Current Advances in Aptasensors for Pesticide Detection

IF 8.6 2区 化学 Q1 Chemistry
Suthira Pushparajah, Mahnaz Shafiei, Aimin Yu
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引用次数: 0

Abstract

The increasing use of pesticides necessitates the development of innovative analytical methods to regulate environmental impacts and ensure food safety. Aptamer-based sensors hold great promise for pesticide detection owing to their superior selectivity, stability, repeatability, and regenerative capabilities. Integrated with nanomaterials, aptasensors have demonstrated enhanced sensitivity for detecting a broad range of pesticides. This study first introduces the aptamer binding mechanism and presents the fundamental concept and justification for selecting aptamer over other biorecognition molecules. It then provides a comprehensive review of recent advancements and applications of various types of aptasensors for targeted pesticide detection, including electrochemical, fluorescent, colorimetric, electrochemiluminescent, and surface-enhanced Raman scattering (SERS) aptasensors. Additionally, it offers a comparative analysis of different aptasensors by evaluating their strengths and limitations. Finally, this review discusses strategies, such as advanced Systemic Evolution of Ligands by Exponential Enrichment (SELEX) technique, self-assembled monolayers (SAMs), and the use of antifouling agents to improve the aptamer’s selectivity, signal-to-noise ratio, and mitigate nonspecific adsorption challenges. These developments are essential for creating highly sensitive and selective aptasensors, facilitating their practical use in environmental monitoring and food safety.

农药检测适配体传感器的研究进展
农药的使用越来越多,需要开发创新的分析方法来调节环境影响并确保食品安全。基于适配体的传感器由于其优越的选择性、稳定性、可重复性和再生能力,在农药检测中具有很大的前景。与纳米材料相结合,适体传感器在检测多种农药方面表现出更高的灵敏度。本研究首先介绍了适体的结合机制,提出了选择适体而非其他生物识别分子的基本概念和理由。然后,全面回顾了用于农药靶向检测的各种类型的适体传感器的最新进展和应用,包括电化学、荧光、比色、电化学发光和表面增强拉曼散射(SERS)适体传感器。此外,它提供了不同的感应传感器的比较分析,通过评估其优势和局限性。最后,本文讨论了通过指数富集(SELEX)技术实现配体的高级系统进化、自组装单层膜(SAMs)和使用防污剂来提高适配体的选择性、信噪比和减轻非特异性吸附挑战的策略。这些发展对于创造高灵敏度和选择性的适体传感器,促进其在环境监测和食品安全中的实际应用至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Topics in Current Chemistry
Topics in Current Chemistry 化学-化学综合
CiteScore
11.70
自引率
1.20%
发文量
0
审稿时长
6-12 weeks
期刊介绍: Topics in Current Chemistry provides in-depth analyses and forward-thinking perspectives on the latest advancements in chemical research. This renowned journal encompasses various domains within chemical science and their intersections with biology, medicine, physics, and materials science. Each collection within the journal aims to offer a comprehensive understanding, accessible to both academic and industrial readers, of emerging research in an area that captivates a broader scientific community. In essence, Topics in Current Chemistry illuminates cutting-edge chemical research, fosters interdisciplinary collaboration, and facilitates knowledge-sharing among diverse scientific audiences.
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