Unlocking the Power of Magnesium: A Systematic Review and Meta-Analysis Regarding Its Role in Oxidative Stress and Inflammation.

IF 6 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Antioxidants Pub Date : 2025-06-16 DOI:10.3390/antiox14060740

Violeta Cepeda, Marina Ródenas-Munar, Silvia García, Cristina Bouzas, Josep A Tur

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Abstract

Magnesium plays a crucial role in over 300 enzymatic reactions related to energy production, muscle contraction, and nerve function. Given its essential biological functions and increasing prevalence of suboptimal intake, magnesium supplementation has gained attention for its potential health benefits, particularly in mitigating oxidative stress and inflammation. This systematic review and meta-analysis aimed to evaluate the antioxidant effects of dietary and supplemental magnesium on several biomarkers related to oxidative stress and inflammation. A systematic search of studies published from 2000 to 2025 identified 28 relevant articles, including both animal and human studies. The meta-analysis assessed the effects of magnesium supplementation on oxidative stress biomarkers such as nitric oxide (NO), total antioxidant capacity (TAC), malondialdehyde (MDA), glutathione (GSH), and C-reactive protein (CRP). While results showed a statistically significant reduction in CRP levels, suggesting an anti-inflammatory effect, no conclusive impact on oxidative stress biomarkers was observed. The findings highlight magnesium's potential role in inflammation regulation, though its direct antioxidant effects remain uncertain. Further high-quality clinical trials are needed to clarify the impact of magnesium supplementation on oxidative stress and to explore its broader health implications.

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解锁镁的力量：关于其在氧化应激和炎症中的作用的系统回顾和荟萃分析。

镁在300多种与能量产生、肌肉收缩和神经功能有关的酶促反应中起着至关重要的作用。鉴于其重要的生物学功能和日益普遍的次优摄入量，镁补充剂因其潜在的健康益处而受到关注，特别是在减轻氧化应激和炎症方面。本系统综述和荟萃分析旨在评估膳食和补充镁对几种与氧化应激和炎症相关的生物标志物的抗氧化作用。对2000年至2025年发表的研究进行了系统检索，确定了28篇相关文章，包括动物和人类研究。荟萃分析评估了镁补充剂对氧化应激生物标志物的影响，如一氧化氮（NO）、总抗氧化能力（TAC）、丙二醛（MDA）、谷胱甘肽（GSH）和c反应蛋白（CRP）。虽然结果显示统计上显著降低CRP水平，表明抗炎作用，但未观察到对氧化应激生物标志物的决定性影响。研究结果强调了镁在炎症调节中的潜在作用，尽管其直接抗氧化作用仍不确定。需要进一步的高质量临床试验来阐明镁补充剂对氧化应激的影响，并探索其更广泛的健康影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Antioxidants Biochemistry, Genetics and Molecular Biology-Physiology

CiteScore

10.60

自引率

11.40%

发文量

2123

审稿时长

16.3 days

期刊介绍： Antioxidants (ISSN 2076-3921), provides an advanced forum for studies related to the science and technology of antioxidants. It publishes research papers, reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.