Annales pharmaceutiques francaises最新文献

{"title":"Montmorillonite: An advanced material with diverse pharmaceutical and medicinal applications","authors":"Sagar Fatale , Javesh K. Patil , Chandrakantsing V. Pardeshi , Vishal V. Pande , Mangesh A. Bhutkar , Komal Parashar , Raju O. Sonawane","doi":"10.1016/j.pharma.2024.11.001","DOIUrl":"10.1016/j.pharma.2024.11.001","url":null,"abstract":"<div><div>Montmorillonite (MMT) clay is composed of naturally layered silicate. The clays were more popular in the pharmaceutical and other various fields due to their beneficial physicochemical properties <em>viz.</em> non-toxicity, high surface area, efficient adsorption capability, high swellability, high dispersibility, thixotropic behaviour, and cation exchange capacity. Chemically modified clay provides significant opportunities in variety of applications. MMT finds very crucial place in pharmaceutical field owing to its medicinal properties, which may be used to delay the drug release in chronic physiological conditions and the targeted drug release as well. It is also used to improve the dissolution rate of certain drug molecules, which increased the attention of the researchers to explore the MMT for drug delivery applications. MMT clay has been used as pharmaceutical aids <em>viz.</em> suspending agent, lubricant, anticaking agent, diluent, emulsifier, nanocomposites-forming material, and sometimes filler. MMT clay have been investigated in the fabrication of different pharmaceutical formulations <em>viz.</em> hydrogel, films, nanocomposites, and matrix-based systems. MMT has obtained industrial importance due to its adsorption property and also finds use in wastewater treatment. Other than this, MMT also finds applications in cosmetic industry, food industry, and paper industry. Considering the wide applicability of MMT, it is need of an hour to explore the MMT for further commercial exploitation.</div></div><div><div>L’argile montmorillonite (MMT) est composée de silicate naturellement stratifié. Les argiles étaient plus populaires dans le domaine pharmaceutique et dans d’autres domaines en raison de leurs propriétés physicochimiques bénéfiques, à savoir la non-toxicité, la grande surface spécifique, la capacité d’adsorption efficace, la capacité de gonflement élevée, la dispersibilité élevée, le comportement thixotrope et la capacité d’échange de cations. L’argile chimiquement modifiée offre des opportunités importantes dans une variété d’applications. La MMT trouve une place très cruciale dans le domaine pharmaceutique en raison de ses propriétés médicinales, qui peuvent être utilisées pour retarder la libération de médicaments dans des conditions physiologiques chroniques et la libération ciblée de médicaments également. Il est également utilisé pour améliorer le taux de dissolution de certaines molécules de médicaments, ce qui a accru l’attention des chercheurs pour explorer la MMT pour les applications d’administration de médicaments. L’argile MMT a été utilisée comme auxiliaire pharmaceutique, à savoir agent de suspension, lubrifiant, agent anti-agglomérant, diluant, émulsifiant, matériau formant des nanocomposites et parfois comme charge. L’argile MMT a été étudiée dans la fabrication de différentes formulations pharmaceutiques, à savoir les hydrogels, les films, les nanocomposites et les systèmes à base de matrice. Le MMT a ac","PeriodicalId":8332,"journal":{"name":"Annales pharmaceutiques francaises","volume":"83 4","pages":"Pages 588-604"},"PeriodicalIF":1.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacological interactions between antihypertensive regimens and drugs prescribed in the emergency department.","authors":"Luque Esparza Lilia Edith, Marco Antonio Osorio García, Dealmy Delgadillo Guzmán, Irais Castillo Maldonado, Citlalli Esmeralda Corvera Aispuro","doi":"10.1016/j.pharma.2025.05.006","DOIUrl":"10.1016/j.pharma.2025.05.006","url":null,"abstract":"<p><p>The risk of drug interactions in patients with HTN is aggravated when prescribing treatments for additional acute pathologies. This can favor adverse reactions to medications or make it difficult to control blood pressure during their stay in the emergency room.</p><p><strong>Objective: </strong>Identify and classify, using CDSS, the IFFs between the antihypertensive treatment regimen and the drugs prescribed in the emergency department.</p><p><strong>Material and methods: </strong>Fifty-three patients with systemic arterial hypertension were treated in the emergency department. Clinical decision support systems are used to identify and classify potential FFs.</p><p><strong>Results: </strong>IFFs were found in 96.2% of hypertensive patients in the emergency department. Those with the highest frequency were of moderate risk. The most frequent mechanism was pharmacodynamic, mainly synergistic by ad-dition.</p><p><strong>Conclusions: </strong>The correlation index between the number of drugs prescribed in the emer-gency room and the presence of IFF shows the need to carry out a scrutiny of the joint pharmaco-logical behavior used in hypertensive patients who attend emergency medical care to rationalize the use of medications reducing the probability of presenting IFF.</p>","PeriodicalId":8332,"journal":{"name":"Annales pharmaceutiques francaises","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[PEDIAB'AIDE: A pediatric diabetes training tool for the pharmacy team].","authors":"Elise Conand, Sabine Baron, Sonia Prot-Labarthe","doi":"10.1016/j.pharma.2025.05.008","DOIUrl":"10.1016/j.pharma.2025.05.008","url":null,"abstract":"<p><strong>Introduction: </strong>In 2023, type 1 diabetes (T1DM) affected more than 31,000 young people under the age of 20 in France, with the number of new cases rising every year. The onset of the disease is acute and abrupt in children, sometimes leading to diagnosis after ketoacidosis and a stay in a pediatric intensive care unit. Healthcare professionals must be trained to diagnose the disease as soon as the first signs appear. What's more, once the diagnosis has been made, a great deal of information needs to be assimilated by the child and his or her parents, to help them cope with the disease. As the dispensing pharmacist is at the heart of the patient's health, it is vital that his or her knowledge is regularly updated.</p><p><strong>Materials and methods: </strong>The working group consisted of a pharmacy student, a hospital pharmacist and a pediatric endocrinologist. The aim was to create an e-learning program on diabetes in children, a fun learning document aimed at health students and health professionals for their continuing education. It was to contain information and best practices in line with the most common first discharge practices for newly-diagnosed diabetic children. The tool was offered to pharmacy students in order to assess the improvement in knowledge via a questionnaire before and after using it, using a Wilcoxon statistical test. They were also asked to complete a satisfaction questionnaire.</p><p><strong>Results: </strong>The tool produced is called PEDIAB'AIDE, in the form of a pdf file with links to navigate between the various slides. The tool details two prescriptions for newly-diagnosed T1DM patients: one case with a pump, the other with pen injections. The tool comprises 40 slides, diagnostic information and advice associated with the patients' discharge prescriptions. A total of 26 DFASP1 students completed the evaluation questionnaire before and after using the tool. Students' marks improved significantly, with an initial average of 13.8/20 and a final average of 16.3/20 (P<0.001). Students found the tool simple (100%), clear (100%) and appreciated its visual appeal (92%). One hundred percent appreciated its use, and 96% thought it could help train healthcare professionals. The positive elements highlighted by the students were the intuitive nature of the tool, the real-life counter situation and the explanations. They also highlighted a few areas for improvement, notably the addition of summary sheets, and access to the tool without an Internet connection.</p><p><strong>Discussion and conclusion: </strong>Delayed diagnosis of T1DM in children can have major consequences for their subsequent care. This tool helps to improve the knowledge of pharmacy students. It remains to be tested with pharmacists and disseminated further.</p>","PeriodicalId":8332,"journal":{"name":"Annales pharmaceutiques francaises","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144131827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lactate is a prognostic marker of acute liver failure in early identification of patients susceptible to liver transplantation following acute acetaminophen poisoning.","authors":"Masoumeh Ebrahimi Medisah, Mahdieh Sadat Badiee, Masoud Mahdavinia, Hassan Motamed, Ali Hasan Rahmani","doi":"10.1016/j.pharma.2025.05.007","DOIUrl":"10.1016/j.pharma.2025.05.007","url":null,"abstract":"<p><strong>Background: </strong>Acetaminophen (APAP) is the most commonly used analgesic and antipyretic drug, and its intentional or accidental overdose can lead to acute liver failure (ALF). Rapid prognosis and the selection of appropriate patients for transplantation in ALF are crucial. Lactate is the end product of anaerobic glycolysis and an indicator for determining the oxygen status in cells. The aim of this study was to investigate the relationship between serum lactate level and the prognosis of ALF due to acute APAP poisoning in patients referred to Razi Hospital, Ahvaz.</p><p><strong>Methods: </strong>This cross-sectional and prospective study was conducted on 34 healthy individuals (as controls) and 34 patients diagnosed with acute APAP poisoning. Serum levels of APAP, lactate, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total bilirubin (T.bil), direct bilirubin (D.bil), and gamma-glutamyl transferase (GGT) were measured in healthy individuals and patients with acute APAP poisoning within 24hours of admission. The relationship between the dose of APAP consumed, the amount of N-acetylcysteine (NAC) received, and the age and gender of the patients with lactate level was also evaluated.</p><p><strong>Results: </strong>The mean dose of APAP in the patients was 10.75g. A total of 85% of the patients received NAC. The mean volume of NAC injection was 4.4mmol/L. The number of women with APAP overdose was higher than men. Lactate level increased with increasing APAP doses. The mean serum lactate level significantly reduced after 24hours compared to the initial admission, and the levels of liver markers increased significantly after 24hours.</p><p><strong>Conclusion: </strong>In order to accept lactate as an international criterion in early identification of liver transplant candidate patients and reduce their mortality, clinical validity studies including definition and validation of clinical conditions related to lactate level and reliability tests are necessary. Therefore, early and periodic determination of serum lactate level seems to be essential as a promising biomarker for the prognosis of ALF caused by acute APAP poisoning.</p>","PeriodicalId":8332,"journal":{"name":"Annales pharmaceutiques francaises","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144131842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In pursuit of software solutions for pharmaceutical regulatory affairs: Insights and trends.","authors":"Shrushti Sharma, Dyandevi Mathure, Shreyas Dingankar, Vividha Dhapte-Pawar","doi":"10.1016/j.pharma.2025.05.005","DOIUrl":"10.1016/j.pharma.2025.05.005","url":null,"abstract":"<p><p>With rapid upsurge in technology and digital tools, the existing systems including the healthcare systems, especially the pharmaceutical sector is experiencing the revolution in the flow and management of data. Use of digital tools in pharmaceutical regulatory framework and compliance has led to development of a more harmonized system globally. This has facilitated growth in pharmaceutical sector internationally along with timely availability of healthcare facilities with assured safety and efficacy. Technological solutions have upgraded the workflow in industry with the assurance of data veracity. Clinical studies demand for a huge controlled study design and data which concerns patient safety; it includes statistical interpretations and analysis. This is mostly time dependent variable and smart use of software and tools accelerate this process. Automation of the work reduces time, efforts and also streamlines timely submissions. Advanced technologies with support of machine learning, artificial intelligence would assist industry and regulatory authorities to build transparency between the documentation and data. Many regulatory agencies have come up with regulations for validation of electronic tools and data integrity to ensure ethical use of these tools. US Federal law, 21CFR is recognized and have been widely accepted. However, most of the countries have their own regulatory agency that governs these regulations. Artificial Intelligence have come up with add-on features which would overcome the lag in the systems and simplify the operations and interpretations of various studies in pharmaceutical sector. Yet, with the advancing technologies there is need for more precise regulations to evaluate it through all parameters.</p>","PeriodicalId":8332,"journal":{"name":"Annales pharmaceutiques francaises","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risques associés à l’acquisition d’un automate de dispensation nominative : analyse après dix ans de mise en service au sein d’une pharmacie à usage intérieur","authors":"Julie Thiec,&nbsp;Delphine Malet,&nbsp;Anne Colombe,&nbsp;Anne-Laure Debruyne,&nbsp;Emmanuelle Queuille","doi":"10.1016/j.pharma.2025.05.003","DOIUrl":"10.1016/j.pharma.2025.05.003","url":null,"abstract":"<div><h3>Objectif</h3><div>Notre pharmacie à usage intérieur a fait l’acquisition d’un automate de dispensation nominative pour sécuriser le circuit du médicament. Le but de cette analyse est de sécuriser le nouveau circuit en identifiant les risques associés à la mise en place du robot.</div></div><div><h3>Méthodes</h3><div>Un groupe de travail a été créé et la méthode d’analyse des modes de défaillance, de leurs effets et de leur criticité (AMDEC) a été choisie. Cette méthode d’analyse des risques a priori permet l’identification exhaustive des modes de défaillance d’un processus et de leurs gravités, fréquences et détectabilités. Le produit de ces trois cotations détermine l’indice de criticité des modes de défaillance dont la valeur permet de hiérarchiser les risques.</div></div><div><h3>Résultats</h3><div>Le processus a été délimité de l’analyse de la prescription jusqu’à la livraison dans les unités. Six étapes et 33 sous-étapes ont été identifiées. Au total, 75 modes de défaillance ont été déterminés : 67 % peuvent entraîner une erreur médicamenteuse. Le groupe de travail a identifié puis priorisé les mesures barrières à mettre en place. Il a été décidé de se concentrer sur les modes de défaillance ayant une criticité élevée et moyenne.</div></div><div><h3>Conclusions</h3><div>Cette analyse a permis d’identifier les faiblesses du nouveau processus suite à l’installation de l’automate. Les sous-étapes identifiées comme le plus à risque sont l’analyse de prescription et les compléments manuels des piluliers. L’AMDEC est une méthode efficace et facile à mettre en place, elle permet la mise en commun des idées des différents professionnels pour être le plus exhaustif possible.</div></div><div><h3>Objectives</h3><div>Our hospital pharmaceutical department acquired an automated drug dispensive system to secure the medication management, from the dispensation to the administration process. The aim of our study was to secure the new circuit by identifying the risks associated with the implementation of the robotic system.</div></div><div><h3>Methods</h3><div>A working-group was set-up and the use of the Failure Modes, Effects and Criticality Analysis (FMECA) method was decided. FMECA is a proactive risk assessment tool that allows the identification of all potential failures. It relies on the identification of failure modes and their severity, frequency and detectability. The product of the three ratings determines the criticality of the failure mode and allows to rank the failure modes according to the criticality: from low, to intermediate and high.</div></div><div><h3>Results</h3><div>The process was delimited from drug analysis to medication delivery to the wards. Six steps and 33 sub-steps were identified. In all, 75 failure modes were identified, 67% of which could lead to a medication error. The working-group identified and prioritised corrective measures to implement. It was decided to focus on the failure modes with a high and intermediat","PeriodicalId":8332,"journal":{"name":"Annales pharmaceutiques francaises","volume":"83 5","pages":"Pages 992-1000"},"PeriodicalIF":1.1,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic anticonvulsant activity of oregano, chamomile, and lavender via intranasal administration: A dose-response modeling approach.","authors":"Samin Sheikholeslami, Marziyeh Amiri-Andebili, Amir Baghaei, Mohammad Mahdi Ahmadian-Attari","doi":"10.1016/j.pharma.2025.05.004","DOIUrl":"10.1016/j.pharma.2025.05.004","url":null,"abstract":"<p><strong>Background: </strong>This short communication presents an analytical approach to evaluate the synergistic anticonvulsant effects of an herbal combination containing hydroalcoholic extracts of Origanum vulgare (oregano), Matricaria chamomilla (chamomile), and Lavandula angustifolia (lavender).</p><p><strong>Objective: </strong>The study aimed to apply linear dose-response modeling to seizure score data to predict the expected outcomes of combination therapy and quantify synergy by comparing predicted and observed effects.</p><p><strong>Methods: </strong>The herbal extracts were obtained through maceration with 70% ethanol. The animal study was performed using 2 different doses of each herb, involving 36 rats in 6 groups. Building on previous in vivo findings, the study utilized linear dose-response modeling to analyze the effects of the combination therapy on seizure scores and to determine the synergistic performance at combination doses of 17mg/kg, 34mg/kg, and 68mg/kg.</p><p><strong>Results: </strong>The results highlighted the synergistic performance of the herbal combination, particularly at the dose of 34mg/kg, demonstrating the pharmacodynamic advantages of combination therapy and confirming the enhanced antiseizure effect of the herbal combination.</p><p><strong>Conclusions: </strong>This study confirms the synergistic anticonvulsant effects of the herbal combination and demonstrates its potential as a new supplementary treatment for seizures via a non-invasive intranasal administration method.</p>","PeriodicalId":8332,"journal":{"name":"Annales pharmaceutiques francaises","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ICH-Q3D based elemental impurities study in an oral drug product: Risk assessment according to the component approach (option 2b) confirmed by the finished product analysis (option 3)","authors":"Ayoub Hamidallah,&nbsp;Mohamed Yafout,&nbsp;Ibrahim Sbai El Otmani","doi":"10.1016/j.pharma.2025.05.002","DOIUrl":"10.1016/j.pharma.2025.05.002","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Elemental impurities (EIs) in pharmaceutical products pose potential health risks, requiring strict regulatory control. The ICH Q3D guideline outlines two approaches for assessing EIs: the component approach, which estimates impurity levels based on supplier data, and the finished product approach, which directly quantifies EIs in the final drug product. This study compares both methods to evaluate their reliability in ensuring compliance with safety limits.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;A risk assessment of EIs in an oral effervescent drug product was performed using the component approach (ICH Q3D option 2b) by compiling impurity data from raw materials and packaging components. The estimated daily exposure levels were compared to permitted daily exposure (PDE) limits. To validate these findings, ICP-MS analysis (ICH Q3D option 3) was conducted on three batches of the finished product, quantifying 24 elemental impurities following USP &lt;233&gt; guidelines.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;The component approach have indicated that all estimated EI levels were well below 30% of PDE, suggesting no need for additional controls. ICP-MS analysis of the finished product confirmed these findings, with actual EI concentrations consistently lower than those predicted by the component approach.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;Both the component and finished product approaches demonstrated compliance with ICH Q3D limits, confirming that no specific control strategy was required. While the finished product approach provides precise impurity quantification, the component approach offers a cost-efficient and predictive alternative, provided that data quality and supplier collaboration are ensured. This study underscores the importance of a risk-based assessment in elemental impurity control, balancing regulatory compliance with practical implementation in pharmaceutical manufacturing.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Contexte&lt;/h3&gt;&lt;div&gt;Les impuretés élémentaires (IE) dans les produits pharmaceutiques présentent des risques potentiels pour la santé, nécessitant un contrôle réglementaire strict. La directive ICH Q3D décrit deux approches pour évaluer les IE : l’approche par composants, qui estime les niveaux d’impuretés en fonction des données des fournisseurs, et l’approche produit fini, qui quantifie directement les IE dans le produit pharmaceutique final. Cette étude compare les deux méthodes pour évaluer leur fiabilité à garantir le respect des limites de sécurité.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Méthode&lt;/h3&gt;&lt;div&gt;Une évaluation des risques des IE dans un médicament effervescent oral a été réalisée à l’aide de l’approche par composants (ICH Q3D option 2b) en compilant les données sur les impuretés des matières premières et des composants de l’emballage. Les niveaux d’exposition journalière estimés ont été comparés aux limites d’exposition journalière autorisée (PDE). Pour valider ces résultats, une analyse ICP-MS (ICH Q3D option 3) a","PeriodicalId":8332,"journal":{"name":"Annales pharmaceutiques francaises","volume":"83 5","pages":"Pages 941-953"},"PeriodicalIF":1.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Release of chlororotetracycline hydrochloride from novel hydrogels based on crosslinked chitosan and PVA","authors":"Mohammed Amine Zitouni ,&nbsp;Mustapha Chabane ,&nbsp;Chikh Melkaoui","doi":"10.1016/j.pharma.2025.05.001","DOIUrl":"10.1016/j.pharma.2025.05.001","url":null,"abstract":"<div><div>Hydrogels based on hydrochloride polyvinyl alcohol (PVA) containing chlortetracycline and crosslinked chitosan (CS) by glutaraldehyde (GLA) were prepared by the freeze-thawing method and then characterized. The swelling properties and gel fraction of these hydrogels were studied and characterized by FTIR spectroscopy, the thermal and mechanical properties were evaluated by DSC and rheology. Controlled release of chlortetracycline hydrochloride from these hydrogels was studied by UV–Visible spectroscopy. The gel fraction decreases with increase of crosslinked chitosan concentration in hydrogel but the swelling was more important due to the relaxation of the hydrogel, and the extension of macromolecular chains in the system. The crystallinity of these hydrogels increased with increasing PVA concentration. All these hydrogels exhibited a gel character with a high crosslinking degree and possessed a network structure. The release of chlortetracycline hydrochloride from these hydrogels was occurred by fickian diffusion, faster at 37<!--> <!-->°C than at 25<!--> <!-->°C because hydrogels were more swollen at 37<!--> <!-->°C and their network densities were decreased to perfect the release of drugs from hydrogels.</div></div><div><div>Des hydrogels à base de polyalcool vinylique (PVA) et de chitosane (CS) réticulé par le glutaraldéhyde (GLA) contenant de la chlortétracycline ont été préparés par la méthode de congélation-décongélation puis caractérisés. Les propriétés de gonflement et la fraction de gel de ces hydrogels ont été étudiées et caractérisées par spectroscopie FTIR. Les propriétés thermiques et mécaniques ont été évaluées par DSC et rhéologie. La libération contrôlée de l’hydrochlorure de chlortétracycline à partir de ces hydrogels a été étudiée par spectroscopie UV–Visible. La fraction de gel diminue avec l’augmentation de la concentration en chitosane réticulé dans l’hydrogel, mais le gonflement est plus important en raison de la relaxation de l’hydrogel et de l’extension des chaînes macromoléculaires dans le système. La cristallinité de ces hydrogels a augmenté avec l’augmentation de la concentration de PVA. Tous ces hydrogels présentent un caractère de gel avec un degré de réticulation élevé et possèdent une structure de réseau. La libération de l’hydrochlorure de chlortétracycline à partir de ces hydrogels s’est produite par diffusion fickienne, plus rapide à 37<!--> <!-->°C qu’à 25<!--> <!-->°C car les hydrogels étaient plus gonflés à 37<!--> <!-->°C et leurs densités de réseau étaient réduites, facilitant ainsi la libération des médicaments à partir des hydrogels.</div></div>","PeriodicalId":8332,"journal":{"name":"Annales pharmaceutiques francaises","volume":"83 5","pages":"Pages 954-967"},"PeriodicalIF":1.1,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Theobromine as a multi-target therapeutic agent: Analgesic, anti-inflammatory, and anti-arthritic potential with network pharmacology insights.","authors":"Hafiza-Sara Afzal, Ambreen-Malik Uttra, Sumera Qasim, Abdul Malik, Aisha Mobashar","doi":"10.1016/j.pharma.2025.04.007","DOIUrl":"10.1016/j.pharma.2025.04.007","url":null,"abstract":"<p><strong>Objective: </strong>Inflammatory disorders, including rheumatoid arthritis (RA) and osteoarthritis, contribute significantly to global health burdens. Theobromine, a xanthine alkaloid present in cocoa, has pharmacological properties with potential therapeutic benefits in inflammatory conditions. Nonetheless, its analgesic and anti-inflammatory attributes remained underexplored.</p><p><strong>Materials and methods: </strong>Analgesic, anti-arthritic and anti-inflammatory efficacy of theobromine was evaluated via experimental models, alongside network pharmacology to understand its molecular mechanisms. Theobromine's effects were assessed in multiple models: acetic acid-induced writhing, tail immersion, and formalin tests to evaluate analgesia; carrageenan- and egg albumin-induced paw edema models for anti-inflammatory activity; and protein denaturation and human red blood cell (HRBC) membrane stabilization for anti-arthritic effects. Network pharmacology was utilized to identify molecular targets and pathways, including KEGG pathway enrichment analysis.</p><p><strong>Results: </strong>Theobromine exhibited significant analgesic effects, reducing writhing behavior by 42.71% at 200mg/kg, and increasing tail-flick latency. Theobromine significantly lowered pain during both early as well as late phase of formalin test. Inflammation was notably reduced in both egg albumin and carrageenan inflammatory models. Theobromine also demonstrated anti-arthritic properties, inhibiting protein denaturation and stabilizing HRBC membranes. Network pharmacology revealed key targets such as COX-2, TNF-α, and NF-kB, implicated in inflammation and immune responses.</p><p><strong>Conclusion: </strong>Theobromine exhibits significant analgesic, anti-inflammatory, and anti-arthritic effects. Network pharmacology provides insights into its molecular mechanisms, suggesting its promise as a therapeutic modality for inflammatory disorders.</p>","PeriodicalId":8332,"journal":{"name":"Annales pharmaceutiques francaises","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}