Aerobic Exercise Alleviates Cardiac Dysfunction Correlated with Lipidomics and Mitochondrial Quality Control.

IF 6 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Kunzhe Li, Sujuan Li, Hao Jia, Yinping Song, Zhixin Chen, Youhua Wang
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Abstract

Cardiac adaptations induced by aerobic exercise have been shown to reduce the risk of cardiovascular disease, and the autonomic nervous system is closely associated with the development of cardiovascular disease. Aerobic exercise intervention has been shown to enhance cardiac function and mitigate myocardial fibrosis and hypertrophy in heart failure mice. Further insights reveal that cardiomyocytes experiencing chronic heart failure undergo modifications in their lipidomic profile, including remodeling of multiple myocardial membrane phospholipids. Notably, there is a decrease in the total content of cardiolipin, as well as in the levels of total lysolipid CL and the CL (22:6). These alterations disrupt mitochondrial quality control processes, leading to abnormal expressions of proteins such as Drp1, MFN2, OPA1, and BNIP3, thereby resulting in a disrupted mitochondrial dynamic network. Whereas aerobic exercise ameliorated mitochondrial damage to a large extent by activating parasympathetic nerves, this beneficial effect was accomplished by modulating myocardial membrane phospholipid remodeling and restoring the mitochondrial dynamic network. In conclusion, aerobic exercise activated the parasympathetic state in mice and attenuated lipid peroxidation and oxidative stress injury, thereby maintaining mitochondrial dynamic homeostasis and improving cardiac function.

有氧运动减轻心功能障碍与脂质组学和线粒体质量控制相关。
有氧运动诱导的心脏适应已被证明可以降低心血管疾病的风险,而自主神经系统与心血管疾病的发生密切相关。有氧运动干预已被证明可以增强心力衰竭小鼠的心功能,减轻心肌纤维化和肥厚。进一步的研究表明,经历慢性心力衰竭的心肌细胞会经历脂质组学特征的改变,包括多种心肌膜磷脂的重塑。值得注意的是,心磷脂的总含量以及总溶脂CL和CL的水平都有所下降(22:6)。这些改变破坏了线粒体质量控制过程,导致Drp1、MFN2、OPA1和BNIP3等蛋白的异常表达,从而导致线粒体动态网络被破坏。尽管有氧运动通过激活副交感神经在很大程度上改善了线粒体损伤,但这种有益效果是通过调节心肌膜磷脂重塑和恢复线粒体动态网络来实现的。综上所述,有氧运动激活小鼠副交感神经状态,减轻脂质过氧化和氧化应激损伤,从而维持线粒体动态稳态,改善心功能。
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来源期刊
Antioxidants
Antioxidants Biochemistry, Genetics and Molecular Biology-Physiology
CiteScore
10.60
自引率
11.40%
发文量
2123
审稿时长
16.3 days
期刊介绍: Antioxidants (ISSN 2076-3921), provides an advanced forum for studies related to the science and technology of antioxidants. It publishes research papers, reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.
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