Applied Organometallic Chemistry最新文献

{"title":"Selective Oxidation of Cyclopentene Over Amphiphilic Heteropolyacid Catalysts Loaded on Modified Activated Carbon","authors":"Xueying Liu,&nbsp;Jiahao Li,&nbsp;Bing Yuan,&nbsp;Fengli Yu","doi":"10.1002/aoc.70172","DOIUrl":"https://doi.org/10.1002/aoc.70172","url":null,"abstract":"<div>\u0000 \u0000 <p>The synthesis of glutaraldehyde and 1,2-cyclopentanediol has great industrial significance. However, the highly selective synthesis of these two compounds, and particularly of glutaraldehyde, is challenging. To improve the reaction rate and product selectivity of cyclopentene oxidation using green hydrogen peroxide (H₂O₂, 30 wt%) as an oxidant, activated carbon (AC)-supported amphiphilic vanadium-doped heteropolyacid (HPA) catalysts (AC-COIMI-C_n-HPA) were prepared by a series of modifications of AC, including acidification, imidazolylation, ammonium saltification, and HPAs loading. The structures and physicochemical properties of the catalysts were characterized by Fourier infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, and nitrogen adsorption–desorption. The developed catalyst exhibits excellent catalytic properties and high selectivity toward glutaraldehyde. The AC carrier increases the number of effective active sites on the catalyst. The amphiphilicity of the catalyst increased the reaction rate. Vanadium doping of HPA enables fine-tuning of the oxidizability of the catalyst. The effects of the different active components of the catalyst, alkyl groups on the imidazole ring, solvent type and dosage, HPA loading on the catalyst, catalyst dosage, oxidant dosage, reaction temperature, and reaction time on the oxidation of cyclopentene were comprehensively examined. Finally, the optimized conditions were determined as follows: HPA doping by four V atoms (PW₈V₄), octyl (C₈) linked to the imidazole, 1 mL of acetonitrile, HPA loading of 35 wt%, 500 mg of the catalyst (AC-COIMI-C₈–35%PW₈V₄), n(H₂O₂):n (cyclopentene) = 2, reaction temperature and time of 40°C and 6 h, respectively. The conversion of cyclopentene was 98.8% and the total selectivity for glutaraldehyde and 1,2-cyclopentanediol was 91.6% (65.2% for glutaraldehyde and 26.4% for 1,2-cyclopentanediol). The catalyst was reused by centrifugation, and high cyclopentene conversion was maintained after three cycles.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 6","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143900913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cobalt (II) and Nickel (II) Complexes of Substituted (Pyrazolyl)amine Ligands: Structural Characterization and Ethylene Oligomerization Studies","authors":"Francis K. Migwi,&nbsp;Ayanda Madlala,&nbsp;George S. Nyamato,&nbsp;Stephen O. Ojwach","doi":"10.1002/aoc.70171","DOIUrl":"https://doi.org/10.1002/aoc.70171","url":null,"abstract":"<p>The cobalt (II) and nickel (II) complexes of the general formula [Co(<b>L1</b>)Cl₂] (<b>Co1</b>), [Co(<b>L2</b>)Cl₂] (<b>Co2</b>), [Co(<b>L3</b>)Cl₂] (<b>Co3</b>), [Ni(<b>L1</b>)Br₂] (<b>Ni1</b>), and [Ni(<b>L2</b>)Br₂] (<b>Ni2</b>) were prepared by the reaction of either CoCl₂ or [NiBr₂(DME)] metal salts with the (pyrazolyl)amine ligands, <i>N</i>-benzyl-2-(3,5-dimethyl-1H-pyrazol-1-yl)ethan-1-amine (<b>L1</b>), 2-(3,5-dimethyl-1H-pyrazol-1-yl)-<i>N</i>-(2-methyl-benzyl)ethan-1-amine (<b>L2</b>) and 2-(3,5-diphenyl-1H-pyrazol-1-yl)-<i>N</i>-(2-methylbenzyl)ethan-1-amine (<b>L3</b>). The new compounds were characterized using NMR spectroscopy (for ligands), IR spectroscopy, mass spectrometry, elemental analysis and single crystal X-ray crystallography. The bidentate coordination modes of ligands <b>L1</b>-<b>L3</b> to form monometallic complexes was confirmed by the solid-state structures of <b>Co1</b>, <b>Co2</b>, <b>Co3</b>, and <b>Ni1</b>. Activation of these complexes with either EtAlCl₂ or MAO resulted in the formation of highly active ethylene oligomerization catalysts (up to 10³ kg [oligomers] mol⁻¹[catalyst]·h⁻¹), to afford predominantly C₄ and C₆ oligomers. The nature and coordination chemistry of the complexes was found to influence the catalytic performance. In general, nickel (II) complexes were more active than the corresponding cobalt (II) analogues. Significantly, cobalt (II) complexes were highly selective (99%) towards the formation of C₄ oligomers.</p>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 6","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aoc.70171","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143900914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Fe(III) Complex of Bispicen Ligand Covalently Attached to an Fe3O4 Nanomagnet: Catalytic Properties in C-H Oxidation and Benzoxazol Synthesis","authors":"Fatemeh Pakpour,&nbsp;Elham Safaei,&nbsp;Jasem Aboonajmi","doi":"10.1002/aoc.70132","DOIUrl":"https://doi.org/10.1002/aoc.70132","url":null,"abstract":"<div>\u0000 \u0000 <p>This study discusses the development of an effective and environmentally friendly C-H oxidation process for the creation of oxygenated compounds in the presence of <i>tert</i>-butyl hydroperoxide by a magnetically recoverable Fe₃O₄@SiO₂-FeL^Bpn nanocomposite. L^Bpn stands for a deprotonated, pyridine-based, four-dentate, bispicen ligand. The synthesised catalyst was characterised by Fourier-transform infrared spectroscopy (FTIR), energy-dispersive X-ray analysis (EDX), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), field emission scanning electron microscopy (FESEM), field emission transmission electron microscopy (FETEM), dynamic light scattering (DLS), thermal gravimetric analysis (TGA), and vibrating sample magnetometer (VSM). Fe₃O₄@SiO₂-FeL^Bpn (40 mg) was introduced as a catalyst in the presence of TBHP (4 eq) for the oxidation of varied C–H bonds to the related carbonyl compounds in high yields. Fe₃O₄@SiO₂-FeL^Bpn (5 mg) was used for the synthesis of benzoxazole derivatives from 1 mmol of every substrate of aldehydes, ammonium acetate, and catechol. By this process, vast amounts of benzoxazoles were satisfyingly obtained in the presence of Fe₃O₄@SiO₂-FeL^Bpn in H₂O under moderated situations, and whole products were gained with excellent results. Fe₃O₄@SiO₂-FeL^Bpn was recovered from the reaction environment through a simple exterior magnet and reused for three times without any remarkable reactivity loss. Moreover, a hot filtration test confirmed the heterogeneous character of the catalyst.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 6","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143900981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Regioselective Ruthenium-Catalyzed Oxidative C–H Alkenylation of 2-Aryl-4H-Benzo[d][1,3] Oxazin-4-Ones","authors":"Sepideh Bahrami Nasab,&nbsp;Seyed Iman Alavioon","doi":"10.1002/aoc.70163","DOIUrl":"https://doi.org/10.1002/aoc.70163","url":null,"abstract":"<div>\u0000 \u0000 <p>2-Aryl-<i>4H</i>-benzo[<i>d</i>][<i>1</i>,<i>3</i>]oxazin-<i>4</i>-one derivatives can be directly alkenylated with alkyl acrylates using a facile Ru (II)-catalyzed process; using Cu (OAc)₂•H₂O as an oxidizer through formation of a pentagon cyclic complex of imine-Ru (II) for C–H activation is described. The unique catalytic reaction is well matched with miscellaneous olefins such as vinyl ketones, acrylonitrile, and acrylates. The aryl rings bearing electronically diverse substituents tolerated the reaction conditions to provide ortho-alkenylation products in high regioselectivities and admissible yields.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 6","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143900982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Luminescent Sensing of 1,3,5-Trinitrotoluene Using a Schiff Base Ligand and Cd(II) Complex: Structural and Photophysical Investigations","authors":"Nevin Turan,&nbsp;Ayhan Altun,&nbsp;Kenan Buldurun,&nbsp;Olcay Aydın","doi":"10.1002/aoc.70178","DOIUrl":"https://doi.org/10.1002/aoc.70178","url":null,"abstract":"<p>The Schiff base (H₂L) was synthesized by condensing 2-amino-6-methyl-4,5,6,7-tetrahydrothieno[2,3-<i>c</i>]pyridine-3-carboxamide with 5-bromo-2-hydroxybenzaldehyde in a 1:2 M ratio, yielding the product with high efficiency. This Schiff base then formed a coordination complex with Cd(II) in a 1:1 M ratio, resulting in the complex [H₂LCd(H₂O)₂]·1.5H₂O. The synthesis and structural characterization of H₂L and its Cd(II) complex were carried out using various techniques, including microanalysis (CHNS), FTIR, ¹H and ¹³C-NMR, mass, UV–visible, magnetic susceptibility, thermogravimetric analysis (TGA), and fluorescence spectroscopy. The spectral data suggested that the Cd(II) complex adopted an octahedral geometry. In addition to the structural studies, the fluorescence properties of H₂L and its Cd(II) complex were investigated. Sensor properties of the Cd(II) complex for detecting nitroaromatic compounds were assessed using fluorescence spectroscopy. Both compounds exhibited high sensitivity for the detection of 1,3,5-trinitrotoluene (TNT). Specifically, H₂L demonstrated a low limit of detection (LOD) of 0.094 μM in the linear range of 1–10 μM. The fluorescence studies revealed that H₂L and its Cd(II) complex displayed strong fluorescence emissions. Furthermore, the Schiff base was employed for detecting TNT through fluorescence quenching, showing excellent selectivity and sensitivity.</p>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 6","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aoc.70178","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143900916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trifluoromethyl-Containing β-Diketiminato-Magnesium Complexes: Synthesis, Structures, and Catalysis for the Hydroboration of Carbodiimides","authors":"Zhiyuan Li,&nbsp;Yanan Dai,&nbsp;Lishuang Shi,&nbsp;Weihao Wu,&nbsp;Hongyan Xie,&nbsp;Zehuai Mou","doi":"10.1002/aoc.70185","DOIUrl":"https://doi.org/10.1002/aoc.70185","url":null,"abstract":"<div>\u0000 \u0000 <p>Trifluoromethyl-containing β-diketiminate ligands (CF₃)BDI^Et-H = (2,6-di-Et₂C₆H₃)N=C (CF₃)CH=C (CF₃)NH(2,6-di-Et₂C₆H₃), (CF₃)BDI^<i>i</i>Pr-H = (2,6-di-^<i>i</i>Pr₂C₆H₃)N=C (CF₃)CH=C (CF₃)NH(2,6-di-^<i>i</i>Pr₂C₆H₃) react with Mg^<i>n</i>Bu₂ readily to provide THF-ligated four-coordinate monomeric magnesium butyl complexes (CF₃)BDI^EtMg^<i>n</i>Bu (THF) (<b>1</b>) and (CF₃)BDI^<i>i</i>PrMg^<i>n</i>Bu (THF) (<b>2</b>) in THF, and three-coordinate monomeric complexes (CF₃)BDI^EtMg^<i>n</i>Bu (<b>3</b>) and (CF₃)BDI^<i>i</i>PrMg^<i>n</i>Bu (<b>4</b>) in toluene, respectively. The alkane elimination between <b>4</b> and NH (SiHMe₂)₂ gives silylamido complex <b>5</b> in toluene. Treatments of <b>4</b> with heterocumulene tert-butyl isothiocyanate, tert-butyl isocyanate, and N,N′-diisopropylcarbodiimide produce single insertion derivatives (CF₃)BDI^<i>i</i>PrMgN (^<i>t</i>Bu)C (^<i>n</i>Bu)S (<b>6</b>), (CF₃)BDI^<i>i</i>PrMgN (^<i>t</i>Bu)C (^<i>n</i>Bu)O (<b>7</b>), and (CF₃)BDI^<i>i</i>PrMgN (^<i>i</i>Pr)C (^<i>n</i>Bu)N (^<i>i</i>Pr) (<b>8</b>), respectively. All these new compounds were characterized by NMR spectroscopy, and the molecular structures of complexes <b>1</b>, <b>2</b>, <b>4</b>–<b>7</b> were further confirmed by single-crystal X-ray diffraction analyses. Moreover, representative complexes <b>2</b>–<b>5</b> were employed as pre-catalysts for the hydroboration of commercially available carbodiimides bearing aliphatic and aromatic substituents with pinacol borane HBpin, including diisopropylcarbodiimide (DIC), dicyclohexylcarbodiimide (DCC), di-<i>tert</i>-butylcarbodiimide, 2,6-diisopropylphenylcarbodiimide, and unsymmetric 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDCI), in which the three-coordinate monomeric complexes <b>3</b> and <b>4</b> showed better efficiency giving corresponding <i>N</i>-boryl formamidine products in high yields. A possible mechanistic pathway of the hydroboration reaction has been proposed.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 6","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143900940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transition Copper-Modified Iron Foam Electrode as a Green and New Method for Electrochemical CO2 Reduction for the Synthesis of Benzyl 3-Phenylpropiolate Derivatives Under Electro-Oxidation Reaction Conditions Using NaCl","authors":"Ali Basem,&nbsp;Ahmed M. Naglah,&nbsp;Amer Alhaj Zen,&nbsp;Yusupova Ugiloy,&nbsp;Usmanov Durbek,&nbsp;Elyor Berdimurodov,&nbsp;Abdulrahman A. Almehizia,&nbsp;Aiham O. Altayeh","doi":"10.1002/aoc.70156","DOIUrl":"https://doi.org/10.1002/aoc.70156","url":null,"abstract":"<div>\u0000 \u0000 <p>This research explores the application of electrocatalytic oxidation in the reduction of CO₂ for the synthesis of benzyl 3-phenylpropiolate derivatives, involving phenylacetylene <b>1(a–e)</b>, carbon dioxide <b>2a</b>, and benzyl chloride <b>3(a–j)</b> under electro-oxidation reaction conditions with sodium chloride (NaCl), utilizing highly efficient catalysts, specifically graphite rod and Cu-modified Fe foam. NaCl serves as an inexpensive and readily available reagent in the roles of electrolyte, cocatalyst, and activator for copper metal. Phenylpropiolate derivatives are crucial in generating a wide range of products in agricultural chemicals, versatile industrial chemicals, pharmaceuticals, and other industries. The utilization of electrocatalysis represents an environmentally sustainable and eco-friendly alternative to conventional methods, highlighting its potential impact on organic synthesis. The noteworthy efficiency exhibited by the graphite rod and Cu-modified Fe foam catalysts emphasizes their crucial role in advancing the field of organic chemistry. This study not only offers a promising path towards the creation of efficient and environmentally friendly methods for synthesizing benzyl 3-phenylpropiolate derivatives <b>5(a–j)</b> using isopropyl alcohol (iPrOH) as a solvent, with a reaction time of 30 min, a counter current of 20 mA, all conducted at room temperature and atmospheric pressure, yielding high percentages (91%–95%), but also details the fabrication and confirmation of Cu-modified Fe foam electrodes through SEM, EDS, XRD, XPS, and CV analysis. Subsequent characterization of the synthesized derivatives involved CHN analysis, ¹H NMR, and melting point determination.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 5","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143880048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amelioration of Motor Recovery After Spinal Cord Injury by Green-Formulated Nickel/Copper bi-Metallic Nanocomposite","authors":"Ruiying Guo,&nbsp;Chenyang Guo,&nbsp;Xulong Sun,&nbsp;Zhengwei Ren","doi":"10.1002/aoc.70153","DOIUrl":"https://doi.org/10.1002/aoc.70153","url":null,"abstract":"<div>\u0000 \u0000 <p>The treatment of spinal cord injury is crucial to prevent further damage and improve long-term outcomes, as early intervention can stabilize the spine, control inflammation, and facilitate recovery of function. In the present study, we synthesized a new metallic NPs and investigated the ability of NPs to treat spinal cord injury. The bimetallic NPs of nickel/copper were synthesized using the aqueous extract of <i>Artemisia annua</i>. The NPs was chemically characterized. Bands at wavenumbers 1053, 1377–1664, 2922, and 3417 cm⁻¹ reveal the functional groups’ presence of C-O, C=C, C=O, C-H, and O-H bonds, which are characteristic of organic compounds such as phenols and flavonoids, abundant in <i>A. annua</i>. Signals around 7.5 keV for NiKα and CuKα, as well as those after 8.0 keV for NiKβ and CuKβ, confirm the formation of Ni/Cu-NCPs. The FE-SEM images reveal the semispherical morphology of Ni/Cu-NCPs nanoparticles with a size of less than 90 nm. In the in vivo study, a total of 40 male Wistar rats were divided into four distinct groups: the sham rats, the intact animals, the control rats, and the Ni/Cu-NCPs group. Hematoxylin and eosin (H&amp;E) staining was performed to analyze the lesions following the injury. The assessment of Glial fibrillary acidic protein (GFAP) expression was conducted to gauge the astrogliosis degree. Additionally, the rat's behavioral performance was monitored weekly through the evaluation of BBB scores following the onset of spinal cord injury. The results from our XRD analysis demonstrated and FE-SEM illustrated a crystallinity structure with a semispherical morphology for the NPs dimensions of less than 50 nm. The findings of the study indicated that the neuroprotective properties of Ni/Cu-NCPs resulted in an improvement. Electromyography (EMG) analysis showed a significant enhancement in hindlimb functionality within the Ni/Cu-NCPs group. The ventral motor neurons quantity experienced a notable increase, whereas the areas of the cavity showed a marked decrease in the Ni/Cu-NCPs group. Additionally, there was a notable reduction in the expression of GFAP within the Ni/Cu-NCPs group. The results revealed the potent ability of the synthesized Ni/Cu NPs to cure spinal cord injury.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 5","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143856895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and Characterization of Octahedral Ni(II) and Cu(II) Complexes With Imidazole-Based Ligands: Structural, DFT, and Molecular Docking, Enhanced Antimicrobial, and Anti-Inflammatory Activity","authors":"Aly Abdou,&nbsp;Mai M. Khalaf,&nbsp;Hany M. Abd El-Lateef","doi":"10.1002/aoc.70158","DOIUrl":"https://doi.org/10.1002/aoc.70158","url":null,"abstract":"<div>\u0000 \u0000 <p>This study presents the synthesis, characterization, and biological evaluation of novel Ni(II) and Cu(II) metal complexes formed with imidazoleacetic acid (IA) and an imidazole-based ligand (IM). The novelty of this work lies in the development of these metal–ligand frameworks and their enhanced biological properties, which surpass those of their free ligands. A comprehensive suite of analytical techniques, including elemental analysis, IR spectroscopy, magnetic moment measurements, electronic spectra, mass spectrometry, thermal analysis, and DFT calculations, confirmed the successful formation of the NiIAIM and CuIAIM complexes with a 1:1:1 (M:IA:IM) stoichiometry and octahedral geometry. DFT calculations revealed that metal coordination effectively lowered the energy gap, increasing the complexes softness and reactivity, thereby enhancing their predicted biological activity. Antimicrobial studies demonstrated that both NiIAIM and CuIAIM complexes exhibited superior antibacterial potency against Gram-positive and Gram-negative bacteria compared to their free ligands, with activity comparable to the standard antibiotic Chloramphenicol. Furthermore, both complexes showed significant antifungal efficacy against <i>Candida albicans</i> and <i>Aspergillus niger</i>, again outperforming the uncoordinated ligands. Minimum inhibition concentration (MIC) values further validate their potent antimicrobial effects. Additionally, the complexes displayed promising anti-inflammatory activity, with the CuIAIM complex demonstrating the highest potency, approaching the efficacy of standard drugs based on IC₅₀ values. Molecular docking studies against DNA gyrase B confirmed the CuIAIM complex as the most potent candidate, showing strong binding affinity through multiple hydrogen bonds with key amino acid residues, highlighting its potential antibacterial mechanism. In conclusion, the synthesized NiIAIM and CuIAIM complexes represent promising new antimicrobial and anti-inflammatory agents, with significantly enhanced biological activity compared to their free ligands. These findings pave the way for further exploration of metal-based therapeutics in combating infectious diseases and inflammation.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 5","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143852750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of ZnO@ZIF-8 Core–Shell Heterostructure for Enhanced Formaldehyde Selective Performances at Room Temperature","authors":"Shaohui Huang,&nbsp;Jin Li","doi":"10.1002/aoc.70166","DOIUrl":"https://doi.org/10.1002/aoc.70166","url":null,"abstract":"<div>\u0000 \u0000 <p>Zinc oxide (ZnO) nanorods were synthesized by hydrothermal method, and ZnO@ZIF-8 nanorods with core–shell heterostructure were prepared by water bath synthesis method. The ZnO nanorods were synthesized by water bath and violently stirred at 50°C and 4 h as the optimal reaction time, in which ZIF-8 was a zeolite imidazolic acid skeleton structure. ZnO nanorods serve as the template for the growth of ZIF-8 shell and provide Zn²⁺ ions for its growth. By X-ray diffraction (XRD), it is proved that the nanorods are composed of ZnO and ZIF-8. By field emission electron microscopy (SEM) and transmission electron microscopy (TEM), it is proved that ZnO@ZIF-8 is composed of ZnO in the middle core and ZIF-8 in the outer shell. According to the test by BET, the specific surface area of ZnO and ZnO@ZIF-8 nanorods is 2.16 and 85.08 m²/g, respectively, and the specific surface area of the latter is much larger than that of the former. Compared with ZnO nanorod sensors, the ZnO@ZIF-8 sensor exhibits comparable response levels to formaldehyde, and the response to other test gases is decreased, and the screening ability of formaldehyde has been improved to a certain extent, because the pore size of the ZIF-8 shell has different restrictions on molecules of different sizes. This study shows that coating ZIFs on the surface of metal oxides is an effective method to improve the performance of gas sensors.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 5","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143835947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}