Topics in Current Chemistry最新文献_第10页

Water-Soluble Non-Ionic PEGylated Porphyrins: A Versatile Category of Dyes for Basic Science and Applications 水溶性非离子聚乙二醇化卟啉:基础科学和应用的多用途染料

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2021-08-11 DOI: 10.1007/s41061-021-00348-4

Valentina Villari, Norberto Micali, Angelo Nicosia, Placido Mineo

{"title":"Water-Soluble Non-Ionic PEGylated Porphyrins: A Versatile Category of Dyes for Basic Science and Applications","authors":"Valentina Villari, Norberto Micali, Angelo Nicosia, Placido Mineo","doi":"10.1007/s41061-021-00348-4","DOIUrl":"10.1007/s41061-021-00348-4","url":null,"abstract":"<div><p>This review arises from the need to rationalize the huge amount of information on the structural and spectroscopic properties of a peculiar class of porphyrin derivatives—the non-ionic PEGylated porphyrins—collected during almost two decades of research. The lack of charged groups in the molecular architecture of these porphyrin derivatives is the leitmotif of the work and plays an outstanding role in highlighting those interactions between porphyrins, or between porphyrins and target molecules (e.g., hydrophobic-, hydrogen bond related-, and coordination-interactions, to name just a few) that are often masked by stronger electrostatic contributions. In addition, it is exactly these weaker interactions between porphyrins that make the aggregated forms more prone to couple efficiently with external perturbative fields like weak hydrodynamic vortexes or temperature gradients. In the absence of charge, solubility in water is very often achieved by covalent functionalization of the porphyrin ring with polyethylene glycol chains. Various modifications, including of chain length or the number of chains, the presence of a metal atom in the porphyrin core, or having two or more porphyrin rings in the molecular architecture, result in a wide range of properties. These encompass self-assembly with different aggregate morphology, molecular recognition of biomolecules, and different photophysical responses, which can be translated into numerous promising applications in the sensing and biomedical field, based on turn-on/turn-off fluorescence and on photogeneration of radical species.</p><h3>Graphic Abstract</h3>\u0000 <figure><div><div><div><picture><source><img></source></picture></div></div></div></figure>\u0000 </div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"379 5","pages":""},"PeriodicalIF":8.6,"publicationDate":"2021-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s41061-021-00348-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4447612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Pyrrolidine in Drug Discovery: A Versatile Scaffold for Novel Biologically Active Compounds 吡咯烷在药物发现中的应用:一种新型生物活性化合物的多功能支架

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2021-08-10 DOI: 10.1007/s41061-021-00347-5

Giovanna Li Petri, Maria Valeria Raimondi, Virginia Spanò, Ralph Holl, Paola Barraja, Alessandra Montalbano

{"title":"Pyrrolidine in Drug Discovery: A Versatile Scaffold for Novel Biologically Active Compounds","authors":"Giovanna Li Petri, Maria Valeria Raimondi, Virginia Spanò, Ralph Holl, Paola Barraja, Alessandra Montalbano","doi":"10.1007/s41061-021-00347-5","DOIUrl":"10.1007/s41061-021-00347-5","url":null,"abstract":"<div><p>The five-membered pyrrolidine ring is one of the nitrogen heterocycles used widely by medicinal chemists to obtain compounds for the treatment of human diseases. The great interest in this saturated scaffold is enhanced by (1) the possibility to efficiently explore the pharmacophore space due to sp<sup>3</sup>-hybridization, (2) the contribution to the stereochemistry of the molecule, (3) and the increased three-dimensional (3D) coverage due to the non-planarity of the ring—a phenomenon called “pseudorotation”. In this review, we report bioactive molecules with target selectivity characterized by the pyrrolidine ring and its derivatives, including pyrrolizines, pyrrolidine-2-one, pyrrolidine-2,5-diones and prolinol described in the literature from 2015 to date. After a comparison of the physicochemical parameters of pyrrolidine with the parent aromatic pyrrole and cyclopentane, we investigate the influence of steric factors on biological activity, also describing the structure–activity relationship (SAR) of the studied compounds. To aid the reader’s approach to reading the manuscript, we have planned the review on the basis of the synthetic strategies used: (1) ring construction from different cyclic or acyclic precursors, reporting the synthesis and the reaction conditions, or (2) functionalization of preformed pyrrolidine rings, e.g., proline derivatives. Since one of the most significant features of the pyrrolidine ring is the stereogenicity of carbons, we highlight how the different stereoisomers and the spatial orientation of substituents can lead to a different biological profile of drug candidates, due to the different binding mode to enantioselective proteins. We believe that this work can guide medicinal chemists to the best approach in the design of new pyrrolidine compounds with different biological profiles.</p></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"379 5","pages":""},"PeriodicalIF":8.6,"publicationDate":"2021-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s41061-021-00347-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4409173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 47

Organic-Molecule-Based Fluorescent Chemosensor for Nerve Agents and Organophosphorus Pesticides 基于有机分子的神经毒剂和有机磷农药荧光化学传感器

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2021-08-04 DOI: 10.1007/s41061-021-00345-7

Muskan Gori, Ashima Thakur, Abha Sharma, S. J. S. Flora

{"title":"Organic-Molecule-Based Fluorescent Chemosensor for Nerve Agents and Organophosphorus Pesticides","authors":"Muskan Gori, Ashima Thakur, Abha Sharma, S. J. S. Flora","doi":"10.1007/s41061-021-00345-7","DOIUrl":"10.1007/s41061-021-00345-7","url":null,"abstract":"<div><p>Organophosphorus (OP) compounds are typically a broad class of compounds that possess various uses such as insecticides, pesticides, etc. One of the most evil utilizations of these compounds is as chemical warfare agents, which pose a greater threat than biological weapons because of their ease of access. OP compounds are highly toxic compounds that cause irreversible inhibition of enzyme acetylcholinesterase, which is essential for hydrolysis of neurotransmitter acetylcholine, leading to series of neurological disorders and even death. Due to the extensive use of these organophosphorus compounds in agriculture, there is an increase in the environmental burden of these toxic chemicals, with severe environmental consequences. Hence, the rapid and sensitive, selective, real-time detection of OP compounds is very much required in terms of environmental protection, health, and survival. Several techniques have been developed over a few decades to easily detect them, but still, numerous challenges and problems remain to be solved. Major advancement has been observed in the development of sensors using the spectroscopic technique over recent years because of the advantages offered over other techniques, which we focus on in the presented review.</p><h3>Graphic Abstract</h3>\u0000 <figure><div><div><div><picture><source><img></source></picture></div></div></div></figure>\u0000 </div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"379 5","pages":""},"PeriodicalIF":8.6,"publicationDate":"2021-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s41061-021-00345-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4149800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Aggregation-Induced Emission in Electrochemiluminescence: Advances and Perspectives 电化学发光中的聚集诱导发射:进展与展望

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2021-06-19 DOI: 10.1007/s41061-021-00343-9

Guillermo Moreno-Alcántar, Alessandro Aliprandi, Luisa De Cola

引用次数: 17

Correction to: Magnetic Nanoparticles as MRI Contrast Agents 修正:磁性纳米颗粒作为MRI造影剂

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2021-06-14 DOI: 10.1007/s41061-021-00340-y

Ashish Avasthi, Carlos Caro, Esther Pozo-Torres, Manuel Pernia Leal, María Luisa García-Martín

引用次数: 1

Recent Advances in Schiff Base Ruthenium Metal Complexes: Synthesis and Applications 希夫碱金属钌配合物的合成与应用

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2021-06-10 DOI: 10.1007/s41061-021-00342-w

Anmol Singh, Pranjit Barman

{"title":"Recent Advances in Schiff Base Ruthenium Metal Complexes: Synthesis and Applications","authors":"Anmol Singh, Pranjit Barman","doi":"10.1007/s41061-021-00342-w","DOIUrl":"https://doi.org/10.1007/s41061-021-00342-w","url":null,"abstract":"<p>This review concentrates on recent developments in ruthenium Schiff bases, whose steric and electronic characteristics can be manipulated easily by selecting suitable condensing aldehydes or ketones and primary amines, and their metal complexes. Ruthenium metal-based complexes and Schiff base ligands are rapidly becoming conventionally considered for biological applications (antioxidant, anticancer, antimicrobial), in catalysis, in functional materials, in sensors, and as pigments for dyes. Ruthenium complexes exhibit a broad variety of activities concerning simple Schiff base ligands. This may be due to the octahedral bonding of both Ru(II) and Ru(III) complexes, which acquire an extended reservoir of a three-dimensional framework, providing the potential for an elevated degree of site selectivity for binding to their biological targets. This review provides an overview of this field, and intends to highlight both ligand design and synthetic methodology development, as well as significant applications of these metal complexes. In this review, we summarize our work on the development of ruthenium complexes, which was performed over the last few years.</p>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"379 4","pages":""},"PeriodicalIF":8.6,"publicationDate":"2021-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s41061-021-00342-w","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4426129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 29

Neo-Porphyrinoids: New Members of the Porphyrinoid Family 新卟啉类:卟啉类家族的新成员

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2021-05-19 DOI: 10.1007/s41061-021-00338-6

Poornenth Pushpanandan, Mangalampalli Ravikanth

{"title":"Neo-Porphyrinoids: New Members of the Porphyrinoid Family","authors":"Poornenth Pushpanandan, Mangalampalli Ravikanth","doi":"10.1007/s41061-021-00338-6","DOIUrl":"https://doi.org/10.1007/s41061-021-00338-6","url":null,"abstract":"<p>The four pyrrole rings and four meso carbons of tetrapyrrolic porphyrins can be arranged in different ways and the resulting porphyrin isomers exhibit very distinct electronic properties. The extensive research carried out on the porphyrins over the years has revealed that porphyrin can have several possible isomers and some of these have been identified and synthesized. Among the porphyrin isomers synthesized so far, porphycene and N-confused porphyrins have been investigated extensively whereas the other porphyrin isomers such as hemiporphycene, corrphycene and isoporphycene remain underdeveloped because of synthetic difficulties and their inherently unstable nature. Neoporphyrinoids are new members of the porphyrinoid family that were discovered serendipitously in 2011. Neoporphyrinoids are structural analogues of porphyrinoids with a confused pyrrole nitrogen linked to a meso carbon or the adjacent pyrrole carbon. Thus, neoporphyrinoids have an unusual structure in which pyrrole N is a part of a porphyrinoid framework and the lone pair of electrons on nitrogen participate in macrocyclic conjugation. It's been a decade since the discovery and different types of neoporphyrinoids, including regular, contracted and expanded neoporphyrinoids, have been synthesized by rational synthetic methodologies and their spectral, structural, aromatic and coordination properties have been studied. There is huge scope to develop different synthetic routes to produce new types of stable neoporphyrinoids to study their properties and potential applications. This article presents a brief overview of the synthesis, structure and properties of the neoporphyrinoids reported in this decade.</p>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"379 4","pages":""},"PeriodicalIF":8.6,"publicationDate":"2021-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s41061-021-00338-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4759413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Recent Strategies in the Synthesis of Spiroindole and Spirooxindole Scaffolds 螺旋吲哚和螺旋吲哚支架合成的最新进展

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2021-05-18 DOI: 10.1007/s41061-021-00337-7

Shima Nasri, Mohammad Bayat, Faezeh Mirzaei

{"title":"Recent Strategies in the Synthesis of Spiroindole and Spirooxindole Scaffolds","authors":"Shima Nasri, Mohammad Bayat, Faezeh Mirzaei","doi":"10.1007/s41061-021-00337-7","DOIUrl":"https://doi.org/10.1007/s41061-021-00337-7","url":null,"abstract":"<p>Spiroindole and spirooxindole scaffolds are very important spiro-heterocyclic compounds in drug design processes. Significant attention has been directed at obtaining molecules based on spiroindole and spirooxindole derivatives that have bioactivity against cancer cells, microbes, and different types of disease affecting the human body. Due to their inherent three-dimensional nature and ability to project functionalities in all three dimensions, they have become biological targets. Considering reports on spiroindole and spirooxindole-containing scaffolds in the past decades, introducing novel synthetic procedures has been an active research field of organic chemistry for well over a century and will be useful in creating new therapeutic agents. This review summarizes the pharmacological significance of spiroindole and spirooxindole scaffolds and highlights the latest strategies for their synthesis, focusing particularly on the past 2 years with typical examples. The spiroindole and spirooxindoles in this review are divided by the type and ring size of the spirocycle that is fused to indole or oxindole. Summarizing these procedures will be very beneficial for discovering novel therapeutic candidate molecules.</p>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"379 4","pages":""},"PeriodicalIF":8.6,"publicationDate":"2021-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s41061-021-00337-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5024999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 29

Recent Advances of Triazine-Based Materials for Adsorbent Based Extraction Techniques 吸附萃取技术中三嗪基材料的研究进展

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2021-05-04 DOI: 10.1007/s41061-021-00336-8

Min Sun, Sen Han, Juanjuan Feng, Chunying Li, Xiangping Ji, Jiaqing Feng, Haili Sun

引用次数: 7

Insights into SARS-CoV-2: Medicinal Chemistry Approaches to Combat Its Structural and Functional Biology 洞察SARS-CoV-2:对抗其结构和功能生物学的药物化学方法

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2021-04-22 DOI: 10.1007/s41061-021-00335-9

Lin-Sheng Zhuo, Ming-Shu Wang, Jing-Fang Yang, Hong-Chuang Xu, Wei Huang, Lu-Qing Shang, Guang-Fu Yang

{"title":"Insights into SARS-CoV-2: Medicinal Chemistry Approaches to Combat Its Structural and Functional Biology","authors":"Lin-Sheng Zhuo, Ming-Shu Wang, Jing-Fang Yang, Hong-Chuang Xu, Wei Huang, Lu-Qing Shang, Guang-Fu Yang","doi":"10.1007/s41061-021-00335-9","DOIUrl":"https://doi.org/10.1007/s41061-021-00335-9","url":null,"abstract":"<p>Coronavirus disease 2019, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is still a pandemic around the world. Currently, specific antiviral drugs to control the epidemic remain deficient. Understanding the details of SARS-CoV-2 structural biology is extremely important for development of antiviral agents that will enable regulation of its life cycle. This review focuses on the structural biology and medicinal chemistry of various key proteins (Spike, ACE2, TMPRSS2, RdRp and M<sup>pro</sup>) in the life cycle of SARS-CoV-2, as well as their inhibitors/drug candidates. Representative broad-spectrum antiviral drugs, especially those against the homologous virus SARS-CoV, are summarized with the expectation they will drive the development of effective, broad-spectrum inhibitors against coronaviruses. We are hopeful that this review will be a useful aid for discovery of novel, potent anti-SARS-CoV-2 drugs with excellent therapeutic results in the near future.</p>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"379 3","pages":""},"PeriodicalIF":8.6,"publicationDate":"2021-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s41061-021-00335-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4844288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4