Rational Design and Applications of Ultrasmall Gold Nanoparticles

IF 8.8 2区 化学 Q1 Chemistry
Javad B. M. Parambath, Mahreen Arooj, Kabali Vijai Anand, Sofian Kanan, Ahmed A. Mohamed
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引用次数: 0

Abstract

Controlling the size of gold nanoparticles (AuNPs) has been critical in diagnostics, biomolecular sensing, targeted therapy, wastewater treatment, catalysis, and sensing applications. Ultrasmall AuNPs (uAuNPs), with sizes Ranging from 2 to 5 nm, and gold nanoclusters (AuNCs), with sizes less than 2 nm, are often dealt with interchangeably in the literature, making it challenging to review them separately. Although they are grouped in our discussion, their chemical and physical properties differ significantly, partly due to their electronic properties. The distinct optoelectronic properties of uAuNPs and AuNCs are usually not observed in gold metal and nanoparticles of larger sizes. Since small AuNPs tend to aggregate, several routes have been developed to prevent the formation of larger sizes, such as nucleation within porous materials. Controlling the particle size using synthesis methods is challenging, and uAuNPs and AuNCs can be fabricated simultaneously in the same preparation, necessitating separation and additional laboratory efforts. AuNCs can be stabilized by the prevalent soft ligands, such as phosphine and thiolate, unlike uAuNPs, in which a wide range of ligand sets can be used for stabilization. This review is organized around core sections concerning the synthesis, medical and environmental applications, and calculation studies of uAuNPs. It remains valuable to address the current stimulating market growth and potential market constraints when reviewing the expanding applications of AuNPs in the healthcare sector. A significant proportion of the synthesis processes involve the fabrication of uAuNPs and AuNCs in aqueous solutions. An obvious advantage of this work is that we focus on the medical and environmental applications, which often require water-dispersible nanoparticles. Calculation investigations explain the structural dynamics and importance of fine-tuning the size of uAuNPs to impart distinct properties. A notable control in the HOMO–LUMO energy gap, associated with the number of gold atoms, significantly affects their performance in various applications.

超小金纳米颗粒的合理设计与应用
控制金纳米颗粒(AuNPs)的大小在诊断、生物分子传感、靶向治疗、废水处理、催化和传感应用中至关重要。超小纳米纳米团簇(uAuNPs)的尺寸在2到5纳米之间,而金纳米团簇(AuNCs)的尺寸小于2纳米,在文献中经常被互换处理,这使得将它们分开进行综述变得很有挑战性。虽然它们在我们的讨论中是分组的,但它们的化学和物理性质有很大的不同,部分原因是它们的电子性质。在较大尺寸的金金属和纳米颗粒中通常没有观察到uAuNPs和AuNCs的独特光电特性。由于小的aunp倾向于聚集,因此已经开发了几种途径来防止更大尺寸的形成,例如多孔材料内的成核。使用合成方法控制粒度是具有挑战性的,并且uaunp和aunc可以在同一制备中同时制备,需要分离和额外的实验室工作。aunc可以通过流行的软配体(如膦和硫酸酯)来稳定,不像uaunp,后者可以使用广泛的配体组合来稳定。本综述围绕uunps的合成、医学和环境应用以及计算研究等核心章节进行。在审查医疗保健部门不断扩大的aunp应用时,解决当前刺激的市场增长和潜在的市场限制仍然很有价值。相当大比例的合成过程涉及在水溶液中制备aunps和AuNCs。这项工作的一个明显优势是我们专注于医疗和环境应用,这通常需要水分散纳米颗粒。计算研究解释了结构动力学和微调uunps的大小以赋予不同性质的重要性。HOMO-LUMO能隙的显著控制与金原子的数量有关,显著影响其在各种应用中的性能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Topics in Current Chemistry
Topics in Current Chemistry 化学-化学综合
CiteScore
11.70
自引率
1.20%
发文量
0
审稿时长
6-12 weeks
期刊介绍: Topics in Current Chemistry provides in-depth analyses and forward-thinking perspectives on the latest advancements in chemical research. This renowned journal encompasses various domains within chemical science and their intersections with biology, medicine, physics, and materials science. Each collection within the journal aims to offer a comprehensive understanding, accessible to both academic and industrial readers, of emerging research in an area that captivates a broader scientific community. In essence, Topics in Current Chemistry illuminates cutting-edge chemical research, fosters interdisciplinary collaboration, and facilitates knowledge-sharing among diverse scientific audiences.
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