Water-Soluble Silver Coordination Polymers Constructed From Bridging Pyrazine Ligands: Syntheses, X-Ray Structures, Anticancer, and Antimicrobial Investigations

IF 3.7 2区 化学 Q2 CHEMISTRY, APPLIED
Mostafa A. El-Naggar, Morsy A. M. Abu-Youssef, Matti Haukka, Assem Barakat, M. Ali, Ayman El-Faham, Saied M. Soliman, Amal Yousri
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引用次数: 0

Abstract

Two novel polymeric complexes were synthesized from the reaction of AgClO4 with 3-amino-6-(chloromethyl)-2-pyrazinecarbonitrile 4-oxide (L1-Cl) or 3-aminopyrazine-2-carboxylic acid (HL2) to give [Ag(L1-OCH3)(μ-OClO3)]n; (1) or [Ag (HL2)(OClO3)]n.nH2O; (2), respectively. 3-Amino-6-(methoxymethyl)-2-pyrazinecarbonitrile 4-oxide (L1-OCH3) is formed by the etherification process that occurred during the synthesis of complex 1. The complexes architectures were investigated by single-crystal XRD (SC-XRD). Both complexes have novel and different polymeric forms based on the pyrazine moiety that adopt a bridging mode between the Ag(I) sites with the difference of donor atoms in each complex. The silver(I) centers in the polymeric chain of complex 1 are connected to one another through the bridging pyrazine ligand and perchlorate anions in an alternative manner. In complex 2, HL2 does not only act as a linker between the silver centers but also as a bidentate ligand. Hirshfeld surface analysis demonstrated the importance of H···O contacts in the supramolecular structures of 1 (41.7%) and 2 (30.2%). Biological investigations indicated promising antimicrobial and anticancer properties of these water-soluble complexes. Particularly, complex 1 displays interesting activity against A-549 (IC50 = 10.53 ± 0.44 𝜇M) and MCF-7 (IC50 = 8.41 ± 0.31 𝜇M) cell lines when contrasted to cis-platin. Regarding antibacterial action, the most promising MIC value and inhibition zone diameter are 8 μg/mL and 20 mm, respectively, for 1 against B. subtilis.

Abstract Image

由桥接吡嗪配体构建的水溶性银配位聚合物:合成、x射线结构、抗癌和抗菌研究
用AgClO4与3-氨基-6-(氯甲基)-2-吡嗪- 4-氧化碳腈(L1-Cl)或3-氨基吡嗪-2-羧酸(HL2)反应合成[Ag(L1-OCH3)(μ-OClO3)]n;(1) [Ag (HL2)(OClO3)]n.nH2O;(2)。3-氨基-6-(甲氧基甲基)-2-吡嗪碳腈- 4-氧化物(L1-OCH3)是在配合物1合成过程中发生醚化反应形成的。用单晶XRD (SC-XRD)研究了配合物的结构。这两种配合物都具有新颖而不同的聚合物形式,基于吡嗪部分,在每个配合物中不同的供体原子的Ag(I)位点之间采用桥接模式。配合物1聚合链上的银(I)中心通过桥接吡嗪配体和高氯酸盐阴离子以另一种方式相互连接。在配合物2中,HL2不仅作为银中心之间的连接体,而且作为双齿配体。Hirshfeld表面分析表明,H···O接触在1(41.7%)和2(30.2%)的超分子结构中起重要作用。生物学研究表明,这些水溶性配合物具有良好的抗菌和抗癌性能。特别是,与顺式铂相比,复合物1对A-549 (IC50 = 10.53±0.44𝜇M)和MCF-7 (IC50 = 8.41±0.31𝜇M)细胞系显示出有趣的活性。抑菌效果方面,1对枯草芽孢杆菌的MIC值和抑菌带直径分别为8 μg/mL和20 mm。
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来源期刊
Applied Organometallic Chemistry
Applied Organometallic Chemistry 化学-无机化学与核化学
CiteScore
7.80
自引率
10.30%
发文量
408
审稿时长
2.2 months
期刊介绍: All new compounds should be satisfactorily identified and proof of their structure given according to generally accepted standards. Structural reports, such as papers exclusively dealing with synthesis and characterization, analytical techniques, or X-ray diffraction studies of metal-organic or organometallic compounds will not be considered. The editors reserve the right to refuse without peer review any manuscript that does not comply with the aims and scope of the journal. Applied Organometallic Chemistry publishes Full Papers, Reviews, Mini Reviews and Communications of scientific research in all areas of organometallic and metal-organic chemistry involving main group metals, transition metals, lanthanides and actinides. All contributions should contain an explicit application of novel compounds, for instance in materials science, nano science, catalysis, chemical vapour deposition, metal-mediated organic synthesis, polymers, bio-organometallics, metallo-therapy, metallo-diagnostics and medicine. Reviews of books covering aspects of the fields of focus are also published.
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