Antioxidants最新文献

{"title":"Novel Antioxidants for Animal Nutrition-2nd Edition.","authors":"Matteo Dell'Anno, Luciana Rossi","doi":"10.3390/antiox15040440","DOIUrl":"10.3390/antiox15040440","url":null,"abstract":"<p><p>Oxidative stress is widely recognized as a major biological challenge affecting animal health, productivity, and reproductive efficiency [...].</p>","PeriodicalId":7984,"journal":{"name":"Antioxidants","volume":"15 4","pages":""},"PeriodicalIF":6.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13113099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147809878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Multi-Omics Integration Analysis Reveals That <i>Mori Fructus</i> Polysaccharide Ameliorates Liver Injury via Regulating Liver Metabolic Function Through Inhibiting Lipid Metabolism, Enhancing Glycolysis, and Promoting Amino Acid Utilization.","authors":"Qingfang Deng, Baitong Jing, Ruhai Chen, Yang Cao, Xiaomei Zhou, Yu Sun, Xin Zhou","doi":"10.3390/antiox15040443","DOIUrl":"10.3390/antiox15040443","url":null,"abstract":"<p><p>Alcohol-associated liver disease (ALD) is a prevalent chronic liver disease worldwide, with unclear pathogenesis and limited effective treatments. <i>Mori Fructus</i> polysaccharide (MFP-1) exhibits good therapeutic potential for ALD, but its mechanism remains unclear. This study aims to elucidate how MFP-1 mitigates ALD. An integrated multi-omics approach, encompassing quantitative proteomics, metabolomics, and lipidomics, was employed to systematically characterize the hepatic response to MFP-1 in ALD. MFP-1 coordinates metabolic reprogramming by regulating fatty acid synthesis and β-oxidation. It also enhances branched-chain amino acid catabolism via the 2-oxocarboxylic acid pathway, optimizing energy generation and amino acid utilization. MFP-1 protects against ALD by simultaneously targeting multiple metabolic vulnerabilities. These findings elucidate the mechanistic basis of MFP-1's hepatoprotective effects and highlight its potential for improving ALD.</p>","PeriodicalId":7984,"journal":{"name":"Antioxidants","volume":"15 4","pages":""},"PeriodicalIF":6.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13113487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147809886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptomic Analysis of Fermented Chinese Chive Selectively Attenuating Deoxynivalenol-Induced Ovarian Toxicity in Mice.","authors":"Hong Zou, Chun-Yan Qin, Teerath Kumar Suthar, Yupeng Xie, Koroloso Phomane Abednicco, Chun-Feng Wang, Min Kyu Kim, Shu-Min Zhang, Wu-Sheng Sun","doi":"10.3390/antiox15040442","DOIUrl":"10.3390/antiox15040442","url":null,"abstract":"<p><p>Deoxynivalenol (DON) is a common mycotoxin linked to ovarian oxidative stress, toxicity, and reduced reproductive performance. Fermented Chinese chive is known for its antioxidant properties and potential reproductive benefits, but their individual and combined effects on ovarian function remain unclear in post-pubertal mice. In this study, a 21-day oral gavage model in female Kunming mice was used to evaluate the effects of DON (2 mg/kg/day), fermented Chinese chive extract (LEEK; 0.2 mL/day), and their combined exposure (LKDON) on ovarian physiology, oocyte quality, and ovarian transcriptomic responses. The results showed that DON exposure significantly reduced the zygote cleavage rate, increased intracellular reactive oxygen species levels, and disrupted oocyte mitochondrial membrane potential. While histological examination revealed disturbed follicular architecture. Transcriptomic hub gene analysis showed that DON exposure down-regulate the key associated with innate immune responses and motile cilia/axonemal structure, including <i>Rsph4a</i>, <i>Drc1</i>, <i>Zmynd10</i>, <i>Hydin</i>, and <i>Tmem212</i>. In contrast, LEEK alone was associated with immunomodulatory upregulated genes, including <i>Il5</i>, <i>Cd27</i>, and <i>Crp</i>. Interestingly, LKDON and DON comparison revealed upregulation of a motile cilia/axoneme gene network (<i>Dnah5</i>, <i>Dnah11</i>, <i>Tekt1</i>, <i>Zmynd10</i>, <i>Cfap44</i>, and <i>Spag6l</i>), rather than a global reversal of DON-induced changes. Overall, finding suggest that DON disrupts ovarian immune and structural pathways, while fermented Chinese chive provides partial protection by modulating specific biological processes. Further studies are needed to confirm the underlying mechanisms.</p>","PeriodicalId":7984,"journal":{"name":"Antioxidants","volume":"15 4","pages":""},"PeriodicalIF":6.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13113495/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147809837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compositional Phenolic Signatures of Antioxidant-Relevant Compounds in Hop (<i>Humulus lupulus</i> L.) Varieties and Local Ecotypes Cultivated in Southern Chile.","authors":"Ignacio Matamala, Manuel Chacón-Fuentes, Daniel Martínez-Cisterna, Pablo Parra-Verdugo, Valeria Asencio-Cancino, Leonardo Bardehle","doi":"10.3390/antiox15040444","DOIUrl":"10.3390/antiox15040444","url":null,"abstract":"<p><p>Hop (<i>Humulus lupulus</i> L.) cones are increasingly recognized as sources of phenolic compounds relevant to antioxidant-oriented applications beyond their traditional brewing role; however, genotype-dependent chemical diversity remains poorly characterized under South American cultivation. This study evaluated phenolic composition and antioxidant-related chemical signatures in 22 hop accessions, including commercial varieties and Chilean local ecotypes, cultivated under homogeneous conditions in southern Chile. Total phenolic content (TPC), total flavonoid content (TFC), and condensed tannins were determined using spectrophotometric assays, while phenolic acids, catechin, and prenylated flavonoids were quantified by HPLC. Antioxidant capacity was evaluated using the ORAC assay, and principal component analysis (PCA) was applied to integrate chemical variables. TPC ranged from 4051 to 8124 mg gallic acid equivalents/100 g dry weight, TFC from 655 to 3011 mg quercetin equivalents/100 g, and condensed tannins from 11.0 to 60.1 mg catechin equivalents/g. ORAC values ranged from 96,405 to 161,815 µmol Trolox equivalents/100 g dry weight, indicating substantial genotype-dependent variation. PCA explained 69.5% of total variance and revealed distinct phenolic composition patterns among genotypes. Pearson correlation analysis showed that antioxidant capacity was strongly associated with condensed tannins and total phenolic content, whereas total flavonoids were not significantly related to ORAC values. Prenylated flavonoids were negatively associated with antioxidant capacity, suggesting a limited contribution to peroxyl radical scavenging activity. These findings highlight the importance of phenolic subclass composition, particularly condensed tannins, in determining antioxidant capacity and support the selection of hop genotypes based on specific phenolic profiles for functional applications.</p>","PeriodicalId":7984,"journal":{"name":"Antioxidants","volume":"15 4","pages":""},"PeriodicalIF":6.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13113253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147809342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Life-Course Regulation of Health and Disease by Nitric Oxide: Mechanistic Insights.","authors":"Chien-Ning Hsu, You-Lin Tain","doi":"10.3390/antiox15040439","DOIUrl":"10.3390/antiox15040439","url":null,"abstract":"<p><p>Nitric oxide (NO) functions as a master integrative regulator of cardiovascular-kidney-metabolic (CKM) homeostasis, yet it displays a profound Janus face, defined by concentration- and context-dependent roles in both health and disease. This narrative review examines NO signaling from a life-course perspective, beginning with fetal programming, during which the NO-asymmetric dimethylarginine (ADMA) axis orchestrates placental development and nephron endowment. Perturbations during this critical window-such as maternal ADMA elevation-can imprint a maladaptive trajectory toward adult-onset hypertension and chronic kidney disease. In adulthood, this initially silent dysregulation of NO signaling is amplified by Western dietary patterns and environmental pollutants, culminating in the clinical manifestation of the CKM triad. This pathological transition is driven by eNOS uncoupling and ADMA accumulation, which shift redox balance toward peroxynitrite formation and precipitate mitochondrial bioenergetic failure. Moreover, while constitutive NO production is essential for vascular homeostasis, pathological induction of inducible NOS generates excessive NO fluxes that promote insulin resistance and tissue injury. With advancing age, a progressive loss of NO resilience further exacerbates multi-organ vulnerability. To mitigate the cumulative burden of CKM disease, this review highlights developmental reprogramming strategies-such as perinatal L-citrulline supplementation and ADMA-lowering interventions-as interventions to restore physiological NO signaling. Integrating such early-life strategies with contemporary pharmacological therapies offers a coherent framework for maintaining NO bioavailability and extending health span across the life course.</p>","PeriodicalId":7984,"journal":{"name":"Antioxidants","volume":"15 4","pages":""},"PeriodicalIF":6.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13113015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147810070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The RAGE-Ferroptosis Axis Drives Oxidative Stress-Associated Inflammatory Lung Injury in Viral Infection.","authors":"Wenhui Guo, Junhao Luo, Siyu Pu, Simin Cui, Haijun Zhu, Peiqing He, Rongbao Gao","doi":"10.3390/antiox15040434","DOIUrl":"10.3390/antiox15040434","url":null,"abstract":"<p><p>The receptor for advanced glycation end-products (RAGE) is a lung-enriched pattern recognition receptor implicated in inflammatory responses. Its role in ferroptosis-mediated lung injury during viral infection, however, remains unclear. Here, we combined bioinformatics analysis with in vitro and in vivo experimental validation to investigate the RAGE-ferroptosis axis in influenza virus infection. Cross-analysis of RAGE- and ferroptosis-related genes identified overlapping candidates, suggesting functional crosstalk. Influenza-infected <i>A549</i> cells exhibited ferroptotic cell death, characterized by Fe²⁺ accumulation, reactive oxygen species (ROS) elevation, and lipid peroxidation, which was markedly attenuated by the RAGE inhibitor FPS-ZM1. In A/PR/8/34 (H1N1)-infected female <i>C57BL/6J</i> mice, FPS-ZM1 treatment improved survival, reduced lung injury, restored redox balance, and modulated key ferroptosis regulators <i>ACSL4</i>, <i>POR</i>, and <i>GPX4</i>. Moreover, RAGE inhibition decreased M1 macrophage and neutrophil infiltration and reduced pro-inflammatory cytokines. Collectively, these findings reveal that RAGE activation drives ferroptosis and amplifies oxidative stress-associated lung injury, whereas RAGE inhibition mitigates tissue damage via the ACSL4/POR/GPX4 pathway and immunomodulation. This study identifies the RAGE-ferroptosis axis as a potential therapeutic target for severe pulmonary inflammation.</p>","PeriodicalId":7984,"journal":{"name":"Antioxidants","volume":"15 4","pages":""},"PeriodicalIF":6.6,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13114047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147809410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatic ACSL4 Loss Boosts Endogenous Gamma-Glutamylcysteine to Alleviate Alcoholic Liver Disease.","authors":"Ran Duan, Xin-Yi Wang, Xue Zhou, Jing-Wen Ding, Zhi-Sen Yang, Zhi-Lin Li, Yue-Yu Wang, Jia-Xin Yu, Jing-Jing Duan","doi":"10.3390/antiox15040438","DOIUrl":"10.3390/antiox15040438","url":null,"abstract":"<p><p>Alcoholic liver disease (ALD), secondary to chronic alcohol abuse, encompasses a spectrum of liver disorders that progress from steatosis and hepatitis to fibrosis, cirrhosis, and acute-on-chronic liver failure. It poses a considerable global health burden due to its elevated rates of associated morbidity and mortality. The rising prevalence of ALD, coupled with the lack of approved pharmacotherapies, presents considerable unmet clinical needs. In this study, long-chain acyl-CoA synthetase 4 (ACSL4) was identified as a pathogenic driver in the context of chronic alcohol consumption. Hepatocyte <i>Acsl4</i> ablation mitigated key pathological manifestations in Gao-Binge model mice, as evidenced by reduced inflammatory cell infiltration and attenuated lipid accumulation. Mechanistically, ACSL4 inhibition augmented cellular antioxidant defence through elevating gamma-glutamylcysteine (γ-GC) levels. In addition, γ-GC bound to and suppressed the expression of protein tyrosine phosphatase type IVA member 1 (PTP4A1). Both genetic silencing and pharmacological inhibition of PTP4A1 attenuated the activation of the downstream MAPK-NF-κB inflammatory cascade. Dronedarone, identified as a novel compound targeting ACSL4, demonstrated efficacy in ameliorating the progression of ALD. Overall, these findings elucidate a novel mechanism wherein ACSL4 modulates antioxidant responses via a small bioactive peptide, highlighting ACSL4 as a potential therapeutic target for ALD.</p>","PeriodicalId":7984,"journal":{"name":"Antioxidants","volume":"15 4","pages":""},"PeriodicalIF":6.6,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13113857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147809910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endothelial Nitric Oxide Synthase-Dependent Mechanism of Hydroxyurea-Induced S-Phase Arrest in Erythroid Cells.","authors":"Teodora Dragojević, Dragoslava Đikić, Slavko Mojsilović, Miloš Lazarević, Dejan Milenković, Olivera Mitrović Ajtić, Emilija Živković, Miloš Diklić, Tijana Subotički, Juan F Santibanez, Vladan P Čokić, Milica Vukotić","doi":"10.3390/antiox15040435","DOIUrl":"10.3390/antiox15040435","url":null,"abstract":"<p><p>Hydroxyurea (HU) is a ribonucleotide reductase inhibitor widely used for the treatment of sickle cell disease and myeloproliferative disorders, yet a precise nitric oxide (NO) synthase (NOS)-dependent mechanism remains incompletely defined. The role of NOS3 in HU-mediated proliferation, cell cycle, and apoptosis was analyzed in HEL92.1.7 erythroleukemic cells and primary mouse erythroid progenitors upon genetic knockdown/knockout and pharmacological NOS2/NOS3 inhibition. NOS3 expression, phosphorylation, NO and citrulline production, and protein nitrosylation were assessed via immunoblotting and biochemical assays. Computational docking and molecular dynamics simulations were performed to examine the interaction between HU and NOS3. HU enhanced NOS3 expression and phosphorylation, leading to increased NO and citrulline production. Computational analysis predicted HU binding within the NOS3 active site, whereas functional activation was AKT1-dependent. A biotin switch assay revealed cooperative NOS2-/NOS3-mediated protein nitrosylation under HU treatment. NOS3 depletion or inhibition abrogated HU-induced S-phase accumulation and restored cell proliferation. NOS3 protein depletion increased late apoptosis in erythroleukemic cells, while in murine erythroid cells, both Nos3 deficiency and inhibition decreased early and increased late apoptosis. NOS2 and NOS3 act as complementary mediators of proliferation and apoptosis, with NOS3 playing a distinct role in HU-induced proliferation arrest in erythroid cells. These findings highlight the therapeutic potential of NOS targeting to enhance the efficacy of HU and overcome resistance in hematologic malignancies.</p>","PeriodicalId":7984,"journal":{"name":"Antioxidants","volume":"15 4","pages":""},"PeriodicalIF":6.6,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13113100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147809791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PIN (Protein Inhibitor of Neuronal Nitric Oxide Synthase) Modulates Glucose Uptake Through NO-Dependent and Independent Mechanisms in Rat Muscle Cells.","authors":"Jérémy Leroy, Karima Mezghenna, Didier Tousch, Jaufret Canovas, Daniel Laune, Martine Pugnière, Jacqueline Azay-Milhau, Anne-Dominique Lajoix","doi":"10.3390/antiox15040436","DOIUrl":"10.3390/antiox15040436","url":null,"abstract":"<p><p>Protein inhibitor of neuronal NO synthase (PIN) or dynein light chain 8 (LC8) is a highly conserved protein interacting with multiple partners, like neuronal NO synthase (nNOS) or myosin Va to modulate a variety of cellular functions. As PIN is expressed in skeletal muscle, our aim was to investigate a possible role of PIN in glucose uptake in L6 and primary muscle cells. PIN overexpression resulted into a decrease in glucose uptake with reduced GLUT4 expression and translocation at the plasma membrane, similarly to the pharmacological blockade of nNOS with L-NAME. PIN effect is mediated by a reduction in nNOS protein level and a direct interaction with nNOS leading to a reduced NO production in L6 myocytes. Surprisingly, a siRNA targeting PIN decreased glucose uptake and GLUT4 translocation, suggesting the involvement of nNOS-independent effects. We therefore focused on myosin Va which interacts with PIN in L6 myocytes. Myosin Va silencing provoked a decrease in glucose uptake. As PIN siRNA also reduced myosin Va expression, this confirms the essential role of myosin Va in the observed effects of PIN silencing on glucose uptake. We conclude that PIN modulates glucose uptake and GLUT4 translocation in rat muscle cells, through NO-dependent and -independent mechanisms.</p>","PeriodicalId":7984,"journal":{"name":"Antioxidants","volume":"15 4","pages":""},"PeriodicalIF":6.6,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13114162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147809972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LC-HRMS-Based Metabolomic Profiling and Antioxidant Activity of <i>Sargassum ilicifolium</i> Under Different Pretreatments, Extraction Methods, and Solvents.","authors":"Anita Dilla Harfiyani, Riyanti, Muhammad Nursid, Till F Schäberle, Maria Alexandra Patras, Jae-Suk Choi, Maria Dyah Nur Meinita","doi":"10.3390/antiox15040433","DOIUrl":"10.3390/antiox15040433","url":null,"abstract":"<p><p><i>Sargassum</i> is a widespread brown seaweed species and a source of bioactive compounds with promising antioxidant potential. Unfortunately, to date, the <i>Sargassum</i> species remains largely unexplored. This study was conducted to explore the bioactive compounds from <i>Sargassum ilicifolium</i> extracts collected from Nguyahan and Sundak Beaches, Gunungkidul, Indonesia, by observing Liquid Chromatography-High Resolution Mass Spectrometry (LC-HRMS)-based metabolomics profiling and antioxidant activity assays. Metabolomic analysis detected 506 molecular features across different extraction methods and solvents, with five metabolites putatively dereplicated, including atractylenolide III, pheophorbide A, 13-docosenamide, 1,3,6,8-tetrahydroxy-2-(1-hydroxyhexyl)anthracene-9,10-dione, and 5-hydroxy-6E,8Z,11Z,14Z,17Z-eicosapentaenoic acid. Extraction parameters, particularly solvent polarity and sample pretreatment, have been shown to affect the metabolite variation. Dried samples showed less variation in metabolites than the fresh sample. Antioxidant activity assay showed a moderate to high radical scavenging activity (30-100%), with methanol extracts as a polar solvent inhibited more than semipolar solvents. This study provides a metabolomics-guided assessment of the antioxidant potential of <i>S. ilicifolium</i>, supporting its value and potential as a source of bioactive compounds for future pharmaceutical and nutraceutical applications.</p>","PeriodicalId":7984,"journal":{"name":"Antioxidants","volume":"15 4","pages":""},"PeriodicalIF":6.6,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13113787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147809923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}