{"title":"Cranio-facial trauma diagnosis using paleo-proteotyping of a blood sample from Robespierre (1794)","authors":"Philippe Charlier , Jean Armengaud","doi":"10.1016/j.pharma.2024.12.011","DOIUrl":null,"url":null,"abstract":"<div><div>Tradition has it that the politician Robespierre, a famous tribune of the French Revolution, was lying, wounded in the face by a bullet from a firearm, on an 18th century desk, and left a trace of blood there, before being guillotined the next day (1794). This piece of furniture is now kept in the National Archives (Paris, France). A paleo-proteomic study was carried out on several brown stains on the leather of the desk, which confirmed the human blood nature of the sample, but also identified the protein signature of different cranio-facial organs. This confirms not only the historical anecdote surrounding this desk, but also the importance of contemporary ballistic lesions on the eve of Robespierre's death. This demonstrates the importance and precision of paleo-proteomics in paleopathology and for the examination and identification of the precise nature of stains and micro-traces on old samples.</div></div><div><div>La tradition rapporte que le politicien Robespierre, célèbre tribun de la Révolution française, aurait été allongé, blessé au visage par un projectile à balle d’arme à feu, sur un bureau du 18<sup>e</sup> siècle, et y aurait laissé une trace de sang, avant d’être guillotiné le lendemain (1794). Ce meuble est désormais conservé aux Archives nationales (Paris, France). Une étude en paléo-protéomique a été réalisée sur plusieurs taches brunes sur le cuir du bureau, qui a permis de confirmer la nature sanguine humaine de l’échantillon, mais aussi d’identifier la signature protéique de différents organes crânio-faciaux. Ainsi est confirmée non seulement l’anecdote historique autour de ce bureau, mais aussi l’importance des lésions balistiques contemporaines de la veille de la mort de Robespierre. Ainsi sont démontrés l’importance et la précision de la paléo-protéomique en paléo-pathologie et pour l’examen et l’identification de la nature précise de taches et micro-traces sur échantillons anciens.</div></div>","PeriodicalId":8332,"journal":{"name":"Annales pharmaceutiques francaises","volume":"83 3","pages":"Pages 445-448"},"PeriodicalIF":1.0000,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annales pharmaceutiques francaises","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0003450924001998","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
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Abstract
Tradition has it that the politician Robespierre, a famous tribune of the French Revolution, was lying, wounded in the face by a bullet from a firearm, on an 18th century desk, and left a trace of blood there, before being guillotined the next day (1794). This piece of furniture is now kept in the National Archives (Paris, France). A paleo-proteomic study was carried out on several brown stains on the leather of the desk, which confirmed the human blood nature of the sample, but also identified the protein signature of different cranio-facial organs. This confirms not only the historical anecdote surrounding this desk, but also the importance of contemporary ballistic lesions on the eve of Robespierre's death. This demonstrates the importance and precision of paleo-proteomics in paleopathology and for the examination and identification of the precise nature of stains and micro-traces on old samples.
La tradition rapporte que le politicien Robespierre, célèbre tribun de la Révolution française, aurait été allongé, blessé au visage par un projectile à balle d’arme à feu, sur un bureau du 18e siècle, et y aurait laissé une trace de sang, avant d’être guillotiné le lendemain (1794). Ce meuble est désormais conservé aux Archives nationales (Paris, France). Une étude en paléo-protéomique a été réalisée sur plusieurs taches brunes sur le cuir du bureau, qui a permis de confirmer la nature sanguine humaine de l’échantillon, mais aussi d’identifier la signature protéique de différents organes crânio-faciaux. Ainsi est confirmée non seulement l’anecdote historique autour de ce bureau, mais aussi l’importance des lésions balistiques contemporaines de la veille de la mort de Robespierre. Ainsi sont démontrés l’importance et la précision de la paléo-protéomique en paléo-pathologie et pour l’examen et l’identification de la nature précise de taches et micro-traces sur échantillons anciens.
期刊介绍:
This journal proposes a scientific information validated and indexed to be informed about the last research works in all the domains interesting the pharmacy. The original works, general reviews, the focusing, the brief notes, subjected by the best academics and the professionals, propose a synthetic approach of the last progress accomplished in the concerned sectors. The thematic Sessions and the – life of the Academy – resume the communications which, presented in front of the national Academy of pharmacy, are in the heart of the current events.