Plant Leaf Aqueous Extract Green-Formulated Zinc Nanoparticles Ameliorate Functional Dyspepsia

The current investigation unveils the utilization of Lycopus lucidus extract for the eco-friendly production of zinc nanoparticles and a study on the efficacy of NPs on dyspepsia in mice. The NPs were characterized by several methods. The XRD analysis confirms the crystallinity of ZnNPs@L. lucidus with the formula of ZnO and a crystal size of 28.4 nm. The particle size of ZnNPs@L. lucidus is revealed through FE-SEM imaging, displaying a spherical structure measuring 40 nm in size. The efficacy of ZnNPs@L. lucidus in improving functional dyspepsia was demonstrated through the assessment of the gut microbiome, gastrointestinal motility, and hormonal changes in mice with reserpine-induced functional dyspepsia. The gut microbiome data indicated that ZnNPs@L. lucidus could regulate the restoration of homeostasis and microbiome structure by reducing harmful bacterial abundance. The use of ZnNPs@L. lucidus resulted in an enhancement of gastrointestinal motility, including an increase in the rates of small intestinal transit and gastric emptying.