasing the potential of OT@COF-RVG in reshaping the immunosuppressive microenvironment of GBM and offering a more effective approach to immunotherapy in clinical settings.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"44 ","pages":"Pages 531-543"},"PeriodicalIF":18.0,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142661136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Conductive polyphenol microneedles coupled with electroacupuncture to accelerate wound healing and alleviate depressive-like behaviors in diabetes 导电多酚微针与电针相结合，加速伤口愈合并缓解糖尿病患者的抑郁样行为

IF 18 1区医学

Bioactive Materials Pub Date : 2024-11-07 DOI: 10.1016/j.bioactmat.2024.11.001

Yue Hou , Xiaochuan Guo , Jinhui Ran , Xiong Lu , Chaoming Xie

{"title":"Conductive polyphenol microneedles coupled with electroacupuncture to accelerate wound healing and alleviate depressive-like behaviors in diabetes","authors":"Yue Hou , Xiaochuan Guo , Jinhui Ran , Xiong Lu , Chaoming Xie","doi":"10.1016/j.bioactmat.2024.11.001","DOIUrl":"10.1016/j.bioactmat.2024.11.001","url":null,"abstract":"<div><div>Inflammation and depression are serious complications of diabetes that interact to form a feedback loop and may hinder diabetic wound healing. They share a common pathophysiological basis of abnormal interactions between diabetic wounds and the brain. Here, we propose a strategy combining electroacupuncture (EA) stimulation of the Dazhui acupoint (GV14) with polyphenol-mediated conductive hydrogel microneedles to promote diabetic wound healing and alleviate depression through local wound–brain interactions. The conductive microneedles comprised methacrylated gelatin, dopamine (DA), DA-modified poly(3,4-ethylenedioxythiophene), and <em>Lycium barbarum</em> polysaccharide. EA at GV14 activated the vagus–adrenal axis to inhibit systemic inflammation while DA coupled electrical signals for long-term inhibition of local wound inflammation. EA at GV14 was also found to elevate 5-hydroxytryptamine levels in rats with diabetic wounds, consequently mitigating depressive-like behaviors. Additionally, the polyphenol-mediated conductive hydrogel microneedles, and coupled with EA stimulation promoted healing of wound tissue and peripheral nerves. This strategy regulated both local and systemic inflammation while alleviating depressive-like behaviors in diabetic rats, providing a new clinical perspective for the treatment of diabetes-related and emotional disorders.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"44 ","pages":"Pages 516-530"},"PeriodicalIF":18.0,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142661009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innovative spiral nerve conduits: Addressing nutrient transport and cellular activity for critical-sized nerve defects 创新性螺旋神经导管：解决临界尺寸神经缺损的营养运输和细胞活动问题

IF 18 1区医学

Bioactive Materials Pub Date : 2024-11-07 DOI: 10.1016/j.bioactmat.2024.10.028

Allen Zennifer , S.K. Praveenn Kumar , Shambhavi Bagewadi , Swathi Unnamalai , Davidraj Chellappan , Sama Abdulmalik , Xiaojun Yu , Swaminathan Sethuraman , Dhakshinamoorthy Sundaramurthi , Sangamesh G. Kumbar

{"title":"Innovative spiral nerve conduits: Addressing nutrient transport and cellular activity for critical-sized nerve defects","authors":"Allen Zennifer , S.K. Praveenn Kumar , Shambhavi Bagewadi , Swathi Unnamalai , Davidraj Chellappan , Sama Abdulmalik , Xiaojun Yu , Swaminathan Sethuraman , Dhakshinamoorthy Sundaramurthi , Sangamesh G. Kumbar","doi":"10.1016/j.bioactmat.2024.10.028","DOIUrl":"10.1016/j.bioactmat.2024.10.028","url":null,"abstract":"<div><div>Large-gap nerve defects require nerve guide conduits (NGCs) for complete regeneration and muscle innervation. Many NGCs have been developed using various scaffold designs and tissue engineering strategies to promote axon regeneration. Still, most are tubular with inadequate pore sizes and lack surface cues for nutrient transport, cell attachment, and tissue infiltration. This study developed a porous spiral NGC to address these issues using a 3D-printed thermoplastic polyurethane (TPU) fiber lattice. The lattice was functionalized with poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) electrospun aligned (aPHBV) and randomly (rPHBV) oriented nanofibers to enhance cellular activity. TPU lattices were made with 25 %, 35 %, and 50 % infill densities to create scaffolds with varied mechanical compliance. The fabricated TPU/PHBV spiral conduits had significantly higher surface areas (25 % TPU/PHBV: 698.97 mm<sup>2</sup>, 35 % TPU/PHBV: 500.06 mm<sup>2</sup>, 50 % TPU/PHBV: 327.61 mm<sup>2</sup>) compared to commercially available nerve conduits like Neurolac™ (205.26 mm<sup>2</sup>). Aligned PHBV nanofibers showed excellent Schwann cell (RSC96) adhesion, proliferation, and neurogenic gene expression for all infill densities. Spiral TPU/PHBV conduits with 25 % and 35 % infill densities exhibited Young's modulus values comparable to Neurotube® and ultimate tensile strength like acellular cadaveric human nerves. A 10 mm sciatic nerve defect in Wistar rats treated with TPU/aPHBV NGCs demonstrated muscle innervation and axon healing comparable to autografts over 4 months, as evaluated by gait analysis, functional recovery, and histology. The TPU/PHBV NGC developed in this study shows promise as a treatment for large-gap nerve defects.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"44 ","pages":"Pages 544-557"},"PeriodicalIF":18.0,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142661137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanoclay gels attenuate BMP2-associated inflammation and promote chondrogenesis to enhance BMP2-spinal fusion 纳米粘土凝胶可减轻 BMP2 相关炎症并促进软骨生成，从而增强 BMP2-脊髓融合能力

IF 18 1区医学

Bioactive Materials Pub Date : 2024-11-05 DOI: 10.1016/j.bioactmat.2024.10.027

Takuya Furuichi , Hiromasa Hirai , Takayuki Kitahara , Masayuki Bun , Masato Ikuta , Yuichiro Ukon , Masayuki Furuya , Richard O.C. Oreffo , Agnieszka A. Janeczek , Jonathan I. Dawson , Seiji Okada , Takashi Kaito

{"title":"Nanoclay gels attenuate BMP2-associated inflammation and promote chondrogenesis to enhance BMP2-spinal fusion","authors":"Takuya Furuichi , Hiromasa Hirai , Takayuki Kitahara , Masayuki Bun , Masato Ikuta , Yuichiro Ukon , Masayuki Furuya , Richard O.C. Oreffo , Agnieszka A. Janeczek , Jonathan I. Dawson , Seiji Okada , Takashi Kaito","doi":"10.1016/j.bioactmat.2024.10.027","DOIUrl":"10.1016/j.bioactmat.2024.10.027","url":null,"abstract":"<div><div>Bone morphogenetic protein 2 (BMP2) is clinically applied for treating intractable fractures and promoting spinal fusion because of its osteogenic potency. However, adverse effects following the release of supraphysiological doses of BMP2 from collagen carriers are widely reported. Nanoclay gel (NC) is attracting attention as a biomaterial, given the potential for localized efficacy of administered agents. However, the efficacy and mechanism of action of NC/BMP2 remain unclear. This study explored the efficacy of NC as a BMP2 carrier in bone regeneration and the enhancement mechanism. Subfascial implantation of NC containing BMP2 elicited superior bone formation compared with collagen sponge (CS). Cartilage was uniformly formed inside the NC, whereas CS formed cartilage only on the perimeter. Additionally, CS induced a dose-dependent inflammatory response around the implantation site, whereas NC induced a minor response, and inflammatory cells were observed inside the NC. In a rat spinal fusion model, NC promoted high-quality bony fusion compared to CS. <em>In vitro,</em> NC enhanced chondrogenic and osteogenic differentiation of hBMSCs and ATDC5 cells while inhibiting osteoclastogenesis. Overall, NC/BMP2 facilitates spatially controlled, high-quality endochondral bone formation without BMP2-induced inflammation and promotes high-density new bone, functioning as a next-generation BMP2 carrier.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"44 ","pages":"Pages 474-487"},"PeriodicalIF":18.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142586421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineered nanoplatform mediated gas therapy enhanced ferroptosis for tumor therapy in vivo 工程纳米平台介导的气体疗法增强了体内治疗肿瘤的铁氧化作用

IF 18 1区医学

Bioactive Materials Pub Date : 2024-11-05 DOI: 10.1016/j.bioactmat.2024.10.024

Kun Xu , Ke Li , Ye He , Yulan Mao , Xuan Li , Liangshuai Zhang , Meijun Tan , Yulu Yang , Zhong Luo , Peng Liu , Kaiyong Cai

{"title":"Engineered nanoplatform mediated gas therapy enhanced ferroptosis for tumor therapy in vivo","authors":"Kun Xu , Ke Li , Ye He , Yulan Mao , Xuan Li , Liangshuai Zhang , Meijun Tan , Yulu Yang , Zhong Luo , Peng Liu , Kaiyong Cai","doi":"10.1016/j.bioactmat.2024.10.024","DOIUrl":"10.1016/j.bioactmat.2024.10.024","url":null,"abstract":"<div><div>The high glutathione (GSH) environment poses a significant challenge for inducing ferroptosis in tumor cells, necessitating the development of nanoplatforms that can deplete intracellular GSH. In this study, we developed an engineered nanoplatform (MIL-100@Era/L-Arg-HA) that enhances ferroptosis through gas therapy. First, we confirmed that the Fe element in the nanoplatform undergoes valence changes under the influence of high GSH and H<sub>2</sub>O<sub>2</sub> in tumor cells. Meanwhile, L-Arg generates NO gas in the presence of intracellular H<sub>2</sub>O<sub>2</sub>, which reacts with GSH. Additionally, Erastin depletes GSH by inhibiting the cystine/glutamate antiporter system, reducing cystine uptake and impairing GPX4, while also increasing intracellular H<sub>2</sub>O<sub>2</sub> levels by activating NOX4 protein expression. Through these combined GSH-depletion mechanisms, we demonstrated that MIL-100@Era/L-Arg-HA effectively depletes GSH levels, disrupts GPX4 function, and increases intracellular lipid ROS levels <em>in vitro</em>. Furthermore, this nanoplatform significantly inhibited tumor cell growth and extended the survival time of tumor-bearing mice <em>in vivo</em>. This engineered nanoplatform, which enhances ferroptosis through gas therapy, shows significant promise for ferroptosis-based cancer therapy and offers potential strategies for clinical tumor treatment.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"44 ","pages":"Pages 488-500"},"PeriodicalIF":18.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142586422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vivo performance of lean bioabsorbable Mg–Ca alloy X0 and comparison to WE43: Influence of surface modification and alloying content 瘦生物可吸收镁钙合金 X0 的体内性能以及与 WE43 的比较：表面改性和合金含量的影响

IF 18 1区医学

Bioactive Materials Pub Date : 2024-11-05 DOI: 10.1016/j.bioactmat.2024.09.036

L. Berger , S. Dolert , T. Akhmetshina , J.-P. Burkhard , M. Tegelkamp , A.M. Rich , W. Rubin , S. Darwiche , G. Kuhn , R.E. Schäublin , B. von Rechenberg , B. Schaller , K.M. Nuss , J.F. Löffler

{"title":"In vivo performance of lean bioabsorbable Mg–Ca alloy X0 and comparison to WE43: Influence of surface modification and alloying content","authors":"L. Berger , S. Dolert , T. Akhmetshina , J.-P. Burkhard , M. Tegelkamp , A.M. Rich , W. Rubin , S. Darwiche , G. Kuhn , R.E. Schäublin , B. von Rechenberg , B. Schaller , K.M. Nuss , J.F. Löffler","doi":"10.1016/j.bioactmat.2024.09.036","DOIUrl":"10.1016/j.bioactmat.2024.09.036","url":null,"abstract":"<div><div>Magnesium alloys present a compelling prospect for absorbable implant materials in orthopedic and trauma surgery. This study evaluates an ultra-high purity, lean magnesium–calcium alloy (X0), both with and without plasma electrolytic oxidation (PEO) surface modification, in comparison to a clinically utilized WE43 magnesium alloy. It is shown that the mechanical properties of X0 can be tuned to yield a high-strength material suitable for bone screws (with an ultimate tensile strength of 336 MPa) or a ductile material appropriate for intraoperatively deformable plates (with an elongation at fracture of 24 %). Four plate-screw combinations were implanted onto the pelvic bones of six sheep without osteotomy for 8 weeks. Subsequent analysis utilized histology, micro-computed tomography, and light and electron microscopy. All implants exhibited signs of degradation and hydrogen-gas evolution, with PEO-coated X0 implants demonstrating the least volume loss and the most substantial new-bone formation on the implant surface and surrounding cancellous bone. Furthermore, the osteoconductive properties of the X0 implants, when uncoated, exceeded those of the uncoated WE43 implants, as evidenced by greater new-bone formation on the surface. This osteoconductivity was amplified with PEO surface modification, which mitigated gas evolution and enhanced osseointegration, encouraging bone apposition in the cancellous bone vicinity. These findings thus indicate that PEO-coated X0 implants hold substantial promise as a biocompatible and absorbable implant material.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"44 ","pages":"Pages 501-515"},"PeriodicalIF":18.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142586437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nucleotide coordinated polymers, a ROS-based immunomodulatory antimicrobial, doubly kill Pseudomonas aeruginosa biofilms of implant infections 核苷酸配位聚合物是一种基于 ROS 的免疫调节抗菌剂，可加倍杀死植入感染的铜绿假单胞菌生物膜

IF 18 1区医学

Bioactive Materials Pub Date : 2024-11-04 DOI: 10.1016/j.bioactmat.2024.10.026

Jinghuang Chen , Xianqing Tang , Qihan Sun , Xin Ji , Xingbo Wang , Zhendong Liu , Xu Zhang , Haijiao Xu , Fan Yang , Jian Sun , Xiurong Yang

{"title":"Nucleotide coordinated polymers, a ROS-based immunomodulatory antimicrobial, doubly kill Pseudomonas aeruginosa biofilms of implant infections","authors":"Jinghuang Chen , Xianqing Tang , Qihan Sun , Xin Ji , Xingbo Wang , Zhendong Liu , Xu Zhang , Haijiao Xu , Fan Yang , Jian Sun , Xiurong Yang","doi":"10.1016/j.bioactmat.2024.10.026","DOIUrl":"10.1016/j.bioactmat.2024.10.026","url":null,"abstract":"<div><div><em>Pseudomonas aeruginosa</em> causes high morbidity and mortality in nosocomial infections, and newly approved antibiotics have been declining for decades. A green and universal deprotonation-driven strategy is used to screen the guanylic acid-metal ion coordination polymer nanoparticles (GMC), instead of the failure of binding occurs when specific metal ion participation. We find that the precise pH-dependent oxidase-like activity of GMC-2 orchestrates a duple symphony of immune modulation for <em>Pseudomonas aeruginosa</em> biofilm infections. Specifically, GMC-2-mediated reactive oxygen species (ROS) regulation triggers mitochondrial dysfunction and releases damage-associated molecular patterns, engaging pattern recognition receptors and resulting in endogenous innate immune activation. Meanwhile, GMC-2-triggered ROS generation in a mildly acidic biofilm environment destroys the biofilm, exposing exogenous pathogen-associated molecular patterns. GMC-2 cannot cause resistance for <em>Pseudomonas aeruginosa</em> compared with conventional antibiotics. In an infected implant mouse model, <em>Pseudomonas aeruginosa</em> biofilms were effectively eliminated by GMC-2-mediated triggering of innate and adaptive immunity. These findings provide a universal approach for facilitating the binding of biomolecules with metal ions and highlight the precise ROS-regulating platform plays a critical role in initiating endogenous and exogenous immune activation targeted for bacterial biofilm infection.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"44 ","pages":"Pages 461-473"},"PeriodicalIF":18.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142578521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metal-phenolic-network-coated gold nanoclusters for enhanced photothermal/chemodynamic/immunogenic cancer therapy 用于增强光热/化学动力/免疫性癌症治疗的金属酚网络包覆金纳米团簇

IF 18 1区医学

Bioactive Materials Pub Date : 2024-10-30 DOI: 10.1016/j.bioactmat.2024.10.021

Tingyu Yang , Liqun Dai , Jie Liu , Yi Lu , Meng Pan , Lili Pan , Lin Ye , Liping Yuan , Xicheng Li , Zhongwu Bei , Zhiyong Qian

{"title":"Metal-phenolic-network-coated gold nanoclusters for enhanced photothermal/chemodynamic/immunogenic cancer therapy","authors":"Tingyu Yang , Liqun Dai , Jie Liu , Yi Lu , Meng Pan , Lili Pan , Lin Ye , Liping Yuan , Xicheng Li , Zhongwu Bei , Zhiyong Qian","doi":"10.1016/j.bioactmat.2024.10.021","DOIUrl":"10.1016/j.bioactmat.2024.10.021","url":null,"abstract":"<div><div>Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, characterised by a short survival period, high malignancy, strong invasiveness, and high rates of recurrence and metastasis. Due to its unique molecular phenotype, TNBC is insensitive to endocrine therapy or molecular targeted therapy. The conventional treatment approach involves systemic chemotherapy for overall management; however, adjuvant chemotherapy after surgery has shown poor efficacy as residual lesions can easily lead to tumour recurrence. Therefore, there is an urgent need to find more effective treatment strategies. Herein, we designed a gold nanocluster coated with a metal-phenol formaldehyde network structure (AuNCs@PDA-Mn) for tumour Photothermal therapy and chemodynamic therapy (PTT and CDT), which induces systemic immune responses to suppress tumour metastasis. Experimental results show that after continuous irradiation for 10 min under an 808 nm laser (1.0W/cm<sup>2</sup>), AuNCs@PDA-Mn not only exhibits better tumour inhibition both in vitro and in vivo but also triggers stronger immune effects systemically. Therefore, this combined PTT and CDT treatment approach has great potential and provides a clinically relevant and valuable option for triple-negative breast cancer.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"44 ","pages":"Pages 447-460"},"PeriodicalIF":18.0,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142555653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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