Antioxidants最新文献

{"title":"Fatty Acid Profile and Some Useful Biological Aspects of Borage, Calophyllum, and Prickly Pear Seed Oils: Implications for Health and Dietary Use.","authors":"Florinda Fratianni, Francesca Coppola, Siria Tavaniello, Maria Neve Ombra, Beatrice De Giulio, Nunzio D'Agostino, Gokhan Zengin, Raffaele Coppola, Filomena Nazzaro","doi":"10.3390/antiox14060661","DOIUrl":"10.3390/antiox14060661","url":null,"abstract":"<p><p>Seed oils from <i>Borago officinalis</i> (borage), <i>Opuntia ficus-indica</i> (prickly pear), and <i>Calophyllum inophyllum</i> (calophyllum or tamanu) are rich in bioactive fatty acids and have been traditionally used in cosmetic and industrial sectors. This study explored their fatty acid composition and investigated their in vitro antioxidant, anti-arthritic, neuroprotective, and antibiofilm activities. Fatty acid profiles were determined via gas chromatography. Antioxidant activity was assessed using DPPH and ABTS radical scavenging assays. Anti-arthritic potential was measured via bovine serum albumin denaturation. Neuroprotective properties were evaluated through acetylcholinesterase, butirylcholinesterase, and tyrosinase inhibition. Antibiofilm activity against five pathogenic strains was analyzed using crystal violet and MTT assays. Correlation analysis was used to associate fatty acid composition with bioactivity. Prickly pear oil exhibited the highest PUFA content (65.1%), mainly linoleic acid. Calophyllum oil was richer in saturated and monounsaturated fatty acids. All oils showed significant radical scavenging ability, with calophyllum oil showing the lowest DPPH IC₅₀ and borage oil, the highest ABTS activity. Borage and prickly pear oils demonstrated strong anti-arthritic potential. Calophyllum oil showed the most potent AChE inhibition. All oils showed tyrosinase inhibition; however, calophyllum did not show BChE inhibitory activity. Antibiofilm activity was species- and dose-dependent, with <i>Staphylococcus aureus</i>, <i>Escherichia coli</i>, and <i>Acinetobacter baumannii</i> being most affected. Thus, the tested oils exhibited multiple biological activities, influenced by their fatty acid composition. The in vitro antioxidant, anti-arthritic, neuroprotective, and antimicrobial properties support their potential use as functional food ingredients or nutraceuticals, especially for aging-related health concerns. Further in vivo and clinical studies are needed to confirm their efficacy.</p>","PeriodicalId":7984,"journal":{"name":"Antioxidants","volume":"14 6","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12189715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144493674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated Transcriptome and Metabolome Analyses Reveal Complex Oxidative Damage Mechanisms in Rice Seedling Roots Under Different Carbonate Stresses.","authors":"Yang Cao, Fei Hao, Jingpeng Li, Bolun Zhang, Zeming Li, Tiantian Liu, Yan Gao, Xuguang Niu, Xiaohu Liu, Hui Zhang, Lijuan Yang","doi":"10.3390/antiox14060658","DOIUrl":"10.3390/antiox14060658","url":null,"abstract":"<p><p>Alkaline stress (AS) is one of the major threats that severely affects rice growth and grain yield. However, the differences in the damage caused by the main components of soda saline-alkali land, sodium carbonate (Na₂CO₃), and sodium bicarbonate (NaHCO₃) to rice seedlings are still unclear. This study explored the effects of different carbonate stresses (Na₂CO₃ and NaHCO₃) on rice seedling growth, root damage, physiological responses, and molecular changes. By administering equivalent concentrations of sodium ions through these different carbonate treatments, we observed that both stresses significantly inhibited rice growth. However, the inhibitory effect was more pronounced under the Na₂CO₃ treatment. Compared with the NaHCO₃ treatment, Na₂CO₃ stress caused more severe damage to root cell membranes and led to a substantial decline in root vigor. Moreover, the contents of reactive oxygen species (ROS) and malondialdehyde (MDA) were markedly increased, indicating that Na₂CO₃ induces more severe oxidative damage. Transcriptomic and metabolomic analyses revealed a greater number of differentially expressed genes (DEGs) and differentially expressed metabolites (DEMs) in the Na₂CO₃ treatment group. The integrative analysis and validation demonstrated that pathways related to auxin, ascorbate, flavonoids, and glutathione metabolism were particularly enriched under Na₂CO₃ stress. These findings suggest that Na₂CO₃ stress may interfere with auxin signaling pathways and exerts a more profound impact on endogenous antioxidant systems, affecting rice growth at multiple levels. In summary, this research highlights the differential impacts of Na₂CO₃ and Na₂CO₃ stresses on rice seedling growth, physiology, and molecular processes, particularly oxidative damage and antioxidant responses. The insights gained provide a valuable theoretical foundation for enhancing rice alkali tolerance and developing strategies for the rational cultivation of rice in saline-alkaline soils.</p>","PeriodicalId":7984,"journal":{"name":"Antioxidants","volume":"14 6","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12190083/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144493693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-Term Inhibition of NOX2 Prevents the Development of Aβ-Induced Pathology in Mice.","authors":"Kristina A Mukhina, Olga I Kechko, Alexander A Osypov, Irina Yu Petrushanko, Alexander A Makarov, Vladimir A Mitkevich, Irina Yu Popova","doi":"10.3390/antiox14060663","DOIUrl":"10.3390/antiox14060663","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is the most common neurodegenerative disorder, characterized by the formation of neurotoxic beta-amyloid (Aβ) oligomers in the central nervous system. One of the earliest pathological effects of Aβ is the induction of oxidative stress in brain tissue, mediated by NADPH oxidase 2 (NOX2). This study aimed to determine whether short-term inhibition of NOX2 could disrupt the pathological cascade and prevent the development of Aβ-induced pathology. We demonstrated that suppressing NOX2 activity by GSK2795039 during the first three days after intracerebral Aβ administration prevented the development of the pathological process in mice. Two weeks after the induction of Aβ pathology, animals treated with GSK2795039 showed no neuropsychiatric-like behavioral changes, which correlated with the absence of chronic oxidative damage in brain tissue. Moreover, GSK2795039 prevented microglial activation and reduced microglia-associated neuroinflammation. These findings indicate that short-term NOX2 inhibition effectively suppresses the development of Aβ-induced pathology, suggesting that NOX2 is a potential target for treatment and prevention of AD pathology.</p>","PeriodicalId":7984,"journal":{"name":"Antioxidants","volume":"14 6","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12189101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144493779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Efficacy of <i>Antrodia cinnamomea</i> on Liver Function Biomarkers in Mice and Rats: A Network Meta-Analysis.","authors":"Chien-Liang Kuo, Berne Ting, Ray Jui-Hung Tseng, Shih-Ping Liu, Jun-Yang Liou","doi":"10.3390/antiox14060660","DOIUrl":"10.3390/antiox14060660","url":null,"abstract":"<p><p>This study systematically evaluates the hepatoprotective effects of different types and doses of <i>Antrodia cinnamomea</i> extracts (triterpenoids, polysaccharides, and ubiquinone derivatives) on liver function biomarkers, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), malondialdehyde (MDA), and tumor necrosis factor-alpha (TNF-α), using a network meta-analysis (NMA) approach. Comprehensive literature searches were conducted in PubMed, Embase, Cochrane CENTRAL, and Web of Science databases to identify eligible animal studies involving standardized mouse and rat models. Interventions were categorized based on extract types and dosage levels (high, medium, low), with controls including negative groups (vehicle-treated) and positive groups (e.g., silymarin, N-acetylcysteine). A random-effects model estimated mean differences (MDs) with 95% confidence intervals (CIs), risk of bias was assessed with the SYRCLE tool, and sensitivity analyses verified robustness. The protocol has been registered in INPLASY (INPLASY202540040). The results indicated that triterpenoids, particularly at high and medium doses, were the most effective in reducing ALT (MD: -42.37, 95% CI: -54.19 to -30.54) and AST (MD: -50.18, 95% CI: -73.31 to -27.05). High-dose polysaccharides also showed notable effects, while other interventions demonstrated variable efficacy. For oxidative stress, high-dose triterpenoids showed the most pronounced reduction in MDA (MD: -19.05, 95% CI: -24.00 to -14.09), followed by medium-dose triterpenoids and all-dose polysaccharides. Regarding inflammation, high- and medium-dose triterpenoids significantly reduced TNF-α levels (high-dose MD: -88.75, 95% CI: -119.68 to -57.82; medium-dose MD: -89.27, 95% CI: -125.51 to -53.02), with overlapping confidence intervals indicating similar efficacy. High- and low-dose polysaccharides also demonstrated moderate anti-inflammatory effects. In conclusion, high-dose triterpenoids showed favorable and consistent effects across multiple biomarkers, which highlights their potential value for future liver-related therapeutic strategies.</p>","PeriodicalId":7984,"journal":{"name":"Antioxidants","volume":"14 6","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12189407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144493611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical Analysis and Antioxidant Activities of <i>Prunus africana</i> Bark, <i>Leea indica</i> and <i>Paullinia pinnata</i> Leaf Extracts.","authors":"Md Rezaul Karim, Karl E Miletti-Gonzalez, Alberta N A Aryee, Samuel A Besong","doi":"10.3390/antiox14060666","DOIUrl":"10.3390/antiox14060666","url":null,"abstract":"<p><p>The phytochemical profile and antioxidant activities of <i>Prunus africana</i> bark, <i>Leea indica</i> and <i>Paullinia pinnata</i> leaves from Cameroon were investigated in this study. The yields of pure methanolic extraction were 11.9%, 11.1% and 10.8% in <i>P. africana</i> bark, <i>L. indica</i> and <i>P. pinnata</i> leaves, respectively. The total phenolic content was 189.0 ± 16.93, 163.6 ± 14.73 and 114.6 ± 10.38 mg GAE/g and total flavonoid content was 43.25 ± 6.43, 28.31 ± 4.44, and 19.75 ± 4.03 mg RU/g in <i>P. africana</i> bark, <i>L. indica</i> and <i>P. pinnata</i> leaves, respectively. The antioxidant activities of the plants were evaluated by DPPH, ABTS and FRAP assays. The IC₅₀ evaluated in <i>P. africana</i> bark, <i>L. indica</i> and <i>P. pinnata</i> leaves was 109.5 ± 13.2, 132.1 ± 18.7 and 156.1 ± 21.9 µg/mL for DPPH and 98.1 ± 4.8, 101.3 ± 12.1 and 133.9 ± 16.0 µg /mL for ABTS assay. The FRAP value was 61.1 ± 1.5, 50.5 ± 1.5 and 43.4 ± 2.1 µMFe²⁺/g in the same sequence. The functional groups for the corresponding phytochemicals, including alkane, alkene, aliphatic ether, ester, amine, α, β-unsaturated ester, alcohol, phenol, carboxylic acid, and aliphatic ketone, were identified through fourier-transform infrared analysis. The identified and quantified phenolic acids in this study were methyl-4-hydroxybenzoic, caffeic, protocatechuic and p-coumaric acid, identified using high-performance liquid chromatography.</p>","PeriodicalId":7984,"journal":{"name":"Antioxidants","volume":"14 6","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12189430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144493748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-Omics and Experimental Validation Identify GPX7 and Glutathione-Associated Oxidative Stress as Potential Biomarkers in Ischemic Stroke.","authors":"Tianzhi Li, Sijie Zhang, Jinshan He, Hongyan Li, Jingsong Kang","doi":"10.3390/antiox14060665","DOIUrl":"10.3390/antiox14060665","url":null,"abstract":"<p><p>Ischemic stroke (IS) is the leading cause of disability and death worldwide, and its high incidence, disability and recurrence rates impose a heavy economic burden on families and society. Recent studies have shown that oxidative stress plays a key role in the pathophysiological mechanisms of ischemic stroke, not only participating in the onset and development of neuronal damage in the acute phase but also significantly influencing the long-term prognosis of ischemic stroke through molecular mechanisms, such as epigenetic modifications. However, the potential targets of oxidative stress-related genes in IS and their mechanisms of action remain to be elucidated. The aim of this study was to systematically analyse the function and significance of oxidative stress-related genes in IS. We obtained IS-related gene expression datasets from the GEO database and integrated known oxidative stress-related genes from the Genecards database for cross-analysis. Multidimensional feature screening using unsupervised consensus clustering and a series of machine learning algorithms led to the identification of the signature gene <i>GPX7</i>. The correlation between this gene and immune cell infiltration was assessed using MCPcounter and a potential therapeutic agent, glutathione, was identified. Binding was verified by molecular docking (MD) analysis. In addition, single-cell RNA sequencing data were analysed to further reveal expression in different cell types and its biological significance. Finally, we performed in vivo experiments using the Wistar rat middle cerebral artery occlusion (MCAO) model, and the results indicated that <i>GPX7</i> plays a key role in IS, providing a new theoretical basis and potential intervention target for the precise treatment of IS.</p>","PeriodicalId":7984,"journal":{"name":"Antioxidants","volume":"14 6","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12189666/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144493734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenols Extraction from Sorghum Byproducts: Upcycling Strategies and Food Applications.","authors":"Tiziana Amoriello, Francesco Mellara, Roberto Ciorba, Danilo Ceccarelli, Monica Amoriello, Federica Taddei, Roberto Ciccoritti","doi":"10.3390/antiox14060668","DOIUrl":"10.3390/antiox14060668","url":null,"abstract":"<p><p>In this research, ultrasound-assisted extraction (UAE) coupled with response surface methodology was used to identify the optimal process parameters (temperature, time, and solvent composition (ethanol-water ratio)) for bioactive compounds extraction from stalks and debranning products. Extraction efficiency was assessed in terms of total phenolic compounds (TPCs) and antioxidant activity (AA), and phenolic profiles were identified using HPLC-DAD for the four samples of byproducts (two samples from stalks, C1 and C2, and two samples for debranning products, C3 and C4, from two different farms). The optimized extract containing the highest amount of TPC at different levels was used to enrich bread to evaluate the ability of extending their shelf life using a hyperspectral imaging device (935-1720 nm). Under the optimal conditions, the amounts of phenolics on average in stalk increased by about 79.5% and 47.0% in debranning products, whereas the relative AA increased by about 28.5% (C1 and C2 samples) and 63.0% (C3 and C4 samples) when UAE was applied with respect to the traditional technique. The characterization of stalk phenolic acids profile revealed that gallic, ferulic, and 4-coumaric acids were the prevalent ones. Otherwise, caffeic, syringic, and 3-coumaric acids were the most abundant in debranning products. As expected, enriched bread showed a significant increase in TPC and AA values without influence on organoleptic characteristics. Finally, enriched bread showed a shelf-life increase of about five days.</p>","PeriodicalId":7984,"journal":{"name":"Antioxidants","volume":"14 6","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12189299/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144493746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depletion of Small HDL Subclasses Predicts Poor Survival in Liver Cirrhosis.","authors":"Anja Pammer, Tobias Madl, Hansjörg Habisch, Jakob Kerbl-Knapp, Florian Rainer, Vanessa Stadlbauer, Angela Horvath, Philipp Douschan, Rudolf E Stauber, Gunther Marsche","doi":"10.3390/antiox14060664","DOIUrl":"10.3390/antiox14060664","url":null,"abstract":"<p><p>Liver cirrhosis is a complex condition characterized by oxidative stress, inflammation, and metabolic dysfunction, contributing to systemic complications and high mortality. High-density lipoprotein (HDL), particularly its small subclasses, is known for its antioxidant, anti-inflammatory, and cholesterol efflux capacities. This study examined changes in HDL subclass distribution and composition in cirrhosis and assessed their prognostic relevance for mortality. We analyzed HDL profiles using nuclear magnetic resonance spectroscopy in patients with compensated (n = 205) and decompensated (n = 158) cirrhosis, compared to healthy controls (n = 16). Across all HDL subclasses in cirrhotic patients, cholesterol content was decreased, and triglyceride levels were elevated. In particular, compensated cirrhosis was associated with a marked reduction in small and extra-small HDL particles, while large HDL levels remained unchanged. This reduction was even more pronounced in decompensated disease. Small HDL particle levels were inversely correlated with oxidative stress markers and liver dysfunction and independently predicted 12-month mortality in patients with compensated cirrhosis, even after adjusting for MELD score. In conclusion, our findings highlight a substantial depletion of small and extra-small HDL particles as a key feature of cirrhosis, linked to oxidative stress and mortality in the compensated stage.</p>","PeriodicalId":7984,"journal":{"name":"Antioxidants","volume":"14 6","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12190158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144493634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recovery from Resistance Exercise with or Without Blood Flow Restriction Results in an Early Biphasic Pattern of Change in Albumin Cys34 Oxidation in Untrained Males.","authors":"Zi Xiang Lim, Jackson Peos, Stefan Ostojic, Peter G Arthur, Paul A Fournier","doi":"10.3390/antiox14060667","DOIUrl":"10.3390/antiox14060667","url":null,"abstract":"<p><strong>Background: </strong>Oxidative stress contributes to the activation of muscle protein synthesis after high-intensity resistance exercise (HIRE) or low-intensity resistance exercise combined with blood flow restriction (LIBFR), but it is unclear if this oxidative stress response post-exercise is monophasic or multiphasic. We aimed to answer this question using albumin Cys34 oxidation as an oxidative stress marker.</p><p><strong>Methods: </strong>Seven untrained individuals completed HIRE and LIBFR on separate days. Albumin Cys34 oxidation (total and reversibly and irreversibly oxidized fractions), muscle oxygenation, oxygen consumption (V˙O2), lactate, and heart rate (HR) were measured before and up to 5 h post-exercise.</p><p><strong>Results: </strong>Both HIRE and LIBFR induced a biphasic increase in total oxidized albumin Cys34, with a transient peak in irreversibly oxidized albumin Cys34 immediately post-exercise (<i>p</i> < 0.001) before a delayed sustained increase in reversibly oxidized albumin Cys34, which peaked at 90-120 min and lasted ≥5 h post-exercise (<i>p</i> < 0.05). Muscle oxygenation decreased immediately post-exercise (<i>p</i> < 0.001) before rising above baseline (<i>p</i> < 0.05). V˙O2, HR, and blood lactate peaked post-exercise (<i>p</i> < 0.001) and returned to baseline within 15-90 min. Irreversibly oxidized albumin Cys34 was positively correlated with lactate and V˙O2 post-exercise (<i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>Here, we show that resistance exercise, with or without blood flow restriction, results in an early biphasic oxidative stress response after exercise.</p>","PeriodicalId":7984,"journal":{"name":"Antioxidants","volume":"14 6","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12189344/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144493766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MAPK Signaling in the Interplay Between Oxidative Stress and Autophagy.","authors":"Enrico Desideri, Serena Castelli, Maria Rosa Ciriolo","doi":"10.3390/antiox14060662","DOIUrl":"10.3390/antiox14060662","url":null,"abstract":"<p><p>The term autophagy identifies several mechanisms that mediate the degradation of intracellular and extracellular components via the lysosomal pathway. Three main forms of autophagy exist, namely macroautophagy, chaperone-mediated autophagy, and endosomal microautophagy, which have distinct mechanisms but share lysosomes as the final destination of their cargo. A basal autophagic flux is crucial for the maintenance of cellular homeostasis, being involved in the physiological turnover of proteins and organelles. Several stressors, including nutrient shortage and genotoxic and oxidative stress, increase the autophagic rate, which prevents the accumulation of damaged and potentially harmful cell components, thus preserving cell viability. In this context, several studies have highlighted the role of MAPKs, serine-threonine kinases activated by several stimuli, in linking oxidative stress and autophagy. Indeed, several oxidative stressors activate autophagy by converging on MAPKs, directly or indirectly. In this regard, the different transcription factors that bridge MAPKs and autophagic activation are here described. In this review, we summarize the current knowledge regarding the regulation of autophagy by MAPK, including the atypical ones, with a particular focus on the regulation of autophagy by oxidative stress.</p>","PeriodicalId":7984,"journal":{"name":"Antioxidants","volume":"14 6","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12189088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144493697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}