Recent Advances in Palladium-Catalyzed [4 + n] Cycloaddition of Lactones, Benzoxazinanones, Allylic Carbonates, and Vinyloxetanes

IF 8.6 2区化学 Q1 Chemistry

Topics in Current Chemistry Pub Date : 2023-11-03 DOI:10.1007/s41061-023-00442-9

Mengyan Guo, Panke Zhang, Er-Qing Li

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Abstract

Palladium-catalyzed allylation cyclization reaction has recently emerged as an efficient and powerful synthetic platform for the construction of diverse and valuable carbo- and heterocycles. Thus the development of new allylic motifs for achieving this type of transformations in high reactivity and selectivity is of great importance. Generally, these substrates have been utilized as 1,3-, 1,4-, 1,5-, 1,6-dipoles in many reactions, which are applied to prepare highly functionalized products with complete control of chemo-, regio-, diastereo-, and enantioselectivity. In this review, we focus our attention on the development of palladium-catalyzed [4 + n] cycloaddition of allylic motifs and describe a comprehensive and impressive advances in this area. Meanwhile, the related mechanism and the application of these annulation strategies in natural product total synthesis will be highlighted in detail.

Graphical Abstract

Abstract Image

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钯催化的最新进展[4] + n] 内酯、苯并恶嗪酮、烯丙基碳酸酯和乙烯氧杂环丁烷的环加成。

钯催化的烯丙基化环化反应最近成为一种高效而强大的合成平台，用于构建各种有价值的碳环和杂环。因此，开发新的烯丙基基序以实现高反应性和选择性的这种类型的转化是非常重要的。通常，这些底物在许多反应中被用作1,3-、1,4-、1,5-、1,6-极，用于制备高度官能化的产物，并完全控制化学、区域、非对映体和对映选择性。在这篇综述中，我们将注意力集中在钯催化[4]的发展上 + n] 烯丙基基序的环加成，并描述了该领域的全面和令人印象深刻的进展。同时，将详细介绍这些环空策略的相关机理及其在天然产物全合成中的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Topics in Current Chemistry 化学-化学综合

CiteScore

11.70

自引率

1.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Topics in Current Chemistry provides in-depth analyses and forward-thinking perspectives on the latest advancements in chemical research. This renowned journal encompasses various domains within chemical science and their intersections with biology, medicine, physics, and materials science. Each collection within the journal aims to offer a comprehensive understanding, accessible to both academic and industrial readers, of emerging research in an area that captivates a broader scientific community. In essence, Topics in Current Chemistry illuminates cutting-edge chemical research, fosters interdisciplinary collaboration, and facilitates knowledge-sharing among diverse scientific audiences.