Topics in Current Chemistry最新文献_第3页

Recent Focuses in the Syntheses and Applications of Magnetic Metal–Organic Frameworks 磁性金属有机框架的合成与应用的最新焦点。

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2024-10-06 DOI: 10.1007/s41061-024-00475-8

Yosra Mostafapour Kandelous, Mohammad Nikpassand, Leila Zare Fekri

引用次数: 0

A Review on Recent Development of Phenothiazine-Based Chromogenic and Fluorogenic Sensors for the Detection of Cations, Anions, and Neutral Analytes 用于检测阳离子、阴离子和中性分析物的吩噻嗪基生色和生氟传感器的最新发展综述。

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2024-09-05 DOI: 10.1007/s41061-024-00474-9

Mohan Ilakiyalakshmi, Kumudhavalli Dhanasekaran, Ayyakannu Arumugam Napoleon

{"title":"A Review on Recent Development of Phenothiazine-Based Chromogenic and Fluorogenic Sensors for the Detection of Cations, Anions, and Neutral Analytes","authors":"Mohan Ilakiyalakshmi, Kumudhavalli Dhanasekaran, Ayyakannu Arumugam Napoleon","doi":"10.1007/s41061-024-00474-9","DOIUrl":"10.1007/s41061-024-00474-9","url":null,"abstract":"<div><p>This review provides an in-depth examination of recent progress in the development of chemosensors, with a particular emphasis on colorimetric and fluorescent probes. It systematically explores various sensing mechanisms, including metal-to-ligand charge transfer (MLCT), ligand-to-metal charge transfer (LMCT), photoinduced electron transfer (PET), intramolecular charge transfer (ICT), and fluorescence resonance energy transfer (FRET), and elucidates the mechanism of action for cation and anion chemosensors. Special attention is given to phenothiazine-based fluorescence probes, highlighting their exceptional sensitivity and rapid detection abilities for a broad spectrum of analytes, including cations, anions, and small molecules. Phenothiazine chemosensors have emerged as versatile tools widely employed in a multitude of applications, spanning environmental and biomedical fields. Furthermore, it addresses existing challenges and offers insights into future research directions, aiming to facilitate the continued advancement of phenothiazine-based fluorescent probes.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"382 3","pages":""},"PeriodicalIF":8.6,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142141670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging Nanomaterials as Versatile Nanozymes: A New Dimension in Biomedical Research 作为多功能纳米酶的新兴纳米材料：生物医学研究的新维度。

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2024-08-14 DOI: 10.1007/s41061-024-00473-w

Evin Jacob, Denno Mathew, Libina Benny, Anitha Varghese

{"title":"Emerging Nanomaterials as Versatile Nanozymes: A New Dimension in Biomedical Research","authors":"Evin Jacob, Denno Mathew, Libina Benny, Anitha Varghese","doi":"10.1007/s41061-024-00473-w","DOIUrl":"10.1007/s41061-024-00473-w","url":null,"abstract":"<div><p>The enzyme-mimicking nature of versatile nanomaterials proposes a new class of materials categorized as nano-enzymes, ornanozymes. They are artificial enzymes fabricated by functionalizing nanomaterials to generate active sites that can mimic enzyme-like functions. Materials extend from metals and oxides to inorganic nanoparticles possessing intrinsic enzyme-like properties. High cost, low stability, difficulty in separation, reusability, and storage issues of natural enzymes can be well addressed by nanozymes. Since 2007, more than 100 nanozymes have been reported that mimic enzymes like peroxidase, oxidase, catalase, protease, nuclease, hydrolase, superoxide dismutase, etc. In addition, several nanozymes can also exhibit multi-enzyme properties. Vast applications have been reported by exploiting the chemical, optical, and physiochemical properties offered by nanozymes. This review focuses on the reported nanozymes fabricated from a variety of materials along with their enzyme-mimicking activity involving tuning of materials such as metal nanoparticles (NPs), metal-oxide NPs, metal–organic framework (MOF), covalent organic framework (COF), and carbon-based NPs. Furthermore, diverse applications of nanozymes in biomedical research are discussed in detail.</p></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"382 3","pages":""},"PeriodicalIF":8.6,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141977223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Hamilton Receptor in Supramolecular Polymer Sciences 超分子聚合物科学中的汉密尔顿受体。

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2024-07-20 DOI: 10.1007/s41061-024-00471-y

Shafieq Ahmad Wagay, Rashid Ali

{"title":"The Hamilton Receptor in Supramolecular Polymer Sciences","authors":"Shafieq Ahmad Wagay, Rashid Ali","doi":"10.1007/s41061-024-00471-y","DOIUrl":"10.1007/s41061-024-00471-y","url":null,"abstract":"<div><p>Supramolecular polymers are polymeric materials of monomeric fragments, held jointly by reversible and directional non-covalent interactions such as multiple hydrogen-bonding, charge transfer effects, host–guest interactions, metal coordination, and aromatic stacking. This review article on the Hamilton-based supramolecular polymers aims to shed light on the molecular recognition achievements by the Hamilton-based polymeric systems, evaluate Hamilton receptor’s future prospects, and capitalize its potential applications in supramolecular chemistry. To the best of our knowledge, this is the first elaborative and sole manuscript in which polymeric Hamilton receptors are being exposed in detail. The first portion of this manuscript is related to the importance and urgency of polymers along with the historic background of Hamilton receptors. The middle section discloses the potential applications of Hamilton-type receptors in various fields, e.g., dendrimers, mechanically polymeric rotaxanes, and self-assemblies. The final section of the manuscript discloses the future aspects and the importance of novel polymer-based Hamilton-type receptors in the modern era. We believe that this first review in this emerging yet immature field will be useful to inspire scientists around the world to find the unseen future prospects, thereby boosting the field related to this valued artificial receptor in the province of supramolecular chemistry and also in other domains of scientific fields and technology, as well.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"382 3","pages":""},"PeriodicalIF":8.6,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141735666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Review on Synthesis of 2-(2-Hydroxyaryl) Benzothiazoles (HBT) for Excited-State Intra-molecular Proton Transfer (ESIPT)-Based Detection of Ions and Biomolecules 基于激发态分子内质子转移 (ESIPT) 的离子和生物大分子检测的 2-(2-羟基芳基) 苯并噻唑 (HBT) 的合成综述。

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2024-07-18 DOI: 10.1007/s41061-024-00472-x

Amandeep Kaur, R. P. Chaudhary

{"title":"Review on Synthesis of 2-(2-Hydroxyaryl) Benzothiazoles (HBT) for Excited-State Intra-molecular Proton Transfer (ESIPT)-Based Detection of Ions and Biomolecules","authors":"Amandeep Kaur, R. P. Chaudhary","doi":"10.1007/s41061-024-00472-x","DOIUrl":"10.1007/s41061-024-00472-x","url":null,"abstract":"<div><p>In this review, we present a systematic and comprehensive summary of the recent developments in the synthetic strategies of 2-(2-hydroxyarylsubstituted)-benzothiazole (HBT) framework along with incorporation of various substituents on phenolic and benzothiazole rings which affect the emission process. The literature, spanning the years 2015–2024, on excited-state intramolecular proton transfer (ESIPT)-based studies of HBT derivatives comprising the effects of solvent polarity, substituents, and extended conjugation on fluorophores has been searched. ESIPT, intramolecular charge transfer, and aggregation-induced emissions enable these fluorescent probes to specifically interact with analytes, thereby altering their luminescence characteristics to achieve analyte detection. These fluorescent probes exhibit large Stokes shifts, high quantum yields, and excellent color transitions. Finally, the applications of HBTs as ESIPT-based fluorescent probes for the detection of cations, anions, and biomolecules have been summarized. We anticipate that this review will provide a comprehensive overview of the current state of research in this field and encourage researchers to develop novel ESIPT-based fluorophores with new applications.</p></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"382 3","pages":""},"PeriodicalIF":8.6,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141632304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in Black Phosphorus Quantum Dots for Cancer Research: Synthesis, Characterization, and Applications 用于癌症研究的黑磷量子点的进展：合成、表征和应用》。

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2024-07-15 DOI: 10.1007/s41061-024-00470-z

Elham Einafshar, Ahmad Ghorbani

{"title":"Advances in Black Phosphorus Quantum Dots for Cancer Research: Synthesis, Characterization, and Applications","authors":"Elham Einafshar, Ahmad Ghorbani","doi":"10.1007/s41061-024-00470-z","DOIUrl":"10.1007/s41061-024-00470-z","url":null,"abstract":"<div><p>In the past few years, there has been notable advancement in nanotechnology, leading to the development of new materials with potential uses in the medical field, especially in cancer diagnosis, imaging, and therapy. Black phosphorus quantum dots (BPQDs) are one of the emerging nanomaterials that have generated interest due to their unique properties and potential in biomedical applications. This review aims to give a detailed overview of how BPQDs are synthesized, characterized, and utilized. The synthesis methods of BPQDs are discussed, with a focus on obtaining size-controlled and high-quality BPQDs. Two main approaches, top-down exfoliation and bottom-up techniques, are described. Despite advancements in synthesis, there are challenges hindering the practical application of BPQDs, such as poor dispersion and short durability. To address these issues, techniques to enhance biocompatibility and reduce potential toxicity, such as surface modifications, are discussed. BPQDs have potential in bioimaging as they offer higher resolution and sensitivity compared with traditional imaging agents. Their small size and expansive surface area make them suitable for drug delivery systems, enabling the effective incorporation of therapeutic substances. By functionalizing BPQDs with targeting ligands, they can selectively bind to cancer cells or tissue, making them ideal for targeted therapies. Moreover, BPQDs can serve as biosensors to detect biomarkers in bodily fluids, further expanding their biomedical applications. However, before they can be successfully translated into clinical settings, further research is needed to optimize the synthesis methods of BPQDs and evaluate their long-term safety profiles. Nonetheless, with ongoing research and development, the medical uses of BPQDs are expected to expand.</p><h3>Graphic Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"382 3","pages":""},"PeriodicalIF":8.6,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141621781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mutually Orthogonal Bioorthogonal Reactions: Selective Chemistries for Labeling Multiple Biomolecules Simultaneously 相互正交的生物正交反应：同时标记多种生物分子的选择性化学。

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2024-07-06 DOI: 10.1007/s41061-024-00467-8

Kevin R. Venrooij, Lucienne de Bondt, Kimberly M. Bonger

引用次数: 0

The State-of-the-Art Overview to Application of Deep Learning in Accurate Protein Design and Structure Prediction 深度学习在精确蛋白质设计和结构预测中的应用现状概述。

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2024-07-04 DOI: 10.1007/s41061-024-00469-6

Saber Saharkhiz, Mehrnaz Mostafavi, Amin Birashk, Shiva Karimian, Shayan Khalilollah, Sohrab Jaferian, Yalda Yazdani, Iraj Alipourfard, Yun Suk Huh, Marzieh Ramezani Farani, Reza Akhavan-Sigari

{"title":"The State-of-the-Art Overview to Application of Deep Learning in Accurate Protein Design and Structure Prediction","authors":"Saber Saharkhiz, Mehrnaz Mostafavi, Amin Birashk, Shiva Karimian, Shayan Khalilollah, Sohrab Jaferian, Yalda Yazdani, Iraj Alipourfard, Yun Suk Huh, Marzieh Ramezani Farani, Reza Akhavan-Sigari","doi":"10.1007/s41061-024-00469-6","DOIUrl":"10.1007/s41061-024-00469-6","url":null,"abstract":"<div><p>In recent years, there has been a notable increase in the scientific community's interest in rational protein design. The prospect of designing an amino acid sequence that can reliably fold into a desired three-dimensional structure and exhibit the intended function is captivating. However, a major challenge in this endeavor lies in accurately predicting the resulting protein structure. The exponential growth of protein databases has fueled the advancement of the field, while newly developed algorithms have pushed the boundaries of what was previously achievable in structure prediction. In particular, using deep learning methods instead of brute force approaches has emerged as a faster and more accurate strategy. These deep-learning techniques leverage the vast amount of data available in protein databases to extract meaningful patterns and predict protein structures with improved precision. In this article, we explore the recent developments in the field of protein structure prediction. We delve into the newly developed methods that leverage deep learning approaches, highlighting their significance and potential for advancing our understanding of protein design.</p></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"382 3","pages":""},"PeriodicalIF":8.6,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11224075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141535958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Significance of Chalcone Scaffolds in Medicinal Chemistry Chalcone 支架在药物化学中的意义。

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2024-06-27 DOI: 10.1007/s41061-024-00468-7

Rishav Mazumder, Ichudaule, Ashmita Ghosh, Subrata Deb, Rajat Ghosh

{"title":"Significance of Chalcone Scaffolds in Medicinal Chemistry","authors":"Rishav Mazumder,  Ichudaule, Ashmita Ghosh, Subrata Deb, Rajat Ghosh","doi":"10.1007/s41061-024-00468-7","DOIUrl":"10.1007/s41061-024-00468-7","url":null,"abstract":"<div><p>Chalcone is a simple naturally occurring <i>α,β</i>-unsaturated ketone with biological importance, which can also be easily synthesized in laboratories by reaction between two aromatic scaffolds. In plants, chalcones occur as polyphenolic compounds of different frameworks which are bioactive molecules that have been in traditional medicinal practice for many years. Chalcone-based lead molecules have been developed, possessing varied potentials such as antimicrobial, antiviral, anti-inflammatory, anticancer, anti-oxidant, antidiabetic, antihyperurecemic, and anti-ulcer effects. Chalcones contribute considerable fragments to give important heterocyclic molecules with therapeutic utilities targeting various diseases. These characteristic features have made chalcone a topic of interest among researchers and have attracted investigations into this widely applicable structure. This review highlights the extensive exploration carried out on the synthesis, biotransformations, chemical reactions, hybridization, and pharmacological potentials of chalcones, and aims to provide an extensive, thorough, and critical review of their importance, with emphasis on their properties, chemistry, and biomedical applications to boost future investigations into this potential scaffold in medicinal chemistry.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div><div><p>This review highlights chalcones derived from natural sources, their synthetic approaches, biotransformation,\u0000chemical reactions undergone, pharmacological potentials, and their significance in drug discovery and drug\u0000design.</p></div></div></figure></div></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"382 3","pages":""},"PeriodicalIF":8.6,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141465342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unraveling the Mechanisms of Cannabidiol’s Pharmacological Actions: A Comprehensive Research Overview 揭示大麻二酚的药理作用机制：研究综述

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2024-06-03 DOI: 10.1007/s41061-024-00465-w

Iqra Kalsoom, Kiran Shehzadi, Han-sheng Li, Hong-liang Wen, Ming-jia Yu

{"title":"Unraveling the Mechanisms of Cannabidiol’s Pharmacological Actions: A Comprehensive Research Overview","authors":"Iqra Kalsoom, Kiran Shehzadi, Han-sheng Li, Hong-liang Wen, Ming-jia Yu","doi":"10.1007/s41061-024-00465-w","DOIUrl":"10.1007/s41061-024-00465-w","url":null,"abstract":"<div><p>Cannabis sativa has long been used for neurological and psychological healing. Recently, cannabidiol (CBD) extracted from cannabis sativa has gained prominence in the medical field due to its non-psychotropic therapeutic effects on the central and peripheral nervous systems. CBD, also acting as a potent antioxidant, displays diverse clinical properties such as anticancer, antiinflammatory, antidepressant, antioxidant, antiemetic, anxiolytic, antiepileptic, and antipsychotic effects. In this review, we summarized the structural activity relationship of CBD with different receptors by both experimental and computational techniques and investigated the mechanism of interaction between related receptors and CBD. The discovery of structural activity relationship between CBD and target receptors would provide a direction to optimize the scaffold of CBD and its derivatives, which would give potential medical applications on CBD-based therapies in various illnesses.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"382 2","pages":""},"PeriodicalIF":8.6,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141201335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0