Construction of 1,4-Dihydropyridines: The Evolution of C4 Source

IF 8.6 2区化学 Q1 Chemistry

Topics in Current Chemistry Pub Date : 2023-09-25 DOI:10.1007/s41061-023-00440-x

Siyu Song, Yongchao Wang, Fuchao Yu

引用次数: 0

Abstract

The field of cascade cyclization for the construction of 1,4-dihydropyridines (1,4-DHPs) has been continuously expanding during the last decades because of their broad-spectrum biological and synthetic importance. To date, many methods have been developed, mainly including the Hantzsch reaction, Hantzsch-like reaction and newly developed cascade cyclization, in which various synthons have been successively developed as C4 sources of 1,4-DHPs. This review presents the cascade cyclization synthesis strategy for the construction of 1,4-DHPs according to various C4 sources from carbonyl compounds, alkenyl fragments, alcohols, aliphatic amines, glycines and other C4 sources.

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1,4-二氢吡啶的构建：C4来源的演化。

在过去的几十年里，用于构建1,4-二氢吡啶（1,4-DHP）的级联环化领域由于其广谱的生物和合成重要性而不断扩大。到目前为止，已经开发了许多方法，主要包括Hantzsch反应、Hantzsch-like反应和新开发的级联环化，其中各种合成子相继被开发为1,4-DHP的C4来源。本文介绍了从羰基化合物、烯基片段、醇、脂族胺、甘氨酸和其他C4来源构建1,4-DHP的级联环化合成策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Topics in Current Chemistry 化学-化学综合

CiteScore

11.70

自引率

1.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Topics in Current Chemistry provides in-depth analyses and forward-thinking perspectives on the latest advancements in chemical research. This renowned journal encompasses various domains within chemical science and their intersections with biology, medicine, physics, and materials science. Each collection within the journal aims to offer a comprehensive understanding, accessible to both academic and industrial readers, of emerging research in an area that captivates a broader scientific community. In essence, Topics in Current Chemistry illuminates cutting-edge chemical research, fosters interdisciplinary collaboration, and facilitates knowledge-sharing among diverse scientific audiences.