Exploring the Structural Versatility and Dynamic Behavior of Acyl/Aroyl Hydrazones: A Comprehensive Review

IF 8.6 2区化学 Q1 Chemistry

Topics in Current Chemistry Pub Date : 2025-04-08 DOI:10.1007/s41061-025-00503-1

Kulbir Kadyan, Rahul Singh, Jayant Sindhu, Parvin Kumar, Meena Devi, Sohan Lal, Ashwani Kumar, Devender Singh, Harish Kumar

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引用次数: 0

Abstract

Acyl and aroyl hydrazones are hydrazine derivatives with unique structural variations and multiple applications in various disciplines, including medicinal chemistry, materials, and agrochemicals research. The presence of numerous reactive sites in acyl hydrazones established it as a privileged structure class in organic chemistry and, hence, serve as an important intermediate in the synthesis of pharmaceutically significant compounds. The intrinsic nature of the acylhydrazone group leads to various dynamic processes, including conformational, configurational, and tautomeric interconversions. Their dynamic behavior in organic frameworks is mainly attributed to hindered rotation around the imine C=N bond and –CONH– amide bond. It is crucial to comprehend the geometrical and conformational behavior of hydrazone derivatives in order to understand their structural attributes, reactivity, and interactions with other molecules. This review article provides an in-depth and up-to-date examination of the geometrical and conformational properties of acyl and aroyl hydrazones showcasing chronological progression of advancements in N-acyl/aroyl hydrazones (NAHs) over time spanning from 1955 to 2025. The insights gained from this analysis will be a helpful resource for researchers and chemists working on designing and developing new compounds with improved characteristics for various applications in chemistry and medicine.

Graphical abstract

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酰基/芳烃酰腙的结构通用性和动力学行为研究综述

酰基和芳基腙是肼衍生物，具有独特的结构变化，在各种学科中有多种应用，包括药物化学，材料和农用化学品研究。酰基腙中大量活性位点的存在使其成为有机化学中的一类特殊结构，因此在合成具有重要药理意义的化合物中起着重要的中间体作用。酰基腙基团的固有性质导致各种动态过程，包括构象、构型和互变异构相互转换。它们在有机骨架中的动力学行为主要归因于亚胺C=N键和- conh -酰胺键周围的旋转受阻。理解腙衍生物的几何和构象行为对于理解它们的结构属性、反应性和与其他分子的相互作用至关重要。这篇综述文章提供了深入和最新的几何和构象性质的研究，展示了从1955年到2025年n-酰基/芳基腙（NAHs）的进展时间顺序。从这一分析中获得的见解将为研究人员和化学家设计和开发具有改进特性的新化合物提供有用的资源，用于化学和医学的各种应用。图形抽象

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来源期刊

Topics in Current Chemistry 化学-化学综合

CiteScore

11.70

自引率

1.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Topics in Current Chemistry provides in-depth analyses and forward-thinking perspectives on the latest advancements in chemical research. This renowned journal encompasses various domains within chemical science and their intersections with biology, medicine, physics, and materials science. Each collection within the journal aims to offer a comprehensive understanding, accessible to both academic and industrial readers, of emerging research in an area that captivates a broader scientific community. In essence, Topics in Current Chemistry illuminates cutting-edge chemical research, fosters interdisciplinary collaboration, and facilitates knowledge-sharing among diverse scientific audiences.