Topics in Current Chemistry最新文献

A Review Study on Sustainable Synthesis of Schiff Bases and Metal Complexes with Implications in Medicinal Chemistry 席夫碱和金属配合物的可持续合成及其在药物化学中的应用研究进展

IF 8.8 2区化学

Topics in Current Chemistry Pub Date : 2026-11-05 DOI: 10.1007/s41061-026-00575-7

Sudeshna Saha

{"title":"A Review Study on Sustainable Synthesis of Schiff Bases and Metal Complexes with Implications in Medicinal Chemistry","authors":"Sudeshna Saha","doi":"10.1007/s41061-026-00575-7","DOIUrl":"10.1007/s41061-026-00575-7","url":null,"abstract":"<div><p>Schiff bases and their transition metal complexes remain foundational architectures in medicinal chemistry due to their versatile structural topography and broad therapeutic spectrum. However, traditional synthetic paradigms carry high environmental costs, heavy solvent burdens, and elevated waste factors. This systematic review maps 115 core studies to evaluate the transition from qualitative eco-friendly descriptions to standardized, quantitative green chemistry performance audits. We examine recent advancements in microwave-assisted, solvent-free, and artificial intelligence (AI)-driven synthetic pathways through strict evaluations of Atom Economy, Environmental Factor (E-Factor), and Process Mass Intensity (PMI) metrics. The structural geometry and spectroscopic properties of complexes coordinating copper, nickel, zinc, iron, and cobalt cores are cross-analyzed with density functional theory (DFT) descriptor models tracking reactivity–selectivity–safety triads. Crucially, this study addresses the biological translation bottleneck by detailing solution speciation profiles, transchelation kinetics, and pharmacokinetic barriers under physiological conditions. Enclosing these systems within advanced nanomedicine matrices, such as layered double hydroxides and metal–organic frameworks, is shown to maximize in vivo oral bioavailability while limiting systemic toxicity. Ultimately, this multi-omic conceptual framework provides an auditable design pathway for developing environmentally sustainable, targeted coordinated therapeutics.</p></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"384 4","pages":""},"PeriodicalIF":8.8,"publicationDate":"2026-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149338309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Macrocycle-Integrated MOF Nanoarchitectures: Cooperative Active Sites from Pillararenes, Calixarenes, and Crown Ethers 大环集成MOF纳米结构：柱芳烃、杯芳烃和冠醚的协同活性位点。

IF 8.8 2区化学

Topics in Current Chemistry Pub Date : 2026-10-30 DOI: 10.1007/s41061-026-00572-w

Brij Mohan, Harish Kumar Sharma, Bakhtiyar Najafov, Ismayil M. Garazade, Khayala Seyidova, Rakesh Kumar Gupta, Virender Virender, M. Fátima C. Guedes da Silva, Armando J. L. Pombeiro, Sang Sub Kim

{"title":"Macrocycle-Integrated MOF Nanoarchitectures: Cooperative Active Sites from Pillararenes, Calixarenes, and Crown Ethers","authors":"Brij Mohan, Harish Kumar Sharma, Bakhtiyar Najafov, Ismayil M. Garazade, Khayala Seyidova, Rakesh Kumar Gupta, Virender Virender, M. Fátima C. Guedes da Silva, Armando J. L. Pombeiro, Sang Sub Kim","doi":"10.1007/s41061-026-00572-w","DOIUrl":"10.1007/s41061-026-00572-w","url":null,"abstract":"<div><p>Metal–organic frameworks (MOFs) offer crystalline porosity, modular structures, and tunable chemical environments, but they often lack the molecular recognition needed for highly selective adsorption, transport, and catalysis. Integrating macrocycles such as pillararenes, calixarenes, and crown ethers provides a route to macrocycle@MOF nanoarchitectures in which supramolecular cavities cooperate with framework pores, metal nodes, and linker functionalities. Calixarene-based MOFs create adaptive pockets for iodine capture, NO<sub>2</sub> sensing, and molecular separation; pillararene systems provide rigid, electron-rich channels for sieving, controlled release, and supramolecular docking; and crown-ether-functionalized MOFs enable selective ion transport, lithium sieving, and Sr<sup>2+</sup>/Cs<sup>+</sup> remediation. Their function arises from coupled host–guest recognition, pore confinement, electrostatic complementarity, and active-site organization. Key challenges include pore blocking, synthetic complexity, structural disorder, incomplete active-site validation, and device integration. This review highlights design principles for converting macrocycle-integrated MOFs from proof-of-concept materials into practical recognition platforms for advanced catalysis, separations, sensing, remediation, energy technologies, and biomedical applications.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"384 4","pages":""},"PeriodicalIF":8.8,"publicationDate":"2026-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149293816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Technetium—Boon or Bane? 科技恩还是灾祸？

IF 8.8 2区化学

Topics in Current Chemistry Pub Date : 2026-10-28 DOI: 10.1007/s41061-026-00573-9

M. A. Volkov

{"title":"Technetium—Boon or Bane?","authors":"M. A. Volkov","doi":"10.1007/s41061-026-00573-9","DOIUrl":"10.1007/s41061-026-00573-9","url":null,"abstract":"<div><p>Technetium currently has no practical applications, yet it holds enormous potential for many industrial sectors. The lack of stable isotopes for element 43 greatly complicates the study of its properties and limits its scope of application. The technetium content in nuclear waste exceeds 6%; currently, virtually all technetium produced in reactors is subject to disposal. The release of technetium compounds into the environment poses significant ecological risks due to the mobility and stability of pertechnetate ions—the thermodynamically most stable form of technetium. To determine the migration pathways of technetium in the biosphere, its behavior in living organisms, and the potential applications of its compounds, information on the chemistry and properties of the element is necessary. At present, approximately 2000 organic and inorganic technetium compounds are known, although their physicochemical and mechanical properties are often not specified by the authors of the studies. Often, the literature provides only information on synthesis, crystal structure, and a set of spectroscopic properties (IR, UV). Information on NMR, EPR, and thermochemical analysis, or very limited chemical properties, is less common. There are studies in which, apart from a description of the structural part, there is no information whatsoever on physical and chemical properties. At the same time, recent discoveries in the field of technetium chemistry indicate that this element can form a number of unique compounds, making its chemistry more diverse and less predictable, while also offering potential for practical applications. The purpose of this review was to identify some new and unresolved issues in the chemistry and technology of technetium compounds. It also presents a brief analysis of the SCDC database, based on which possible directions for further research in the field of coordination chemistry of element 43 are proposed.</p></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"384 4","pages":""},"PeriodicalIF":8.8,"publicationDate":"2026-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149293805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging Morphology-Controlled Microspheres for Next-Generation Functional Materials and Devices: From Formation Mechanisms to Applications 新一代功能材料和器件的新兴形态控制微球：从形成机制到应用

IF 8.8 2区化学

Topics in Current Chemistry Pub Date : 2026-10-22 DOI: 10.1007/s41061-026-00571-x

Shahzeb Hussain, Hassan Akbar, Ayesha Bibi, S. A. Abd El-Azeem, Jeong Ryeol Choi, Asghar Ali

{"title":"Emerging Morphology-Controlled Microspheres for Next-Generation Functional Materials and Devices: From Formation Mechanisms to Applications","authors":"Shahzeb Hussain, Hassan Akbar, Ayesha Bibi, S. A. Abd El-Azeem, Jeong Ryeol Choi, Asghar Ali","doi":"10.1007/s41061-026-00571-x","DOIUrl":"10.1007/s41061-026-00571-x","url":null,"abstract":"<div><p>Controlling hierarchical organization across multiple length scales is a central challenge in materials science. Microspherical architectures offer powerful platforms for addressing this challenge because their confined geometry enables the integration of nanoscale interfaces, internal porosity, and structural hierarchy within a single functional unit. These features have driven extensive exploration of microspheres for applications in biomedicine, catalysis, photonics, and energy systems. However, the mechanistic connections between microsphere formation pathways and emergent functionality remain fragmented, limiting predictive materials design. Here, we present a unified perspective on morphology-controlled microspheres by integrating thermodynamic principles, kinetic processes, and hierarchical materials design. We examine key formation mechanisms, including nucleation, growth dynamics, phase separation, Ostwald ripening, and interfacial energy regulation, and analyze how major fabrication strategies such as sol–gel processing, hydrothermal synthesis, spray assembly, emulsification, and co-precipitation govern nanoscale organization and structural evolution. By linking formation mechanisms with functional outcomes, this Review establishes general design principles and highlights emerging opportunities for predictive nanoarchitectonic engineering of microsphere-based functional materials.</p></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"384 4","pages":""},"PeriodicalIF":8.8,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149234770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Advances in the Gewald Reaction: A Valuable Tool for the Synthesis of Thiophene Derivatives 格瓦尔德反应的最新进展：一个合成噻吩衍生物的有价值的工具。

IF 8.8 2区化学

Topics in Current Chemistry Pub Date : 2026-10-12 DOI: 10.1007/s41061-026-00567-7

Lubna Khan, Maryam Abbasi, Mohd Kamil Hussain, Rashid Ali

引用次数: 0

Synthetic Pathways to 1, 2-Dicarbonyl Compounds: Progress, Challenges, and Opportunities 1,2 -二羰基化合物的合成途径：进展、挑战和机遇

IF 8.8 2区化学

Topics in Current Chemistry Pub Date : 2026-10-08 DOI: 10.1007/s41061-026-00570-y

Priyanka Nath, Mohit L. Deb, Pranjal K. Baruah

{"title":"Synthetic Pathways to 1, 2-Dicarbonyl Compounds: Progress, Challenges, and Opportunities","authors":"Priyanka Nath, Mohit L. Deb, Pranjal K. Baruah","doi":"10.1007/s41061-026-00570-y","DOIUrl":"10.1007/s41061-026-00570-y","url":null,"abstract":"<div><p>1,2-Dicarbonyl compounds or α-dicarbonyls are important synthetic intermediates widely used in organic synthesis, medicinal chemistry, and materials science due to their unique reactivity and versatility. In recent years, significant progress has been made in developing efficient methods for synthesizing them from diverse substrates, including heterocycles, alkenes, alkynes, ketones, and aromatic systems. This review provides an overview of recent advances reported between 2014 and 2026, covering transition-metal-catalyzed, metal-free, photocatalytic, electrochemical, and catalyst-free strategies. Emphasis is placed on reaction mechanisms, substrate scope, functional-group tolerance, and sustainability. The limitations associated with substrate compatibility, cost-effectiveness, and sustainability are also critically discussed. Finally, emerging directions, such as green oxidants, heterogeneous catalysis, photocatalysis, and electrochemical methods, are highlighted as promising avenues for future development. This review aims to provide a comprehensive resource to guide the design of efficient and sustainable strategies for synthesizing 1,2-dicarbonyl compounds.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"384 4","pages":""},"PeriodicalIF":8.8,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149133057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in Perimidine Derivative Synthesis: From Classical Condensation to Dehydrogenative Coupling and Borrowing Hydrogen Strategies 吡啶衍生物的合成进展：从经典缩合到脱氢偶联及借氢策略。

IF 8.8 2区化学

Topics in Current Chemistry Pub Date : 2026-09-23 DOI: 10.1007/s41061-026-00568-6

Manickaraj Meena, Tapas Ghatak

{"title":"Advances in Perimidine Derivative Synthesis: From Classical Condensation to Dehydrogenative Coupling and Borrowing Hydrogen Strategies","authors":"Manickaraj Meena, Tapas Ghatak","doi":"10.1007/s41061-026-00568-6","DOIUrl":"10.1007/s41061-026-00568-6","url":null,"abstract":"<div><p>Perimidine derivatives are an important class of nitrogen-containing fused heterocycles that have drawn considerable attention owing to their prominent biological activity and valuable applications in materials science. In recent years, considerable effort has been dedicated to diverse synthetic methodologies for the construction of perimidine frameworks, mainly through the reaction of 1,8-diaminonaphthalene with various carbonyl compounds or nitrile precursors. Developments include aldehyde and nitrile routes, alcohol-derived routes, and the use of substituted carbonyl surrogates such as aldehyde bisulfite adducts. Many of these approaches rely on recyclable catalysts, solvent-free methods, or renewable feedstocks, reflecting core green-chemistry principles. Perimidine derivatives have shown significance in medicinal chemistry, fluorescence sensing, catalysis, functional materials, and synthetic developments. The application of heterogeneous nanocatalysts, metal complexes, organocatalysts, and mechanochemical approaches has significantly increased the efficiency, selectivity, and environmental friendliness of reactions. This review summarizes the main advances in the synthesis of perimidine derivatives in the period of 2020–2026 with emphasis on reaction pathways involving different starting materials and catalytic systems. The review considers perspectives on the sustainable development of perimidine chemistry and innovative applications of perimidine-based compounds.</p></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"384 4","pages":""},"PeriodicalIF":8.8,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149031825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research Progress on the Applications of Cyclopropenones in Organic Synthesis 环丙烯在有机合成中的应用研究进展。

IF 8.8 2区化学

Topics in Current Chemistry Pub Date : 2026-09-23 DOI: 10.1007/s41061-026-00569-5

Yu Xu, Li Chen, Fuchao Yu

{"title":"Research Progress on the Applications of Cyclopropenones in Organic Synthesis","authors":"Yu Xu, Li Chen, Fuchao Yu","doi":"10.1007/s41061-026-00569-5","DOIUrl":"10.1007/s41061-026-00569-5","url":null,"abstract":"<div><p>Cyclopropenones represent a unique class of highly reactive cyclic ketones that possess remarkable ring strain and amphiphilic electronic characteristics, making them ideal synthetic building blocks for the construction of complex molecular architectures. This field has received considerable attention and witnessed significant progress in recent years, driven by breakthrough advances in transition‑metal catalysis, organocatalysis, photochemistry, and electrochemistry. This review, with a focus on contributions over the past decade, aimed to provide a comprehensive and up‑to‑date overview of the applications of cyclopropenone derivatives in organic synthesis and medicinal chemistry. We systematically categorize the literature according to their multifaceted roles as organocatalysts, carbonyl donors, and key precursors in ring-opening reactions. It highlights their excellent reactivity in functionalization and cyclization reactions associated with ring‑opening transformations, including C–H activation, cycloadditions, and transition‑metal‑catalyzed coupling reactions. These strategies enable the efficient assembly of diverse heterocyclic scaffolds, such as butenolides, pyrones, indoles, and spirocyclic compounds.</p></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"384 4","pages":""},"PeriodicalIF":8.8,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149031837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in MOF-Based Transdermal Drug Delivery Systems: Mechanisms, Applications, and Future Prospects 基于mof的经皮给药系统的研究进展：机制、应用和未来展望

IF 8.8 2区化学

Topics in Current Chemistry Pub Date : 2026-09-20 DOI: 10.1007/s41061-026-00566-8

Deyun Ma, Sirui Guo, Ruohan Liu, Yingzi Feng, Alireza Nezamzadeh-Ejhieh, Lu Lu, Ying Pan, Shuze Zhuang

{"title":"Advances in MOF-Based Transdermal Drug Delivery Systems: Mechanisms, Applications, and Future Prospects","authors":"Deyun Ma, Sirui Guo, Ruohan Liu, Yingzi Feng, Alireza Nezamzadeh-Ejhieh, Lu Lu, Ying Pan, Shuze Zhuang","doi":"10.1007/s41061-026-00566-8","DOIUrl":"10.1007/s41061-026-00566-8","url":null,"abstract":"<div><p>Transdermal drug delivery offers a noninvasive alternative to conventional administration by avoiding gastrointestinal degradation and hepatic first-pass metabolism. However, its broader clinical application remains limited by the barrier function of the stratum corneum and insufficient drug accumulation within target tissues. Metal–organic frameworks (MOFs), characterized by their high surface area, tunable pore structures, and versatile surface chemistry, have recently emerged as promising platforms for transdermal drug delivery. This review summarizes the key advantages of MOF-based transdermal systems, including high drug-loading capacity, particularly for hydrophobic compounds and macromolecules, programmable multidrug delivery, favorable biocompatibility, and the integration of diagnostic and therapeutic functions with complementary physical treatment modalities. We further discuss recent advances in the rational design of MOF-based transdermal platforms across major biomedical applications, including diabetic wound management, skin regeneration, skin cancer therapy, and cosmetic delivery. Despite these advances, clinical translation remains challenged by insufficient long-term biosafety evaluation, incomplete understanding of degradation behavior and biodistribution, limited manufacturing scalability, and regulatory requirements for complex multifunctional systems. Recent developments in artificial intelligence (AI) provide new opportunities to address several of these challenges by accelerating MOF design, predicting structure–property relationships, optimizing stimuli-responsive drug release, and supporting the development of personalized transdermal therapies. Overall, this review provides an integrated perspective on the design principles, therapeutic applications, and translational challenges of MOF-based transdermal systems, while outlining future directions for their successful clinical development.</p></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"384 4","pages":""},"PeriodicalIF":8.8,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research Progress on Fluorescent Probes for Detecting Phosgene: Mechanism, Reaction, and Performance 光气荧光探针的研究进展：机理、反应及性能

IF 8.8 2区化学

Topics in Current Chemistry Pub Date : 2026-08-21 DOI: 10.1007/s41061-026-00563-x

Zeyu Song, Jinchao Shen, Hui Guo, Wei He

{"title":"Research Progress on Fluorescent Probes for Detecting Phosgene: Mechanism, Reaction, and Performance","authors":"Zeyu Song, Jinchao Shen, Hui Guo, Wei He","doi":"10.1007/s41061-026-00563-x","DOIUrl":"10.1007/s41061-026-00563-x","url":null,"abstract":"<div><p>Phosgene is a highly toxic chemical warfare agent that continues to pose a serious threat to public health and safety, thereby creating a strong demand for rapid, sensitive, and reliable onsite detection methods. Among currently available analytical approaches, fluorescent probes offer distinct advantages, including high sensitivity, high selectivity, fast response, and operational simplicity, which make them particularly attractive for phosgene monitoring. This review summarizes small-molecule fluorescent probes for phosgene detection with well-defined sensing mechanisms reported since 2020. Particular emphasis is placed on the fundamental relationships among response mechanism, reaction type, fluorophore architecture, and recognition site. On this basis, a mechanistic framework integrating sensing mechanism, reaction pathway, and analytical performance is proposed to clarify the structure–property relationships underlying successful probe design. It is anticipated that this review will provide a useful reference for the rational design of next-generation and high-performance fluorescent probes for phosgene detection.</p></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"384 3","pages":""},"PeriodicalIF":8.8,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148783330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0