Topics in Current Chemistry最新文献

{"title":"Toward Realization of Bioorthogonal Chemistry in the Clinic","authors":"Kim E. de Roode,&nbsp;Raffaella Rossin,&nbsp;Marc S. Robillard","doi":"10.1007/s41061-025-00495-y","DOIUrl":"10.1007/s41061-025-00495-y","url":null,"abstract":"<div><p>In the last decade, the use of bioorthogonal chemistry toward medical applications has increased tremendously. Besides being useful for the production of pharmaceuticals, the efficient, nontoxic reactions open possibilities for the development of therapies that rely on in vivo chemistry between two bioorthogonal components. Here we discuss the latest developments in bioorthogonal chemistry, with a focus on their use in living organisms, the translation from model systems to humans, and the challenges encountered during preclinical development. We aim to provide the reader a broad presentation of the current state of the art and demonstrate the numerous possibilities that bioorthogonal reactions have for clinical use, now and in the near future.</p></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"383 2","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s41061-025-00495-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143554060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CO2 Fixation into Useful Aromatic Carboxylic Acids via C (sp2)–X Bonds Functionalization","authors":"Youwen Chen,&nbsp;Meihua Chen,&nbsp;Xinyu Li,&nbsp;Xinhua Xu,&nbsp;Shuang-Feng Yin,&nbsp;Renhua Qiu","doi":"10.1007/s41061-025-00496-x","DOIUrl":"10.1007/s41061-025-00496-x","url":null,"abstract":"<div><p>Carbon dioxide (CO₂) is an abundant and readily available carbon source. Its transformation into high-added-value chemicals is a beneficial strategy, which mitigates greenhouse gas emissions and provides new raw material sources for the chemical industry. Among these chemicals, the aromatic carboxylic acids and derivatives have broad applications in medicine, pesticides, and materials science. Therefore, the carboxylation of C(sp²)-X (X = metal, halide, H, O, or S) bonds with CO₂ to efficiently construct aromatic carboxylic acids and their derivatives is a synthetic strategy of significance. This review highlights the recent progress in constructing carboxylic acids and derivatives through the carboxylation of C(sp²)-X bonds with CO₂ including literature published from 2000 to December 2024.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"383 1","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143529917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Fundamentals to Synthesis: Covalent Organic Frameworks as Promising Materials for CO2 Adsorption","authors":"Awais Ali Aslam,&nbsp;Sania Amjad,&nbsp;Adnan Irshad,&nbsp;Osama Kokab,&nbsp;Mudassar Sana Ullah,&nbsp;Awais Farid,&nbsp;Rana Adeel Mehmood,&nbsp;Sadaf Ul Hassan,&nbsp;Muhammad Shahid Nazir,&nbsp;Mahmood Ahmed","doi":"10.1007/s41061-025-00494-z","DOIUrl":"10.1007/s41061-025-00494-z","url":null,"abstract":"<div><p>Covalent organic frameworks (COFs) are highly crystalline polymers that possess exceptional porosity and surface area, making them a subject of significant research interest. COF materials are synthesized by chemically linking organic molecules in a repetitive arrangement, creating a highly effective porous crystalline structure that adsorbs and retains gases. They are highly effective in removing impurities, such as CO₂, because of their desirable characteristics, such as durability, high reactivity, stable porosity, and increased surface area. This study offers a background overview, encompassing a concise discussion of the current issue of excessive carbon emissions, and a synopsis of the materials most frequently used for CO₂ collection. This review provides a detailed overview of COF materials, particularly emphasizing their synthesis methods and applications in carbon capture. It presents the latest research findings on COFs synthesized using various covalent bond formation techniques. Moreover, it discusses emerging trends and future prospects in this particular field.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"383 1","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143471936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the Electrochemical MOF Sensors in Detecting Cancer with Special Emphasis on Breast Carcinoma Biomarkers","authors":"Brij Mohan,&nbsp;Krunal Modi,&nbsp;Gurjaspreet Singh,&nbsp;Anup Paul,&nbsp;Ismayil M. Garazade,&nbsp;Armando J. L. Pombeiro,&nbsp;Xuefeng Liu,&nbsp;Wei Sun,&nbsp;Sang Sub Kim","doi":"10.1007/s41061-025-00493-0","DOIUrl":"10.1007/s41061-025-00493-0","url":null,"abstract":"<div><p>Cancer is a disease that claims millions of lives each year, often because early symptoms go unnoticed, a situation which severely impacts society. Point-of-care biosensors using metal–organic frameworks (MOFs) have the power to transform cancer biomarker detection due to their exceptional structural and conductive properties. This review discusses the electrochemical sensor’s design and development of electroactive MOF materials with mechanistic insights. It highlights recent advancements in utilizing MOF composites to effectively detect cancer biomarkers in real samples. The emphasis on the critical application of MOFs in breast cancer biomarker detection presents its importance for women’s health. The review thoroughly examines the adjustable structures, porosity, and fabrication capabilities of MOFs in identifying cancer biomarkers. It provides a detailed analysis of methods to enhance the sensitivity and applicability of MOF composites for cancer detection. Furthermore, the review explores strategies to boost sensor performance, tackles existing challenges head-on, and outlines promising prospects. It emphasizes the urgent need for advanced cancer detection tools and aims to motivate researchers to develop innovative solutions.</p><h3>Graphical Abstract</h3><p>The paper discusses cancer’s impact, electrochemical sensing with MOFs, and recent advances in detecting biomarkers in real samples. It focuses on using MOFs for breast cancer detection in women, highlighting their potential in identifying cancer biomarkers. It also explores strategies to enhance sensor capacity, address challenges, and outline prospects to inspire researchers to develop advanced cancer detection tools.</p>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"383 1","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143438611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in Coordination Chemistry of Schiff Base Complexes: A Journey from Nanoarchitectonic Design to Biomedical Applications","authors":"Ahmad Abd-El-Aziz,&nbsp;Zexuan Li,&nbsp;Xinyue Zhang,&nbsp;Sherif Elnagdy,&nbsp;Mohamed S. Mansour,&nbsp;Ahmed ElSherif,&nbsp;Ning Ma,&nbsp;Alaa S. Abd-El-Aziz","doi":"10.1007/s41061-025-00489-w","DOIUrl":"10.1007/s41061-025-00489-w","url":null,"abstract":"<div><p>Since the discovery of Schiff bases over one and a half centuries ago, there has been tremendous research activity in the design of various Schiff bases and examination of their diverse structures and versatile applications. This family of compounds has continued to captivate many research groups due to the simplicity of their synthesis through the condensation of amines with carbonyl compounds. While conventional synthesis has been the most widely used, green synthetic methodologies have been also explored for this reaction, including sonication, microwave-assisted, natural acid-catalyzed and mechanochemical syntheses as well as utilizing ionic liquid solvents or deep eutectic solvents. Schiff bases have been utilized as excellent ligands for coordination to transition metals and late transition metals (lanthanides and actinides). These Schiff base compounds can be mono-, di-, or polydentate ligands. The aim of this review is to examine the biological applications of Schiff base complexes over the past decade with particular focus on their antimicrobial, antiviral, anticancer, antidiabetic, and anti-inflammatory activity. Schiff base complexes have been found effective in combating bacterial and fungal infections with numerous examples in the literature. The review addressed this area by focusing on the very recent examples while using tables to summarize the vast breadth of research according to the metallic moieties. Viruses have continued to be a target of many researchers in light of their continuous mutations and impact on human health, and therefore some examples of Schiff base complexes with antiviral activity are described. Cancer continues to be among the leading causes of death worldwide. In this article, the use of Schiff base complexes for, and the mechanisms associated with, their anticancer activity are highlighted. The production of reactive oxygen species (ROS) or intercalation with DNA base pairs leading to cell cycle arrest were the main mechanisms described. While there have been some efforts made to use Schiff base complexes as antidiabetic or anti-inflammatory agents, there are limited examples when compared with antimicrobial and anticancer studies. The conclusion of this review highlights the emerging areas of research and future perspectives with an emphasis on the potential uses of Schiff bases in the treatment of infectious and noninfectious diseases.</p></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"383 1","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143107869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Petasis Reaction: Applications and Organic Synthesis—A Comprehensive Review","authors":"Nilesh T. Pandit,&nbsp;Santosh B. Kamble","doi":"10.1007/s41061-025-00491-2","DOIUrl":"10.1007/s41061-025-00491-2","url":null,"abstract":"<div><p>The Petasis reaction has introduced significant advancements through the use of various catalysts, solvents, methodologies, and substrates in diverse areas of chemistry, including medicinal, organic, combinatorial, biochemical, and heterocyclic chemistry. It is a prominent method for synthesizing compounds such as α-amino acids, β-amino alcohols, Aza-beta-lactams, alkylaminophenols, α-arylglycines, 2H-chromenes, aminophenols, and hydrazide alcohols. With the increasing demand for medicines, drugs, industrial products, insecticides, and pesticides, the Petasis reaction has become an indispensable and versatile tool. This review explores the range of reaction components, key mechanisms, and reaction conditions associated with the Petasis reaction. Additionally, the paper delves into the potential future directions of this reaction and highlights its various applications.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"383 1","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143042537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Advances in Radical Coupling Reactions Directly Involving Bicyclo[1.1.1]pentane (BCP)","authors":"Jiayan Jin,&nbsp;Huimin Yang,&nbsp;Huan Xiang,&nbsp;Yue Lu,&nbsp;Yang Ye","doi":"10.1007/s41061-025-00490-3","DOIUrl":"10.1007/s41061-025-00490-3","url":null,"abstract":"<div><p>BCP (bicyclo[1.1.1]pentane) is an ideal saturated carbon bioisostere, instead of the traditional benzene group, which has been extensively developed. As a novel building block, BCP could be directly involved in a variety of synthetic methods and widely used in the last-stage modification of drugs, attracting much attention from organic chemists and pharmacists. Radical-type cross-coupling reactions involving BCP enable the simultaneous formation of multiple chemical bonds (e.g., C−C, C−N, C−B, C−S, and C−Si) through metal catalysis, photocatalysis, metal-photo synergistic catalysis, and other catalytic systems. Various radical precursors have been explored, facilitating cross-coupling reactions that directly incorporate BCP. This review highlights these state-of-the-art radical couplings of BCP since 2017, organized by reaction components with emphasis on the scope of substrates, reaction mechanisms, and synthetic applications.</p><h3>Graphic Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"383 1","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142995419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis And Photovoltaic Performance of Carbazole (Donor) Based Photosensitizers in Dye-Sensitized Solar Cells (DSSC): A Review","authors":"Ramsha Munir,&nbsp;Ameer Fawad Zahoor,&nbsp;Muhammad Naveed Anjum,&nbsp;Usman Nazeer,&nbsp;Atta Ul Haq,&nbsp;Asim Mansha,&nbsp;Aijaz Rasool Chaudhry,&nbsp;Ahmad Irfan","doi":"10.1007/s41061-024-00488-3","DOIUrl":"10.1007/s41061-024-00488-3","url":null,"abstract":"<div><p>Carbazoles are nitrogen-containing aromatic heterocycles, having widespread applications in the field of photovoltaics. Carbazole-based photosensitizers have tunable features for absorption on semi-conductor (tellurium dioxide or zinc oxide) layers to create sufficient push–pull force in the conversion of sunlight into electrical energy, thus presenting as promising heterocyclic donor candidates to be used in dye-sensitized solar cells. For the synthesis of these dyes, various structural designs are available, namely, D-A, D-π-A, D-D-π-A, D-A-π-A, A-π-D-π-A-π-A, and D2-π-A that all involve incorporating carbazole as a donor (D), along with spacer (π-extender) moieties, such as thiophene, phenol, ethynylene, nitromethane, azine, thiadiazole, or acetonitrile. Additionally, acceptors (A) employed in the designs include cyanoacrylic acids, carboxylic acids, malononitrile, rhodanine-3-acetic acid, 4-aminobenzoic acid, or 4-amino salicylic acid. This comprehensive review explores the synthesis and photovoltaic performances of numerous carbazole-based photosensitizers tailored for dye-sensitized solar cells, covering the period of 2019–2023.</p></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"383 1","pages":""},"PeriodicalIF":8.6,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142906076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Intervention into the Diverse Utilities of Fluorenes: A Brobdingnagian Family","authors":"Anjana Sreekumar,&nbsp;Ajil R. Nair,&nbsp;C. Raksha,&nbsp;Sujith Sudheendran Swayamprabha,&nbsp;Akhil Sivan","doi":"10.1007/s41061-024-00485-6","DOIUrl":"10.1007/s41061-024-00485-6","url":null,"abstract":"<div><p>The keyword “Fluorene” search in SciFinder found more than 57,000 results, including high-impact journal articles, review articles, patents, books, proceedings, etc. Against this background, a detailed enquiry has been made by our group on various classes of fluorenes and their relevancy. For the past several decades, fluorene and its related compounds have experienced extensive studies, which are attributed to the vast range of applications they possess in various fields like sensors, polymers, OLED devices and even in the pharmaceutical industries. Since fluorene is an important member of the ‘polyaromatic-hydrocarbon’ family and has proved its relevancy in multidisciplinary areas, summarising those milestones might be worthwhile for future researchers. Here, we intend to highlight the key applications of fluorene derivatives in the form of a review article and have put much effort into consolidating some of their most imperative applications, including those in sensors and medicinal, optoelectronic and electrochemical fields. The manuscript divides the fluorene family into multiple subclasses, counting mono- and polyfluorenes, spirofluorenes, silicon-cored fluorenes, indenofluorenes, etc., based on their structure, and portrays all the critical properties of each class. Since fluorenes are globally accepted as outstanding candidates for numerous applications and practicalities, our effort may find crucial acceptance in the near future.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"383 1","pages":""},"PeriodicalIF":8.6,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hybrid Metal-Organic Frameworks (MOFs) for Various Catalysis Applications","authors":"Virender Virender,&nbsp;Vandana Pandey,&nbsp;Gurjaspreet Singh,&nbsp;Pawan Kumar Sharma,&nbsp;Pankaj Bhatia,&nbsp;Alexander A. Solovev,&nbsp;Brij Mohan","doi":"10.1007/s41061-024-00486-5","DOIUrl":"10.1007/s41061-024-00486-5","url":null,"abstract":"<div><p>Porous materials have been gaining popularity in catalysis applications, solving the current ecological challenges. Metal-organic frameworks (MOFs) are especially noteworthy for their high surface areas and customizable chemistry, giving them a wide range of potential applications in catalysis remediation. The review study delves into the various applications of MOFs in catalysis and provides a comprehensive summary. This review thoroughly explores MOF materials, specifically focusing on their diverse catalytic applications, including Lewis catalysis, oxidation, reduction, photocatalysis, and electrocatalysis. Also, this study emphasizes the significance of high-performance MOF materials, which possess adjustable properties and exceptional features, as a novel approach to tackling technological challenges across multiple sectors. MOFs make it an ideal candidate for catalytic reactions, as it enables efficient conversion rates and selectivity. Furthermore, the tunable properties of MOF make it possible to tailor its structure to suit specific catalytic requirements. This feature improves performance and reduces costs associated with traditional catalysts. In conclusion, MOF materials have revolutionized the field of catalysis and offer immense potential in solving various technological challenges across different industries.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"383 1","pages":""},"PeriodicalIF":8.6,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}