Annales pharmaceutiques francaises最新文献

{"title":"Application progress of nanomaterials in the treatment of prostate cancer","authors":"Xuewu Wu ,&nbsp;Longtu Ma ,&nbsp;Yang Zhang ,&nbsp;Shuai Liu ,&nbsp;Long Cheng ,&nbsp;Chengyu You ,&nbsp;Zhilong Dong","doi":"10.1016/j.pharma.2024.08.009","DOIUrl":"10.1016/j.pharma.2024.08.009","url":null,"abstract":"<div><div>Prostate cancer is one of the most common malignant tumors in men, which seriously threatens the survival and quality of life of patients. At present, there are serious limitations in the treatment of prostate cancer, such as drug tolerance, drug resistance and easy recurrence. Sonodynamic therapy and chemodynamic therapy are two emerging tumor treatment methods, which activate specific drugs or sonosensitizers through sound waves or chemicals to produce reactive oxygen species and kill tumor cells. Nanomaterials are a kind of nanoscale materials with many excellent physical properties such as high targeting, drug release regulation and therapeutic monitoring. Sonodynamic therapy and chemodynamic therapy combined with the application of nanomaterials can improve the therapeutic effect of prostate cancer, reduce side effects and enhance tumor immune response. This article reviews the application progress of nanomaterials in the treatment of prostate cancer, especially the mechanism, advantages and challenges of nanomaterials in sonodynamic therapy and chemodynamic therapy, which provides new ideas and prospects for research in this field.</div></div><div><div>Le cancer de la prostate est l’un des plus courants des cancers chez l’homme, qui menace sérieusement la survie et la qualité de vie des patients. Actuellement, il y a des limitations graves dans le traitement du cancer de la prostate, tels que la tolérance au médicament, la résistance au médicament et la récidive facile. La thérapie sonodynamique et la thérapie chimiodynamique sont deux méthodes émergentes de traitement des tumeurs, qui activent des médicaments spécifiques ou des sonosensibilisants par des ondes sonores ou des produits chimiques pour produire des espèces réactives de l’oxygène et tuer les cellules tumorales. Les nanomatériaux sont des matériaux à nano-échelle avec de nombreuses excellentes propriétés physiques, telles que la haute ciblage, la régulation de la libération du médicament et la surveillance thérapeutique. La thérapie sonodynamique et la chimiodynamique combinées à l’application de nanomatériaux peuvent améliorer l’effet thérapeutique du cancer de la prostate, réduire les effets secondaires et renforcer la réponse immunitaire des tumeurs. Cet article passe en revue les progrès de l’application des nanomatériaux dans le traitement du cancer de la prostate, en particulier le mécanisme, les avantages et les défis des nanomatériaux dans la thérapie sonodynamique et chimiodynamique, ce qui offre de nouvelles idées et des perspectives pour la recherche dans ce domaine.</div></div>","PeriodicalId":8332,"journal":{"name":"Annales pharmaceutiques francaises","volume":"83 1","pages":"Pages 1-12"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142071888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An investigative review for pharmaceutical analysis of angiotensin receptor blockers: Olmesartan medoxomil","authors":"Vinod Ambalal Chaure,&nbsp;Atul Arun Shirkhedkar","doi":"10.1016/j.pharma.2024.10.001","DOIUrl":"10.1016/j.pharma.2024.10.001","url":null,"abstract":"<div><div>Hypertension is often asymptomatic and can substantially elevate the risk of cardiovascular complications. Olmesartan medoxomil works by competitively blocking the angiotensin II receptors, preventing angiotensin II from constructing the blood vessels and releasing aldosterone. This discussion is focused on the critical analytical methods used to analyze olmesartan medoxomil in pharmaceutical and biological samples. A variety of analytical methods have been employed to both qualitatively and quantitatively determine the analyte, including high-performance thin-layer chromatography (HPTLC), high-performance liquid chromatography (HPLC), voltammetry, capillary zone electrophoresis, UV/Vis spectrophotometry, and 96-microwell assays. The review also includes official methods published in the Indian Pharmacopoeia. Based on existing literature, simple spectrophotometry and liquid chromatography are commonly used to analyze olmesartan medoxomil. These findings provide a solid foundation for future olmesartan medoxomil drug analysis research.</div></div><div><div>L’hypertension est souvent asymptomatique et peut augmenter considérablement le risque de complications cardiovasculaires. L’olmésartan médoxomil agit en bloquant de manière compétitive les récepteurs de l’angiotensine II, empêchant l’angiotensine II de construire les vaisseaux sanguins et de libérer de l’aldostérone. Cette discussion se concentre sur les méthodes analytiques critiques utilisées pour analyser l’olmésartan médoxomil dans des échantillons pharmaceutiques et biologiques. Diverses techniques analytiques telles que la chromatographie sur couche mince haute performance, la chromatographie liquide haute performance, la voltamétrie, l’électrophorèse de zone capillaire, la spectrophotométrie UV/Vis et les analyses à 96 micropuits ont été utilisées pour estimer qualitativement et quantitativement l’analyte. La revue inclut également les méthodes officielles publiées dans la Pharmacopée indienne. Sur la base de la littérature existante, une simple spectrophotométrie et une chromatographie liquide sont couramment utilisées pour analyser l’olmésartan médoxomil. Ces résultats constituent une base solide pour les futures recherches sur l’analyse des médicaments liés à l’olmésartan médoxomil.</div></div>","PeriodicalId":8332,"journal":{"name":"Annales pharmaceutiques francaises","volume":"83 1","pages":"Pages 33-44"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142456830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cranio-facial trauma diagnosis using paleo-proteotyping of a blood sample from Robespierre (1794).","authors":"Philippe Charlier, Jean Armengaud","doi":"10.1016/j.pharma.2024.12.011","DOIUrl":"10.1016/j.pharma.2024.12.011","url":null,"abstract":"<p><p>Tradition has it that the politician Robespierre, a famous tribune of the French Revolution, was lying, wounded in the face by a bullet from a firearm, on an 18th century desk, and left a trace of blood there, before being guillotined the next day (1794). This piece of furniture is now kept in the National Archives (Paris, France). A paleo-proteomic study was carried out on several brown stains on the leather of the desk, which confirmed the human blood nature of the sample, but also identified the protein signature of different cranio-facial organs. This confirms not only the historical anecdote surrounding this desk, but also the importance of contemporary ballistic lesions on the eve of Robespierre's death. This demonstrates the importance and precision of paleo-proteomics in paleopathology and for the examination and identification of the precise nature of stains and micro-traces on old samples.</p>","PeriodicalId":8332,"journal":{"name":"Annales pharmaceutiques francaises","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142880933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Development of a cost-satisfaction indicator for monitoring implantable medical devices on loan and in permanent storage].","authors":"François Franceschi, Charlotte Debanne, Valérie Archer, Lionel Tortolano","doi":"10.1016/j.pharma.2024.12.009","DOIUrl":"10.1016/j.pharma.2024.12.009","url":null,"abstract":"<p><p>The implantable medical devices (IMDs) in the operating rooms of our hospital are managed through permanent deposits. Recently, a shift in supplier practices seems to limit the opening of permanent deposits in favor of iterative loans. Their increasing number appears to complicate the flow of IMDs. The aim of this study was to estimate the costs associated with these circuits while considering the satisfaction of the key stakeholders involved. The flows of deposits and loans in the orthopedic operating room were analyzed retrospectively over the course of a year. In parallel, a prospective assessment was made of the hours dedicated to managing both permanent and temporary deposits by the preparers and operating room managers. A satisfaction survey was conducted for all stakeholders: preparers, managers, pharmacists, surgeons, nurses, and suppliers. The cost per unit of IMD managed through permanent deposit is €1.89, compared to €2.66 for loans. The overall satisfaction for deposit management is 81%, compared to 55% for the same implant managed through loans (P<0.001). Furthermore, an implant in loan proves to be 68% more expensive for the hospital when the unit cost is weighted by satisfaction (€4.84 vs. €2.33). Managing IMDs through loans is thus more costly for the hospital. This difference becomes even more pronounced when professional satisfaction is factored into all the roles involved in the IMD flows. This study focuses specifically on aspects of IMD management on the ground (renewals, labeling, expired items, and returns). No similar studies were found in literature. The reliance on loans is increasingly burdensome for stakeholders, generating stress and sometimes demotivating work due to a lack of recognition.</p>","PeriodicalId":8332,"journal":{"name":"Annales pharmaceutiques francaises","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142833813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolomic analysis of 18th-19th pipes from the kingdom of Dahomey (actual Benin) indicates smoking of caffeine-bearing plants.","authors":"Philippe Charlier, Mario Zimmermann, Anna Berim, Shannon Tushingham, David Gang, Samson Tokannou, Didier N'Dah","doi":"10.1016/j.pharma.2024.12.008","DOIUrl":"10.1016/j.pharma.2024.12.008","url":null,"abstract":"<p><p>Increasingly, molecular chemistry and pharmacology are complementing classical studies in the field of archaeology. In this case, we present the results of the chemical study of pipe residues found in the context of an archaeological mission (AROMA mission: Archaeology of the Exercise of Royal and Magico-Religious Power) in the royal palaces of Abomey (Benin), dating from the 17th-19th century. The search for many products was carried out (mainly tobacco, cannabis) but surprisingly only highlighted the presence of caffeine residues. This result is discussed and compared with field notions and in particular with ethnological surveys where coffee was consumed in the old way, smoked in a pipe (peripheral part or shell, and not the bean itself or the leaves).</p>","PeriodicalId":8332,"journal":{"name":"Annales pharmaceutiques francaises","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142833814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inter-relational dynamics of factors affecting the emergence of orphan drugs.","authors":"Rinchen Gensapa, Vivek Pandey, Saibal Kumar Saha, Samrat Kumar Mukherjee, Ajeya Jha","doi":"10.1016/j.pharma.2024.12.005","DOIUrl":"10.1016/j.pharma.2024.12.005","url":null,"abstract":"<p><p>Orphan drugs are medications that are produced for the treatment of rare diseases. As there is less number of patients, the drug manufacturing companies are not keen in producing these drugs. Due to high costs of research and development and low profitability, companies do not want to invest in manufacturing of orphan drugs. Several laws have been passed by Governments of different nations to encourage the development of orphan drugs and make it available to patients. This study explores the interrelation dynamics of factors that has resulted in the greater availability of orphan drugs in recent times. Ten factors: internet technology, legislation, online patient support groups, government subsidiary, biotechnological advancements, corporate social responsibility, awareness and diagnosis of rare diseases and exclusive budgeting by pharmaceutical industries for orphan drugs related research and development and production were taken for the study. With a sample size of 38 experts, the technique of decision-making trial and evaluation laboratory (DEMATEL) was used for the study. It was found that information technology, legislation, support groups, and budget were the causes and the factors awareness, diagnosis, medicine availability, subsidiary, CSR and biotechnology emerged to be the effect.</p>","PeriodicalId":8332,"journal":{"name":"Annales pharmaceutiques francaises","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polysaccharide-based implant drug delivery systems for precise therapy: Recent developments, and future trends.","authors":"Suraj Kumar, Rishabha Malviya, Sathvik Belagodu Sridhar, Tarun Wadhwa, Javedh Shareef, Dhanalekshmi Unnikrishnan Meenakshi","doi":"10.1016/j.pharma.2024.12.004","DOIUrl":"10.1016/j.pharma.2024.12.004","url":null,"abstract":"<p><p>Implantable drug delivery systems offer numerous benefits, including effective drug administration at lower concentrations, fewer side effects, and improved patient compliance. Various polymers are used for fabricating implants, with biopolymers, particularly polysaccharides, being notable for their ability to modulate drug delivery characteristics. The review aims to describe the strategies employed in the development of polysaccharide-based implants and provide a comprehensive understanding of various polysaccharides such as starch, cellulose, alginate, chitosan, pullulan, carrageenan, dextran, hyaluronic acid, agar, pectin, and gellan gum in the fabrication of implant for targeted therapy. The review explores the biomedical applications of polysaccharide-based implantable devices, highlighting recent advancements in the development of these systems. Detailed discussions cover implants used in the oral cavity, nasal cavity, bone, ocular applications, and antiviral therapy. Additionally, regulatory considerations concerning implantable drug delivery are emphasized. The findings of the study show that polysaccharides can be used for the development of implants for drug delivery applications.</p>","PeriodicalId":8332,"journal":{"name":"Annales pharmaceutiques francaises","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Emergence of antifungal resistance: A creeping environmental threat?]","authors":"Guillaume Decocq, Jean-Noël Colin, Anne-Lise Bienvenu","doi":"10.1016/j.pharma.2024.12.010","DOIUrl":"10.1016/j.pharma.2024.12.010","url":null,"abstract":"<p><p>Antifungal resistance in humans is a clinical reality of increasing incidence that raises problems for patient care. In this current event, we discuss the link that can be made between the presence of antifungals in the environment and the development of resistance in humans, as well as the ecotoxicology of antifungals. The presence of antifungals in the environment has a health, but also an ecological impact. A \"One Health\" approach will help to address this environmental health challenge.</p>","PeriodicalId":8332,"journal":{"name":"Annales pharmaceutiques francaises","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amorolfine hydrochloride loaded solid lipid nanoparticles: Preparation, characterization and ex vivo nail permeation study to treat onychomycosis.","authors":"Tasleem Ahmed, Nithya Shanthi, Arun Kumar Mahato","doi":"10.1016/j.pharma.2024.12.002","DOIUrl":"10.1016/j.pharma.2024.12.002","url":null,"abstract":"<p><p>Onychomycosis is a disease of the nail plate caused by fungi, leading to the progressive defacing of the nail. The infection requires a longer period of treatment orally and topically. The treatment with the topical route is difficult due to the low availability of drugs across the infected nail. This failure in topical treatment is the drawback of the conventional drug delivery system (DDS), particularly drug penetration issues across the nail plate. The solid lipid nanoparticle (SLN) approach was used to overcome such issues. The drug amorolfine hydrochloride (AOF) was incorporated into SLN by using the micro-emulsion cold dilution method. Monostrearin and stearic acid were used as solid lipids in the formulation of drug-loaded SLNs. The nanoparticle formulation was optimized by varying the type of solid lipids and bile salts. Sodium taurocholate (STC) and sodium tauroglycholate (STG) are the bile salts used as biosurfactants in the formulation. The SLNs prepared with stearic acid and STG demonstrated higher drug encapsulation efficiency (71.73%) and drug loading efficiency (13.03%) than monostearin. Bile salts have affected the particle size range and STG was found to produce smaller size particles with stearic acid (406nm) than STC. Process parameter homogenization speed was also optimized and 403 relative centrifugal force (RCF) was optimal to produce smaller-size particles (406nm). The drug permeation through the nail plate and anti-fungal studies were also performed for AOF-SLNs loaded cream and marketed cream (Amfocin). The SLNs have improved the permeation (1.63-fold) and anti-fungal activity (2.50-fold) of AOF. Transmission electron microscopy (TEM) images revealed a spherical shape of SLNs with no aggregation. The physical stability was performed and SLNs have higher stability at refrigeration storage. The SLNs were incorporated in cream for the final application for onychomycosis. The analytical method of high-performance liquid chromatography (HPLC) was used for the quantification of AOF in the formulations.</p>","PeriodicalId":8332,"journal":{"name":"Annales pharmaceutiques francaises","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Handling and decontamination of live medications: What challenges for hospital pharmacies in France?","authors":"Adélie Riazi, Élodie Allouis, Céline Sakr, Muriel Paul, Morgane Renault-Mahieux, Muriel Carvalho","doi":"10.1016/j.pharma.2024.12.003","DOIUrl":"10.1016/j.pharma.2024.12.003","url":null,"abstract":"<p><strong>Objectives: </strong>To review the literature and national practices concerning the handling and decontamination of live medications, in order to revise our local practices.</p><p><strong>Methods: </strong>Literature searches and questionnaire sent to establishments handling live medications on several themes, including: preparation activity, circuits, preparation equipment, decontamination techniques and agents, personal protective equipment, viruses and genetically modified organisms.</p><p><strong>Results: </strong>Twenty establishments responded to the questionnaire (response rate: 66%) with 16 responses usable. The main live medications handled were viral vector (n=16) or cell-based gene therapies (n=14). The majority of respondents handled at least three types of live medication. The most popular and the most used preparation equipment was the biosafety cabinet (13/16). Handling was carried out in 9/16 establishments on a single piece of equipment, and in 7/16 on several. All the establishments decontaminated between two preparations of different types of live medication, and 15/16 between two preparations of the same type. None used ultraviolet decontamination. Although recommended in the literature, only five respondents distinguished between naked and enveloped viruses for decontamination. Seven out of 16 establishments had specific decontamination procedures for genetically modified organisms. There were few or no guidelines from French competent authorities or learned societies.</p><p><strong>Conclusions: </strong>The diversification of live medications is not accompanied by guidelines or scientific publications, which makes risk assessment difficult for hospital pharmacists. Nevertheless, this work has enabled us to take stock of current practices and revise our protocols, even if the decisions we take are still based on free will.</p>","PeriodicalId":8332,"journal":{"name":"Annales pharmaceutiques francaises","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}