过渡金属催化的嘧啶合成:最新进展、机理、范围和未来展望

IF 8.6 2区 化学 Q1 Chemistry
Vipin K. Maikhuri, Divya Mathur, Ankita Chaudhary, Rajesh Kumar, Virinder S. Parmar, Brajendra K. Singh
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引用次数: 0

摘要

嘧啶是一种具有重要药理作用的分子,具有多种生物活性。本综述反映了过渡金属催化反应在合成嘧啶方面日益重要的作用(没有讨论过渡金属催化的嘧啶官能化)。本文介绍了不同催化剂对嘧啶选择性/产率和催化剂可回收性(如适用)的影响,并试图通过机理说明催化剂的作用。尽管人们已经研究出多种合成这种特殊支架的方法,但仍在大力推广过渡金属催化的、可持续的、高效的和选择性的嘧啶合成策略。作者通过本次更新(2017-2023 年)的目的是推动设计新的过渡金属介导的嘧啶合成方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Transition-Metal Catalyzed Synthesis of Pyrimidines: Recent Advances, Mechanism, Scope and Future Perspectives

Transition-Metal Catalyzed Synthesis of Pyrimidines: Recent Advances, Mechanism, Scope and Future Perspectives

Transition-Metal Catalyzed Synthesis of Pyrimidines: Recent Advances, Mechanism, Scope and Future Perspectives

Pyrimidine is a pharmacologically important moiety that exhibits diverse biological activities. This review reflects the growing significance of transition metal-catalyzed reactions for the synthesis of pyrimidines (with no discussion being made on the transition metal-catalyzed functionalization of pyrimidines). The effect of different catalysts on the selectivity/yields of pyrimidines and catalyst recyclability (wherever applicable) are described, together with attempts to illustrate the role of the catalyst through mechanisms. Although several methods have been researched for synthesizing this privileged scaffold, there has been a considerable push to expand transition metal-catalyzed, sustainable, efficient and selective synthetic strategies leading to pyrimidines. The aim of the authors with this update (2017–2023) is to drive the designing of new transition metal-mediated protocols for pyrimidine synthesis.

Graphical Abstract

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来源期刊
Topics in Current Chemistry
Topics in Current Chemistry 化学-化学综合
CiteScore
11.70
自引率
1.20%
发文量
0
审稿时长
6-12 weeks
期刊介绍: Topics in Current Chemistry provides in-depth analyses and forward-thinking perspectives on the latest advancements in chemical research. This renowned journal encompasses various domains within chemical science and their intersections with biology, medicine, physics, and materials science. Each collection within the journal aims to offer a comprehensive understanding, accessible to both academic and industrial readers, of emerging research in an area that captivates a broader scientific community. In essence, Topics in Current Chemistry illuminates cutting-edge chemical research, fosters interdisciplinary collaboration, and facilitates knowledge-sharing among diverse scientific audiences.
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