Reports (MDPI)最新文献

{"title":"The PATH Protocol for Integrated Facial Rejuvenation: A Preliminary Three-Patient Case Report Series and Narrative Review of the Literature.","authors":"Enrica Filigheddu, Luigi Sardellitti, Manuela Astrid Chessa, Edoardo Filigheddu, Alessio Pirino, Egle Patrizia Milia","doi":"10.3390/reports9030282","DOIUrl":"10.3390/reports9030282","url":null,"abstract":"<p><p><b>Background and Clinical Significance:</b> Facial aging is a multifactorial process involving the skin, subcutaneous tissues, facial fat compartments, muscles, ligaments, and skeletal structures. Integrated minimally invasive protocols are increasingly used to improve facial harmony and skin quality while preserving natural expression. The PATH (Profundity, Action, Timing, and Home care) protocol combines chemical peeling, hyaluronic acid-succinate filler, intradermal biorevitalization, and post-procedural homecare in a sequential and individualized approach to facial rejuvenation; <b>Case Presentation:</b> Three female patients aged 52-58 years with clinical signs of facial aging were treated according to the PATH protocol. Assessments were performed at baseline and after 60 days using standardized photography, OBSERV 520^®, Antera 3D PRO^®, and QuantifiCare LifeViz^® Infinity Pro. No serious adverse events or systemic complications were reported during the 60-day follow-up period. Mild edema, erythema, and ecchymosis resolved spontaneously within 48-72 h. At 60 days, all patients showed natural improvement in facial appearance, with better midface and lower-face balance, increased skin brightness, improved texture, and no overcorrection or alteration of facial expression. Instrumental evaluations supported the clinical findings, showing improvements in skin regularity, chromatic uniformity, microrelief, and soft-tissue distribution; <b>Conclusions:</b> This preliminary case series suggests that the PATH protocol may represent a coherent multimodal strategy for integrated facial rejuvenation. The main clinical lesson is that a sequential, depth-oriented, and individualized approach may achieve natural aesthetic improvement. No serious adverse events were reported in the three patients during the 60-day follow-up period; however, the limited sample size and short follow-up do not allow definitive conclusions regarding safety. Further controlled studies with larger samples and longer follow-up are needed to confirm these exploratory findings.</p>","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":"9 3","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13611034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149042641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unexpected Long-Term Survival in Resected Pancreatic Ductal Adenocarcinoma Harboring KRAS G12R with an Ultra-Low-VAF SMAD4 Mutation: A Case Report and Mini-Review.","authors":"Bianca Varzaru, Adina Emilia Croitoru, Razvan Andrei Iacob, Simona Olimpia Dima, Cristian Gheorghe","doi":"10.3390/reports9030285","DOIUrl":"10.3390/reports9030285","url":null,"abstract":"<p><p><b>Background and Clinical Significance</b>: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a poor prognosis, even in resectable disease. Molecular alterations in the four major driver genes (<i>KRAS</i>, <i>SMAD4</i>, <i>CDKN2A</i>, and <i>TP53</i>) have been associated with disease progression and patient outcomes. However, reliable prognostic biomarkers remain limited, particularly in resected PDAC, where recurrence rates remain high; <b>Case presentation:</b> We report the case of a 71-year-old woman incidentally diagnosed with PDAC carrying <i>KRAS</i> G12R with an ultra-low-variant allele frequency (VAF) <i>SMAD4</i> mutation, with low baseline neutrophil-to-lymphocyte ratio (NLR) and circulating cell-free DNA (ccfDNA) levels. The patient underwent distal pancreatectomy with splenectomy and portal vein resection with multiple postoperative complications requiring re-intervention. The patient demonstrated excellent tolerance to the therapy, experiencing no significant adverse events and reaching an overall survival of 53 months. <b>Conclusions:</b> This case highlights the potential value of integrating molecular alterations with inflammatory and liquid biopsy biomarkers, including NLR and ccfDNA levels for improving risk stratification in PDAC. A focused review of the literature further supports the need for multimodal prognostic assessment in resected disease.</p>","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":"9 3","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13611010/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149042608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe Pediatric Diabetic Ketoacidosis Complicated by Dialysis-Requiring Acute Tubular Injury, in a Child Newly Diagnosed with Type 1 Diabetes Mellitus: A Case Report.","authors":"Ali Alamer, Sajjad Alkadhem, Osama Kattih, Ahmed Al-Amoudi, Aida Al Jabri, Maali Alali, Ahmed Soliman","doi":"10.3390/reports9030283","DOIUrl":"10.3390/reports9030283","url":null,"abstract":"<p><p><b>Background and Clinical Significance</b>: Diabetic ketoacidosis (DKA) is a common presentation of new-onset type 1 diabetes mellitus in children; however, severe DKA complicated by acute pancreatitis, dialysis-requiring acute kidney injury (AKI), severe hypertension, and neurological involvement is uncommon. Early recognition of these complications is essential because they may substantially increase morbidity and complicate standard DKA management; <b>Case Presentation</b>: An 11-year-old Saudi girl with morbid obesity (BMI 43 kg/m²), previously in good health, was brought to the emergency department after being found semi-conscious. She had experienced intermittent abdominal pain for five weeks and vomiting for four days. On presentation, she was critically ill, dehydrated, and confused (Glasgow Coma Scale 11/15) and exhibited Kussmaul breathing and abdominal tenderness. Laboratory investigations confirmed severe new-onset DKA, with a blood glucose level of 684 mg/dL, pH < 7.0, HbA1c 12.2% and an anion gap > 37 mEq/L. Despite standard DKA management, metabolic acidosis persisted and renal function progressively deteriorated, accompanied by oliguria and severe hypertension reaching 200 mmHg. By day 4, the patient developed anuria and marked creatinine elevation to 560 µmol/L. Brain magnetic resonance imaging demonstrated cerebral microhemorrhages in the setting of multifactorial encephalopathy. Continuous kidney replacement therapy was initiated for KDIGO stage 3 AKI with refractory metabolic acidosis. Autoimmune testing supported the diagnosis of type 1 diabetes mellitus, while renal biopsy demonstrated acute tubular injury; <b>Conclusions</b>: This case highlights a rare, severe multisystem presentation of pediatric DKA. Close monitoring for renal, neurological, pancreatic, and hypertensive complications is crucial, particularly when the clinical course does not improve as expected with standard therapy.</p>","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":"9 3","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13611801/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149042636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Utilization of Inclisiran for the Optimization of Lipid Management in People Living with HIV: A Clinical Case Series and Comprehensive Review.","authors":"Vasileios Petrakis, Maria Panopoulou, Anastasia Grapsa, Andreas G Tsantes, Periklis Panagopoulos","doi":"10.3390/reports9030284","DOIUrl":"10.3390/reports9030284","url":null,"abstract":"<p><p><b>Background and Clinical Significance</b>: People with HIV (PWH) experience an elevated risk of atherosclerotic cardiovascular disease (ASCVD), driven by chronic immune activation, metabolic toxicities of antiretroviral therapy (ART), and traditional risk factors. Achieving target low-density lipoprotein cholesterol (LDL-C) levels is frequently impeded by adherence barriers, pharmacokinetic drug interactions, or muscle-related symptoms. Inclisiran is a hepatocyte-targeted small interfering RNA that halts proprotein convertase subtilisin/kexin type 9 synthesis, providing a long-acting therapeutic alternative. <b>Case Presentation</b>: We present two PWH with severe hypercholesterolemia and elevated cardiovascular risk on stable ART. Case 1 describes a 54-year-old male with a history of myocardial infarction presenting with persistent, refractory hypercholesterolemia on rosuvastatin and ezetimibe (baseline LDL-C 142 mg/dL). Case 2 describes a 58-year-old male with verified statin intolerance and inadequate response to ezetimibe (baseline LDL-C 194 mg/dL). Following subcutaneous inclisiran administration at Day 1 and Day 90, Case 1 achieved an 80.2% LDL-C reduction to 28 mg/dL at Month 6, and Case 2 achieved a 54.6% reduction to 88 mg/dL at Month 6 as monotherapy. Both patients tolerated therapy well, with stable CD4+ counts and sustained virological suppression. <b>Conclusions</b>: These cases illustrate that inclisiran can effectively lower LDL-C levels across primary and secondary prevention settings in PWH facing oral therapy limitations or statin intolerance. Provider-administered dosing every 6 months overcomes adherence challenges, supporting the inclusion of PWH in broader clinical pathways pending ongoing cardiovascular outcome trials.</p>","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":"9 3","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13611130/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149042592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rubber Band Ligation for Treatment of Mucoceles: A Potential Minimally Invasive Treatment Approach.","authors":"Satoru Kusaka, Tatsuya Akitomo, Masashi Ogawa, Yuto Shoji, Jimei Zhao, Ryota Nomura","doi":"10.3390/reports9030281","DOIUrl":"10.3390/reports9030281","url":null,"abstract":"<p><p>Mucoceles are benign lesions caused by the accumulation of mucus such as saliva, and are common in children. Surgical intervention is effective but is not well tolerated by children because of its invasiveness, and alternative treatment methods are being explored. A boy aged 2 years and 5 months presented at our hospital with a chief complaint of mucocele. Considering the patient's age, micro-marsupialization was initially selected to avoid surgical excision; however, the cyst did not resolve. We decided to apply the rubber band ligation method used for treatment of internal hemorrhoids, and ligated the mucocele using an orthodontic elastic separator. At the 3-week follow-up visit, the mucocele had disappeared. According to the patient's guardian, the rubber band fell off after 1 week, and the mucocele subsequently detached and fell off spontaneously shortly thereafter. Although further studies are needed to establish the effectiveness of this treatment method, this report suggests that rubber band ligation may represent a novel, minimally invasive, and safe therapeutic option for the treatment of mucoceles.</p>","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":"9 3","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13611013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149042620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Clear Margins: Oncologic Risk and Reconstructive Planning in Head and Neck Cutaneous Squamous Cell Carcinoma-A Structured Narrative Review.","authors":"Iris-Iuliana Adam, Liliana Vecerzan, Bogdan Moldovan, Raluca-Gabriela Miulescu, Alexandru-Petru Ciucu, Alina-Bianca Iacob, Alina Ormenișan","doi":"10.3390/reports9030280","DOIUrl":"10.3390/reports9030280","url":null,"abstract":"<p><strong>Background: </strong>Head and neck cutaneous squamous cell carcinoma (HNcSCC) presents intersecting oncologic, functional, and reconstructive challenges. Although numerous clinicopathologic factors have been associated with recurrence, metastasis, and survival, their relationship with reconstructive complexity and patient-centered outcomes remains insufficiently studied. This review aimed to examine how established oncologic risk factors might inform reconstructive planning while distinguishing measured reconstructive evidence from hypothesis-generating clinical inferences.</p><p><strong>Methods: </strong>A structured PubMed/MEDLINE search conducted through 15 July 2026 was used to identify the literature addressing clinicopathologic prognostic factors in HNcSCC. Twenty-nine prognostic publications were retained for structured charting. Additional reconstructive, functional, aesthetic, and patient-reported outcome sources were identified through reference-list screening and were used solely for narrative contextualization. Because no dedicated multi-database systematic search of reconstructive outcomes was performed, the article is presented as a structured narrative review and hypothesis-generating research framework rather than a systematic review of reconstructive evidence.</p><p><strong>Results: </strong>The prognostic literature reported associations between adverse oncologic outcomes and factors including tumor size and depth, perineural invasion, lymphovascular invasion, poor differentiation, immunosuppression, recurrent disease, positive margins, nodal involvement, and extranodal extension. However, most of these studies did not measure post-excision defect characteristics, reconstructive technique, wound complications, functional recovery, scar quality, aesthetic outcomes, or patient-reported outcomes. Direct reconstructive evidence was limited and predominantly derived from site-specific, mixed-histology, technical, or methodological publications. Consequently, clinicopathologic factors should be regarded as potential upstream variables for future investigation rather than validated predictors of reconstructive outcomes.</p><p><strong>Conclusions: </strong>Current evidence supports oncologic risk stratification more strongly than prediction of reconstructive difficulty or patient-centered outcomes in HNcSCC. Prospective studies should jointly measure patient, tumor, treatment-field, defect, reconstructive, functional, aesthetic, and patient-reported variables. The proposed framework is intended to guide such research and is not a validated clinical prediction model.</p>","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":"9 3","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13611058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149042717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immediate Implant Placement in the Mandibular Molar Septum Using Osseodensification: A Case Report with 4-Year Follow-Up.","authors":"Márcio de Carvalho Formiga, Jucielly Santos Lesnik de Souza, Gustavo Dos Santos Coura, Sérgio Alexandre Gehrke","doi":"10.3390/reports9030278","DOIUrl":"10.3390/reports9030278","url":null,"abstract":"<p><p><b>Background and Clinical Significance</b>: Immediate implant placement in mandibular molars represents a clinical challenge due to lower trabecular bone density and anatomical limitations of the interradicular septum. Osseodensification has been proposed as an alternative to improve primary stability in sites with low bone quality. <b>Case Presentation</b>: This report describes the case of a 54-year-old female patient with a mesial root fracture in the lower right first molar, treated by atraumatic extraction followed by immediate implant placement using a densifying drilling protocol. After careful root removal, the interradicular septum was expanded using Versah burs at 1200 rpm, allowing placement of a 4.0 × 7 mm Implacil Duecone implant with a final insertion torque of 25 Ncm. The residual gap was filled with a xenogeneic bone substitute and covered with a dense polytetrafluorethylene membrane for alveolar preservation. Healing progressed uneventfully and, after four months, adequate bone formation was observed, enabling prosthetic rehabilitation with a single ceramic crown. After 4 postoperative years we could find peri-implant tissue stability. <b>Conclusions</b>: The clinical outcome supports current evidence indicating that osseodensification may enhance initial stability and predictability of immediate implants placed in posterior mandibular regions.</p>","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":"9 3","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13511105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148835555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Talar Fracture Caused by Direct High-Impact Trauma.","authors":"Nikolaos A Stavropoulos, Fotios Kantas, Dimitrios V Papadopoulos, Rizos Tsaknis, Vasileios S Nikolaou, George C Babis","doi":"10.3390/reports9030279","DOIUrl":"10.3390/reports9030279","url":null,"abstract":"<p><p>Fractures of the lateral process of the talus are uncommon injuries. We present a direct force trauma-induced talus lateral process fracture sustained in a 60-year-old male. The fracture was eventually diagnosed with computed tomography (CT) imaging and managed conservatively due to the patient's co-morbidities and fracture type. The patient achieved an AOFAS Hindfoot Score of 90 at one year and remained asymptomatic at 78 months. Through this case, we aim to underscore the variability in clinical manifestations of the talus' lateral process fractures as well as increase physician awareness for this type of fracture.</p>","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":"9 3","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13511007/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148834936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Lichen Planus and Oral Lichenoid Lesion in Pediatric Patients: A Narrative Review of Published Case Reports.","authors":"Konstantinos Poulopoulos, Christina Charisi, Filippos Fytros, Asterios Katsagkolis, Stefanos Zisis, Maria Kalyva, Nikolaos Spantidakis, Petros Papadopoulos, Athanasios Poulopoulos, Vasileios Zisis","doi":"10.3390/reports9030277","DOIUrl":"10.3390/reports9030277","url":null,"abstract":"<p><p><b>Background:</b> Oral lichen planus (OLP) is a chronic inflammatory mucocutaneous disorder that is well documented in adults but remains relatively uncommon in the pediatric population. Due to its rarity, knowledge regarding its epidemiology, etiology, clinical behavior, diagnosis, and management in children remains limited. <b>Objective:</b> To review the current literature regarding epidemiology, pathogenesis, clinical presentation, diagnosis, histopathological characteristics, treatment, and outcomes of OLP in pediatric patients. <b>Materials and Methods:</b> An electronic search of the literature was conducted in the PubMed, Scopus, and Cochrane Library databases to identify OLP-associated case reports in the pediatric population. The search was limited to English-written publications of the past decade. The initial PubMed search yielded 228 publications. Following restriction to studies published between 2016 and 2026, 97 records remained. Limiting the search to English-language publications resulted in 95 studies. Screening for patients younger than 18 years identified 51 potentially relevant publications. After title, abstract, and full-text review, 10 studies fulfilled the inclusion criteria. To ensure comprehensive literature coverage, supplementary searches were subsequently conducted in the Scopus and Cochrane Library databases, identifying three additional eligible studies after excluding the duplicates. Consequently, a total of 13 studies were included in the final review. <b>Results:</b> Pediatric OLP is considerably less common than adult disease. The available evidence suggests an immune-mediated pathogenesis, although the exact mechanism remains unclear. Clinical presentations include reticular, erosive, plaque-like, linear, and severe mucocutaneous forms, with the reticular subtype being the most frequently reported. Histopathological findings consistently demonstrate basal cell degeneration and a dense subepithelial lymphocytic infiltrate. Topical corticosteroids remain the most commonly prescribed treatment and are generally associated with favorable clinical outcomes. <b>Conclusions:</b> Although relatively uncommon, OLP should be considered in the differential diagnosis of persistent oral white lesions in children. Early diagnosis and appropriate management are essential for symptom control and prevention of complications. Additional research is needed to better understand disease pathogenesis and establish evidence-based treatment protocols for pediatric patients.</p>","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":"9 3","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13511729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148835614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Respiratory Oscillometry Findings in Chronic Epipharyngitis.","authors":"Manabu Mogitate","doi":"10.3390/reports9030276","DOIUrl":"10.3390/reports9030276","url":null,"abstract":"<p><strong>Background: </strong>Chronic nasopharyngeal inflammation (chronic epipharyngitis) is associated with various upper airway and systemic symptoms. However, the relationship between endoscopic inflammatory findings and functional respiratory abnormalities remains unclear. This study aimed to evaluate respiratory oscillometry parameters measured by the MostGraph system in patients with chronic epipharyngitis and to investigate their changes following Epipharyngeal Abrasive Therapy (EAT).</p><p><strong>Methods: </strong>In this retrospective observational study, patients diagnosed with chronic epipharyngitis who underwent MostGraph examination were analyzed. Respiratory resistance and reactance parameters, including R5-R20, X5, inspiratory X5 (Xin5), resonant frequency (Fres), and low-frequency reactance area (ALX), were assessed. Endoscopic findings were scored using a standardized grading system. Comparisons were performed between patients and healthy controls, and pre- and post-EAT measurements were evaluated. Correlations between endoscopic severity and oscillometric parameters were analyzed using Spearman's rank correlation coefficient.</p><p><strong>Results: </strong>Patients with chronic epipharyngitis demonstrated significant abnormalities in oscillometric reactance parameters compared with healthy controls. Following EAT, a significant change was observed in R5-R20, whereas other oscillometric parameters did not show significant changes. In addition, endoscopic severity scores showed no significant correlation with oscillometric measurements. These findings suggest that respiratory oscillometry may detect physiological abnormalities that are not directly reflected by endoscopic inflammatory severity.</p><p><strong>Conclusions: </strong>Patients with chronic epipharyngitis exhibited abnormalities in respiratory oscillometry parameters despite the absence of significant associations with endoscopic severity scores. The observed dissociation between endoscopic findings and oscillometric measurements suggests that morphological inflammation and physiological dysfunction may represent distinct dimensions of the disease. Respiratory oscillometry may therefore provide complementary information regarding the pathophysiology of chronic epipharyngitis beyond conventional endoscopic assessment.</p>","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":"9 3","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13511274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148835583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}