探索Horner-Wadsworth-Emmons反应合成聚酮类天然产物的潜力

IF 8.6 2区化学 Q1 Chemistry

Topics in Current Chemistry Pub Date : 2025-04-26 DOI:10.1007/s41061-025-00504-0

Javeria Babar, Sajjad Ahmad, Bushra Parveen, Kulsoom Ghulam Ali, Aqsa Mushtaq, Ameer Fawad Zahoor, Raheel Ahmad, Asim Mansha, Ahmad Irfan

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引用次数: 0

摘要

霍纳-沃兹沃斯-埃蒙斯反应（HWE）是有机化学中一种常用且可靠的碳-碳烯烃反应，它是通过用膦酸酯处理醛或酮来生成取代烯烃而进行的。人们还观察到HWE反应参与了天然化合物的立体控制合成，这些天然化合物获得了治疗各种疾病的药物特征。本文综述了近年来利用霍纳-沃兹沃思-埃蒙斯反应合成天然化合物（如聚酮类化合物）的研究进展。

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Exploring the Synthetic Potential of Horner-Wadsworth-Emmons Reaction Toward the Synthesis of Polyketide Based Natural Products: A Review

The Horner-Wadsworth-Emmons (HWE) reaction is a commonly used and reliable phenomenon for carbon–carbon olefination in organic chemistry, carried out by treating aldehyde or ketones with phosphonate esters to afford the substituted alkenes. HWE reaction has also been observed to be involved in the stereo-controlled syntheses of naturally occurring compounds that acquire pharmaceutical profiles against various diseases. In this article, recent implementations of Horner-Wadsworth-Emmons reaction towards the notable total syntheses of naturally occurring compounds such as polyketides have been summarized.

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来源期刊

Topics in Current Chemistry 化学-化学综合

CiteScore

11.70

自引率

1.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Topics in Current Chemistry provides in-depth analyses and forward-thinking perspectives on the latest advancements in chemical research. This renowned journal encompasses various domains within chemical science and their intersections with biology, medicine, physics, and materials science. Each collection within the journal aims to offer a comprehensive understanding, accessible to both academic and industrial readers, of emerging research in an area that captivates a broader scientific community. In essence, Topics in Current Chemistry illuminates cutting-edge chemical research, fosters interdisciplinary collaboration, and facilitates knowledge-sharing among diverse scientific audiences.