Science China Materials最新文献

{"title":"Engineered bacteria for cancer therapy: synergistic innovations in synthetic biology and materials science","authors":"Peng-Shuo Dong \u0000 (,&nbsp;),&nbsp;Yi-Tong Zhou \u0000 (,&nbsp;),&nbsp;Wei-Ling Yu \u0000 (,&nbsp;),&nbsp;Jia-Hua Zou \u0000 (,&nbsp;),&nbsp;Tian Yao \u0000 (,&nbsp;),&nbsp;Jin-Xuan Fan \u0000 (,&nbsp;),&nbsp;Di-Wei Zheng \u0000 (,&nbsp;),&nbsp;Yuan-Di Zhao \u0000 (,&nbsp;)","doi":"10.1007/s40843-025-3438-6","DOIUrl":"10.1007/s40843-025-3438-6","url":null,"abstract":"<div><p>The unique physiological characteristics and complexity of tumor, in addition to drug resistance result in traditional therapies, such as chemotherapy and radiotherapy, being unable to achieve complete elimination of cancer cells. Meanwhile, the emerging immunotherapy suffers from a low patient response rate. Bacterial therapies are highly targeted. Bacteria can penetrate deep into the tumor and show good tumor inhibition. However, natural bacteria have the limitation of high toxicity and inability to meet the demand for efficient therapeutics. Recent advances in synthetic biology and materials science relate to the safety and efficacy of bacterial therapeutics, promising to develop engineered bacteria with low toxicity and complex therapeutic functions. Engineered bacteria that express anticancer drug molecules can target the tumor region, synthesizing and releasing payloads in response to internal and external stimuli. This process leads to the regression of the tumor and the effective inhibition of recurrence. This review outlines the recent advancements in the field of engineered bacteria research, particularly focusing on their applications in anti-tumor therapy. It also includes the advantageous features and mechanisms of engineered bacteria therapy, synthetic biology modification methods, and future challenges and directions of engineered bacteria therapy.\u0000</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":"68 8","pages":"2670 - 2687"},"PeriodicalIF":7.4,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145164791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Water-unquenchable ultralong room-temperature phosphorescent CDs@SiO2 composites for information encryption and anticounterfeiting applications","authors":"Yuanfen Huang \u0000 (,&nbsp;),&nbsp;Xiaoyuan Zhang \u0000 (,&nbsp;),&nbsp;Jiajia Kong \u0000 (,&nbsp;),&nbsp;Yanqing Liu \u0000 (,&nbsp;),&nbsp;Xin Liu \u0000 (,&nbsp;),&nbsp;Dongzhi Chen \u0000 (,&nbsp;)","doi":"10.1007/s40843-025-3450-6","DOIUrl":"10.1007/s40843-025-3450-6","url":null,"abstract":"<div><p>Room-temperature phosphorescence (RTP) materials play a vital role in security domain due to their unique optical properties. However, most average lifetimes of available RTP materials remain less than 1 s in aqueous-phase media, which is unfavorable to practical applications. Herein, an <i>ex-situ</i> covalent coupling strategy is proposed to fabricate liquid-phase long-lived RTP materials by combining SiO₂ microspheres with the feather-derived carbon dots (CDs). Astonishingly, the aqueous dispersion of the resulting CDs@SiO₂ microspheres exhibits a lifetime of up to 2.38 s with an absolute quantum yield of 22%. Moreover, the average lifetime of the solid CDs@SiO₂ is as long as 3.04 s, which is superior to that of existing RTP carbon-based materials. The striking enhancements in the RTP of the CDs@SiO₂ composites are mainly attributed to the immobilization of the formed Si–O–C covalent bonds and Si–O–Si rigid networks. The CDs@SiO₂ composites were subsequently applied in the fields of information encryption and anti-fake. Interestingly, the CDs@SiO₂ composites possess intriguing, reversible and stable optical properties, including water-responsive structural colors, blue fluorescence and cyan RTP, exhibiting excellent covert performance in applications of information encryption and decryption, and high-level anticounterfeiting. These findings provide not only a straightforward strategy for developing multiresponsive optical materials but also a more secure anticounterfeiting technology.\u0000</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":"68 8","pages":"2714 - 2724"},"PeriodicalIF":7.4,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145164841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Second-generation rotaxane ion transporters: boosting transport activity via enhanced transport flux across lipid bilayers","authors":"Zexin Yan \u0000 (,&nbsp;),&nbsp;Jiayi Zhu \u0000 (,&nbsp;),&nbsp;Tianlong Li \u0000 (,&nbsp;),&nbsp;Juejiao Fan \u0000 (,&nbsp;),&nbsp;Chuantao Wang \u0000 (,&nbsp;),&nbsp;Li Zhao \u0000 (,&nbsp;),&nbsp;Chunyan Bao \u0000 (,&nbsp;)","doi":"10.1007/s40843-025-3475-2","DOIUrl":"10.1007/s40843-025-3475-2","url":null,"abstract":"<div><p>Inspired by natural transmembrane molecular machines, rotaxane-based synthetic molecules have demonstrated significant potential in constructing ion transporters capable of performing complex tasks akin to their biological counterparts. Addressing the need to enhance the ion transport activity of rotaxane transporters, we herein report a new strategy for developing second-generation rotaxane transporters by modifying the ring structure to boost transport flux, in which the ring component TCE features a tricyclic architecture incorporating two K⁺ recognition sites. This innovative design allows the rotaxanes to transport two K⁺ ions in a single shuttle-mediated transport cycle, leading to a tenfold reduction in EC₅₀ values compared to first-generation rotaxane transporters, which possess only one K⁺ recognition site. By further implementing a cooperative shuttle-relay mechanism, [3]R-TCE2—where two rings traverse the thread within the lipid membrane—achieved an EC₅₀ value as low as 60 nM (0.18 mol%, relative to lipid). It represents one of the highest K⁺ transport activities reported to date for molecular machine-based transporters. This work marks a significant advancement in improving the ion transport performance of rotaxane-based systems, offering robust technical support for their ability to mimic natural channel functions and paving the way for potential biomedical applications.</p></div>","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":"68 8","pages":"2973 - 2980"},"PeriodicalIF":7.4,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145163662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mixed ionic/electronic conducting framework enabled by transition metal-ion reduction in Li-LLTO composite anodes for ultrafast lithium diffusion","authors":"Huilin Zhu \u0000 (,&nbsp;),&nbsp;Shiwei Deng \u0000 (,&nbsp;),&nbsp;Xinyi Kong \u0000 (,&nbsp;),&nbsp;Xing Xiang \u0000 (,&nbsp;),&nbsp;Yan Duan \u0000 (,&nbsp;),&nbsp;Jian-Fang Wu \u0000 (,&nbsp;),&nbsp;Jilei Liu \u0000 (,&nbsp;)","doi":"10.1007/s40843-025-3452-9","DOIUrl":"10.1007/s40843-025-3452-9","url":null,"abstract":"<div><p>The development of Li₇La₃Zr₂O₁₂ (LLZO) solid electrolytes is challenged by the unstable Li/LLZO interface during lithium stripping and plating processes, which impedes interfacial charge transport and accelerates lithium dendrite growth. Here, a freestanding ultrathin Li-Li_0.3La_0.5TiO₃ (LLTO) composite anode with a three-dimensional interconnected mixed ionic/electronic conducting LLTO framework was developed. The mixed ionic/electronic conduction of LLTO arises from the <i>in-situ</i> reduction of transition metal ions (Ti⁴⁺) by metallic lithium. The Li-LLTO composite anode possesses good affinity toward LLZO solid electrolytes, achieving a low interfacial resistance of 11.7 Ω cm², and a high lithium self-diffusion coefficient reaching 4.5×10⁻¹¹ cm²/s, about one order of magnitude higher than that of pure lithium anode. These features collectively enhance the Li-LLTO/LLZO interfacial stability, increasing the critical current density fourfold and enabling a 1300-h symmetrical cell cycling life. It delivers high-performance solid-state lithium batteries with an 80% capacity retention after 220 cycles. This advancement not only improves the performance of lithium metal anodes in solid-state batteries but also offers promising insights for next-generation high-energy-density electrochemical energy storage systems.</p></div>","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":"68 8","pages":"2775 - 2782"},"PeriodicalIF":7.4,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145163853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optoelectronic interconnection applications from growth-based monolithic in-plane integration of CsPbBr3 nanowire arrays with CdSSe nanoribbon trunks","authors":"Xue Xia \u0000 (,&nbsp;),&nbsp;Long Chen \u0000 (,&nbsp;),&nbsp;Yaonan Xiong \u0000 (,&nbsp;),&nbsp;Qi Deng \u0000 (,&nbsp;),&nbsp;Wei Mou \u0000 (,&nbsp;),&nbsp;Junxin Gong \u0000 (,&nbsp;),&nbsp;Wenbin Zhang \u0000 (,&nbsp;),&nbsp;Shulin Chen \u0000 (,&nbsp;),&nbsp;Qinglin Zhang \u0000 (,&nbsp;)","doi":"10.1007/s40843-025-3435-3","DOIUrl":"10.1007/s40843-025-3435-3","url":null,"abstract":"<div><p>Semiconductor nanowires (NWs) have been extensively applied in light sources, waveguides, photodetectors (PDs), etc., which provide abundant components for optoelectronic interconnection applications. However, the efficient in-plane integration of various devices remains challenging, which is a prerequisite for the practical application of NWs. Here, the growth-based integration of CsPbBr₃ NW arrays with CdSSe ribbons transferred onto mica is achieved via a vapor deposition route. The transferred ribbons not only act as preferential nucleation sites for CsPbBr₃, but also break the growth symmetry of CsPbBr₃ NWs on mica, allowing wires with the largest angle to the ribbon edge to grow longer and form arrays. The waveguide studies show that the CsPbBr₃ NW arrays can confine and guide the light emission from both themselves and the CdSSe ribbon well. Importantly, the optoelectronic interconnection was successfully demonstrated based on the achieved heterostructures, where the CsPbBr₃ NWs served as the light source and waveguide, and PDs were made from the CdSSe ribbon. When a single CsPbBr₃ NW was illuminated by a focused 457 nm laser at a distance of 37.5 µm from the CdSSe ribbon, the on/off ratio of the system reached 8.3×10³, resulting from the efficient response of the PD to the guided light. Moreover, the system can distinguish the pulsed light excitation well below 2000 Hz, limited by the response speed of the PDs. This work paves the way for the on-chip integration of nanoscale light emitters, waveguides, and detectors, promoting the practical application of semiconductor NWs in photonic circuits.</p></div>","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":"68 8","pages":"2697 - 2705"},"PeriodicalIF":7.4,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145163854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facile phase tuning of CsCdCl3:Mn2+ phosphor for nearly-unity quantum yield and extended afterglow","authors":"Yeqi Liu \u0000 (,&nbsp;),&nbsp;Xiangzhou Zhang \u0000 (,&nbsp;),&nbsp;Jun Wei \u0000 (,&nbsp;),&nbsp;Xiaojia Wang \u0000 (,&nbsp;),&nbsp;Yuhai Zhang \u0000 (,&nbsp;)","doi":"10.1007/s40843-025-3442-0","DOIUrl":"10.1007/s40843-025-3442-0","url":null,"abstract":"<div><p>While the hexagonal-phase CsCdCl₃ was extensively reported due to its high photoluminescence quantum yield and ultralong afterglow duration, the cubic-phase CsCdCl₃ remained elusive. Herein, the cubic-phase CsCdCl₃ microcrystals were synthesized via a solid-state synthesis at room temperature. After 10%-Mn²⁺ doping, the photo-luminescence quantum yield (PL QY) was improved to near unity and the afterglow duration was extended to 10 h. Importantly, the cubic phase was found meta-stable toward thermal treatment, where a transition to hexagonal phase was observed upon heating at 100 °C. In addition, the phase transition was also sensitive to Mn²⁺-doping concentration, which provided a facile tool to manipulate the lattice structure of octahedra dimers (hexagonal) or monomers (cubic). The mechanism of phase transition was theoretically explained through both phonon spectrum and lattice formation energy. This work opened many avenues to advanced applications such as information storage, X-ray imaging and anti-counterfeiting.</p></div>","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":"68 8","pages":"2735 - 2741"},"PeriodicalIF":7.4,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145163754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxygen-independent photoactivation of kinetically trapped persistent room-temperature phosphorescence state for smart cold-chain monitoring","authors":"Shulin Liu \u0000 (,&nbsp;),&nbsp;Chensheng Li \u0000 (,&nbsp;),&nbsp;Weijia Xie \u0000 (,&nbsp;),&nbsp;Aoyuan Cheng \u0000 (,&nbsp;),&nbsp;Yingxiao Mu \u0000 (,&nbsp;),&nbsp;Yanping Huo \u0000 (,&nbsp;),&nbsp;Fushun Liang \u0000 (,&nbsp;),&nbsp;Guoqing Zhang \u0000 (,&nbsp;)","doi":"10.1007/s40843-025-3441-9","DOIUrl":"10.1007/s40843-025-3441-9","url":null,"abstract":"<div><p>Stimuli-responsive room-temperature phosphorescence (RTP) materials face challenges in environmental robustness and spatiotemporal controllability, particularly for oxygen- and temperature-sensitive applications. Here, by taking advantage of the high oxygen-permeability barrier of polyvinyl alcohol (PVA) and its photochemical reaction toward certain polyaromatic hydrocarbons, we present phenanthrene- and triphenylene-doped PVA films that exhibit photoactivatable and persistent RTP, with an observable afterglow time &gt;70 s by the naked eye, likely via a kinetically trapped radical pathway. Specifically, such UV-enhanced persistent RTP occurs under both aerobic and anaerobic conditions, contrasting with a regular RTP turn-on mechanism via photo-induced molecular oxygen depletion. The activated RTP state shows temperature-dependent kinetic persistence, i.e., lasting ∼5 h at 25°C vs. ∼72 h at 4°C, creating irreversible RTP switching from “on” to “off” ideal for cumulative temperature monitoring. The PVA-based ink patterns printed on perishables (e.g., fresh milk bottles) can be used to quantify ambient exposure via RTP decay kinetics (relative intensity loss &gt;84.2% after 3 h at 25°C vs. at 4°C). The current study establishes a kinetic-control strategy for designing programmable RTP materials, addressing unmet needs in smart sensing and quality assurance.</p></div>","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":"68 8","pages":"2688 - 2696"},"PeriodicalIF":7.4,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145163154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"All-fibrous multimodal sensor patch for synchronous monitoring of biomechanical and bioelectrical signals","authors":"Jiale Sun \u0000 (,&nbsp;),&nbsp;Yaqi Chen \u0000 (,&nbsp;),&nbsp;Xiangheng Du \u0000 (,&nbsp;),&nbsp;Rouhui Yu \u0000 (,&nbsp;),&nbsp;Tao Zhou \u0000 (,&nbsp;),&nbsp;Zhonghua Yang \u0000 (,&nbsp;),&nbsp;Jiexin Qiu \u0000 (,&nbsp;),&nbsp;Zishuo Zhang \u0000 (,&nbsp;),&nbsp;Meifang Zhu \u0000 (,&nbsp;),&nbsp;Shaowu Pan \u0000 (,&nbsp;)","doi":"10.1007/s40843-025-3426-8","DOIUrl":"10.1007/s40843-025-3426-8","url":null,"abstract":"<div><p>Monitoring physiological signals is essential for individual healthcare. Muscles, which are the primary components responsible for human movement, produce biomechanical and bioelectrical signals during contraction and relaxation. However, the simultaneous monitoring of these two types of signals remains challenging. In this work, a four-layered all-fibrous multimodal sensor patch (FMSP) is developed, comprising a structured pressure sensor unit and an electrophysiological electrode unit. This patch utilizes a pressure sensor to monitor force myography (FMG) signal and an electrophysiological electrode to track electromyogram (EMG) signal, enabling simultaneous monitoring of both during muscle activity. The pressure sensor, featuring a micro-hump structure on the fibrous membrane surface, achieves a high sensitivity of 148.1 kPa⁻¹ and a broad monitoring range of 0.054 to 200 kPa. Additionally, an adhesive fibrous membrane enables the electrophysiological electrode to maintain a high adhesion strength of 67.6 kPa. This ensures a stable and low skin-electrode interface impedance and demonstrates a high signal-to-noise ratio (SNR) of 21.8 dB for the EMG signal, significantly improving upon commercial gel electrodes. The FMSP can synchronously monitor both FMG and EMG signals during arm movements, distinguishing between different bending angles and lifting weights. This multimodal sensor patch shows promising applications in muscle health monitoring, wearable intelligent sensing, and human-machine interfaces.\u0000</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":"68 8","pages":"2809 - 2818"},"PeriodicalIF":7.4,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145163156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced photoluminescence quantum yield in metal halide perovskites via trace Ag doping","authors":"Machao Wang \u0000 (,&nbsp;),&nbsp;Yangmin Tang \u0000 (,&nbsp;),&nbsp;Guiqiang Pu \u0000 (,&nbsp;),&nbsp;Chengbin Kang \u0000 (,&nbsp;),&nbsp;Zhiqiang Wang \u0000 (,&nbsp;),&nbsp;Lijia Liu \u0000 (,&nbsp;),&nbsp;Jing Li \u0000 (,&nbsp;),&nbsp;Zhenzhen Zhou \u0000 (,&nbsp;),&nbsp;Wei Chen \u0000 (,&nbsp;),&nbsp;Dong Wang \u0000 (,&nbsp;),&nbsp;Jiacheng Wang \u0000 (,&nbsp;)","doi":"10.1007/s40843-025-3458-1","DOIUrl":"10.1007/s40843-025-3458-1","url":null,"abstract":"<div><p>Self-trapped excitons are prevalent in metal halide perovskites (MHPs) characterized by soft lattices and strong exciton-phonon coupling, emitting photons with broadband emission and large Stokes shifts, rendering them particularly well-suited for applications in light-emitting diodes. But their photoluminescence quantum yields (PLQY) are limited by both high exciton binding energy and halogen-vacancy-associated non-radiative recombination. Here, we show that PLQY could be enhanced by a factor of 5.6 from 16% to 89% through doping trace Ag into Cs₂NaBiCl₆ double perovskites, superior to those of previous Cs₂NaBiCl₆-based emitters. Experimental and theoretical studies reveal that trace Ag-initiated covalent interactions could reduce the exciton binding energy by 0.12 eV due to local symmetry breaking, thus improving the photoexcitation process. Also, this covalent interaction could passivate Cl vacancy defects, suppressing non-radiative recombination. Therefore, Cs₂NaBiCl₆: 0.7% Ag⁺ could accumulate active self-trapped excitons to obtain high PLQY. Assembly of near-infrared light-emitting diodes using Cs₂NaBiCl₆: 0.7% Ag⁺ illustrates their valuable applications in nondestructive spectral analysis and night vision illumination. This work shows an effective strategy of improving photoemission of MHPs with high PLQY for advanced optoelectronic applications.\u0000</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":"68 8","pages":"2725 - 2734"},"PeriodicalIF":7.4,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145162730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chimeric peptide-engineered photodynamic PD-L1 degrader for activating colorectal cancer immunity in combination with exosomal PD-L1 inhibition","authors":"Yuxuan Wei \u0000 (,&nbsp;),&nbsp;Zuxiao Chen \u0000 (,&nbsp;),&nbsp;Wenfeng Zhu \u0000 (,&nbsp;),&nbsp;Rongrong Zheng \u0000 (,&nbsp;),&nbsp;Chuyu Huang \u0000 (,&nbsp;),&nbsp;Ni Yang \u0000 (,&nbsp;),&nbsp;Jing Wen \u0000 (,&nbsp;),&nbsp;Dawei Zhang \u0000 (,&nbsp;),&nbsp;Hong Cheng \u0000 (,&nbsp;),&nbsp;Shiying Li \u0000 (,&nbsp;)","doi":"10.1007/s40843-025-3431-y","DOIUrl":"10.1007/s40843-025-3431-y","url":null,"abstract":"<div><p>The immunotherapy effect of colorectal cancer is severely compromised by the expression of programmed cell death ligand 1 (PD-L1) on tumor cells and exosomes. Herein, a chimeric peptide engineered photodynamic degrader (NPPM) is developed for colorectal cancer immunotherapy, combining photodynamic degradation of PD-L1 with inhibition of exosomal PD-L1 expression. Among these, NPPM integrates protoporphyrin IX (PpIX) with a PD-L1-targeting peptide sequence (CVRARTR), forming an amphiphilic chimeric peptide to load macitentan (MAC). NPPM demonstrates specific colorectal cancer targeting ability through PD-L1 recognition and generates substantial reactive oxygen species (ROS) upon light irradiation, thereby destroying tumor cells via photodynamic therapy (PDT). More interestingly, PDT not only triggers immunogenic cell death (ICD) to enhance tumor immunogenicity, but also induces PD-L1 degradation in tumor cells. Concurrently, the delivery of MAC synergistically decreases the expression of exosomal PD-L1, thus amplifying the immunotherapeutic effect. The synergistic functions of NPPM result in significant activation of systemic anti-tumor immunity, characterized by increased infiltration of T cells and reduced presence of regulatory T cells, effectively suppressing both primary and metastatic tumors. This study provides a new strategy to degrade the proteins of interest and also proposes a sophisticated mechanism to potentiate immunotherapy by overcoming multiple immunosuppressive factors.\u0000</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":"68 8","pages":"2928 - 2939"},"PeriodicalIF":7.4,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145163224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}