Topics in Current Chemistry最新文献

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Porous Polymer Sorbents in Micro Solid Phase Extraction: Applications, Advantages, and Challenges 微固相萃取中的多孔聚合物吸附剂:应用、优势和挑战。
IF 8.6 2区 化学
Topics in Current Chemistry Pub Date : 2024-11-18 DOI: 10.1007/s41061-024-00481-w
Sayyed Hossein Hashemi, Massoud Kaykhaii
{"title":"Porous Polymer Sorbents in Micro Solid Phase Extraction: Applications, Advantages, and Challenges","authors":"Sayyed Hossein Hashemi,&nbsp;Massoud Kaykhaii","doi":"10.1007/s41061-024-00481-w","DOIUrl":"10.1007/s41061-024-00481-w","url":null,"abstract":"<div><p>In recent years, porous polymers have gained significant attention for their application as powerful and selective sorbents in micro solid phase extraction (µSPE). In this review we explore the preparation and utilization of various porous polymer sorbents, highlighting their impact on enhancing µSPE techniques. Molecularly imprinted polymers (MIPs), graphene oxide-modified frameworks, and zeolitic imidazole frameworks (ZIFs) are among the innovative materials discussed. These innovative materials have significantly improved µSPE methods, offering enhanced extraction efficiencies, superior selectivity, and reduced solvent consumption, all of which align with the principles of green chemistry. Key findings of this review include the demonstration that MIPs exhibit excellent target specificity, making them ideal for complex matrices, while graphene oxide frameworks and ZIFs provide increased surface area and stability for diverse analytical applications. Despite these advancements, challenges remain, particularly the high cost of certain innovative materials, limited reusability, and the absence of automation in µSPE workflows. Furthermore, controlling the precise synthesis and functionalization of these sorbents continues to be a limiting factor. To address these issues, future research should focus on developing cost-effectiveness methods, the use of biopolymer or sustainable feedstocks, and scalable synthesis methods; integrating automation into µSPE; and exploring new polymeric materials with enhanced properties. Additionally, novel hybrid materials that combine the strengths of multiple sorbents offer a promising direction for future exploration. We critically analyze the advantages and limitations of each sorbent type, providing a comprehensive overview of their applications in µSPE. This paper also examines the synthesis, characterization, and unique properties of these porous polymers, emphasizing their role in advancing analytical chemistry towards more efficient and environmentally friendly practices. The need for continued development of high-performance, low-cost, and sustainable sorbents is underscored to further enhance the effectiveness of µSPE techniques.</p></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"382 4","pages":""},"PeriodicalIF":8.6,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Comprehensive Exploration of the Synergistic Relationship between DMSO and Peroxide in Organic Synthesis 有机合成中二甲基亚砜与过氧化物协同作用的全面探索。
IF 8.6 2区 化学
Topics in Current Chemistry Pub Date : 2024-11-15 DOI: 10.1007/s41061-024-00482-9
Sumit Kumar, Ashutosh Dey, Barnali Maiti, Soumyadip Das, Sai Deepak Pasuparthy, Kishor Padala
{"title":"A Comprehensive Exploration of the Synergistic Relationship between DMSO and Peroxide in Organic Synthesis","authors":"Sumit Kumar,&nbsp;Ashutosh Dey,&nbsp;Barnali Maiti,&nbsp;Soumyadip Das,&nbsp;Sai Deepak Pasuparthy,&nbsp;Kishor Padala","doi":"10.1007/s41061-024-00482-9","DOIUrl":"10.1007/s41061-024-00482-9","url":null,"abstract":"<div><p>In the realm of organic synthesis, reagents can serve not only as solvents but also as synthons. Dimethyl sulfoxide (DMSO) is recognized for its efficiency in this dual capacity, enabling diverse chemical transformations. DMSO can generate various synthons, including methyl, methylene, methine, oxygen, and methyl sulfoxide, broadening the accessible compound repertoire. Activation of DMSO as a reagent relies heavily on synergies with secondary agents like peroxide, persulfate, or iodine. Recent years have witnessed a surge in innovative synthetic techniques harnessing the synergistic interplay of DMSO and peroxide, leading to environmentally friendly and cost-effective reactions with mild conditions. This review highlights the synergistic effects of DMSO and peroxides (up to 2023), detailing their activation mechanisms and the generation of various synthons, along with numerous reported derivatives. Although this topic has received considerable attention in recent years, there are numerous discrepancies and a plethora of possibilities yet to be explored. We anticipate that this review will significantly support researchers in advancing their innovations to a greater extent in the future.</p><h3>Graphical Abstract</h3><p>This review accentuates the synergistic effects of DMSO and peroxides like potassium persulfate (K<sub>2</sub>S<sub>2</sub>O<sub>8</sub>), sodium persulfate (Na<sub>2</sub>S<sub>2</sub>O<sub>8</sub>), ammonium persulfate ((NH<sub>4</sub>)<sub>2</sub>S<sub>2</sub>O<sub>8</sub>), hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>), and tertbutyl hydroperoxide (TBHP), as well as Oxone. It highlights their collaborative role in generating diverse synthons and elucidates the mechanisms of activation.</p>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"382 4","pages":""},"PeriodicalIF":8.6,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142640435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Schiff Base-Based Molybdenum Complexes as Green Catalyst in the Epoxidation Reaction: A Minireview 基于希夫碱的钼络合物作为环氧化反应中的绿色催化剂:小视角。
IF 8.6 2区 化学
Topics in Current Chemistry Pub Date : 2024-10-25 DOI: 10.1007/s41061-024-00480-x
Soumen Mistri, Keshab Mondal
{"title":"Schiff Base-Based Molybdenum Complexes as Green Catalyst in the Epoxidation Reaction: A Minireview","authors":"Soumen Mistri,&nbsp;Keshab Mondal","doi":"10.1007/s41061-024-00480-x","DOIUrl":"10.1007/s41061-024-00480-x","url":null,"abstract":"<div><p>Epoxides are class of cyclic ether and have been extensively used in petrochemicals and pharmaceuticals industries as raw materials. Due to this reasons, development of the synthetic strategy of epoxides are getting enormous interest among the research chemists. In terms of “development of the synthetic strategy”, the use of a catalyst, especially, Schiff base-based complex is of potential interest due to alternative easy routes and significant advances in metal-mediated pathways giving rise to diverse degree of substrate–reagent interactions. In addition, the synthetic strategy that follows the 12 principles of green chemistry, particularly (i) reduce the use of organic solvent, especially toxic solvents, and (ii) increasing the use of catalysts to obtain selective and quick processes in terms of atom economy, are of great attention now a days. The present review encompasses the Schiff base-based molybdenum complexes as green catalyst in the epoxidation reaction. Molybdenum complexes have grown interest owing to lower cost, environmental protection and commercialization as well as its abundance in different metalloenzymes. On the other hand, molybdenum complexes speed up the O–O bond break of <i>tert</i>-butylhydroperoxide (TBHP); as a result, it accelerates the oxygen transfer process from TBHP to the olefin. This review mainly focused on the catalytic activity of molybdenum-based Schiff base complexes for the epoxidation reaction in water/solvent free condition.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"382 4","pages":""},"PeriodicalIF":8.6,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142512869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent Advances in the Synthesis of Acyclic Nucleosides and Their Therapeutic Applications 无环核苷合成及其治疗应用的最新进展。
IF 8.6 2区 化学
Topics in Current Chemistry Pub Date : 2024-10-23 DOI: 10.1007/s41061-024-00476-7
Sumit Kumar, Aditi Arora, Riya Chaudhary, Rajesh Kumar, Christophe Len, Monalisa Mukherjee, Brajendra K. Singh, Virinder S. Parmar
{"title":"Recent Advances in the Synthesis of Acyclic Nucleosides and Their Therapeutic Applications","authors":"Sumit Kumar,&nbsp;Aditi Arora,&nbsp;Riya Chaudhary,&nbsp;Rajesh Kumar,&nbsp;Christophe Len,&nbsp;Monalisa Mukherjee,&nbsp;Brajendra K. Singh,&nbsp;Virinder S. Parmar","doi":"10.1007/s41061-024-00476-7","DOIUrl":"10.1007/s41061-024-00476-7","url":null,"abstract":"<div><p>DNA is commonly known as the “molecule of life” because it holds the genetic instructions for all living organisms on Earth. The utilization of modified nucleosides holds the potential to transform the management of a wide range of human illnesses. Modified nucleosides and their role directly led to the 2023 Nobel prize. Acyclic nucleosides, due to their distinctive physiochemical and biological characteristics, rank among the most adaptable modified nucleosides in the field of medicinal chemistry. Acyclic nucleosides are more resistant to chemical and biological deterioration, and their adaptable acyclic structure makes it possible for them to interact with various enzymes. A phosphonate group, which is linked via an aliphatic functionality to a purine or a pyrimidine base, distinguishes acyclic nucleoside phosphonates (ANPs) from other nucleotide analogs. Acyclic nucleosides and their derivatives have demonstrated various biological activities such as anti-viral, anti-bacterial, anti-cancer, anti-microbial, etc. Ganciclovir, Famciclovir, and Penciclovir are the acyclic nucleoside-based drugs approved by FDA for the treatment of various diseases. Thus, acyclic nucleosides are extremely useful for generating a variety of unique bioactive chemicals. Their biological activities as well as selectivity is significantly influenced by the stereochemistry of the acyclic nucleosides because chiral acyclic nucleosides have drawn a lot of interest due to their intriguing biological functions and potential as medicines. For example, tenofovir's (<i>R</i>) enantiomer is roughly 50 times more potent against HIV than its (<i>S</i>) counterpart. We can confidently state, “The most promising developments are yet to come in the realm of acyclic nucleosides!” Herein, we have covered the most current developments in the field of chemical synthesis and therapeutic applications of acyclic nucleosides based upon our continued interest and activity in this field since mid-1990’s.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"382 4","pages":""},"PeriodicalIF":8.6,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142512968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Benzoxazole Heterocycle: A Comprehensive Review of the Most Recent Medicinal Chemistry Developments of Antiproliferative, Brain-Penetrant, and Anti-inflammatory Agents 苯并恶唑杂环:抗增殖、脑穿透和抗炎药物的最新药物化学发展综述
IF 8.6 2区 化学
Topics in Current Chemistry Pub Date : 2024-10-21 DOI: 10.1007/s41061-024-00477-6
Simona Di Martino, Maria De Rosa
{"title":"The Benzoxazole Heterocycle: A Comprehensive Review of the Most Recent Medicinal Chemistry Developments of Antiproliferative, Brain-Penetrant, and Anti-inflammatory Agents","authors":"Simona Di Martino,&nbsp;Maria De Rosa","doi":"10.1007/s41061-024-00477-6","DOIUrl":"10.1007/s41061-024-00477-6","url":null,"abstract":"<div><p>The benzoxazole is one of the most widely exploited heterocycles in drug discovery. Natural occurring and synthetic benzoxazoles show a broad range of biological activities. Many benzoxazoles are available for treating several diseases, and, to date, a few are in clinical trials. Moreover, an ever-increasing number of benzoxazole derivatives are under investigation in the early drug discovery phase and as potential hit or lead compounds. This perspective is an attempt to thoroughly review the rational design, the structure–activity relationship, and the biological activity of the most notable benzoxazoles developed during the past 5 years (period 2019–to date) in cancers, neurological disorders, and inflammation. We also briefly overviewed each target and its role in the disease. The huge amount of work examined suggests the great potential of the scaffold and the high interest of the scientific community in novel biologically active compounds containing the benzoxazole core.</p></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"382 4","pages":""},"PeriodicalIF":8.6,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142452913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unveiling the Significance of tert-Butoxides in Transition Metal-Free Cross-Coupling Reactions 揭示叔丁氧基在无过渡金属交叉偶联反应中的重要作用。
IF 8.6 2区 化学
Topics in Current Chemistry Pub Date : 2024-10-11 DOI: 10.1007/s41061-024-00478-5
Vipin Kumar, Suman Majee, Km. Anjali, Biswajit Saha, Devalina Ray
{"title":"Unveiling the Significance of tert-Butoxides in Transition Metal-Free Cross-Coupling Reactions","authors":"Vipin Kumar,&nbsp;Suman Majee,&nbsp;Km. Anjali,&nbsp;Biswajit Saha,&nbsp;Devalina Ray","doi":"10.1007/s41061-024-00478-5","DOIUrl":"10.1007/s41061-024-00478-5","url":null,"abstract":"<div><p>The astounding reactivity of <i>tert</i>-butoxides in transition metal-free coupling reactions is driving the scientific community towards a new era of environmental friendly, as well as cost-effective, transformation strategies. Transition metal-catalyzed coupling reactions generate hazardous wastes and require harsh reaction conditions, mostly at elevated temperature, which increases not only costs but also environmental concerns regarding the methodology. <i>Tert</i>-butoxide-catalyzed/mediated coupling reactions have several advantages and potential applications. They can form carbon–carbon, carbon–heteroatom, and heteroatom–heteroatom bonds under mild reaction conditions. Mechanistic insights into these reactions include both ionic and radical pathways, with the fate of the intermediates depending on the reaction conditions and/or additives used in the reactions. Among all of the known <i>tert</i>-butoxides, potassium <i>tert</i>-butoxide has pronounced applications in transition metal-free coupling reactions as compared to other <i>tert</i>-butoxides, such as sodium and lithium <i>tert</i>-butoxides, because of the higher electropositivity of potassium compared to sodium and lithium. Moreover, potassium <i>tert</i>-butoxide can act as a source of base, nucleophile and single electron donors in various important transformations. In this review, we provide an extensive overview and complete compilation of transition metal-free cross-coupling reactions catalyzed/promoted by <i>tert-</i>butoxides during the past 10 years.</p><h3>Graphical Abstract</h3><p><i> Tert</i>-butoxide-mediated/activated cross-coupling reactions under the transition metal-free condition for benign organic transformation using a greener approach.</p>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"382 4","pages":""},"PeriodicalIF":8.6,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142405884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research Progress of Deep-Red to Near-Infrared Electroluminescent Materials Based on Organic Cyclometallated Platinum(II) Complexes 基于有机环金属化铂(II)配合物的深红至近红外电致发光材料的研究进展。
IF 8.6 2区 化学
Topics in Current Chemistry Pub Date : 2024-10-09 DOI: 10.1007/s41061-024-00479-4
Cheng Zhang, Yuanyuan Fang, Danfeng He, Keyue Xu, Yuzhu Bian, Yiru Li, Mingsheng Peng, Wenjing Xiong
{"title":"Research Progress of Deep-Red to Near-Infrared Electroluminescent Materials Based on Organic Cyclometallated Platinum(II) Complexes","authors":"Cheng Zhang,&nbsp;Yuanyuan Fang,&nbsp;Danfeng He,&nbsp;Keyue Xu,&nbsp;Yuzhu Bian,&nbsp;Yiru Li,&nbsp;Mingsheng Peng,&nbsp;Wenjing Xiong","doi":"10.1007/s41061-024-00479-4","DOIUrl":"10.1007/s41061-024-00479-4","url":null,"abstract":"<div><p>In recent years, the near-infrared (NIR) light-emitting materials have attracted increasing attention due to the broad application prospects in the fields of military industry, aerospace, lighting, display and wearable devices. As the transition metal complexes, platinum(II) complexes have been shown to emit luminescence efficiently in NIR organic light-emitting diodes because of the unique d<sup>8</sup> electron structure. This structure ensures that the platinum(II) complex molecules exhibit a high planarity, variety of excited states, and strong intermolecular interactions. This review summarizes the research progress of deep red to NIR organic light-emitting materials based on platinum(II) complexes in recent years and provides a certain reference for the further design and synthesis of NIR platinum(II) complex luminescent materials with superior performance.</p></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"382 4","pages":""},"PeriodicalIF":8.6,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142395304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent Focuses in the Syntheses and Applications of Magnetic Metal–Organic Frameworks 磁性金属有机框架的合成与应用的最新焦点。
IF 8.6 2区 化学
Topics in Current Chemistry Pub Date : 2024-10-06 DOI: 10.1007/s41061-024-00475-8
Yosra Mostafapour Kandelous, Mohammad Nikpassand, Leila Zare Fekri
{"title":"Recent Focuses in the Syntheses and Applications of Magnetic Metal–Organic Frameworks","authors":"Yosra Mostafapour Kandelous,&nbsp;Mohammad Nikpassand,&nbsp;Leila Zare Fekri","doi":"10.1007/s41061-024-00475-8","DOIUrl":"10.1007/s41061-024-00475-8","url":null,"abstract":"<div><p>In this article, we examine the recent uses of magnetic metal–organic frameworks (MMOFs). MMOFs can be used in various fields such as water purification, laboratory, food, environment, etc. Their materials can be composed of different metals and ligands, each of which has its own properties. Also, the presence of a magnetic property in these absorbents adds good features such as easy separation, faster absorption, and better interaction with other particles, which improves their application and performance. In recent years, various types of these compounds have been made, and, in this article, while classifying them, we will discuss the structure and application of some MMOFs.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"382 4","pages":""},"PeriodicalIF":8.6,"publicationDate":"2024-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142378962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Review on Recent Development of Phenothiazine-Based Chromogenic and Fluorogenic Sensors for the Detection of Cations, Anions, and Neutral Analytes 用于检测阳离子、阴离子和中性分析物的吩噻嗪基生色和生氟传感器的最新发展综述。
IF 8.6 2区 化学
Topics in Current Chemistry Pub Date : 2024-09-05 DOI: 10.1007/s41061-024-00474-9
Mohan Ilakiyalakshmi, Kumudhavalli Dhanasekaran, Ayyakannu Arumugam Napoleon
{"title":"A Review on Recent Development of Phenothiazine-Based Chromogenic and Fluorogenic Sensors for the Detection of Cations, Anions, and Neutral Analytes","authors":"Mohan Ilakiyalakshmi,&nbsp;Kumudhavalli Dhanasekaran,&nbsp;Ayyakannu Arumugam Napoleon","doi":"10.1007/s41061-024-00474-9","DOIUrl":"10.1007/s41061-024-00474-9","url":null,"abstract":"<div><p>This review provides an in-depth examination of recent progress in the development of chemosensors, with a particular emphasis on colorimetric and fluorescent probes. It systematically explores various sensing mechanisms, including metal-to-ligand charge transfer (MLCT), ligand-to-metal charge transfer (LMCT), photoinduced electron transfer (PET), intramolecular charge transfer (ICT), and fluorescence resonance energy transfer (FRET), and elucidates the mechanism of action for cation and anion chemosensors. Special attention is given to phenothiazine-based fluorescence probes, highlighting their exceptional sensitivity and rapid detection abilities for a broad spectrum of analytes, including cations, anions, and small molecules. Phenothiazine chemosensors have emerged as versatile tools widely employed in a multitude of applications, spanning environmental and biomedical fields. Furthermore, it addresses existing challenges and offers insights into future research directions, aiming to facilitate the continued advancement of phenothiazine-based fluorescent probes.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"382 3","pages":""},"PeriodicalIF":8.6,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142141670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging Nanomaterials as Versatile Nanozymes: A New Dimension in Biomedical Research 作为多功能纳米酶的新兴纳米材料:生物医学研究的新维度。
IF 8.6 2区 化学
Topics in Current Chemistry Pub Date : 2024-08-14 DOI: 10.1007/s41061-024-00473-w
Evin Jacob, Denno Mathew, Libina Benny, Anitha Varghese
{"title":"Emerging Nanomaterials as Versatile Nanozymes: A New Dimension in Biomedical Research","authors":"Evin Jacob,&nbsp;Denno Mathew,&nbsp;Libina Benny,&nbsp;Anitha Varghese","doi":"10.1007/s41061-024-00473-w","DOIUrl":"10.1007/s41061-024-00473-w","url":null,"abstract":"<div><p>The enzyme-mimicking nature of versatile nanomaterials proposes a new class of materials categorized as nano-enzymes, ornanozymes. They are artificial enzymes fabricated by functionalizing nanomaterials to generate active sites that can mimic enzyme-like functions. Materials extend from metals and oxides to inorganic nanoparticles possessing intrinsic enzyme-like properties. High cost, low stability, difficulty in separation, reusability, and storage issues of natural enzymes can be well addressed by nanozymes. Since 2007, more than 100 nanozymes have been reported that mimic enzymes like peroxidase, oxidase, catalase, protease, nuclease, hydrolase, superoxide dismutase, etc. In addition, several nanozymes can also exhibit multi-enzyme properties. Vast applications have been reported by exploiting the chemical, optical, and physiochemical properties offered by nanozymes. This review focuses on the reported nanozymes fabricated from a variety of materials along with their enzyme-mimicking activity involving tuning of materials such as metal nanoparticles (NPs), metal-oxide NPs, metal–organic framework (MOF), covalent organic framework (COF), and carbon-based NPs. Furthermore, diverse applications of nanozymes in biomedical research are discussed in detail.</p></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"382 3","pages":""},"PeriodicalIF":8.6,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141977223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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