Annales pharmaceutiques francaises最新文献

{"title":"Place de la cranioplastie dans la prise en charge des crâniectomies décompressives : étude de la cohorte de l’Hôpital Fondation Adolphe de Rothschild sur 7 ans","authors":"Zohra Gachouch , Georges Nicolaos , Claire Judel , Chloé Dupont , Caroline Le Guerinel","doi":"10.1016/j.pharma.2024.09.004","DOIUrl":"10.1016/j.pharma.2024.09.004","url":null,"abstract":"<div><h3>Objectifs</h3><div>L’objectif de notre étude est de faire un état des lieux des implants de cranioplastie utilisés au sein de notre établissement.</div></div><div><h3>Matériels et méthode</h3><div>Nous avons analysé les dossiers des patients ayant subi une crâniectomie suivie d’une cranioplastie entre 2017 et 2023, avec au moins 1 an de suivi après la cranioplastie (<em>n</em> <!-->=<!--> <!-->75). Les données ont été extraites du dossier patient informatisé (DxCare®, Dédalus) et de l’outil de gestion pharmaceutique des médicaments et des dispositifs médicaux stériles (Pharma®, Computer Engineering). Le sex-ratio, l’indication de la crâniectomie, la durée opératoire, le délai entre la crâniectomie et la cranioplastie, les complications et le résultat esthétique ont été statistiquement analysés.</div></div><div><h3>Résultats</h3><div>Les principales indications sont les accidents vasculaires cérébraux (<em>n</em> <!-->=<!--> <!-->59 ; 78,5 %) et les anévrismes (<em>n</em> <!-->=<!--> <!-->7 ; 9,5 %). Parmi les 75 patients, 52 ont bénéficié de la pose d’un implant sur mesure (PolyEtherEtherCetone/PEEK ou hydroxyapatite) et 23 d’une cimentoplastie. Le temps opératoire était significativement plus court (<em>p</em> <!--><<!--> <!-->0,05) pour une cranioplastie sur mesure (1,93<!--> <!-->±<!--> <!-->0,61<!--> <!-->h vs 1,62<!--> <!-->±<!--> <!-->0,53). Seul 4 patients (5,3 %) n’étaient pas satisfaits du résultat esthétique suite à la pose d’un implant sur mesure. Un risque infectieux plus important était retrouvé dans le cadre d’une cimentoplastie (43 % pour les cimentoplasties vs 25 % pour l’implant sur mesure, soit χ<sup>2</sup> (<em>p</em> <!-->=<!--> <!-->0,1095), cette différence n’étant pas statistiquement significative.</div></div><div><h3>Conclusion</h3><div>Ce travail collaboratif entre la pharmacie et le service de neurochirurgie adulte a servi à établir un registre initial pour le suivi des patients ayant bénéficié d’une cranioplastie dont l’implant idéal reste à déterminer.</div></div><div><h3>Objectives</h3><div>The objective of our study is to take stock of the cranioplasty implants used within our establishment.</div></div><div><h3>Materials and method</h3><div>We analyzed the patients files who underwent craniectomy followed by cranioplasty between 2017 and 2023, with at least 1 year of follow-up after cranioplasty (<em>n</em> <!-->=<!--> <!-->75). The data were extracted from the computerized patient file (DxCare®, Dédalus) and the pharmaceutical management tool for drugs and sterile medical devices (Pharma®, Computer Engineering). The sex ratio, indication for craniectomy, operating time, time between craniectomy and cranioplasty, complications and aesthetic result were statistically analyzed.</div></div><div><h3>Results</h3><div>The main indications are stroke (<em>n</em> <!-->=<!--> <!-->59; 78.5%) and aneurysms (<em>n</em> <!-->=<!--> <!-->7; 9.5%). Among the 75 patients, 52 benefited from the placement of a custom imp","PeriodicalId":8332,"journal":{"name":"Annales pharmaceutiques francaises","volume":"83 1","pages":"Pages 141-145"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction d’une méthodologie d’évaluation clinique des dispositifs médicaux grâce aux outils de simulation et illustration à travers trois études","authors":"Cordélia Salomez-Ihl ,&nbsp;Claire Chapuis ,&nbsp;Pierre Albaladejo ,&nbsp;Marielle Picard ,&nbsp;Aline Baron ,&nbsp;Paz Pardo Garcia ,&nbsp;Jean-Noël Evain ,&nbsp;Joris Giai ,&nbsp;Maud Barbado ,&nbsp;Alexandre Moreau-Gaudry ,&nbsp;Jean-Luc Bosson ,&nbsp;Julien Picard ,&nbsp;Pierrick Bedouch","doi":"10.1016/j.pharma.2024.09.003","DOIUrl":"10.1016/j.pharma.2024.09.003","url":null,"abstract":"<div><h3>Introduction</h3><div>La réglementation européenne a récemment évolué vers des exigences renforcées en termes de démonstration de la sécurité et de la performance des dispositifs médicaux (DM).</div></div><div><h3>Objectif</h3><div>Appliquer une méthode de test innovante utilisant la simulation médicale à l’évaluation de trois dispositifs médicaux à différents stades de leur cycle de vie.</div></div><div><h3>Méthode</h3><div>La méthodologie d’évaluation des DM par la simulation s’articule autour de sept étapes : définition du contexte, formation, construction d’un scénario permettant de tester le DM, validation du scénario, réalisation du scénario, évaluation du scénario par les acteurs et validation et exploitation des résultats.</div></div><div><h3>Résultats</h3><div>Notre méthodologie d’évaluation nous a permis d’évaluer trois DM à différents stades de leur développement : un dispositif de protection respiratoire au stade initial (définition du prototype), un masque de protection respiratoire (optimisation du prototype) et des adaptateurs pour flacon (post-commercialisation).</div></div><div><h3>Conclusion</h3><div>La simulation est un outil précieux pour évaluer les DM. La méthodologie proposée permet son utilisation et son adaptation selon différents contextes. Elle répond aux spécificités de l’évaluation clinique de cette classe de produits et permet de mieux anticiper certains risques.</div></div><div><h3>Introduction</h3><div>European regulations have recently moved towards more stringent requirements for demonstrating the safety and performance of medical devices (MDs).</div></div><div><h3>Objective</h3><div>To apply an innovative testing method using medical simulation to the evaluation of three medical devices at different stages of their life cycle.</div></div><div><h3>Method</h3><div>The methodology for evaluating DMs using simulation is based on seven stages: definition of the context, training, construction of a scenario to test the DM, validation of the scenario, realization of the scenario, evaluation of the scenario by the players and validation and exploitation of the results.</div></div><div><h3>Results</h3><div>Our evaluation methodology enabled us to assess three DMs at different stages of their development: a respiratory protection device at the initial stage (prototype definition), a respiratory protection mask (prototype optimization) and bottle adapters (post-marketing).</div></div><div><h3>Conclusion</h3><div>Simulation is a valuable tool for evaluating DM. The proposed methodology enables it to be used and adapted to different contexts. It responds to the specificities of clinical evaluation of this class of products, and helps to better anticipate certain risks.</div></div>","PeriodicalId":8332,"journal":{"name":"Annales pharmaceutiques francaises","volume":"83 1","pages":"Pages 131-140"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review on novel pharmaceutical applications of hupu gum: A versatile natural polymer","authors":"Rajeswari Aleti,&nbsp;Monika Nijhawan,&nbsp;Pavan Kumar Thota,&nbsp;Bhavana Jidige","doi":"10.1016/j.pharma.2024.09.008","DOIUrl":"10.1016/j.pharma.2024.09.008","url":null,"abstract":"<div><div>The pharmaceutical research on natural excipients with diverse physicochemical properties useful in various novel drug delivery systems is a growing interest. The market for natural gums like hupu gum (gum kondagogu) is growing globally, driven by increasing consumer preference for natural and sustainable ingredients. This review covers botanical origin, geographical distribution, chemical constituents, identification tests, toxicology studies and potential applications of hupu gum in novel drug delivery systems. Emphasis is placed on its traditional uses in indigenous medicine and current research findings and patents that highlight its emulsifying, stabilizing, film forming, and thickening properties. Hupu gum is a tree exudate from <em>Cochlospermum religiosum</em> belonging to the family <em>Bixaceae</em>. It is traditionally used for various medicinal and industrial purposes as it has a unique chemical composition and physical properties. Moreover, the current research and use of hupu gum as a biopolymer in the formulation and stabilization of nanoparticles (NP) is expanding the application spectrum of hupu gum. This writeup typically conclude with insights into future research directions, such as, exploring new applications, or enhancing its functional properties through modification.</div></div><div><div>La recherche pharmaceutique sur les excipients naturels aux propriétés physicochimiques diverses utiles dans divers nouveaux systèmes d’administration de médicaments suscite un intérêt croissant. Le marché des gommes naturelles comme la gomme Hupu (gomme kondagogu) est en pleine croissance à l’échelle mondiale, stimulé par la préférence croissante des consommateurs pour les ingrédients naturels et durables. Cette revue couvre l’origine botanique, la répartition géographique, les constituants chimiques, les tests d’identification, les études de toxicologie et les applications potentielles de la gomme hupu dans de nouveaux systèmes d’administration de médicaments. L’accent est mis sur ses utilisations traditionnelles en médecine indigène et sur les résultats de recherche actuels et les brevets qui mettent en évidence ses propriétés émulsifiantes, stabilisantes, filmogènes et épaississantes. La gomme hupu est un exsudat d’arbre de <em>Cochlospermum religiosum</em> appartenant à la famille des <em>Bixaceae</em>. Elle est traditionnellement utilisée à diverses fins médicinales et industrielles car elle possède une composition chimique et des propriétés physiques uniques. De plus, la recherche et l’utilisation actuelles de la gomme hupu comme biopolymère dans la formulation et la stabilisation des nanoparticules (NP) élargissent le spectre d’application de la gomme hupu. Ce document se termine généralement par des aperçus sur les orientations de recherche futures, telles que l’exploration de nouvelles applications ou l’amélioration de ses propriétés fonctionnelles par modification.</div></div>","PeriodicalId":8332,"journal":{"name":"Annales pharmaceutiques francaises","volume":"83 1","pages":"Pages 22-32"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vie de l’Académie – 2e semestre 2024","authors":"","doi":"10.1016/j.pharma.2024.12.006","DOIUrl":"10.1016/j.pharma.2024.12.006","url":null,"abstract":"","PeriodicalId":8332,"journal":{"name":"Annales pharmaceutiques francaises","volume":"83 1","pages":"Pages 173-192"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143171240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sommaire / Contents","authors":"","doi":"10.1016/S0003-4509(24)00186-X","DOIUrl":"10.1016/S0003-4509(24)00186-X","url":null,"abstract":"","PeriodicalId":8332,"journal":{"name":"Annales pharmaceutiques francaises","volume":"83 1","pages":"Pages v-vi"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143172076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing antibiotic prescribing practices at the main military training hospital of Tunis: A study of pharmaceutical interventions","authors":"Aloui Ghaith ,&nbsp;Sana Bennour ,&nbsp;Yousfi Mohamed Ali","doi":"10.1016/j.pharma.2024.09.006","DOIUrl":"10.1016/j.pharma.2024.09.006","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Bacterial infections have historically posed significant challenges until the discovery of antibiotics, which revolutionized infectious disease treatment. However, bacterial adaptation mechanisms over time have led to increased antimicrobial resistance, necessitating judicious antibiotic use.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objectives&lt;/h3&gt;&lt;div&gt;This study aims to comprehensively analyze pharmaceutical interventions related to antibiotic prescriptions governed by antibiotic order forms to identify and rectify medication errors, optimizing antibiotic prescribing practices.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Material and methods&lt;/h3&gt;&lt;div&gt;Approval for this research was obtained from the institutional review board of the Main Military Training Hospital of Tunis, Tunisia. A retrospective study was conducted at the main military training hospital of Tunis over 4 months. Pharmaceutical validation of antibiotic prescriptions through antibiotic order forms was conducted by a pharmacy resident. Pharmaceutical interventions were initiated upon detection of errors, and patient records were accessed through institutional software.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Out of 1100 prescription forms analyzed, 41 pharmaceutical interventions were conducted for 7 antibiotics. Twenty-four percent of all interventions were related to antibiotic order forms, with the intensive care unit accounting for the highest number of errors. Under-dosage and prescription errors were common.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;Our pharmaceutical interventions related to antibiotic order forms are crucial for optimizing antibiotic therapy. Feedback mechanisms to healthcare teams are essential for enhancing prescription quality and patient care outcomes. Ongoing surveillance and improvement efforts are necessary to address medication errors and enhance antimicrobial stewardship.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Contexte&lt;/h3&gt;&lt;div&gt;Les infections bactériennes ont toujours posé des défis importants jusqu’à la découverte des antibiotiques, qui ont révolutionné le traitement des maladies infectieuses. Cependant, les mécanismes d’adaptation des bactéries ont conduit à une résistance accrue, ce qui nécessite une utilisation judicieuse des antibiotiques.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objectif&lt;/h3&gt;&lt;div&gt;Cette étude vise à analyser de manière exhaustive les interventions pharmaceutiques liées aux prescriptions d’antibiotiques régies par les formulaires de prescription d’antibiotiques afin d’identifier et de rectifier les erreurs médicamenteuses et d’optimiser les pratiques de prescription d’antibiotiques.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Matériels et méthodes&lt;/h3&gt;&lt;div&gt;Cette recherche a été approuvée par le comité d’éthique institutionnel de l’hôpital militaire principal de Tunis, Tunisie. Une étude rétrospective a été menée à l’hôpital militaire principal de Tunis pendant 4 mois. La validation pharmaceutique des prescriptions d’antibiotiques par les fiches de prescription d’antibiotiques a été effectuée par un résident en ","PeriodicalId":8332,"journal":{"name":"Annales pharmaceutiques francaises","volume":"83 1","pages":"Pages 124-130"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design of in-situ implant for the brain-targeted drug delivery using cross-linked gellan gum polymer through response surface methodology","authors":"Imran Kazmi ,&nbsp;Hemant K.S. Yadav ,&nbsp;Fahad A. Al-Abbasi ,&nbsp;Muhammad Afzal ,&nbsp;Muhammad Shahid Nadeem ,&nbsp;Hisham N. Altayb ,&nbsp;Abhay Raizaday ,&nbsp;Md Sadique Hussain ,&nbsp;Haider Ali ,&nbsp;Faisal Imam ,&nbsp;Gaurav Gupta","doi":"10.1016/j.pharma.2024.10.004","DOIUrl":"10.1016/j.pharma.2024.10.004","url":null,"abstract":"<div><div>The analysis aimed to prepare an in-situ implant (ISFI) formulation holding dimethyl fumarate as (a model drug) using cross-linked gellan gum by homogenization method. Cross-linking of gellan gum was done with L-cysteine to improve its gelation properties. Fourier transform infrared spectroscopy (FTIR) and (DSC) Differential scanning calorimetry were used to test the compatibility of the drug-polymer. The diverse formulations were prepared and tested using Design Expert® ver 8.0.1 software to optimize the experiment technique and employ the response surface. The tissue compatibility of the test verified the existence of non-irritants in the established formulation. All preparations contained the drug content from approximately 97.98 to 99.88%. Viscosities are ideal for injection in the optimized formulation (1,55 percent w/w in water). The optimized formula was monitored, and up to 156<!--> <!-->hours, it was found to be 95.7%. The result was that ISFI can effectively monitor and control the delivery of several powerful drug products.</div></div><div><div>L’étude visait à créer une formulation d’implant in situ (ISFI) contenant du fumarate de diméthyle comme médicament test, en utilisant de la gomme gellane (GG) réticulée et en appliquant le processus d’homogénéisation. La GG a été réticulée avec de la L-cystéine pour améliorer ses caractéristiques de gélification. La spectroscopie infrarouge à transformée de Fourier (FTIR) et la calorimétrie différentielle à balayage (DSC) ont été utilisées pour tester la compatibilité du médicament-polymère. En utilisant le logiciel Design Expert® version 8.0.1 pour la conception optimale de la technique expérimentale et en appliquant la méthodologie de surface de réponse, la formulation diversifiée a été préparée et testée. Le test de compatibilité tissulaire a vérifié la nature non irritante de la formulation établie. Toutes les préparations contenaient une teneur en médicament d’environ 97,98 à 99,88 %. Les viscosités sont idéales pour l’injection dans la formulation optimisée. La formule optimisée a été surveillée et jusqu’à 156<!--> <!-->heures, elle s’est avérée être efficace à 95,7 %. Le résultat est que l’ISFI peut être utilisé pour surveiller et contrôler efficacement la délivrance de plusieurs médicaments puissants.</div></div>","PeriodicalId":8332,"journal":{"name":"Annales pharmaceutiques francaises","volume":"83 1","pages":"Pages 68-80"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142456832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application progress of nanomaterials in the treatment of prostate cancer","authors":"Xuewu Wu ,&nbsp;Longtu Ma ,&nbsp;Yang Zhang ,&nbsp;Shuai Liu ,&nbsp;Long Cheng ,&nbsp;Chengyu You ,&nbsp;Zhilong Dong","doi":"10.1016/j.pharma.2024.08.009","DOIUrl":"10.1016/j.pharma.2024.08.009","url":null,"abstract":"<div><div>Prostate cancer is one of the most common malignant tumors in men, which seriously threatens the survival and quality of life of patients. At present, there are serious limitations in the treatment of prostate cancer, such as drug tolerance, drug resistance and easy recurrence. Sonodynamic therapy and chemodynamic therapy are two emerging tumor treatment methods, which activate specific drugs or sonosensitizers through sound waves or chemicals to produce reactive oxygen species and kill tumor cells. Nanomaterials are a kind of nanoscale materials with many excellent physical properties such as high targeting, drug release regulation and therapeutic monitoring. Sonodynamic therapy and chemodynamic therapy combined with the application of nanomaterials can improve the therapeutic effect of prostate cancer, reduce side effects and enhance tumor immune response. This article reviews the application progress of nanomaterials in the treatment of prostate cancer, especially the mechanism, advantages and challenges of nanomaterials in sonodynamic therapy and chemodynamic therapy, which provides new ideas and prospects for research in this field.</div></div><div><div>Le cancer de la prostate est l’un des plus courants des cancers chez l’homme, qui menace sérieusement la survie et la qualité de vie des patients. Actuellement, il y a des limitations graves dans le traitement du cancer de la prostate, tels que la tolérance au médicament, la résistance au médicament et la récidive facile. La thérapie sonodynamique et la thérapie chimiodynamique sont deux méthodes émergentes de traitement des tumeurs, qui activent des médicaments spécifiques ou des sonosensibilisants par des ondes sonores ou des produits chimiques pour produire des espèces réactives de l’oxygène et tuer les cellules tumorales. Les nanomatériaux sont des matériaux à nano-échelle avec de nombreuses excellentes propriétés physiques, telles que la haute ciblage, la régulation de la libération du médicament et la surveillance thérapeutique. La thérapie sonodynamique et la chimiodynamique combinées à l’application de nanomatériaux peuvent améliorer l’effet thérapeutique du cancer de la prostate, réduire les effets secondaires et renforcer la réponse immunitaire des tumeurs. Cet article passe en revue les progrès de l’application des nanomatériaux dans le traitement du cancer de la prostate, en particulier le mécanisme, les avantages et les défis des nanomatériaux dans la thérapie sonodynamique et chimiodynamique, ce qui offre de nouvelles idées et des perspectives pour la recherche dans ce domaine.</div></div>","PeriodicalId":8332,"journal":{"name":"Annales pharmaceutiques francaises","volume":"83 1","pages":"Pages 1-12"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142071888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An investigative review for pharmaceutical analysis of angiotensin receptor blockers: Olmesartan medoxomil","authors":"Vinod Ambalal Chaure,&nbsp;Atul Arun Shirkhedkar","doi":"10.1016/j.pharma.2024.10.001","DOIUrl":"10.1016/j.pharma.2024.10.001","url":null,"abstract":"<div><div>Hypertension is often asymptomatic and can substantially elevate the risk of cardiovascular complications. Olmesartan medoxomil works by competitively blocking the angiotensin II receptors, preventing angiotensin II from constructing the blood vessels and releasing aldosterone. This discussion is focused on the critical analytical methods used to analyze olmesartan medoxomil in pharmaceutical and biological samples. A variety of analytical methods have been employed to both qualitatively and quantitatively determine the analyte, including high-performance thin-layer chromatography (HPTLC), high-performance liquid chromatography (HPLC), voltammetry, capillary zone electrophoresis, UV/Vis spectrophotometry, and 96-microwell assays. The review also includes official methods published in the Indian Pharmacopoeia. Based on existing literature, simple spectrophotometry and liquid chromatography are commonly used to analyze olmesartan medoxomil. These findings provide a solid foundation for future olmesartan medoxomil drug analysis research.</div></div><div><div>L’hypertension est souvent asymptomatique et peut augmenter considérablement le risque de complications cardiovasculaires. L’olmésartan médoxomil agit en bloquant de manière compétitive les récepteurs de l’angiotensine II, empêchant l’angiotensine II de construire les vaisseaux sanguins et de libérer de l’aldostérone. Cette discussion se concentre sur les méthodes analytiques critiques utilisées pour analyser l’olmésartan médoxomil dans des échantillons pharmaceutiques et biologiques. Diverses techniques analytiques telles que la chromatographie sur couche mince haute performance, la chromatographie liquide haute performance, la voltamétrie, l’électrophorèse de zone capillaire, la spectrophotométrie UV/Vis et les analyses à 96 micropuits ont été utilisées pour estimer qualitativement et quantitativement l’analyte. La revue inclut également les méthodes officielles publiées dans la Pharmacopée indienne. Sur la base de la littérature existante, une simple spectrophotométrie et une chromatographie liquide sont couramment utilisées pour analyser l’olmésartan médoxomil. Ces résultats constituent une base solide pour les futures recherches sur l’analyse des médicaments liés à l’olmésartan médoxomil.</div></div>","PeriodicalId":8332,"journal":{"name":"Annales pharmaceutiques francaises","volume":"83 1","pages":"Pages 33-44"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142456830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cranio-facial trauma diagnosis using paleo-proteotyping of a blood sample from Robespierre (1794).","authors":"Philippe Charlier, Jean Armengaud","doi":"10.1016/j.pharma.2024.12.011","DOIUrl":"10.1016/j.pharma.2024.12.011","url":null,"abstract":"<p><p>Tradition has it that the politician Robespierre, a famous tribune of the French Revolution, was lying, wounded in the face by a bullet from a firearm, on an 18th century desk, and left a trace of blood there, before being guillotined the next day (1794). This piece of furniture is now kept in the National Archives (Paris, France). A paleo-proteomic study was carried out on several brown stains on the leather of the desk, which confirmed the human blood nature of the sample, but also identified the protein signature of different cranio-facial organs. This confirms not only the historical anecdote surrounding this desk, but also the importance of contemporary ballistic lesions on the eve of Robespierre's death. This demonstrates the importance and precision of paleo-proteomics in paleopathology and for the examination and identification of the precise nature of stains and micro-traces on old samples.</p>","PeriodicalId":8332,"journal":{"name":"Annales pharmaceutiques francaises","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142880933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}