Green Synthesis of Novel Cyclopenta[1,2-d]pyrimidins Using Ag/Fe3O4@GO Nanocatalyst: Characterization and Biological Activity

In this research, novel derivatives of cyclopenta[1,2-d]pyrimidin with a high level of efficiency were synthesized using Ag/Fe₃O₄@Graphene oxide (Ag/Fe₃O₄@GO) employing multicomponent reaction including vinylidenes, aldehydes, ethyl 2-amino-4-dioxo-4-arylbutanoates, alkyl bromides, and guanidine in water at room temperature. The produced compounds exhibit antioxidant activity as a result of the evaluation processes conducted on their NH group. Furthermore, an evaluation was performed on the antibacterial effectiveness of newly created pyridines using a disk diffusion technique, utilizing two different strains of Gram-negative bacteria. Significantly, the substances that were evaluated showed inhibitory effects on the development of Gram-positive bacteria as well. This method has several benefits, including quick response times, high product yields, and easy separation of catalyst and product using simple procedures.