催化不对称叠氮化的新进展

IF 8.8 2区化学 Q1 Chemistry

Topics in Current Chemistry Pub Date : 2025-09-10 DOI:10.1007/s41061-025-00519-7

Iurre Olaizola, Ana María Ochoa de Retana, Jesús M. de los Santos

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引用次数: 0

摘要

叠氮吡啶是有机化学中最具挑战性和最具吸引力的杂环化合物之一，其在不对称合成、药物化学和材料科学中的应用越来越广泛。这些三元含氮环是合成手性胺、复杂分子和药学相关化合物的关键中间体。本文综述了催化不对称叠氮化的最新进展，重点介绍了新的方法，分析了每种方法的范围和局限性，以及机理见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Recent Developments in Catalytic Asymmetric Aziridination

Aziridines, structurally related to epoxides, are among the most challenging and fascinating heterocycles in organic chemistry due to their increasing applications in asymmetric synthesis, medicinal chemistry, and materials science. These three-membered nitrogen-containing rings serve as key intermediates in the synthesis of chiral amines, complex molecules, and pharmaceutically relevant compounds. This review provides an overview of recent progress in catalytic asymmetric aziridination, focusing on novel methodologies, an analysis of the scope and limitations of each approach, and mechanistic insights.

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来源期刊

Topics in Current Chemistry 化学-化学综合

CiteScore

11.70

自引率

1.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Topics in Current Chemistry provides in-depth analyses and forward-thinking perspectives on the latest advancements in chemical research. This renowned journal encompasses various domains within chemical science and their intersections with biology, medicine, physics, and materials science. Each collection within the journal aims to offer a comprehensive understanding, accessible to both academic and industrial readers, of emerging research in an area that captivates a broader scientific community. In essence, Topics in Current Chemistry illuminates cutting-edge chemical research, fosters interdisciplinary collaboration, and facilitates knowledge-sharing among diverse scientific audiences.