Structure-Based Drug Design of RdRp Inhibitors against SARS-CoV-2

IF 8.6 2区化学 Q1 Chemistry

Topics in Current Chemistry Pub Date : 2023-06-15 DOI:10.1007/s41061-023-00432-x

Kiran Shehzadi, Afsheen Saba, Mingjia Yu, Jianhua Liang

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引用次数: 2

Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a worldwide pandemic since 2019, spreading rapidly and posing a significant threat to human health and life. With over 6 billion confirmed cases of the virus, the need for effective therapeutic drugs has become more urgent than ever before. RNA-dependent RNA polymerase (RdRp) is crucial in viral replication and transcription, catalysing viral RNA synthesis and serving as a promising therapeutic target for developing antiviral drugs. In this article, we explore the inhibition of RdRp as a potential treatment for viral diseases, analysing the structural information of RdRp in virus proliferation and summarizing the reported inhibitors’ pharmacophore features and structure–activity relationship profiles. We hope that the information provided by this review will aid in structure-based drug design and aid in the global fight against SARS-CoV-2 infection.

Graphical Abstract

Abstract Image

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基于结构的抗SARS-CoV-2 RdRp抑制剂药物设计

2019年以来，严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)在全球范围内大流行，传播迅速，对人类健康和生命构成重大威胁。由于该病毒确诊病例超过60亿，对有效治疗药物的需求比以往任何时候都更加迫切。RNA依赖性RNA聚合酶(RdRp)在病毒复制和转录中起着至关重要的作用，催化病毒RNA合成，是开发抗病毒药物的一个有希望的治疗靶点。在本文中，我们探讨了抑制RdRp作为一种潜在的病毒性疾病的治疗方法，分析了RdRp在病毒增殖中的结构信息，总结了已报道的抑制剂的药效团特征和构效关系。我们希望本综述提供的信息将有助于基于结构的药物设计，并有助于全球抗击SARS-CoV-2感染。图形抽象

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Topics in Current Chemistry 化学-化学综合

CiteScore

11.70

自引率

1.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Topics in Current Chemistry provides in-depth analyses and forward-thinking perspectives on the latest advancements in chemical research. This renowned journal encompasses various domains within chemical science and their intersections with biology, medicine, physics, and materials science. Each collection within the journal aims to offer a comprehensive understanding, accessible to both academic and industrial readers, of emerging research in an area that captivates a broader scientific community. In essence, Topics in Current Chemistry illuminates cutting-edge chemical research, fosters interdisciplinary collaboration, and facilitates knowledge-sharing among diverse scientific audiences.