Topics in Current Chemistry最新文献

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Curcumin Delivery Systems: From Importance and Microencapsulation Techniques to Molecular Docking and Dynamics for Rational Formulation Design 姜黄素传递系统:从重要性和微胶囊技术到分子对接和动力学的合理配方设计
IF 8.8 2区 化学
Topics in Current Chemistry Pub Date : 2026-05-01 DOI: 10.1007/s41061-026-00553-z
Romică Crețu, Simona Butan, Veronica Filimon, Alexandra Virginia Bounegru, Aurel Tăbăcaru
{"title":"Curcumin Delivery Systems: From Importance and Microencapsulation Techniques to Molecular Docking and Dynamics for Rational Formulation Design","authors":"Romică Crețu,&nbsp;Simona Butan,&nbsp;Veronica Filimon,&nbsp;Alexandra Virginia Bounegru,&nbsp;Aurel Tăbăcaru","doi":"10.1007/s41061-026-00553-z","DOIUrl":"10.1007/s41061-026-00553-z","url":null,"abstract":"<div><p>Curcumin, a polyphenolic compound from <i>Curcuma longa</i>, has many biological effects, including antioxidant, anti-inflammatory, anticancer, and neuroprotective properties. However, its use in food, pharmaceutical, and biomedical systems is limited owing to poor water solubility, chemical instability, fast metabolism, and very low oral bioavailability. To address these issues, various formulation strategies have been created. Microencapsulation is one of the most effective methods for improving the stability, bioaccessibility, and controlled release of curcumin. At the same time, computational tools such as molecular docking and molecular dynamics simulations have become more important for understanding curcumin–carrier interactions and predicting formulation stability at the molecular level. Although both experimental encapsulation techniques and in silico modeling are well-established, research in these areas often occurs separately, leading to fragmented understanding of curcumin delivery systems. This review offers a detailed analysis of curcumin research by connecting its physicochemical properties and degradation pathways with microencapsulation strategies and computational modeling. Key encapsulation techniques such as spray drying, ionotropic gelation, complex coacervation, and nanostructured delivery systems are examined in terms of their mechanisms, benefits, drawbacks, and uses. Additionally, recent progress in molecular docking and molecular dynamics simulations is discussed to emphasize their growing role in helping choose carriers and design formulations. By linking formulation science with predictions at the molecular level, this review presents a framework to promote the development of effective, stable, and bioavailable curcumin-based delivery systems for food, pharmaceutical, and biomedical purposes.</p></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"384 2","pages":""},"PeriodicalIF":8.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s41061-026-00553-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147796728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rare-Earth High-Entropy Oxides: Bridging Energy Catalysis and Optoelectronic Innovation 稀土高熵氧化物:桥接能量催化与光电创新
IF 8.8 2区 化学
Topics in Current Chemistry Pub Date : 2026-04-22 DOI: 10.1007/s41061-026-00552-0
Santosh Chackrabarti
{"title":"Rare-Earth High-Entropy Oxides: Bridging Energy Catalysis and Optoelectronic Innovation","authors":"Santosh Chackrabarti","doi":"10.1007/s41061-026-00552-0","DOIUrl":"10.1007/s41061-026-00552-0","url":null,"abstract":"<div><p>Rare-earth high-entropy oxides (RE-HEOs) represent a distinct class of entropy-stabilized ceramics in which multiple lanthanide cations occupy a common crystallographic sublattice, generating strong chemical disorder, lattice distortion, and complex defect landscapes. Unlike transition-metal-based high-entropy oxides, RE-HEOs are governed by localized 4f electronic states, weak crystal-field coupling, and variable redox chemistry, leading to emergent structural, electronic, magnetic, and optical phenomena that challenge conventional solid-state descriptions. This review provides a physics-oriented analysis of RE-HEOs, focusing on the thermodynamic foundations of configurational entropy stabilization, the interplay between enthalpy, entropy, and kinetic trapping, and the consequences of severe chemical disorder for crystal structure and phase stability. We review how lattice distortion, oxygen vacancy disorder, and cation randomness modify phonon spectra, ionic transport pathways, and electronic structures, with particular emphasis on the role of localized 4f states, defect-induced in-gap levels, and disorder-broadened excitation spectra. Spectroscopic manifestations of disorder including crystal-field relaxation, line broadening, lifetime modification, and energy transfer processes are discussed within a unified framework linking local symmetry breaking to macroscopic response. We further discuss the optoelectronic properties of RE-HEOs, including photoluminescence from intra-4f transitions, upconversion mechanisms, and disorder-induced modifications of radiative lifetimes and quantum efficiency. The application landscape spans both energy conversion (electrocatalysis, solid oxide fuel cells, thermal barrier coatings) and optoelectronic technologies (phosphors, scintillators, optical thermometry, and anti-counterfeiting). Likewise, we assess theoretical and computational approaches, including density functional theory with strong correlation corrections, statistical thermodynamics, and emerging machine-learning models, highlighting their ability and current limitations in capturing disorder-driven physics in multi-component oxides. Finally, we identify open questions central to condensed-matter physics, including the nature of entropy-stabilized metastability, the limits of band theoretical descriptions in highly disordered 4f systems, and the role of configurational entropy in tuning electron–phonon and defect interactions. By consolidating experimental and theoretical insights, this review establishes RE-HEOs as a platform for exploring disorder-dominated solid-state physics beyond conventional crystalline oxides.</p></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"384 2","pages":""},"PeriodicalIF":8.8,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147738432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent Progress of N,N-Dimethylformamide (DMF) as Versatile Synthons in Organic Synthesis N,N-二甲基甲酰胺(DMF)在有机合成中的研究进展
IF 8.8 2区 化学
Topics in Current Chemistry Pub Date : 2026-04-09 DOI: 10.1007/s41061-026-00543-1
Hao Lu, Meng Yu, Xiaohui Tian, Xiaorong Suo, Xiaomei Hei, Juan Yang, Jianqi Yao, Renhua Qiu
{"title":"Recent Progress of N,N-Dimethylformamide (DMF) as Versatile Synthons in Organic Synthesis","authors":"Hao Lu,&nbsp;Meng Yu,&nbsp;Xiaohui Tian,&nbsp;Xiaorong Suo,&nbsp;Xiaomei Hei,&nbsp;Juan Yang,&nbsp;Jianqi Yao,&nbsp;Renhua Qiu","doi":"10.1007/s41061-026-00543-1","DOIUrl":"10.1007/s41061-026-00543-1","url":null,"abstract":"<div><p><i>N</i>,<i>N</i>-Dimethylformamide (DMF), as an indispensable and versatile reagent in organic synthesis, has evolved from a traditional solvent to a synthetic building block with rich reactivity. Due to its unique molecular structure, DMF can participate in the construction of various complex organic molecules through multiple reaction pathways under different reaction conditions. Accordingly, this review aims to provide a comprehensive and in-depth summary of the latest research progress in organic synthesis using DMF as a versatile synthon, covering all relevant literature reports published between May 1, 2020, and May 1, 2025. Furthermore, in-depth studies of the underlying reaction mechanisms help to precisely understand the essence of DMF’s involvement in reactions, thereby providing a solid theoretical foundation for optimizing reaction conditions and developing novel reaction pathways. This review serves as a crucial reference guide for expanding the application scope of DMF in organic synthesis and developing more environmentally friendly organic synthesis methods.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"384 2","pages":""},"PeriodicalIF":8.8,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147640463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
COFs in Action: Advanced Approaches for Monitoring Uranium, Mercury, Lead, and Nitro Compounds in Environmental Contaminants COFs在行动:监测环境污染物中铀、汞、铅和硝基化合物的先进方法。
IF 8.8 2区 化学
Topics in Current Chemistry Pub Date : 2026-04-08 DOI: 10.1007/s41061-026-00548-w
Virender Virender, Bakhtiyar Najafov, Krishan Kumar, Ismayil M. Garazade, Armando J. L. Pombeiro, Rakesh Kumar Gupta, M. Fátima C. Guedes da Silva, Brij Mohan
{"title":"COFs in Action: Advanced Approaches for Monitoring Uranium, Mercury, Lead, and Nitro Compounds in Environmental Contaminants","authors":"Virender Virender,&nbsp;Bakhtiyar Najafov,&nbsp;Krishan Kumar,&nbsp;Ismayil M. Garazade,&nbsp;Armando J. L. Pombeiro,&nbsp;Rakesh Kumar Gupta,&nbsp;M. Fátima C. Guedes da Silva,&nbsp;Brij Mohan","doi":"10.1007/s41061-026-00548-w","DOIUrl":"10.1007/s41061-026-00548-w","url":null,"abstract":"<div><p>Covalent organic frameworks (COFs) are crystalline, porous polymers with tunable architectures, high surface areas, and robust chemical stability, making them promising platforms for chemical sensing. This review surveys recent advances in luminescent COFs (LCOFs) for the selective detection of hazardous contaminants via fluorescence-based mechanisms, including photo-induced electron transfer and energy transfer. Representative studies discuss ultra-low detection limits for UO<sub>2</sub><sup>2+</sup>, Hg<sup>2+</sup>, and Pb<sup>2+</sup>, along with rapid response times, high adsorption capacities, and strong recyclability. Sensitivity and selectivity are further enhanced through functionalization strategies such as amidoxime grafting, lanthanide incorporation, and linkage engineering. Beyond actinide sensing, LCOFs have demonstrated effectiveness toward mercury, lead, nitro-aromatic explosives, and biological markers, underscoring their functional versatility. Despite these advances, key challenges persist, including scalable synthesis, structural stability in complex matrices, and integration into deployable sensing devices. Future progress leveraging hybrid material systems, computation-guided design, and portable detection platforms could position LCOFs as transformative tools for environmental monitoring, nuclear safety, and public health protection.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"384 2","pages":""},"PeriodicalIF":8.8,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147640338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lithium-Ion Batteries as a Cornerstone of Electric Vehicle Advancement: Innovations, Challenges, and Policy Implications 锂离子电池作为电动汽车发展的基石:创新、挑战和政策影响。
IF 8.8 2区 化学
Topics in Current Chemistry Pub Date : 2026-04-07 DOI: 10.1007/s41061-026-00550-2
Benedict Nnachi Alum, Darlington Arinze Echegu, Esther Ugo Alum, Daniel Ejim Uti, Simeon Ikechukwu Egba, Jude Uchechukwu Aleke
{"title":"Lithium-Ion Batteries as a Cornerstone of Electric Vehicle Advancement: Innovations, Challenges, and Policy Implications","authors":"Benedict Nnachi Alum,&nbsp;Darlington Arinze Echegu,&nbsp;Esther Ugo Alum,&nbsp;Daniel Ejim Uti,&nbsp;Simeon Ikechukwu Egba,&nbsp;Jude Uchechukwu Aleke","doi":"10.1007/s41061-026-00550-2","DOIUrl":"10.1007/s41061-026-00550-2","url":null,"abstract":"<div><p>Lithium-ion batteries (LIBs) are the key technology that allows the adoption of electric vehicles (EVs) and integration of renewable energy, but their development faces a complex of technical, environmental, and policy issues that require a multidimensional analysis. This review critically evaluates electrochemical activities, structural innovations, environmental effects, and regulatory frameworks used to deploy LIBs in EVs to inform the current development strategies. A narrative literature review was conducted across Google Scholar, ScienceDirect, Web of science, IEEE Xplore, ACS, and Scopus where peer-reviewed articles, technical reports, and policy documents published between 2015 and 2025 were searched. Thematic synthesis melded discoveries in electrochemical processes, materials science, and policy space. LIBs have a better energy density (130–275 Wh kg<sup>−1</sup>) and life- cycle greenhouse gas emission reductions of 46–52% compared to internal combustion engines with manufacturing emission (5075 kg CO<sub>2</sub>-eq) payback within 1.5–3 years of average driving. Major industrial innovation includes high-nickel cathodes, e.g., NMC811 and NCA, allow EV ranges of 400–500 km, silicon–graphite composite anodes with up to 550–650 mAh g<sup>−1</sup> capacity, and cell-to-pack designs. These innovations have been commercialized by CATL and BYD (Build Your Dreams) and raise cell-level energy density by 10–15% via removal of module-level components. The regulatory frameworks in the EU, US, and China are analyzed as the sources of market growth and the shift in the circular economy. The review finds that steady electrification must have an integrated policy to cover supply-chain equity, set chemistry-independent performance standards, and facilitated commercialization routes to solid-state and sodium-ion technologies that will characterize the post-lithium-ion phase.</p><h3>Graphical Abstract</h3><p>Created with BioRender.com.</p>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"384 2","pages":""},"PeriodicalIF":8.8,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147626891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MXene Nanomaterial Interfaces: Pioneering Neural Signal Recording for Brain–Computer Interfaces and Cognitive Therapy MXene纳米材料接口:脑机接口和认知治疗的神经信号记录先驱。
IF 8.8 2区 化学
Topics in Current Chemistry Pub Date : 2026-04-06 DOI: 10.1007/s41061-026-00549-9
Anila Mukhtiar, Nabisab Mujawar Mubarak, Mohamed Aly Saad Aly
{"title":"MXene Nanomaterial Interfaces: Pioneering Neural Signal Recording for Brain–Computer Interfaces and Cognitive Therapy","authors":"Anila Mukhtiar,&nbsp;Nabisab Mujawar Mubarak,&nbsp;Mohamed Aly Saad Aly","doi":"10.1007/s41061-026-00549-9","DOIUrl":"10.1007/s41061-026-00549-9","url":null,"abstract":"<div><p>The development of cost-effective, high-accuracy MXene-based electrode devices is a promising approach for monitoring brain activity. The high conductivity and controllable surface chemistry make MXenes viable for neural stimulation and recording applications. In this review article of MXene integration into neural devices, we analyze the role of MXenes in advancing next-generation brain–computer interfaces (BCIs). High-resolution neural interfaces can be studied through cognitive rehabilitation investigations that examine real-time signal decoding capabilities and feedback systems in these devices. In addition to a summary of recent experimental findings from in vitro and in vivo models, the article also discusses engineering strategies for optimizing MXene-based systems for neural applications. The clinical implementation of future technologies must address challenges related to material stability and compatibility with biological tissues, as well as device miniaturization requirements. This investigation aims to evaluate MXenes as transformative materials that could drive breakthroughs in neural interface technology while advancing brain–machine interface functionality.</p></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"384 2","pages":""},"PeriodicalIF":8.8,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147621393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insights into Small Organic Molecule Self-Luminous Probes: a Flourishing Frontier in Bioimaging and Sensing 洞察小有机分子自发光探针:在生物成像和传感蓬勃发展的前沿。
IF 8.8 2区 化学
Topics in Current Chemistry Pub Date : 2026-03-29 DOI: 10.1007/s41061-026-00545-z
Meihui Liu, Shuai Huang, Yiyang Zhou, Shuang Huang, Yalin Bai, Ao Yang, Jie Dong, Fei Chen, Wenbin Zeng
{"title":"Insights into Small Organic Molecule Self-Luminous Probes: a Flourishing Frontier in Bioimaging and Sensing","authors":"Meihui Liu,&nbsp;Shuai Huang,&nbsp;Yiyang Zhou,&nbsp;Shuang Huang,&nbsp;Yalin Bai,&nbsp;Ao Yang,&nbsp;Jie Dong,&nbsp;Fei Chen,&nbsp;Wenbin Zeng","doi":"10.1007/s41061-026-00545-z","DOIUrl":"10.1007/s41061-026-00545-z","url":null,"abstract":"<div><p>Self-luminescence imaging, which eliminates the need for external excitation, offers a compelling advantage in bioimaging by providing superior signal-to-background ratios for visualizing deep-seated biological structures and events. The performance of this advanced technique hinges on the properties of its self-luminous probes. Among various options, small-molecule organic probes (SOMSPs) have emerged as a promising class due to their exceptional molecular programmability, high sensitivity, and tunable optical characteristics. Recent breakthroughs in novel SOMSP design, their synergistic integration with advanced nanomaterials, and innovative combinations with therapeutic modalities have further amplified their sensitivity, selectivity, and versatility in diverse biomedical applications. This provides a comprehensive synthesis of the current state-of-the-art in organic small-molecule probes for self-luminescence techniques, with a specific focus on chemiluminescence, bioluminescence, and afterglow luminescence. We delineate key interdisciplinary strategies for their design and optimization, highlighting their broad applications in cancer diagnosis and targeted therapy, as well as real-time neuronal activity monitoring. Finally, we discuss the persistent challenges and offer a forward-looking perspective on future directions to accelerate the clinical translation of SOMSP-based self-luminescence imaging, bridging fundamental materials science with advanced biomedical engineering.</p></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"384 2","pages":""},"PeriodicalIF":8.8,"publicationDate":"2026-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147576106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and Properties of Energetic Materials with Catenated Nitrogen Chains 阳离子氮链含能材料的合成与性能研究。
IF 8.8 2区 化学
Topics in Current Chemistry Pub Date : 2026-03-23 DOI: 10.1007/s41061-026-00544-0
Hongwei Zhu, Lianghe Sun, Ming Lu, Haidong Liu, Yuangang Xu
{"title":"Synthesis and Properties of Energetic Materials with Catenated Nitrogen Chains","authors":"Hongwei Zhu,&nbsp;Lianghe Sun,&nbsp;Ming Lu,&nbsp;Haidong Liu,&nbsp;Yuangang Xu","doi":"10.1007/s41061-026-00544-0","DOIUrl":"10.1007/s41061-026-00544-0","url":null,"abstract":"<div><p>Energetic materials containing catenated nitrogen chains have attracted considerable attention from chemists because of their high heats of formation and unique properties. Although researchers have studied compounds with catenated nitrogen chains for more than 100 years, designing compounds with longer nitrogen chains and excellent energetic properties has long been a research hotspot in the field of energetic materials. The properties of the synthesized catenated nitrogen chain-containing energetic materials demonstrate their promising application prospects in explosives, pyrotechnics, and propellants, as well as significant research value. This prompted this review, which summarizes the synthetic methods and properties of energetic materials containing N<sub>5</sub>–N<sub>11</sub> and N<sub>18</sub> chains to establish a valuable theoretical basis for the extension of catenated nitrogen chains.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"384 2","pages":""},"PeriodicalIF":8.8,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147502904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AI and Robotics Advancement in Analytical Mineral Characterization and Mining Processes: A Review and Research Trends Analysis 人工智能和机器人技术在分析矿物表征和采矿过程中的进展:综述和研究趋势分析。
IF 8.8 2区 化学
Topics in Current Chemistry Pub Date : 2026-03-23 DOI: 10.1007/s41061-026-00541-3
Andile Mkhohlakali, Mothwethwi Priscilla Toona, Tumelo Mogashane, Tshilidzi Rampfumedzi, Portia Madzivha, Mokgehle R. Letsoalo, Napo Ntsasa, James Sehata, Nehemiah Mukwevho, Thembakazi Ncedo, Mothepane Happy Mabowa, James Tshilongo
{"title":"AI and Robotics Advancement in Analytical Mineral Characterization and Mining Processes: A Review and Research Trends Analysis","authors":"Andile Mkhohlakali,&nbsp;Mothwethwi Priscilla Toona,&nbsp;Tumelo Mogashane,&nbsp;Tshilidzi Rampfumedzi,&nbsp;Portia Madzivha,&nbsp;Mokgehle R. Letsoalo,&nbsp;Napo Ntsasa,&nbsp;James Sehata,&nbsp;Nehemiah Mukwevho,&nbsp;Thembakazi Ncedo,&nbsp;Mothepane Happy Mabowa,&nbsp;James Tshilongo","doi":"10.1007/s41061-026-00541-3","DOIUrl":"10.1007/s41061-026-00541-3","url":null,"abstract":"<div><p>The mining sector is undergoing a major transformation, as it moves shifting from traditional, labor-intensive methods to adopting digital technologies within the framework of Industry 4.0. Machine learning (ML), artificial intelligence (AI), and robotics are emerging as key innovative tools to improve safety, operational efficiency, and sustainability across the entire mining value-chain, from exploration and mineral processing to mineral characterization and environmental management. The integration of AI and ML with spectroscopic techniques has revolutionized the mining industry by enhancing efficiency, accuracy, throughput, and operational performance. This review discusses recent advances in AI, ML, and robotics applications in mining processes and mineral characterization. It explores the influence and highlights the integration of ML tools such as ANN, PCA, k-NN, and SVM with advanced analytical chemistry techniques, including XRF, XRD, SEM–EDX, LIBS, ICP-OES, ICP-MS, LA-ICP-MS, and HSI for mineral identification. Additionally, a bibliometric analysis using Scopus publications over the past 20 years provides insights into research trends and hotspots, providing recent insights into publication patterns and research. The review further offers an overview of recent technological developments, economic benefits, policy implication changes, and future directions, while emphasizing gaps related to the standardization of prospects for mining, demonstrating substantial growth in the integration of AI-driven analytical technologies within the analytical chemistry characterization of minerals, while also highlighting gaps related to the standardization of technologies.</p></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"384 2","pages":""},"PeriodicalIF":8.8,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13009105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147502906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanoparticles for Doxorubicin Delivery: Advances in Carrier Design and Synergistic Cancer Therapy 用于阿霉素递送的纳米颗粒:载体设计和协同癌症治疗的进展。
IF 8.8 2区 化学
Topics in Current Chemistry Pub Date : 2026-03-19 DOI: 10.1007/s41061-026-00547-x
Anna M. Nechaeva, Alexander A. Artyukhov, Alina Yu Svistunova, Mikhail Il’in, Tatiana P. Loginova, Oleg V. Baranov, Anton M. Shulgin, Lyudmila G. Komarova, Tatiana M. Estifeeva, Pavel S. Kuzmin, Roman A. Barmin, Vasily Gerasimov, Aristides M. Tsatsakis, Ramin Rezaee, Polina G. Rudakovskaya, Yaroslav O. Mezhuev
{"title":"Nanoparticles for Doxorubicin Delivery: Advances in Carrier Design and Synergistic Cancer Therapy","authors":"Anna M. Nechaeva,&nbsp;Alexander A. Artyukhov,&nbsp;Alina Yu Svistunova,&nbsp;Mikhail Il’in,&nbsp;Tatiana P. Loginova,&nbsp;Oleg V. Baranov,&nbsp;Anton M. Shulgin,&nbsp;Lyudmila G. Komarova,&nbsp;Tatiana M. Estifeeva,&nbsp;Pavel S. Kuzmin,&nbsp;Roman A. Barmin,&nbsp;Vasily Gerasimov,&nbsp;Aristides M. Tsatsakis,&nbsp;Ramin Rezaee,&nbsp;Polina G. Rudakovskaya,&nbsp;Yaroslav O. Mezhuev","doi":"10.1007/s41061-026-00547-x","DOIUrl":"10.1007/s41061-026-00547-x","url":null,"abstract":"<div><p>Doxorubicin is an anthracycline-class medication with a broad spectrum of antitumor activity, although significant adverse cardiac toxicity limits its use. This dictates the need for its encapsulation in drug delivery systems, as nanoparticles can eliminate cardiac toxicity and enhance tumor uptake. This review focuses on advances in inorganic/polymeric nanocarrier engineering that can (1) provide sites for doxorubicin immobilization, (2) ensure colloidal stability, and (3) allow multifunctional capabilities for synergistic cancer treatment. Focusing mainly on polymeric and polymer-capped inorganic nanomaterials owing to their high control over composition, we describe approaches to obtain nanoparticles for synergistic chemotherapy using doxorubicin in combination with magnetic hyperthermia, photothermal, and photodynamic cancer therapies. In addition, the review outlines selected chemical routes for the synthesis of the macromolecules required for efficient doxorubicin incorporation. The prospects for the use of doxorubicin carriers as theranostics described in this review underscore the need for innovation in carrier design for efficient cancer therapy.</p></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"384 2","pages":""},"PeriodicalIF":8.8,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147484209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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