Antioxidants最新文献_第2页

Antioxidant and Anti-Inflammatory Effects of Opuntia Extracts on a Model of Diet-Induced Steatosis. 鸦胆子提取物对饮食诱发脂肪肝模型的抗氧化和抗炎作用

IF 6 2区医学

Antioxidants Pub Date : 2024-11-19 DOI: 10.3390/antiox13111416

Irene Besné-Eseverri, María Ángeles Martín, Gloria Lobo, M Pilar Cano, María P Portillo, Jenifer Trepiana

{"title":"Antioxidant and Anti-Inflammatory Effects of Opuntia Extracts on a Model of Diet-Induced Steatosis.","authors":"Irene Besné-Eseverri, María Ángeles Martín, Gloria Lobo, M Pilar Cano, María P Portillo, Jenifer Trepiana","doi":"10.3390/antiox13111416","DOIUrl":"10.3390/antiox13111416","url":null,"abstract":"Oxidative stress and inflammation are widely recognised as factors that can initiate and facilitate the development of MAFLD. The aim of this study is to analyse the effect of low and high doses of Opuntia stricta var. dillenii peel extract (L-OD and H-OD, respectively) and Opuntia ficus-indica var. colorada pulp extract (L-OFI and H-OFI, respectively), which are rich in betalains and phenolic compounds, on oxidative stress, inflammation, DNA damage and apoptosis in rat livers with diet-induced steatosis. Steatotic diet led to increased final body and liver weight, serum transaminases, hepatic TG content, oxidative status and cell death. H-OFI treatment decreased serum AST levels, while L-OFI reduced hepatic TG accumulation. Oxidative stress was partially prevented with H-OD and H-OFI supplementation, and pro-inflammatory cytokines levels were especially improved with H-OFI treatment. Moreover, H-OFI appears to prevent DNA damage markers. Finally, H-OD and L-OFI supplementation down-regulated the apoptotic pathway. In conclusion, both H-OD and H-OFI supplementation were effective in regulating the progression to metabolic steatohepatitis, triggering different mechanisms of action.","PeriodicalId":7984,"journal":{"name":"Antioxidants","volume":"13 11","pages":""},"PeriodicalIF":6.0,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11591152/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142724749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Edible Coatings for Fish Preservation: Literature Data on Storage Temperature, Product Requirements, Antioxidant Activity, and Coating Performance-A Review. 用于鱼类保鲜的可食用涂层：有关储存温度、产品要求、抗氧化活性和涂层性能的文献数据--综述。

IF 6 2区医学

Antioxidants Pub Date : 2024-11-19 DOI: 10.3390/antiox13111417

Mia Kurek, Petra Pišonić, Mario Ščetar, Tibor Janči, Iva Čanak, Sanja Vidaček Filipec, Nasreddine Benbettaieb, Frédéric Debeaufort, Kata Galić

{"title":"Edible Coatings for Fish Preservation: Literature Data on Storage Temperature, Product Requirements, Antioxidant Activity, and Coating Performance-A Review.","authors":"Mia Kurek, Petra Pišonić, Mario Ščetar, Tibor Janči, Iva Čanak, Sanja Vidaček Filipec, Nasreddine Benbettaieb, Frédéric Debeaufort, Kata Galić","doi":"10.3390/antiox13111417","DOIUrl":"10.3390/antiox13111417","url":null,"abstract":"Fresh fish is among the most nutritive foodstuffs, but it is also the most perishable one. Therefore, huge efforts have been made to find the most suitable tools to deliver fish of the highest quality to exigent consumers. Scientific studies help the industry to exploit the newest findings to scale up emerging industrial technologies. In this review article, the focus is on the latest scientific findings on edible films used for fish coatings and storage. Since today's packaging processing and economy are governed by sustainability, naturality underpins packaging science. The synthesis of edible coatings, their components, processing advantages, and disadvantages are outlined with respect to the preservation requirements for sensitive fish. The requirements of coating properties are underlined for specific scenarios distinguishing cold and freezing conditions. This review raises the importance of antioxidants and their role in fish storage and preservation. A summary of their impact on physical, chemical, microbiological, and sensory alterations upon application in real fish is given. Studies on their influence on product stability, including pro-oxidant activity and the prevention of the autolysis of fish muscle, are given. Examples of lipid oxidation and its inhibition by the antioxidants embedded in edible coatings are given together with the relationship to the development of off-odors and other unwanted impacts. This review selects the most significant and valuable work performed in the past decade in the field of edible coatings whose development is on the global rise and adheres to food waste and sustainable development goals 2 (zero hunger), 3 (good health and well-being), and 12 (responsible consumption and production).","PeriodicalId":7984,"journal":{"name":"Antioxidants","volume":"13 11","pages":""},"PeriodicalIF":6.0,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11591116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142725140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Green Recovery and Identification of Antioxidant and Enzyme Inhibitor Molecules from Pisco Grape Pomace by Targeted Effects Analysis Using Thin-Layer Chromatography, Bioassay, and Mass Spectrometry. 利用薄层色谱法、生物测定法和质谱法进行靶向效应分析，从皮斯科葡萄渣中绿色回收并鉴定抗氧化剂和酶抑制剂分子。

IF 6 2区医学

Antioxidants Pub Date : 2024-11-19 DOI: 10.3390/antiox13111418

Jacqueline Poblete, Joaquín Fernández-Martínez, Mario Aranda, Issis Quispe-Fuentes

{"title":"Green Recovery and Identification of Antioxidant and Enzyme Inhibitor Molecules from Pisco Grape Pomace by Targeted Effects Analysis Using Thin-Layer Chromatography, Bioassay, and Mass Spectrometry.","authors":"Jacqueline Poblete, Joaquín Fernández-Martínez, Mario Aranda, Issis Quispe-Fuentes","doi":"10.3390/antiox13111418","DOIUrl":"10.3390/antiox13111418","url":null,"abstract":"The search and identification of inhibitory molecules from novel natural sources, such as pisco grape pomace extract obtained by green techniques, may help to develop agents with therapeutic potential that are beneficial to health with fewer adverse effects than drugs. Many drugs act as enzyme inhibitors, decreasing their activity and thus correcting a metabolic imbalance. This study aims to identify bioactive molecules with antioxidant and inhibitory activity over acetylcholinesterase and cyclooxygenase enzymes present in pisco grape pomace green extracts. Bioactive molecules were detected and identified applying directed effect analysis on planar chromatography coupled to mass spectrometry. For the first time, the presence of antioxidant molecules (quercetin-3-O-glucuronide, quercetin-3-O-glucoside, and gallic acid) and inhibitors of acetylcholinesterase (kaempferol-3-O-glucoside) and cyclooxygenase (gallic acid) enzymes are reported in pisco grape pomace. According to the results, grape pomace could be an alternative to develop novel functional foods and nutraceuticals that provide health benefits and, at the same time, generate a circular economy in the industry.","PeriodicalId":7984,"journal":{"name":"Antioxidants","volume":"13 11","pages":""},"PeriodicalIF":6.0,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11591367/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142724988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective Contribution of Rosmarinic Acid in Rosemary Extract Against Copper-Induced Oxidative Stress. 迷迭香提取物中的迷迭香酸对铜诱导的氧化应激的保护作用

IF 6 2区医学

Antioxidants Pub Date : 2024-11-19 DOI: 10.3390/antiox13111419

Arian Kola, Ginevra Vigni, Stefania Lamponi, Daniela Valensin

{"title":"Protective Contribution of Rosmarinic Acid in Rosemary Extract Against Copper-Induced Oxidative Stress.","authors":"Arian Kola, Ginevra Vigni, Stefania Lamponi, Daniela Valensin","doi":"10.3390/antiox13111419","DOIUrl":"10.3390/antiox13111419","url":null,"abstract":"Rosemary extract (Rosmarinus officinalis) is a natural source of bioactive compounds with significant antioxidant properties. Among these, rosmarinic acid is celebrated for its potent antioxidant, anti-inflammatory, antimicrobial, and neuroprotective properties, making it a valuable component in both traditional medicine and modern therapeutic research. Neurodegenerative diseases like Alzheimer's and Parkinson's are closely linked to oxidative damage, and research indicates that rosmarinic acid may help protect neurons by mitigating this harmful process. Rosmarinic acid is able to bind cupric ions (Cu2+) and interfere with the production of reactive oxygen species (ROS) produced by copper through Fenton-like reactions. This study aims to further evaluate the contribution of rosmarinic acid within rosemary extract by comparing its activity to that of isolated rosmarinic acid. By using a detailed approach that includes chemical characterization, antioxidant capacity assessment, and neuroprotective activity testing, we have determined whether the combined components in rosemary extract enhance or differ from the effects of rosmarinic acid alone. This comparison is crucial for understanding whether the full extract offers added benefits beyond those of isolated rosmarinic acid in combating oxidative stress and Aβ-induced toxicity.","PeriodicalId":7984,"journal":{"name":"Antioxidants","volume":"13 11","pages":""},"PeriodicalIF":6.0,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11590892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142725122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nitroxyl Hybrids with Curcumin and Stilbene Scaffolds Display Potent Antioxidant Activity, Remodel the Amyloid Beta Oligomer, and Reverse Amyloid Beta-Induced Cytotoxicity. 具有姜黄素和芪萜支架的硝基杂化物显示出强大的抗氧化活性、重塑淀粉样β寡聚体并逆转淀粉样β诱导的细胞毒性。

IF 6 2区医学

Antioxidants Pub Date : 2024-11-18 DOI: 10.3390/antiox13111411

Madhu S Budamagunta, Hidetoshi Mori, Joshua Silk, Ryan R Slez, Balázs Bognár, Ulises Ruiz Mendiola, Tamás Kálai, Izumi Maezawa, John C Voss

{"title":"Nitroxyl Hybrids with Curcumin and Stilbene Scaffolds Display Potent Antioxidant Activity, Remodel the Amyloid Beta Oligomer, and Reverse Amyloid Beta-Induced Cytotoxicity.","authors":"Madhu S Budamagunta, Hidetoshi Mori, Joshua Silk, Ryan R Slez, Balázs Bognár, Ulises Ruiz Mendiola, Tamás Kálai, Izumi Maezawa, John C Voss","doi":"10.3390/antiox13111411","DOIUrl":"10.3390/antiox13111411","url":null,"abstract":"The disorder and heterogeneity of low-molecular-weight amyloid-beta oligomers (AβOs) underlie their participation in multiple modes of cellular dysfunction associated with the etiology of Alzheimer's disease (AD). The lack of specified conformational states in these species complicates efforts to select or design small molecules to targeting discrete pathogenic states. Furthermore, targeting AβOs alone may be therapeutically insufficient, as AD progresses as a multifactorial, self-amplifying cascade. To address these challenges, we have screened the activity of seven new candidates that serve as Paramagnetic Amyloid Ligand (PAL) candidates. PALs are bifunctional small molecules that both remodel the AβO structure and localize a potent antioxidant that mimics the activity of SOD within live cells. The candidates are built from either a stilbene or curcumin scaffold with nitroxyl moiety to serve as catalytic antioxidants. Measurements of PAL AβO binding and remolding along with assessments of bioactivity allow for the extraction of useful SAR information from screening data. One candidate (HO-4450; PMT-307), with a six-membered nitroxyl ring attached to a stilbene ring, displays the highest potency in protecting against cell-derived Aβ. A preliminary low-dose evaluation in AD model mice provides evidence of modest treatment effects by HO-4450. The results for the curcumin PALs demonstrate that the retention of the native curcumin phenolic groups is advantageous to the design of the hybrid PAL candidates. Finally, the PAL remodeling of AβO secondary structures shows a reasonable correlation between a candidate's bioactivity and its ability to reduce the fraction of antiparallel β-strand.","PeriodicalId":7984,"journal":{"name":"Antioxidants","volume":"13 11","pages":""},"PeriodicalIF":6.0,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11591036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142724632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determination of the Botanical Origin and Physicochemical Properties of a Propolis Sample Through an Integrated Methodology. 通过综合方法确定蜂胶样品的植物来源和理化性质

IF 6 2区医学

Antioxidants Pub Date : 2024-11-18 DOI: 10.3390/antiox13111412

Jose Juan Alcivar-Saldaña, Marco Aurelio Rodriguez-Monroy, Arturo Aguirre-Gómez, Liborio Carrillo-Miranda, Benjamin Velasco-Bejarano, Maria Margarita Canales-Martinez

{"title":"Determination of the Botanical Origin and Physicochemical Properties of a Propolis Sample Through an Integrated Methodology.","authors":"Jose Juan Alcivar-Saldaña, Marco Aurelio Rodriguez-Monroy, Arturo Aguirre-Gómez, Liborio Carrillo-Miranda, Benjamin Velasco-Bejarano, Maria Margarita Canales-Martinez","doi":"10.3390/antiox13111412","DOIUrl":"10.3390/antiox13111412","url":null,"abstract":"The growing interest in products of natural origin has led to the implementation of products such as propolis because they possess biological properties that are useful in the treatment of various ailments, so it is relevant to know the botanical origin of the physicochemical compounds that provide propolis with its biological properties. To identify the floral sources that provide resources to bees for the manufacture of propolis, several methodologies have been implemented, such as palynological analysis, which, through pollen content, has made it possible to identify the plant species that provide resources to bees. On the other hand, analysis of the physicochemical components of propolis has revealed that phenols and flavonoids are mainly responsible for the biological activity of propolis. Evaluation of the antibacterial and antifungal potential of propolis revealed the inhibitory potential of both Gram (+) and Gram (-) bacteria, as well as Candida albicans. However, all these investigations have been carried out individually and not always with the same sample. Therefore, the objective of this research was to design a methodology that allows the use of a single sample of propolis and uses sufficient resources for different research areas to evaluate most of the physical and chemical properties of propolis, as well as its botanical origin. With the implemented methodology, it was possible to obtain sufficient resources that provided results for each of the research areas, taking advantage of the propolis sample.","PeriodicalId":7984,"journal":{"name":"Antioxidants","volume":"13 11","pages":""},"PeriodicalIF":6.0,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11591193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142725157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Imeglimin Halts Liver Damage by Improving Mitochondrial Dysfunction in a Nondiabetic Male Mouse Model of Metabolic Dysfunction-Associated Steatohepatitis. Imeglimin 通过改善代谢功能障碍相关性脂肪性肝炎非糖尿病雄性小鼠模型中的线粒体功能障碍来阻止肝损伤。

IF 6 2区医学

Antioxidants Pub Date : 2024-11-18 DOI: 10.3390/antiox13111415

Kosuke Kaji, Soichi Takeda, Satoshi Iwai, Norihisa Nishimura, Shinya Sato, Tadashi Namisaki, Takemi Akahane, Hitoshi Yoshiji

{"title":"Imeglimin Halts Liver Damage by Improving Mitochondrial Dysfunction in a Nondiabetic Male Mouse Model of Metabolic Dysfunction-Associated Steatohepatitis.","authors":"Kosuke Kaji, Soichi Takeda, Satoshi Iwai, Norihisa Nishimura, Shinya Sato, Tadashi Namisaki, Takemi Akahane, Hitoshi Yoshiji","doi":"10.3390/antiox13111415","DOIUrl":"10.3390/antiox13111415","url":null,"abstract":"Imeglimin promotes glucose-stimulated insulin secretion in the pancreas in a glucose-dependent manner and inhibits gluconeogenesis in the liver. Meanwhile, imeglimin can improve mitochondrial function in hepatocytes. We used a nondiabetic metabolic dysfunction-associated steatohepatitis (MASH) model to examine the effects of imeglimin on MASH independent of its glucose-lowering action. Mice fed a choline-deficient high-fat diet (CDA-HFD) were orally administered imeglimin (100 and 200 mg/kg twice daily), and MASH pathophysiology was evaluated after 8 weeks. Moreover, an in vitro study investigated the effects of imeglimin on palmitic acid (PA)-stimulated lipid accumulation, apoptosis, and mitochondrial dysfunction in human hepatocytes. CDA-HFD-fed mice showed hepatic steatosis, inflammation, and fibrosis without hyperglycemia. Imeglimin reduced hepatic steatosis in response to increased expression of β-oxidation-related markers. Imeglimin reduced reactive oxygen species accumulation and increased mitochondrial biogenesis in CDA-HFD-fed mice. Consequently, imeglimin suppressed hepatocyte apoptosis and decreased macrophage infiltration with reduced proinflammatory cytokine expression, suppressing hepatic fibrosis development. PA-stimulated hepatocytes induced lipogenesis, inflammatory cytokine production, and apoptosis, which were significantly suppressed by imeglimin. In mitochondrial function, imeglimin improved PA-stimulated decrease in mitochondrial membrane potential, mitochondrial complexes activity, oxygen consumption rate, and mitochondrial biogenesis marker expression. In conclusion, imeglimin could contribute to prevention of MASH progression through suppressing de novo lipogenesis and enhancing fatty acid oxidation.","PeriodicalId":7984,"journal":{"name":"Antioxidants","volume":"13 11","pages":""},"PeriodicalIF":6.0,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11591211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142724973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

N-3 Fatty Acids in Seafood Influence the Association Between the Composite Dietary Antioxidant Index and Depression: A Community-Based Prospective Cohort Study. 海产品中的 N-3 脂肪酸影响膳食抗氧化剂综合指数与抑郁症之间的关系：一项基于社区的前瞻性队列研究。

IF 6 2区医学

Antioxidants Pub Date : 2024-11-18 DOI: 10.3390/antiox13111413

Junhwi Moon, Minji Kim, Yangha Kim

{"title":"N-3 Fatty Acids in Seafood Influence the Association Between the Composite Dietary Antioxidant Index and Depression: A Community-Based Prospective Cohort Study.","authors":"Junhwi Moon, Minji Kim, Yangha Kim","doi":"10.3390/antiox13111413","DOIUrl":"10.3390/antiox13111413","url":null,"abstract":"Accumulating evidence suggests that seafood and its components, such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are associated with mental health. However, little is known regarding whether the status of n-3 polyunsaturated fatty acids (PUFAs) modify the effect of dietary antioxidants on depression. The main purpose of study is to investigate longitudinal associations between seafood consumption and depression among 2564 participants aged 40-69 years using data from the Korean Genome and Epidemiology Study. The composite dietary antioxidant index (CDAI) and dietary intake were measured by a validated 106-item food frequency questionnaire and depression was assessed using the Beck Depression Inventory (BDI). The Cox's proportional hazard model was used to examine the risk of depression according to seafood consumption. During an 8-year follow-up period, 165 (11.9%) men and 224 (18.9%) women experienced depression. After adjustment for confounders, the risk of depression was inversely associated with seafood consumption, with a 42% lower risk (HR T5 vs. T1 = 0.58, 95% CI: 0.35-0.98, p = 0.040) only being found among women. In a group with a high n-3 PUFA intake, CDAI scores were negatively correlated with BDI scores (r = -0.146, p < 0.001) among women. Seafood consumption might lead to more favorable outcomes against depression if accompanied by an increased intake of foods that are rich in antioxidants.","PeriodicalId":7984,"journal":{"name":"Antioxidants","volume":"13 11","pages":""},"PeriodicalIF":6.0,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11591020/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142725010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Mahmoud et al. Coriander Oil Reverses Dexamethasone-Induced Insulin Resistance in Rats. Antioxidants 2022, 11, 441. 更正：Mahmoud 等人，《芫荽油能逆转地塞米松诱导的大鼠胰岛素抵抗》。Antioxidants 2022, 11, 441.

IF 6 2区医学

Antioxidants Pub Date : 2024-11-18 DOI: 10.3390/antiox13111410

Mona F Mahmoud, Noura Ali, Islam Mostafa, Rehab A Hasan, Mansour Sobeh

引用次数: 0

Exogenous GABA-Ca Alleviates Growth Inhibition Induced by a Low-P Environment in Peanuts (Arachis hypogaea). 外源 GABA-Ca 可缓解花生（Arachis hypogaea）在低 P 环境中的生长抑制。

IF 6 2区医学

Antioxidants Pub Date : 2024-11-18 DOI: 10.3390/antiox13111414

Zhiyu Sun, Mingzhu Ma, Huan Liu, Dongbing Tao, Shaikh Amjad Salam, Xiaori Han, Yifei Liu, Jean Wan Hong Yong

{"title":"Exogenous GABA-Ca Alleviates Growth Inhibition Induced by a Low-P Environment in Peanuts (Arachis hypogaea).","authors":"Zhiyu Sun, Mingzhu Ma, Huan Liu, Dongbing Tao, Shaikh Amjad Salam, Xiaori Han, Yifei Liu, Jean Wan Hong Yong","doi":"10.3390/antiox13111414","DOIUrl":"10.3390/antiox13111414","url":null,"abstract":"Phosphorus (P) deficiency is a major global factor constraining peanut production. Exogenous γ-aminobutyric acid (GABA) and Ca2+ are essential to improve stress resilience in peanuts growing under low-P conditions. This study therefore examined the detailed physiological effects of GABA-Ca on restoring peanut growth under low-P conditions. These included the root-shoot ratio, leaf nutrients, photochemical activity, reactive oxygen species (ROS), cyclic electron flow (CEF), ATP synthase activity, and the proton gradient (∆pH), all of which were measured under low-P (LP, 0.5 mM) and optimized-P (1 mM) conditions. Specifically, supplying GABA-Ca under LP conditions regulated the ∆pH by causing adjustments in CEF and ATP synthase activities, buffering the photosystems' activities, restoring the antioxidant enzyme system, and lowering ROS production. Interestingly, exogenous GABA-Ca restored peanut growth under low-P conditions, possibly by the putative signaling crosstalk between GABA and Ca2+. The plausible signal amplification between GABA and Ca2+ suggested that the combination of GABA and Ca, may offer an effective strategy for enhancing peanut adaptation to low-P conditions. Moving forward, the strategic supplementation of GABA-Ca, either during cultivation or through the formulation of novel fertilizers, opens up many possibilities for better and more resilient plant production in soils with low P.","PeriodicalId":7984,"journal":{"name":"Antioxidants","volume":"13 11","pages":""},"PeriodicalIF":6.0,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11590983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142724448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0