[Development and validation of a conductimetric method for determining traces of detergent in final rinse water].

IF 1 Q4 PHARMACOLOGY & PHARMACY

Annales pharmaceutiques francaises Pub Date : 2025-01-28 DOI:10.1016/j.pharma.2025.01.010

Safae Alaoui, Ismail Bennani, Sara Hajjaj, Abdeslam El Kartouti

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引用次数: 0

Abstract

Objective: The aim of our work is to develop a simple, rapid and inexpensive method for the detection and quantification of a detergent (phosphoric acid) in final rinse water using conductivity.

Methods: The conductimetric method was used. A calibration curve was obtained by measuring the conductivity of successive dilutions of a stock solution of the detergent. The conductivity of the sample was measured using the water from the last rinse. Detergent concentration in the sample was calculated using the regression equation of the calibration curve. Analytical validation was carried out in accordance with international harmonization conference guidelines ICH Q2. Data analysis was performed using jamovi software version 2.3.28.

Results: Linearity was proved by the correlation between concentration and conductivity with r=0.98. The coefficient of variation for repeatability and intermediate precision were low, and the mean recovery rates ranged from 98 to 102%. Calculated sample concentrations were below 5ppm.

Conclusions: The conductimetric method proposed in our study has been validated for the determination of phosphoric acid. It has the advantage of being rapid, inexpensive and simple. This makes the method the first choice for the determination of trace amounts of detergent in the pharmaceutical and research laboratories.

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[电导法测定最终漂洗水中洗涤剂残留量的开发和验证]。

目的：建立一种简单、快速、廉价的方法，利用电导率法检测和定量最终漂洗水中的洗涤剂（磷酸）。方法：采用电导法。通过测量洗涤剂原液连续稀释的电导率，得到了校准曲线。样品的电导率是用最后一次冲洗的水来测量的。用标定曲线的回归方程计算样品中洗涤剂的浓度。分析验证按照国际协调会议指南ICH Q2进行。数据分析采用jamovi软件版本为2.3.28。结果：浓度与电导率呈线性关系，r =0.98。重复性和中间精密度的变异系数较低，平均回收率为98 ~ 102%。计算出的样品浓度低于5ppm。结论：本研究建立的电导法可用于磷酸的测定。它具有快速、廉价和简单的优点。这使该方法成为制药和研究实验室中痕量洗涤剂测定的首选方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annales pharmaceutiques francaises PHARMACOLOGY & PHARMACY-

CiteScore

1.70

自引率

7.70%

发文量

期刊介绍： This journal proposes a scientific information validated and indexed to be informed about the last research works in all the domains interesting the pharmacy. The original works, general reviews, the focusing, the brief notes, subjected by the best academics and the professionals, propose a synthetic approach of the last progress accomplished in the concerned sectors. The thematic Sessions and the – life of the Academy – resume the communications which, presented in front of the national Academy of pharmacy, are in the heart of the current events.