Plant Leaf Aqueous Extract Green-Formulated Zinc Nanoparticles Ameliorate Functional Dyspepsia

IF 3.7 2区化学 Q2 CHEMISTRY, APPLIED

Applied Organometallic Chemistry Pub Date : 2025-09-14 DOI:10.1002/aoc.70379

Xinyan Li

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Abstract

The current investigation unveils the utilization of Lycopus lucidus extract for the eco-friendly production of zinc nanoparticles and a study on the efficacy of NPs on dyspepsia in mice. The NPs were characterized by several methods. The XRD analysis confirms the crystallinity of ZnNPs@L. lucidus with the formula of ZnO and a crystal size of 28.4 nm. The particle size of ZnNPs@L. lucidus is revealed through FE-SEM imaging, displaying a spherical structure measuring 40 nm in size. The efficacy of ZnNPs@L. lucidus in improving functional dyspepsia was demonstrated through the assessment of the gut microbiome, gastrointestinal motility, and hormonal changes in mice with reserpine-induced functional dyspepsia. The gut microbiome data indicated that ZnNPs@L. lucidus could regulate the restoration of homeostasis and microbiome structure by reducing harmful bacterial abundance. The use of ZnNPs@L. lucidus resulted in an enhancement of gastrointestinal motility, including an increase in the rates of small intestinal transit and gastric emptying.

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植物叶水提取物绿色配方锌纳米颗粒改善功能性消化不良

目前的研究揭示了利用番茄提取物环保生产锌纳米粒子和研究NPs对小鼠消化不良的功效。用几种方法对NPs进行了表征。XRD分析证实了ZnNPs@L的结晶度。采用氧化锌分子式制备的lucidus晶体尺寸为28.4 nm。ZnNPs@L的粒度。通过FE-SEM成像发现lucidus为40 nm大小的球形结构。ZnNPs@L的功效。通过评估利血平诱导的功能性消化不良小鼠的肠道微生物群、胃肠运动和激素变化，证明了Lucidus改善功能性消化不良的作用。肠道微生物组数据表明ZnNPs@L。Lucidus可以通过降低有害细菌丰度来调节体内平衡和微生物群结构的恢复。使用ZnNPs@L。Lucidus导致胃肠运动增强，包括小肠运输和胃排空率的增加。

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来源期刊

Applied Organometallic Chemistry 化学-无机化学与核化学

CiteScore

7.80

自引率

10.30%

发文量

408

审稿时长

2.2 months

期刊介绍： All new compounds should be satisfactorily identified and proof of their structure given according to generally accepted standards. Structural reports, such as papers exclusively dealing with synthesis and characterization, analytical techniques, or X-ray diffraction studies of metal-organic or organometallic compounds will not be considered. The editors reserve the right to refuse without peer review any manuscript that does not comply with the aims and scope of the journal. Applied Organometallic Chemistry publishes Full Papers, Reviews, Mini Reviews and Communications of scientific research in all areas of organometallic and metal-organic chemistry involving main group metals, transition metals, lanthanides and actinides. All contributions should contain an explicit application of novel compounds, for instance in materials science, nano science, catalysis, chemical vapour deposition, metal-mediated organic synthesis, polymers, bio-organometallics, metallo-therapy, metallo-diagnostics and medicine. Reviews of books covering aspects of the fields of focus are also published.