Topics in Current Chemistry最新文献

Exploring the Synthetic Potential of Horner-Wadsworth-Emmons Reaction Toward the Synthesis of Polyketide Based Natural Products: A Review 探索Horner-Wadsworth-Emmons反应合成聚酮类天然产物的潜力

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2025-04-26 DOI: 10.1007/s41061-025-00504-0

Javeria Babar, Sajjad Ahmad, Bushra Parveen, Kulsoom Ghulam Ali, Aqsa Mushtaq, Ameer Fawad Zahoor, Raheel Ahmad, Asim Mansha, Ahmad Irfan

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Polymer Anchored Cinchona Alkaloids: Synthesis and their Applications in Organo-Catalysis 聚合物锚定金鸡纳生物碱的合成及其在有机催化中的应用

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2025-04-09 DOI: 10.1007/s41061-025-00499-8

Patra Haripriya, Rajat Rai, Kari Vijayakrishna

{"title":"Polymer Anchored Cinchona Alkaloids: Synthesis and their Applications in Organo-Catalysis","authors":"Patra Haripriya, Rajat Rai, Kari Vijayakrishna","doi":"10.1007/s41061-025-00499-8","DOIUrl":"10.1007/s41061-025-00499-8","url":null,"abstract":"<div><p>Cinchona alkaloids are naturally occurring chiral molecules that have emerged as catalysts in asymmetric organocatalysis especially in enantioselective transformations because of their inherent chirality and unique structural features. Immobilizing these alkaloids on polymeric supports has significantly influenced their use in catalysis. Polymer-anchored cinchona alkaloids combine the catalytic efficacy of cinchona derivatives with additional benefits of polymer chain, such as ease of recovery, recyclability, reusability, and reduced environmental impact. These polymer-supported cinchona alkaloids have found wide applications in enantioselective reactions such as Michael addition, aldol condensations, Henry reaction, dimerization reaction, dihydroxylation, and benzylation. Various strategies have been employed for anchoring cinchona alkaloids onto polymers, including covalent attachment of alkaloids in the polymer side chain or main chain, and ionic attachment of alkaloids via quaternization in the main chain or side chain of polymer. This review focuses on the various synthetic methodologies for the preparation of polymer-anchored cinchona alkaloids and their application in numerous asymmetric transformations.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"383 2","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the Structural Versatility and Dynamic Behavior of Acyl/Aroyl Hydrazones: A Comprehensive Review 酰基/芳烃酰腙的结构通用性和动力学行为研究综述

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2025-04-08 DOI: 10.1007/s41061-025-00503-1

Kulbir Kadyan, Rahul Singh, Jayant Sindhu, Parvin Kumar, Meena Devi, Sohan Lal, Ashwani Kumar, Devender Singh, Harish Kumar

{"title":"Exploring the Structural Versatility and Dynamic Behavior of Acyl/Aroyl Hydrazones: A Comprehensive Review","authors":"Kulbir Kadyan, Rahul Singh, Jayant Sindhu, Parvin Kumar, Meena Devi, Sohan Lal, Ashwani Kumar, Devender Singh, Harish Kumar","doi":"10.1007/s41061-025-00503-1","DOIUrl":"10.1007/s41061-025-00503-1","url":null,"abstract":"<div><p>Acyl and aroyl hydrazones are hydrazine derivatives with unique structural variations and multiple applications in various disciplines, including medicinal chemistry, materials, and agrochemicals research. The presence of numerous reactive sites in acyl hydrazones established it as a privileged structure class in organic chemistry and, hence, serve as an important intermediate in the synthesis of pharmaceutically significant compounds. The intrinsic nature of the acylhydrazone group leads to various dynamic processes, including conformational, configurational, and tautomeric interconversions. Their dynamic behavior in organic frameworks is mainly attributed to hindered rotation around the imine C=N bond and –CONH– amide bond. It is crucial to comprehend the geometrical and conformational behavior of hydrazone derivatives in order to understand their structural attributes, reactivity, and interactions with other molecules. This review article provides an in-depth and up-to-date examination of the geometrical and conformational properties of acyl and aroyl hydrazones showcasing chronological progression of advancements in <i>N</i>-acyl/aroyl hydrazones (NAHs) over time spanning from 1955 to 2025. The insights gained from this analysis will be a helpful resource for researchers and chemists working on designing and developing new compounds with improved characteristics for various applications in chemistry and medicine.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"383 2","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143793237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current Advances in Aptasensors for Pesticide Detection 农药检测适配体传感器的研究进展

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2025-03-23 DOI: 10.1007/s41061-025-00498-9

Suthira Pushparajah, Mahnaz Shafiei, Aimin Yu

{"title":"Current Advances in Aptasensors for Pesticide Detection","authors":"Suthira Pushparajah, Mahnaz Shafiei, Aimin Yu","doi":"10.1007/s41061-025-00498-9","DOIUrl":"10.1007/s41061-025-00498-9","url":null,"abstract":"<div><p>The increasing use of pesticides necessitates the development of innovative analytical methods to regulate environmental impacts and ensure food safety. Aptamer-based sensors hold great promise for pesticide detection owing to their superior selectivity, stability, repeatability, and regenerative capabilities. Integrated with nanomaterials, aptasensors have demonstrated enhanced sensitivity for detecting a broad range of pesticides. This study first introduces the aptamer binding mechanism and presents the fundamental concept and justification for selecting aptamer over other biorecognition molecules. It then provides a comprehensive review of recent advancements and applications of various types of aptasensors for targeted pesticide detection, including electrochemical, fluorescent, colorimetric, electrochemiluminescent, and surface-enhanced Raman scattering (SERS) aptasensors. Additionally, it offers a comparative analysis of different aptasensors by evaluating their strengths and limitations. Finally, this review discusses strategies, such as advanced Systemic Evolution of Ligands by Exponential Enrichment (SELEX) technique, self-assembled monolayers (SAMs), and the use of antifouling agents to improve the aptamer’s selectivity, signal-to-noise ratio, and mitigate nonspecific adsorption challenges. These developments are essential for creating highly sensitive and selective aptasensors, facilitating their practical use in environmental monitoring and food safety.</p></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"383 2","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s41061-025-00498-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Applications of Bridgehead Heterocycles in Drug Design and Medicinal Chemistry 桥头堡杂环化合物在药物设计和药物化学中的应用

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2025-03-21 DOI: 10.1007/s41061-025-00502-2

Simona Di Martino, Pietro Amico, Maria De Rosa

{"title":"Applications of Bridgehead Heterocycles in Drug Design and Medicinal Chemistry","authors":"Simona Di Martino, Pietro Amico, Maria De Rosa","doi":"10.1007/s41061-025-00502-2","DOIUrl":"10.1007/s41061-025-00502-2","url":null,"abstract":"<div><p>Bridged heterocycles are highly relevant in medicinal chemistry and drug discovery due to the unique features associated with their three-dimensional configuration that ensures great scaffold complexity. In general, inserting bridged systems into a chemical structure positively influences the pharmacokinetic (PK) profile of leads, reducing lipophilicity and enhancing metabolic stability. Several optimization studies show that bridged systems often promoted a significant improvement of the small molecule–enzyme binding interaction due to conformational changes within the biological target active site. To date, many drugs including bridged cores are available in the market to cure several diseases. Given the broad range of biological activities of naturally occurring and (semi)-synthetic bridgehead heterocycles, here, we have thoroughly reviewed the rational design and the structure–activity relationship (SAR) studies of the most remarkable bridged compounds developed during the past decade, to highlight both the chemical and biological roles of these motifs.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"383 2","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143667984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Advances in the Mitsunobu and Related Reactions: A Review from 2010 to 2024

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2025-03-18 DOI: 10.1007/s41061-025-00501-3

Abdeslem Bouzina, Zineb Aouf, Aϊcha Amira, Yousra Ouafa Bouone, Houria Bentoumi, Yasmine Chemam, Malika Ibrahim-Ouali, Rachida Zerrouki, Nour-Eddine Aouf

{"title":"Recent Advances in the Mitsunobu and Related Reactions: A Review from 2010 to 2024","authors":"Abdeslem Bouzina, Zineb Aouf, Aϊcha Amira, Yousra Ouafa Bouone, Houria Bentoumi, Yasmine Chemam, Malika Ibrahim-Ouali, Rachida Zerrouki, Nour-Eddine Aouf","doi":"10.1007/s41061-025-00501-3","DOIUrl":"10.1007/s41061-025-00501-3","url":null,"abstract":"<div><p>This review discusses recent progress in the most significant synthetic approaches involving transformations under the Mitsunobu reaction. The Mitsunobu reaction entails the \"redox\" condensation of an acidic pronucleophile ‘<i>Nu</i>-H’ and an electrophilic primary or secondary alcohol, facilitated by stoichiometric amounts of phosphines and azodicarboxylate reagents. Widely utilized for dehydrative oxidation–reduction condensation, this reaction shows synthetic utility through its tolerance of a broad range of acidic pronucleophiles, including carboxylic acids, pro-imides, hydroxamates, phenols, thiols, fluorinated alcohols, oximes, thioamides, pyridinium and imidazolium salts, pyrimidine bases, <i>α</i>-ketoesters, and trimethylmethane tricarboxylate, thereby yielding a variety of functional and potentially biologically active compounds. The purpose of this review is to focus on recent advances and applications of Mitsunobu reaction chemistry, particularly from 2010 to 2024. In addition to discussing newer reagents that facilitate purification, we will describe contemporary applications of this chemistry, especially concerning the synthesis of potential biological compounds and their precursors. This focus review of the Mitsunobu reaction summarizes its origins, the current understanding of its mechanism, and recent improvements and applications. We aim for this work to serve as a useful resource for scientists working in this research domain.</p></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"383 2","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143638452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endohedral Metallofullerenes: Unveiling Synthesis Mechanisms and Advancing Photoelectric Energy Conversion Applications

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2025-03-14 DOI: 10.1007/s41061-025-00500-4

Weifeng Chen, Meiyan Huang, Mixue Wu, Yizhu Lei

{"title":"Endohedral Metallofullerenes: Unveiling Synthesis Mechanisms and Advancing Photoelectric Energy Conversion Applications","authors":"Weifeng Chen, Meiyan Huang, Mixue Wu, Yizhu Lei","doi":"10.1007/s41061-025-00500-4","DOIUrl":"10.1007/s41061-025-00500-4","url":null,"abstract":"<div><p>Endohedral metallofullerenes (EMFs) have garnered significant attention for their distinctive properties and potential integration into cutting-edge photoelectric devices. This review provides a comprehensive overview of recent advancements in EMF synthesis, highlighting the novel “self-driven carbon atom implantation” approach that sheds new light on the underlying mechanisms of EMF formation. The discussion delves into pivotal challenges related to yield optimization and purification processes, addressing current limitations and the imperative need for scalable synthesis and improved stability. Furthermore, the review explores the burgeoning applications of EMFs in photoelectric energy conversion, focusing on their capacity to enhance the efficiency of photovoltaic devices. Their unique electronic structures and tunable energy levels are highlighted as key factors contributing to improved charge separation and overall performance. In conclusion, this review offers a forward-looking perspective on interdisciplinary research avenues essential for harnessing the full potential of EMFs. It underscores the need for collaborative efforts across materials science, chemistry, and nanotechnology to overcome existing hurdles and to integrate EMFs into next-generation energy conversion technologies, thereby paving the way for more efficient and sustainable energy solutions.</p></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"383 2","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143622142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Advances in Smart Linkage Strategies for Developing Drug Conjugates for Targeted Delivery

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2025-03-13 DOI: 10.1007/s41061-025-00497-w

Jie Zhang, Zeyu Yang, Yu Liu, Yuying Liu, Jingkun Qu, Xiaoyan Pan

{"title":"Recent Advances in Smart Linkage Strategies for Developing Drug Conjugates for Targeted Delivery","authors":"Jie Zhang, Zeyu Yang, Yu Liu, Yuying Liu, Jingkun Qu, Xiaoyan Pan","doi":"10.1007/s41061-025-00497-w","DOIUrl":"10.1007/s41061-025-00497-w","url":null,"abstract":"<div><p>Targeted drug delivery systems effectively solve the problem of off-target toxicity of chemotherapeutic drugs by combining chemotherapeutic drugs with antibodies or peptides, thereby promoting drug targeting to the tumor site and bringing further hope for cancer treatment. The development of stimulus-responsive smart linkage technologies has led to the emergence of drug conjugates. Linkage technologies play a crucial role in the design, synthesis, and in vivo circulation of drug conjugates, as they determine the release of cytotoxic drugs from the conjugates and their subsequent therapeutic efficacy. This article reviews some of the smart linkage strategies used in designing drug conjugates, with a focus on the tumor microenvironment and exogenous stimuli as conditions influencing controlled drug release. This review introduces linker classifications and cleavage mechanisms, discusses modular linkers that promote the efficient synthesis of conjugates, and discusses the differences between linkage strategies. Furthermore, this article focuses on the implementation of self-assembly in drug conjugates, which is currently of great interest. Related concepts are introduced and relevant examples of their applications are provided. Furthermore, a comprehensive discourse is presented on the challenges that may arise in the research and clinical implementation of diverse linkage strategies, along with the associated enhancement measures. Finally, the factors that should be considered when designing linkage strategies for drug conjugates are summarized, offering strategies and ideas for scientists involved in drug conjugate research. It is particularly noteworthy that appropriate linkage strategies allow for the intracellular release of drugs after internalization of the conjugates, thereby maximizing their tumor cell-killing effect.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"383 2","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143602160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toward Realization of Bioorthogonal Chemistry in the Clinic

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2025-03-05 DOI: 10.1007/s41061-025-00495-y

Kim E. de Roode, Raffaella Rossin, Marc S. Robillard

引用次数: 0

CO2 Fixation into Useful Aromatic Carboxylic Acids via C (sp2)–X Bonds Functionalization 通过 C (sp2)-X 键官能化将二氧化碳固定为有用的芳香族羧酸

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2025-03-03 DOI: 10.1007/s41061-025-00496-x

Youwen Chen, Meihua Chen, Xinyu Li, Xinhua Xu, Shuang-Feng Yin, Renhua Qiu

引用次数: 0