Topics in Current Chemistry最新文献_第9页

Technological Advances in Remote Collaborations 远程协作中的技术进步

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2021-10-15 DOI: 10.1007/s41061-021-00354-6

Rika Kobayashi

引用次数: 1

Research Progress and Application of Bioorthogonal Reactions in Biomolecular Analysis and Disease Diagnosis 生物正交反应在生物分子分析和疾病诊断中的研究进展及应用

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2021-09-29 DOI: 10.1007/s41061-021-00352-8

Zilong Li, Qinhua Chen, Jin Wang, Xiaoyan Pan, Wen Lu

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引用次数: 5

Emergence of 2-Pyrone and Its Derivatives, from Synthesis to Biological Perspective: An Overview and Current Status 2-吡咯酮及其衍生物的出现:从合成到生物学的观点:综述与现状

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2021-09-23 DOI: 10.1007/s41061-021-00350-w

Tanveer Ahmad, Tahir Rasheed, Majid Hussain, Komal Rizwan

引用次数: 5

Web-Based Quantitative Structure–Activity Relationship Resources Facilitate Effective Drug Discovery 基于网络的定量构效关系资源促进有效的药物发现

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2021-09-23 DOI: 10.1007/s41061-021-00349-3

Yu-Liang Wang, Jing-Yi Li, Xing-Xing Shi, Zheng Wang, Ge-Fei Hao, Guang-Fu Yang

{"title":"Web-Based Quantitative Structure–Activity Relationship Resources Facilitate Effective Drug Discovery","authors":"Yu-Liang Wang, Jing-Yi Li, Xing-Xing Shi, Zheng Wang, Ge-Fei Hao, Guang-Fu Yang","doi":"10.1007/s41061-021-00349-3","DOIUrl":"10.1007/s41061-021-00349-3","url":null,"abstract":"<div><p>Traditional drug discovery effectively contributes to the treatment of many diseases but is limited by high costs and long cycles. Quantitative structure–activity relationship (QSAR) methods were introduced to evaluate the activity of compounds virtually, which saves the significant cost of determining the activities of the compounds experimentally. Over the past two decades, many web tools for QSAR modeling with various features have been developed to facilitate the usage of QSAR methods. These web tools significantly reduce the difficulty of using QSAR and indirectly promote drug discovery. However, there are few comprehensive summaries of these QSAR tools, and researchers may have difficulty determining which tool to use. Hence, we systematically surveyed the mainstream web tools for QSAR modeling. This work may guide researchers in choosing appropriate web tools for developing QSAR models, and may also help develop more bioinformatics tools based on these existing resources. For nonprofessionals, we also hope to make more people aware of QSAR methods and expand their use.</p><h3>Graphic Abstract</h3>\u0000 <figure><div><div><div><picture><source><img></source></picture></div></div></div></figure>\u0000 </div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"379 6","pages":""},"PeriodicalIF":8.6,"publicationDate":"2021-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4915153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Natural Feedstock in Catalysis: A Sustainable Route Towards Organic Transformations 催化中的天然原料:通往有机转化的可持续途径

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2021-08-13 DOI: 10.1007/s41061-021-00346-6

U. P. Patil, Suresh S. Patil

{"title":"Natural Feedstock in Catalysis: A Sustainable Route Towards Organic Transformations","authors":"U. P. Patil, Suresh S. Patil","doi":"10.1007/s41061-021-00346-6","DOIUrl":"10.1007/s41061-021-00346-6","url":null,"abstract":"<div><p>Catalysts are the jewel in the crown of the chemical industry, accelerating reaction kinetics and augmenting the efficiency of desired reaction paths. Natural feedstock is a renewable resource capable of providing valuable functional products; in addition, it confers an opportunity to create catalysts. As an alternative to stoichiometric reagents, and as a part of a sustainable approach, the implications of using natural feedstocks as a source of new catalysts has attracted considerable interest. Natural feedstock-derived catalysts can promote chemical transformations more efficiently. Recent reports have highlighted the significant role of these biogenic, cost-effective, innocuous, biodegradable materials as catalysts in many biologically and pharmacologically important protocols. This review outlines the decisive organic transformations for which feedstock-derived catalysts have been employed effectively and successfully, along with their economic and environmental benefits over traditional catalytic systems.</p><h3>Graphic Abstract</h3>\u0000 <figure><div><div><div><picture><source><img></source></picture></div></div></div></figure>\u0000 </div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"379 5","pages":""},"PeriodicalIF":8.6,"publicationDate":"2021-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s41061-021-00346-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4524368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Water-Soluble Non-Ionic PEGylated Porphyrins: A Versatile Category of Dyes for Basic Science and Applications 水溶性非离子聚乙二醇化卟啉:基础科学和应用的多用途染料

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2021-08-11 DOI: 10.1007/s41061-021-00348-4

Valentina Villari, Norberto Micali, Angelo Nicosia, Placido Mineo

{"title":"Water-Soluble Non-Ionic PEGylated Porphyrins: A Versatile Category of Dyes for Basic Science and Applications","authors":"Valentina Villari, Norberto Micali, Angelo Nicosia, Placido Mineo","doi":"10.1007/s41061-021-00348-4","DOIUrl":"10.1007/s41061-021-00348-4","url":null,"abstract":"<div><p>This review arises from the need to rationalize the huge amount of information on the structural and spectroscopic properties of a peculiar class of porphyrin derivatives—the non-ionic PEGylated porphyrins—collected during almost two decades of research. The lack of charged groups in the molecular architecture of these porphyrin derivatives is the leitmotif of the work and plays an outstanding role in highlighting those interactions between porphyrins, or between porphyrins and target molecules (e.g., hydrophobic-, hydrogen bond related-, and coordination-interactions, to name just a few) that are often masked by stronger electrostatic contributions. In addition, it is exactly these weaker interactions between porphyrins that make the aggregated forms more prone to couple efficiently with external perturbative fields like weak hydrodynamic vortexes or temperature gradients. In the absence of charge, solubility in water is very often achieved by covalent functionalization of the porphyrin ring with polyethylene glycol chains. Various modifications, including of chain length or the number of chains, the presence of a metal atom in the porphyrin core, or having two or more porphyrin rings in the molecular architecture, result in a wide range of properties. These encompass self-assembly with different aggregate morphology, molecular recognition of biomolecules, and different photophysical responses, which can be translated into numerous promising applications in the sensing and biomedical field, based on turn-on/turn-off fluorescence and on photogeneration of radical species.</p><h3>Graphic Abstract</h3>\u0000 <figure><div><div><div><picture><source><img></source></picture></div></div></div></figure>\u0000 </div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"379 5","pages":""},"PeriodicalIF":8.6,"publicationDate":"2021-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s41061-021-00348-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4447612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Pyrrolidine in Drug Discovery: A Versatile Scaffold for Novel Biologically Active Compounds 吡咯烷在药物发现中的应用:一种新型生物活性化合物的多功能支架

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2021-08-10 DOI: 10.1007/s41061-021-00347-5

Giovanna Li Petri, Maria Valeria Raimondi, Virginia Spanò, Ralph Holl, Paola Barraja, Alessandra Montalbano

{"title":"Pyrrolidine in Drug Discovery: A Versatile Scaffold for Novel Biologically Active Compounds","authors":"Giovanna Li Petri, Maria Valeria Raimondi, Virginia Spanò, Ralph Holl, Paola Barraja, Alessandra Montalbano","doi":"10.1007/s41061-021-00347-5","DOIUrl":"10.1007/s41061-021-00347-5","url":null,"abstract":"<div><p>The five-membered pyrrolidine ring is one of the nitrogen heterocycles used widely by medicinal chemists to obtain compounds for the treatment of human diseases. The great interest in this saturated scaffold is enhanced by (1) the possibility to efficiently explore the pharmacophore space due to sp<sup>3</sup>-hybridization, (2) the contribution to the stereochemistry of the molecule, (3) and the increased three-dimensional (3D) coverage due to the non-planarity of the ring—a phenomenon called “pseudorotation”. In this review, we report bioactive molecules with target selectivity characterized by the pyrrolidine ring and its derivatives, including pyrrolizines, pyrrolidine-2-one, pyrrolidine-2,5-diones and prolinol described in the literature from 2015 to date. After a comparison of the physicochemical parameters of pyrrolidine with the parent aromatic pyrrole and cyclopentane, we investigate the influence of steric factors on biological activity, also describing the structure–activity relationship (SAR) of the studied compounds. To aid the reader’s approach to reading the manuscript, we have planned the review on the basis of the synthetic strategies used: (1) ring construction from different cyclic or acyclic precursors, reporting the synthesis and the reaction conditions, or (2) functionalization of preformed pyrrolidine rings, e.g., proline derivatives. Since one of the most significant features of the pyrrolidine ring is the stereogenicity of carbons, we highlight how the different stereoisomers and the spatial orientation of substituents can lead to a different biological profile of drug candidates, due to the different binding mode to enantioselective proteins. We believe that this work can guide medicinal chemists to the best approach in the design of new pyrrolidine compounds with different biological profiles.</p></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"379 5","pages":""},"PeriodicalIF":8.6,"publicationDate":"2021-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s41061-021-00347-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4409173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 47

Organic-Molecule-Based Fluorescent Chemosensor for Nerve Agents and Organophosphorus Pesticides 基于有机分子的神经毒剂和有机磷农药荧光化学传感器

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2021-08-04 DOI: 10.1007/s41061-021-00345-7

Muskan Gori, Ashima Thakur, Abha Sharma, S. J. S. Flora

{"title":"Organic-Molecule-Based Fluorescent Chemosensor for Nerve Agents and Organophosphorus Pesticides","authors":"Muskan Gori, Ashima Thakur, Abha Sharma, S. J. S. Flora","doi":"10.1007/s41061-021-00345-7","DOIUrl":"10.1007/s41061-021-00345-7","url":null,"abstract":"<div><p>Organophosphorus (OP) compounds are typically a broad class of compounds that possess various uses such as insecticides, pesticides, etc. One of the most evil utilizations of these compounds is as chemical warfare agents, which pose a greater threat than biological weapons because of their ease of access. OP compounds are highly toxic compounds that cause irreversible inhibition of enzyme acetylcholinesterase, which is essential for hydrolysis of neurotransmitter acetylcholine, leading to series of neurological disorders and even death. Due to the extensive use of these organophosphorus compounds in agriculture, there is an increase in the environmental burden of these toxic chemicals, with severe environmental consequences. Hence, the rapid and sensitive, selective, real-time detection of OP compounds is very much required in terms of environmental protection, health, and survival. Several techniques have been developed over a few decades to easily detect them, but still, numerous challenges and problems remain to be solved. Major advancement has been observed in the development of sensors using the spectroscopic technique over recent years because of the advantages offered over other techniques, which we focus on in the presented review.</p><h3>Graphic Abstract</h3>\u0000 <figure><div><div><div><picture><source><img></source></picture></div></div></div></figure>\u0000 </div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":"379 5","pages":""},"PeriodicalIF":8.6,"publicationDate":"2021-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s41061-021-00345-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4149800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Aggregation-Induced Emission in Electrochemiluminescence: Advances and Perspectives 电化学发光中的聚集诱导发射:进展与展望

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2021-06-19 DOI: 10.1007/s41061-021-00343-9

Guillermo Moreno-Alcántar, Alessandro Aliprandi, Luisa De Cola

引用次数: 17

Correction to: Magnetic Nanoparticles as MRI Contrast Agents 修正:磁性纳米颗粒作为MRI造影剂

IF 8.6 2区化学

Topics in Current Chemistry Pub Date : 2021-06-14 DOI: 10.1007/s41061-021-00340-y

Ashish Avasthi, Carlos Caro, Esther Pozo-Torres, Manuel Pernia Leal, María Luisa García-Martín

引用次数: 1