Angiogenesis in rheumatoid Arthritis: Pathological characterization, pathogenic mechanisms, and nano-targeted therapeutic strategies

IF 18 1区医学 Q1 ENGINEERING, BIOMEDICAL

Bioactive Materials Pub Date : 2025-05-02 DOI:10.1016/j.bioactmat.2025.04.026

Fang Zhao , Zeyu Hu , Gejing Li , Min Liu , Qiong Huang , Kelong Ai , Xiong Cai

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Abstract

Angiogenesis is critical from early development through the progression of life-threatening diseases. In rheumatoid arthritis (RA), angiogenesis is markedly heightened and undergoes aberrant changes that exacerbate the progression of synovitis. However, the intricate mechanisms underlying these changes remain poorly understood. Despite the development of numerous anti-angiogenic agents, their clinical efficacy is often compromised by adverse effects and the emergence of adaptive resistance, leading to disease relapse or progression. Nanomedicine has gained significant attention owing to its excellent biocompatibility, precise biological targeting, and enhanced therapeutic outcomes. Anti-angiogenic nanoagents have shown transformative potential in treating cancer and retinal diseases. Nevertheless, a comprehensive review addressing the fundamental mechanisms of anti-angiogenic nanoagents in RA has yet to be undertaken. Herein, this review provides an in-depth description of the unique structural and functional aspects of pathological angiogenesis in RA and its negative consequences. The mechanisms of pro-angiogenic mediators contributing to RA angiogenesis are further explored. Subsequently, biological activities of nanomedicines for the treatment of RA are summarized. Finally, the cutting-edge developments in the anti-angiogenic nanoagents of RA engineered based on these mechanisms and bioactivities are outlined. A helpful introduction to anti-angiogenic strategies for treatment of RA, which may offer novel perspectives for the development of nanoagents, is opening a new horizon in the fight against RA.

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类风湿性关节炎中的血管生成：病理特征、致病机制和纳米靶向治疗策略

从早期发育到危及生命的疾病进展，血管生成都是至关重要的。在类风湿性关节炎（RA）中，血管生成明显增加，并经历异常变化，加剧滑膜炎的进展。然而，这些变化背后的复杂机制仍然知之甚少。尽管开发了许多抗血管生成药物，但其临床疗效往往受到不良反应和适应性耐药的影响，导致疾病复发或进展。纳米医学因其优异的生物相容性、精确的生物靶向性和提高的治疗效果而受到广泛关注。抗血管生成纳米药物在治疗癌症和视网膜疾病方面显示出变革性的潜力。然而，关于抗血管生成纳米药物在类风湿性关节炎中的基本机制的全面综述尚未开展。在此，这篇综述提供了一个深入的描述独特的结构和功能方面的病理性血管生成在类风湿性关节炎及其负面后果。进一步探讨促血管生成介质促进RA血管生成的机制。随后，综述了纳米药物治疗类风湿性关节炎的生物活性。最后，综述了基于这些机制和生物活性的RA纳米抗血管生成药物的最新研究进展。本文对抗血管生成治疗类风湿性关节炎的策略进行了有益的介绍，这可能为纳米药物的开发提供新的视角，为治疗类风湿性关节炎开辟了新的视野。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioactive Materials Biochemistry, Genetics and Molecular Biology-Biotechnology

CiteScore

28.00

自引率

6.30%

发文量

436

审稿时长

20 days

期刊介绍： Bioactive Materials is a peer-reviewed research publication that focuses on advancements in bioactive materials. The journal accepts research papers, reviews, and rapid communications in the field of next-generation biomaterials that interact with cells, tissues, and organs in various living organisms. The primary goal of Bioactive Materials is to promote the science and engineering of biomaterials that exhibit adaptiveness to the biological environment. These materials are specifically designed to stimulate or direct appropriate cell and tissue responses or regulate interactions with microorganisms. The journal covers a wide range of bioactive materials, including those that are engineered or designed in terms of their physical form (e.g. particulate, fiber), topology (e.g. porosity, surface roughness), or dimensions (ranging from macro to nano-scales). Contributions are sought from the following categories of bioactive materials: Bioactive metals and alloys Bioactive inorganics: ceramics, glasses, and carbon-based materials Bioactive polymers and gels Bioactive materials derived from natural sources Bioactive composites These materials find applications in human and veterinary medicine, such as implants, tissue engineering scaffolds, cell/drug/gene carriers, as well as imaging and sensing devices.