Dystonia Versus Redox Balance: A Preliminary Assessment of Oxidative Stress in Patients.

IF 6.6 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Antioxidants Pub Date : 2025-08-27 DOI:10.3390/antiox14091052

Jan Koptielow, Emilia Szyłak, Anna Koptielowa, Magdalena Sarnowska, Katarzyna Kapica-Topczewska, Edyta Adamska-Patruno, Katarzyna Socha, Jan Kochanowicz, Alina Kułakowska, Monika Chorąży

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Abstract

Dystonia is defined as a movement disorder, the etiology of which may be linked to oxidative stress. The objective of this study was to evaluate the serum levels of zinc, copper, and selenium, as well as oxidative stress parameters, in patients diagnosed with focal dystonia, in comparison to a control group. The study comprised 39 patients and 30 healthy subjects. Patients demonstrated a marked decrease in Total Antioxidant Status (TAS) (p = 0.0002) and an increase in Total Oxidant Status (TOS) and Oxidative Stress Index (OSI) (both p < 0.0001), suggesting a redox imbalance. Of the elements examined, only copper exhibited a significant elevation (p = 0.0061), while zinc and selenium levels remained unchanged. The results of this study suggest that oxidative stress may play a significant role in the pathophysiology of dystonia and represent a potential target for adjunctive therapy.

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肌张力障碍与氧化还原平衡：对患者氧化应激的初步评估。

肌张力障碍被定义为一种运动障碍，其病因可能与氧化应激有关。本研究的目的是评估局灶性肌张力障碍患者的血清锌、铜和硒水平，以及氧化应激参数，并与对照组进行比较。该研究包括39名患者和30名健康受试者。患者总抗氧化状态（TAS）显著降低（p = 0.0002），总氧化状态（TOS）和氧化应激指数（OSI）显著升高（p < 0.0001），提示氧化还原失衡。在被检测的元素中，只有铜表现出显著的升高（p = 0.0061），而锌和硒的水平保持不变。本研究结果表明，氧化应激可能在肌张力障碍的病理生理中发挥重要作用，并代表了辅助治疗的潜在靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Antioxidants Biochemistry, Genetics and Molecular Biology-Physiology

CiteScore

10.60

自引率

11.40%

发文量

2123

审稿时长

16.3 days

期刊介绍： Antioxidants (ISSN 2076-3921), provides an advanced forum for studies related to the science and technology of antioxidants. It publishes research papers, reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.