产前缺氧后心肌病发生的分子生化机制——以NO系统为中心。

IF 6 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Olena Popazova, Igor Belenichev, Nina Bukhtiyarova, Victor Ryzhenko, Nadia Gorchakova, Valentyn Oksenych, Oleksandr Kamyshnyi
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引用次数: 0

摘要

产前缺氧(PH)对胎儿心脏的发育有不利影响,有助于产后生活中持续的心血管损伤。调节心脏生理的一个关键组成部分是一氧化氮(NO)系统,它在发育过程中影响血管张力、心肌收缩力和内皮完整性。暴露于PH会破坏no相关的信号通路,导致内皮功能障碍、线粒体损伤和氧化应激升高,所有这些都会加剧心脏损伤并引发心肌细胞凋亡。过量生成活性氮驱动亚硝化应激,从而加剧炎症过程和细胞损伤。此外,NO和缺氧诱导因子(HIF)之间的相互作用形成了对ph的适应性反应。NO还调节热休克蛋白70 (HSP70)的合成,HSP70是细胞防御应激的关键因素。这篇综述强调了一氧化氮在PH引起的心血管损伤中的作用,并研究了一氧化氮调节剂——血管素、硫三唑啉、米屈膦酸盐和l -精氨酸——作为前瞻性治疗药物的心脏保护潜力。这些药物可以降低氧化应激,增强内皮细胞的功能,减轻PH对心脏的有害影响,为预防产前缺氧的后代心血管疾病提供了潜在的新策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Molecular and Biochemical Mechanisms of Cardiomyopathy Development Following Prenatal Hypoxia-Focus on the NO System.

Prenatal hypoxia (PH) adversely affects the development of the fetal heart, contributing to persistent cardiovascular impairments in postnatal life. A key component in regulating cardiac physiology is the nitric oxide (NO) system, which influences vascular tone, myocardial contractility, and endothelial integrity during development. Exposure to PH disrupts NO-related signaling pathways, leading to endothelial dysfunction, mitochondrial damage, and an escalation of oxidative stress-all of which exacerbate cardiac injury and trigger cardiomyocyte apoptosis. The excessive generation of reactive nitrogen species drives nitrosative stress, thereby intensifying inflammatory processes and cellular injury. In addition, the interplay between NO and hypoxia-inducible factor (HIF) shapes adaptive responses to PH. NO also modulates the synthesis of heat shock protein 70 (HSP70), a critical factor in cellular defense against stress. This review emphasizes the involvement of NO in cardiovascular injury caused by PH and examines the cardioprotective potential of NO modulators-Angiolin, Thiotriazoline, Mildronate, and L-arginine-as prospective therapeutic agents. These agents reduce oxidative stress, enhance endothelial performance, and alleviate the detrimental effects of PH on the heart, offering potential new strategies to prevent cardiovascular disorders in offspring subjected to prenatal hypoxia.

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来源期刊
Antioxidants
Antioxidants Biochemistry, Genetics and Molecular Biology-Physiology
CiteScore
10.60
自引率
11.40%
发文量
2123
审稿时长
16.3 days
期刊介绍: Antioxidants (ISSN 2076-3921), provides an advanced forum for studies related to the science and technology of antioxidants. It publishes research papers, reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.
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