Bioactive Materials最新文献

{"title":"Cyclodextrins as multifunctional tools for advanced biomaterials in tissue repair and regeneration","authors":"Yu Bin Lee ,&nbsp;Mi-Lang Kyun ,&nbsp;Young Ju Lee ,&nbsp;Hye-Eun Shim ,&nbsp;Kang Moo Huh ,&nbsp;Sun-Woong Kang","doi":"10.1016/j.bioactmat.2025.03.018","DOIUrl":"10.1016/j.bioactmat.2025.03.018","url":null,"abstract":"<div><div>Cyclodextrins (CDs), characterized by their unique cyclic oligosaccharide structure and exceptional capacity for molecular encapsulation through host-guest interactions, have garnered significant attention as versatile building blocks in advanced biomaterials. This review explores the application of CD-based biomaterials in tissue engineering and regenerative medicine, emphasizing their synthesis, physicochemical characterization, biocompatibility, and translational potential. Special emphasis is placed on the development of CD-modified hydrogels, their interaction with host-guest molecules, and their use in advanced therapeutic strategies. Additionally, we discuss various fabrication methods for CD-based biomaterials, including physical and covalent crosslinking, self-assembly, and enzymatic crosslinking, each providing unique properties suited for advanced therapeutic strategies. Safety considerations and potential regulatory challenges associated with these materials are also examined. By providing a comprehensive overview of recent advancements, this review aims to highlight the promising role of cyclodextrins as multifunctional tools in enhancing tissue repair and regeneration, paving the way for innovative therapeutic solutions in clinical settings.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"49 ","pages":"Pages 627-651"},"PeriodicalIF":18.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143715794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Continuous mechanical-gradient hydrogel with on-demand distributed Mn2+/Mg-doped hydroxyapatite@Fe3O4 for functional osteochondral regeneration","authors":"Junwei Xu ,&nbsp;Yi Cui ,&nbsp;Ping Li ,&nbsp;Xuemei Sun ,&nbsp;Zhiheng Chen ,&nbsp;Jingxi Wang ,&nbsp;Xuenan Gu ,&nbsp;Xiaogang Wang ,&nbsp;Yubo Fan","doi":"10.1016/j.bioactmat.2025.03.013","DOIUrl":"10.1016/j.bioactmat.2025.03.013","url":null,"abstract":"<div><div>Traditional layered gradient scaffolds are susceptible to delamination owing to abrupt stress alterations, thereby rendering them inefficacious for the integrated repair of osteochondral defects. This study proposed a novel hydrogel possessing continuous magnetic-mechanical and multiple functional metal elements gradients. The establishment of these gradients within the hydrogel was accomplished by first applying a magnetic field to FMHM particles (Fe₃O₄ deposited with Mg-doped hydroxyapatite (MgHA@Fe₃O₄) and grafted with γ-(methacryloyloxy) propyl trimethoxysilane) dispersed in poly (ethylene glycol) diacrylate/sodium alginate solution to create a gradient, followed by thermal polymerization to achieve the magnetic and mechanical gradients. Subsequently secondary crosslinking with Mn²⁺ realized the gradient distribution of Mn²⁺ which was reverse to the gradient of MgHA@Fe₃O₄. The on-demand gradient distributions of Mn²⁺ and MgHA@Fe₃O₄ enhanced cartilage and osteogenic differentiation of bone marrow-derived mesenchymal stem cells, respectively. The continuous gradient hydrogel attained remarkable repair effects on full-thickness osteochondral defects in rat knee joints. Its capacity to foster the growth of both cartilage and subchondral bone may be associated with the fact that the mechanical gradient modulated the gradient nuclear localization and expression of the mechanosensitive factor Yes-associated protein 1. With stiffness and magnetism gradients, along with the on-demand synergistic impacts of multi-gradient metal elements Mn-Fe/Mg/Ca, this hydrogel presents a prospective option for the regeneration of tissues/interface tissues exhibiting physiological gradients.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"49 ","pages":"Pages 608-626"},"PeriodicalIF":18.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143715796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic effects of electrical and chemical cues with biodegradable scaffolds for large peripheral nerve defect regeneration","authors":"Rosalie Bordett ,&nbsp;Sama Abdulmalik ,&nbsp;Allen Zennifer ,&nbsp;Suranji Wijekoon ,&nbsp;Sai Sadhananth Srinivasan ,&nbsp;Ergin Coskun ,&nbsp;Yeshavanth Kumar Banasavadi Siddegowda ,&nbsp;Xiaojun Yu ,&nbsp;Sangamesh G. Kumbar","doi":"10.1016/j.bioactmat.2025.03.017","DOIUrl":"10.1016/j.bioactmat.2025.03.017","url":null,"abstract":"<div><div>Large-gap peripheral nerve injuries (PNI) are often treated with autografts, allografts, or synthetic grafts to facilitate nerve regeneration, but these options are often limited in their availability or functionality. To address these issues, we developed ionically conductive (IC) nerve guidance conduits (NGCs) of sufficient biodegradability, mechanical strength, and bioactivity to support large-gap nerve regeneration. These chitosan-based NGCs release 4-aminopyridine (4-AP) from embedded halloysite nanotubes, and the NGC's IC properties enable transcutaneous electrical stimulation (ES) without invasive electrodes. <em>In vitro</em>, we found scaffolds with ES+4-AP synergistically enhanced Schwann cell adhesion, proliferation, and neurotrophin secretion, significantly improving axonal growth and neurite extension. <em>In vivo</em>, these scaffolds in large-gap PNI boosted neurotrophin levels, myelination, nerve function, and muscle weight while promoting angiogenesis and reducing fibrosis. Upregulated Trk receptors and PI3K/Akt and MAPK pathway highlight the regenerative potential. This study advances understanding of ES-mediated regeneration and supports innovative strategies for nerve and musculoskeletal repair.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"49 ","pages":"Pages 586-607"},"PeriodicalIF":18.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143715625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimally invasive snakebite inspired microneedle delivery system for internal organs","authors":"Xuan Mei ,&nbsp;Dashuai Zhu ,&nbsp;Junlang Li ,&nbsp;Ke Huang ,&nbsp;Shiqi Hu ,&nbsp;Malcolm Xing ,&nbsp;Ke Cheng","doi":"10.1016/j.bioactmat.2025.03.004","DOIUrl":"10.1016/j.bioactmat.2025.03.004","url":null,"abstract":"<div><div>Efficient distribution of therapeutics to the targeted site, particularly internal organs, is essential for their therapeutic success. Here, we developed a therapeutic delivery system targeting internal organs, which features a mechanism akin to a snake's jaw for grasping and deploying detachable microneedles (MNs) embedded with therapeutics. This solves the current challenges of delivering microneedle patches without open chest or abdominal wall surgery. We showed an example of this technology via delivering exosomes derived from mesenchymal stem cells (MSCs) directly to the heart's damaged regions via percutaneous minimally invasive surgery. The shell of MNs is fabricated from methacrylated hyaluronic acid (MeHA), which ensures mechanical strength for myocardium penetration, while the hyaluronic acid (HA) core allows a sustained release of exosomes. In a rat model of myocardial infarction (MI), the delivery of exosomes-loaded microneedles (XOs-MNs) resulted in angiomyogenesis and promoted cardiac function. The feasibility of this microneedle delivery method was also confirmed in a pig model. With its capability to encapsulate a wide range of therapeutic formulations, our system presents a versatile platform for the minimally invasive administration of treatments to internal organs.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"49 ","pages":"Pages 576-585"},"PeriodicalIF":18.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioprinting of Alginate-Norbornene bioinks to create a versatile platform for kidney in vitro modeling","authors":"Francesca Perin ,&nbsp;Anna Ricci ,&nbsp;Sveva Fagiolino ,&nbsp;Aleksandra Rak-Raszewska ,&nbsp;Helen Kearney ,&nbsp;Jopeth Ramis ,&nbsp;Ivo Bereen ,&nbsp;Matthew Baker ,&nbsp;Devid Maniglio ,&nbsp;Antonella Motta ,&nbsp;Lorenzo Moroni ,&nbsp;Carlos Mota","doi":"10.1016/j.bioactmat.2025.03.010","DOIUrl":"10.1016/j.bioactmat.2025.03.010","url":null,"abstract":"<div><div>Chronic kidney diseases affect a significant portion of the global population and their prevalence is expected to increase in the coming years. Advanced <em>in vitro</em> models are crucial for understanding disease onset and for improving drug testing. Emerging strategies have enhanced the accuracy of these models by incorporating 3D culture and perfusion systems. Notably, efforts have focused on modeling the nephron, particularly endothelialized and epithelialized tubular structures, with perfusion to simulate toxin exchange for nephrotoxicity testing. New approaches combining biomaterials with patient-derived kidney epithelial cells show promise for high-throughput personalized drug screening. However, these methods often rely on decellularized extracellular matrix materials, such as Matrigel® and collagen, which suffer from batch-to-batch variability. To address reproducibility issues, we used norbornene-functionalized alginate to produce peptide-functionalized thiol-ene crosslinked hydrogels. By varying the composition of crosslinkers and peptide functionalization, we tuned the cell interaction with the hydrogels. The rapid reaction kinetics enabled the bioprinting of cell-laden tubular structures using microfluidic bioprinting, without the need for ionic crosslinking, by adapting the printer with UV irradiation at the nozzle. The bioprinted fibers successfully formed monolayers, indicating their potential for creating advanced kidney <em>in vitro</em> models. Thiol-ene crosslinked hydrogels proved to be highly tunable and adaptable to microfluidic bioprinting, demonstrating significant promise for further application to create kidney <em>in vitro</em> models.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"49 ","pages":"Pages 550-563"},"PeriodicalIF":18.0,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Two decades of continuous progresses and breakthroughs in the field of bioactive ceramics and glasses driven by CICECO-hub scientists” [Bioact. Mater. 40 (2024) 104–147]","authors":"H.R. Fernandes ,&nbsp;S. Kannan ,&nbsp;M. Alam ,&nbsp;G.E. Stan ,&nbsp;A.C. Popa ,&nbsp;R. Buczyński ,&nbsp;P. Gołębiewski ,&nbsp;J.M.F. Ferreira","doi":"10.1016/j.bioactmat.2025.02.044","DOIUrl":"10.1016/j.bioactmat.2025.02.044","url":null,"abstract":"","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"49 ","pages":"Page 549"},"PeriodicalIF":18.0,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial multienzyme nanoflower composite hydrogel for efficiently promoting MRSA-infected diabetic wound healing via glucose-activated NO releasing and microenvironment regulation","authors":"Hui Ma ,&nbsp;Yuanhao Luo ,&nbsp;Yifu Wang ,&nbsp;Yi Hao ,&nbsp;Jinjin Li ,&nbsp;Xiaolan Gao ,&nbsp;Yamin Xiong ,&nbsp;Leiliang He","doi":"10.1016/j.bioactmat.2025.03.014","DOIUrl":"10.1016/j.bioactmat.2025.03.014","url":null,"abstract":"<div><div>Diabetic wound repair is a global challenge due to bacterial infection and the typical microenvironments of hyperglycemia, high pH value, hypoxia, persistent inflammation and insufficient angiogenesis. Herein, a glucose-activated nitric oxide (NO) releasing and microenvironment regulation hydrogel dressing (COH-GB) has been developed for efficiently promoting infectious diabetic wound healing. Specifically, an artificial multienzyme nanoflower (GB nanoflower) composed of glucose oxidase (GOx) and hemoglobin (Hb) was synthesized and incorporated into the hydrogel formed by carboxymethyl chitosan (CMCS), oxidized sodium alginate (OSA) and hydroxyurea (HU). In which, the hyperglycemia-triggered cascade reaction could consume glucose, while providing hydrogen peroxide (H₂O₂) for the generation of NO by HU in the presence of Hb with peroxidase-mimicking activity. The COH-GB hydrogel with essential wound dressing characteristics could remodel the microenvironment of diabetic wounds by reducing local glucose and pH levels, alleviating hypoxia, and scavenging excessive ROS; and releasing NO under different blood glucose levels for antibacterial or angiogenesis. Importantly, the prepared COH-GB hydrogel significantly accelerated the MRSA-infected diabetic wound healing by effectively reducing wound infection, inhibiting inflammation, and promoting collagen deposition, angiogenesis and the migration and differentiation of fibroblasts and keratinocytes. Notably, the formation of GB nanoflowers could enhance the activity and stability of enzymes, and improve the cascade reaction efficiency, thereby inducing a more efficient performance in microenvironment regulation, antibacterial and angiogenesis, as well as wound healing. Hence, the prepared artificial multienzyme nanoflower composite hydrogel provides an efficient and secure dressing for promoting infectious diabetic wound healing via glucose-activated NO releasing and microenvironment regulation.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"49 ","pages":"Pages 531-548"},"PeriodicalIF":18.0,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive vascular buds promote collateral vessel formation by grafting on the artificial vessel walls","authors":"Yulian Yang ,&nbsp;Yonghao Qiu ,&nbsp;Shijing Xu ,&nbsp;Huichang Gao ,&nbsp;Chunhui Wang ,&nbsp;Haohui Huang ,&nbsp;Zhengyu Yang ,&nbsp;Xiaofeng Chen ,&nbsp;Fujian Zhao","doi":"10.1016/j.bioactmat.2025.03.015","DOIUrl":"10.1016/j.bioactmat.2025.03.015","url":null,"abstract":"<div><div>Vascular injury and some chronic ischemic lesions usually lead to insufficient blood supply to tissues, which will lead to tissue ischemia or even necrosis in severe cases. Current artificial blood vessels lack effective collateral vascularization capabilities to provide adequate blood supply in areas with restricted blood flow. Herein, inspired by the grafting of tree buds to form lateral branches, the vascular buds model was successfully constructed by inoculating HUVECs into bioactive hydrogel microspheres. Under the influence of ions dissolved from bioactive glass and three-dimensional culture environment, the cytoskeleton was remodeled, the cells showed obvious outward migration and budding trend, which significantly enhanced the angiogenesis ability. After grafted vascular buds to the lateral wall of the artificial blood vessel, a large number of collateral vessels are formed, which effectively alleviates the tissue ischemia in the region through which blood vessels pass. This study confirms the impact of bioactive ions on angiogenesis in a three-dimensional environment and offers novel insights for the development of lateral branches in artificial blood vessels.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"49 ","pages":"Pages 564-575"},"PeriodicalIF":18.0,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exosomes from young plasma stimulate the osteogenic differentiation and prevent osteoporosis via miR-142-5p","authors":"Zhikun Li ,&nbsp;Qifeng Yu ,&nbsp;Xiang Cui ,&nbsp;Yi Wang ,&nbsp;Ruijun Xu ,&nbsp;Renjie Lu ,&nbsp;Jiahao Chen ,&nbsp;Xiaohan Zhou ,&nbsp;Chi Zhang ,&nbsp;Lanya Li ,&nbsp;Wei Xu","doi":"10.1016/j.bioactmat.2025.03.012","DOIUrl":"10.1016/j.bioactmat.2025.03.012","url":null,"abstract":"<div><div>Osteoporosis (OP) is a multifactorial metabolic bone disorder commonly observed in the elderly, particularly prevalent in postmenopausal women. However, many conventional anti-osteoporosis drugs have undesirable side effects, limiting their long-term use. Here, we demonstrated that exosomes derived from both young and old healthy human plasma, which exhibited similar morphology, could significantly enhance the proliferation and migration of mesenchymal stem cells (MSCs). Furthermore, treatment with these exosomes increased alkaline phosphatase (ALP) activity, enhanced the mineralization of MSCs, and decreased the number of osteoclasts in vitro. When intravenously injected into rats, these exosomes accumulated in bone tissue. In vivo experiments demonstrated that both types of exosomes had a beneficial effect on osteoporosis by facilitating bone formation and suppressing osteoclast differentiation in an ovariectomized (OVX)-induced osteoporotic rat model. Strikingly, exosomes derived from young healthy human plasma exhibited stronger anti-osteoporosis effect. The miRNA sequencing analysis showed that miR-142-5p expression was significantly higher in the exosomes from young healthy adult plasma compared to in exosomes from older controls. Importantly, miR-142-5p overexpression exerted similar pro-osteogenic effects to those of exosomes from young healthy human plasma, while miR-142-5p downregulation had the opposite effect on osteogenic differentiation of MSCs. The anti-osteoporosis effect of exosomes from young healthy adult plasma were reversed upon miR-142-5p inhibition. In addition, ZFPM2 was a potential target of miR-142-5p involved in osteoporosis. Therefore, our study reveals the potential anti-osteoporosis effects of plasma exosomes and their underlying mechanisms, thereby providing an effective therapeutic strategy for clinical treatment of osteoporosis.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"49 ","pages":"Pages 502-514"},"PeriodicalIF":18.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exosomes derived from MSCs exposed to hypoxic and inflammatory environments slow intervertebral disc degeneration by alleviating the senescence of nucleus pulposus cells through epigenetic modifications","authors":"Yongzhao Zhao ,&nbsp;Longting Chen ,&nbsp;Shuai Jiang ,&nbsp;Zhenquan Wu ,&nbsp;Qian Xiang ,&nbsp;Jialiang Lin ,&nbsp;Shuo Tian ,&nbsp;Zhuoran Sun ,&nbsp;Chuiguo Sun ,&nbsp;Weishi Li","doi":"10.1016/j.bioactmat.2025.02.046","DOIUrl":"10.1016/j.bioactmat.2025.02.046","url":null,"abstract":"<div><div>Intervertebral disc degeneration (IDD) is the leading cause of low back pain, which places heavy burdens on society and individuals. Surgical intervention is the conventional therapy for IDD, but patients who undergo surgery face relatively high risks of recurrence and complications. Therefore, a relatively less invasive and efficient treatment for IDD is urgently needed. In this study, we constructed a novel nanobiomaterial, named Hi-Exos, to slow IDD. Hi-Exos are exosomes derived from mesenchymal stem cells exposed to hypoxic and inflammatory environments. Hi-Exos could relieve the senescence of nucleus pulposus cells and slow IDD through an epigenetic modification mechanism by introducing the epigenetic factor miR-221-3p into senescent nucleus pulposus cells to reduce DDIT4 expression and inhibit the activation of NF-κB signalling pathway. This study provided a novel strategy for IDD treatment involving the use of Hi-Exos to deliver miR-221-3p to reduce the senescence of nucleus pulposus cells and repair IDD via epigenetic modifications.</div></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"49 ","pages":"Pages 515-530"},"PeriodicalIF":18.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}