Design of in-situ implant for the brain-targeted drug delivery using cross-linked gellan gum polymer through response surface methodology.

IF 1 Q4 PHARMACOLOGY & PHARMACY

Annales pharmaceutiques francaises Pub Date : 2024-10-16 DOI:10.1016/j.pharma.2024.10.004

Imran Kazmi, Hemant K S Yadav, Fahad A Al-Abbasi, Muhammad Afzal, Muhammad Shahid Nadeem, Hisham N Altayb, Abhay Raizaday, Md Sadique Hussain, Haider Ali, Faisal Imam, Gaurav Gupta

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Abstract

The analysis aimed to prepare an in-situ implant (ISFI) formulation holding dimethyl fumarate as (a model drug) using cross-linked gellan gum by homogenization method. Cross-linking of gellan gum was done with L-cysteine to improve its gelation properties. Fourier transform infrared spectroscopy (FTIR) and (DSC) Differential scanning calorimetry were used to test the compatibility of the drug-polymer. The diverse formulations were prepared and tested using Design Expert® ver 8.0.1 software to optimize the experiment technique and employ the response surface. The tissue compatibility of the test verified the existence of non-irritants in the established formulation. All preparations contained the drug content from approximately 97.98 to 99.88%. Viscosities are ideal for injection in the optimized formulation (1,55 percent w/w in water). The optimized formula was monitored, and up to 156hours, it was found to be 95.7%. The result was that ISFI can effectively monitor and control the delivery of several powerful drug products.

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通过响应面方法学设计使用交联结冷胶聚合物的脑靶向药物原位植入物。

该分析旨在利用均质化方法，使用交联结冷胶制备一种以富马酸二甲酯为模型药物的原位植入（ISFI）制剂。用 L-半胱氨酸对结冷胶进行交联，以改善其凝胶特性。傅立叶变换红外光谱法（FTIR）和差示扫描量热法（DSC）用于测试药物与聚合物的相容性。使用 Design Expert® ver 8.0.1 软件制备和测试了各种配方，以优化实验技术并采用响应面。组织相容性测试验证了既定配方中无刺激性物质的存在。所有制剂的药物含量约为 97.98 % 至 99.88 %。优化配方的粘度（在水中的重量比为 1.55%）非常适合注射。对优化配方进行了监测，结果表明，在 156 小时内，其药物含量为 95.7%。结果表明，ISFI 可以有效监测和控制几种强效药物的输送。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annales pharmaceutiques francaises PHARMACOLOGY & PHARMACY-

CiteScore

1.70

自引率

7.70%

发文量

期刊介绍： This journal proposes a scientific information validated and indexed to be informed about the last research works in all the domains interesting the pharmacy. The original works, general reviews, the focusing, the brief notes, subjected by the best academics and the professionals, propose a synthetic approach of the last progress accomplished in the concerned sectors. The thematic Sessions and the – life of the Academy – resume the communications which, presented in front of the national Academy of pharmacy, are in the heart of the current events.