Reports (MDPI)最新文献

{"title":"Adjunctive Antimicrobial Therapy in Peri-Implant Diseases: A Narrative Review.","authors":"Dorothea Pliaka, Filippos Fytros, Stefanos Zisis, Vasileios Zisis, Panagiota Dimitropoulou, Konstantinos Poulopoulos, Christina Charisi, Amalia Syrioti, Nikolaos Shinas, Athanasios Poulopoulos","doi":"10.3390/reports9040365","DOIUrl":"https://doi.org/10.3390/reports9040365","url":null,"abstract":"<p><p><b>Background</b>: Effective management of peri-implant disease relies primarily on mechanical removal of the bacterial biofilm. However, achieving adequate surface decontamination can be challenging due to complex implant-surface morphology and restricted access to deep peri-implant pockets. This has prompted the use of adjunctive antimicrobial agents to complement mechanical therapy and improve therapeutic outcomes. <b>Objective</b>: To investigate whether the adjunctive use of antimicrobial strategies improves clinical, microbiological, and radiographic outcomes in patients with peri-implant mucositis and peri-implantitis. <b>Materials and Methods</b>: A structured narrative review was conducted using PubMed/MEDLINE and Scopus in July 2026. No database filters concerning language, human participants or study design were applied. During the screening process, only randomized controlled clinical trials involving human participants and available as English-language full texts were selected. Eligible interventions included locally or systemically administered antibiotics, antiseptics, antimicrobial drug-delivery systems, antimicrobial photodynamic therapy (aPDT), ozone-based therapies, and microbiome-modulating adjuncts. Conventional laser therapy was not classified as an eligible antimicrobial intervention. The database searches retrieved 462 records, including 252 from PubMed and 210 from Scopus. Following duplicate removal and eligibility assessment, 100 publications representing 93 independent clinical trials were included. <b>Results</b>: adjunctive antimicrobial efficacy was highly variable and appeared to depend on disease severity, debridement strategy, antimicrobial agent, delivery modality, and follow-up period. Repeated or sustained local antimicrobial delivery was associated with modest, short-term benefits in several studies, whereas chlorhexidine (CHX) generally provided limited additional benefit over mechanical therapy. Evidence for systemic antibiotics remained inconsistent and insufficient to support routine use, while aPDT offered potential benefits that varied according to treatment protocol. Ozone therapy, herbal agents, and novel drug-delivery systems yielded encouraging preliminary results, although evidence remains scarce. Moreover, reductions in bleeding and probing depth (PD) did not reliably correspond to superior microbiological outcomes, radiographic bone gain, or complete disease resolution. <b>Conclusions</b>: Mechanical debridement (MD) and effective plaque control remain central to peri-implant disease management. Some adjunctive interventions produced modest short-term improvements in individual studies; however, the available evidence does not demonstrate durable disease control or support routine use. Therapeutic decisions should be tailored to disease severity, patient and implant characteristics, and the balance between potential benefits and antimicrobial-associated risks. Further well-designed and adeq","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":"9 4","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149278467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of Chikungunya Virus Infection in the Philippines.","authors":"Nestor S Arce, Hisham A Imad, Prakaykaew Charunwatthana","doi":"10.3390/reports9040364","DOIUrl":"https://doi.org/10.3390/reports9040364","url":null,"abstract":"<p><p><b>Background:</b> Chikungunya virus (CHIKV) has circulated in the Philippines for more than six decades. We systematically reviewed the epidemiology of CHIKV in the Philippines, integrating evidence on transmission, seroprevalence, diagnostics and molecular lineages. <b>Methods:</b> We searched PubMed and Embase to March 2026 for original studies reporting incidence, prevalence, seroprevalence, outbreak characteristics, or surveillance findings in human populations in the Philippines. The gray literature from the Department of Health (DOH) Epidemiology Bureau's national chikungunya surveillance (2018-March 2026) was included separately. Findings were synthesized narratively because of substantial heterogeneity. <b>Results:</b> Sixteen studies and one national surveillance dataset were included. National surveillance recorded 12,662 cases from 2018 to early 2026, including 722 laboratory-confirmed cases and three fatalities. The Asian genotype predominated during the 2011-2013 epidemic, while Indian Ocean lineage (IOL) viruses were detected in southern Mindanao. <b>Conclusions:</b> Transmission of CHIKV in the Philippines is mostly sporadic with periods of low-level transmission. Because the clinical features overlap with dengue, acute febrile illness surveillance should test for both viruses.</p>","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":"9 4","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13692436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149278525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incomplete Uterine Artery Embolization Secondary to Collateral Parasitization from Celiac and Superior Mesenteric Arterial Branches: A Case Report and Literature Review.","authors":"Haidara Almansour, Mohammadhossein Ghasempourabadi, Darren Klass","doi":"10.3390/reports9040363","DOIUrl":"https://doi.org/10.3390/reports9040363","url":null,"abstract":"<p><p><b>Background and Clinical Significance:</b> Uterine artery embolization (UAE) is a well-established treatment for symptomatic leiomyomas; however, treatment failure may occur owing to collateral arterial supply from extra-uterine sources. While ovarian artery collaterals are the most commonly reported cause, parasitic vascularization from the celiac axis and superior mesenteric artery (SMA) remains exceedingly rare and poorly documented; <b>Case Presentation:</b> A 41-year-old woman with symptomatic fibroids underwent technically successful bilateral UAE. Follow-up imaging revealed persistent vascularity of a dominant 19 cm pedunculated fibroid supplied by collateral branches from the celiac axis and SMA. As surgery was contraindicated owing to a recent pulmonary embolism that occurred after UAE, gonadotropin-releasing hormone (GnRH) agonist therapy was initiated, resulting in partial fibroid shrinkage and symptomatic improvement; <b>Conclusions:</b> Persistent fibroid vascularization after technically successful UAE may result from unrecognized extra-uterine arterial feeders. Cross-sectional angiographic imaging is essential for identifying atypical collateral pathways and guiding subsequent management in cases of treatment failure.</p>","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":"9 4","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13692452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149278385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Full-Endoscopic Interlaminar Approach for a Posteriorly Migrated Lumbar Disc Sequestration in a Patient Presenting with Cauda Equina Syndrome and Atypical Magnetic Resonance Imaging Findings: Case Report.","authors":"Marios Theologou, Kassiani Boulogeorgou, Nikolaos Syrmos, Nicoleta Pastelli, Panagiotis Kyriakongonas","doi":"10.3390/reports9040361","DOIUrl":"https://doi.org/10.3390/reports9040361","url":null,"abstract":"<p><p><b>Background and Clinical Significance</b>: Posterior epidural migration of a sequestered disc fragment is a very rare entity that may present significant diagnostic challenges, due to radiological characteristics that may mimic other lesions; <b>Case Presentation</b>: A young adult male presented with acute deteriorating low back pain, paraparesis, and urinary incontinence. Magnetic Resonance Imaging (MRI) revealed a massive posterior intraspinal mass causing critical canal stenosis. Although the dorsal location and severe mass effect initially suggested a neoplasm, the complete absence of contrast enhancement strongly pointed toward an avascular lesion. Given the patient's rapid neurological decline, an emergency full-endoscopic left-sided L₄-L₅ interlaminar approach was employed, and a massive free disc fragment was removed. The patient achieved complete motor and sphincter recovery within a month, with mild paresthesia resolving by six months; <b>Conclusions:</b> Posterior epidural migration of a sequestered disc fragment is a rare entity that should be included in the differential diagnosis of posterior intraspinal masses with atypical MRI characteristics. The full-endoscopic interlaminar approach is a viable minimally invasive surgical option.</p>","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":"9 4","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13692387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149278439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of a Polylactic Acid Membrane for Wound Care After Severe Herpes Zoster (Shingles): A Case Report.","authors":"Víctor Manuel Loza-González, Patricia Aurea Cervantes-Báez, Andrea Paola Saucedo-Quintero, José Luis Ramírez-GarcíaLuna, Mario Aurelio Martínez-Jiménez","doi":"10.3390/reports9040362","DOIUrl":"https://doi.org/10.3390/reports9040362","url":null,"abstract":"<p><p><b>Background and Clinical Significance:</b> Herpes zoster (HZ) results from reactivation of latent varicella-zoster virus and disproportionately affects older adults. Antiviral therapy and systemic analgesia are well established, but local wound care of the eroded skin remains largely empirical: no dressing has been validated in controlled trials for this indication, and denuded HZ lesions are frequently mismanaged with dry gauze that adheres to the wound bed and aggravates pain. <b>Case Presentation:</b> An 85-year-old man with no known chronic disease presented with a one-week history of thoracic HZ unresponsive to outpatient antiviral therapy, requiring admission for uncontrolled pain (9/10 on the Numeric Rating Scale, NRS), vomiting, asthenia, and hyporexia. Examination revealed confluent, superficial-partial-thickness erosions across the T6-T8 dermatomes (12.5 × 24 cm). After a negative wound culture, a single polylactic-acid-based membrane (Suprathel^®250) was applied over the entire denuded area. Pain decreased from 9/10 to 2/10 on the NRS within seven days and complete re-epithelialization was observed by day 12, under concurrent antiviral and systemic analgesic therapy and the patient resumed independent daily activities by the third week without scarring. <b>Conclusions:</b> In this single uncontrolled case, pain reduction and wound closure followed one application of a polylactic acid membrane to an extensive HZ lesion. Because antiviral and analgesic therapy were given concurrently and HZ improves spontaneously over time, no causal or comparative inference is possible; the observation is hypothesis-generating and supports further controlled investigation. Suprathel^® is CE-marked and FDA-cleared for burn and wound care, so its use for HZ erosions extends an established burn indication.</p>","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":"9 4","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13692323/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149278496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical-Radiological Discordance in the Detection of Chronic Constipation in Children Newly Diagnosed with Autism Spectrum Disorder: A Retrospective Study.","authors":"Hamza A Alsayouf, Redab Al-Ghawanmeh, Luay S Alhawawsha, Osama Alsarhan, Hala Abdulsalam Hamada","doi":"10.3390/reports9040360","DOIUrl":"https://doi.org/10.3390/reports9040360","url":null,"abstract":"<p><p><b>Background/Objectives:</b> Chronic constipation in patients with autism spectrum disorder (ASD) may be undetected during routine care and can exacerbate ASD symptoms such as irritability and hyperactivity. This retrospective study evaluated the prevalence of radiographic findings suggestive of chronic constipation in children newly diagnosed with ASD, and it compared these findings with those based on routine clinical history and examination alone. <b>Methods:</b> A retrospective chart review of pediatric patients diagnosed with ASD at neurology clinics in Jordan between 2022 and 2025 was conducted. Informed consent was required for an abdominal radiographic examination at screening to initiate the standard treatment protocol at participating clinics. A more stringent version of the Leech criteria, equivalent to a total Leech score of ≥10, was applied to the radiographic images to identify patients with findings suggestive of chronic constipation. Data were extracted via retrospective chart review using a standardized data collection form. <b>Results:</b> Among the 455 patients who met the study eligibility criteria, the mean ± SD age was 6.7 ± 3.3 years (median, 6 years; range, 2-18 years) and 80.2% were male. Most patients had radiographic findings suggestive of chronic constipation at baseline (81.5%, n = 371/455), whereas 5.3% (24/455) had findings suggestive of constipation based on their medical history and clinical examination alone. <b>Conclusions:</b> Radiographic findings suggestive of chronic constipation were common in children newly diagnosed with ASD and were identified substantially more frequently than constipation identified through routine history-taking and clinical examination in the same patients. Prospective studies are warranted to determine whether the use of alternative, standardized methods as adjunct diagnostic tools can improve clinical outcomes in this population.</p>","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":"9 4","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13692523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149278526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraprocedural Embolization of a Tricuspid Edge-to-Edge Repair Device and Its Percutaneous Retrieval: A Case Report.","authors":"Andrija Matetic, Frane Runjić, Ivona Mustapić, Darija Baković Kramarić","doi":"10.3390/reports9040359","DOIUrl":"https://doi.org/10.3390/reports9040359","url":null,"abstract":"<p><p><b>Background and Clinical Significance:</b> Tricuspid transcatheter edge-to-edge repair (T-TEER) is an established therapy for severe tricuspid regurgitation (TR) in selected patients. Single-leaflet device attachment (SLDA) is the commonest device-related complication, but complete intraprocedural detachment with embolization is rare, and percutaneous retrieval of an embolized tricuspid device has been reported only exceptionally. <b>Case Presentation:</b> An inoperable elderly patient with previous transcatheter aortic valve implantation (TAVI) and torrential functional TR underwent T-TEER. After implantation of the first clip at the anteroseptal commissure with apparently adequate leaflet capture, anterior SLDA was identified and progressed to complete detachment and right atrial embolization of the device. Despite this, the T-TEER was completed by successful implantation of the second clip, leaving only mild residual central TR. In the same session, the embolized device was retrieved percutaneously from the femoral venous system using a 15 mm gooseneck snare advanced through a 22 Fr sheath, with a safety wire and en-bloc removal, without forcing ensheathing and without venous injury. The patient was discharged on post-procedure day 2 with durable TR reduction and clinical improvement. <b>Conclusions:</b> Complete leaflet detachment is a possible complication of T-TEER. Confirming deep, symmetric insertion in multiple echocardiographic windows before every release is essential. When embolization occurs, knowledge of device dimensions and immediate availability of a complete snare kit is important. Although this approach may be considered in selected patients, particularly those at high surgical risk, the available evidence is limited to isolated case reports and does not allow general conclusions on its safety or efficacy.</p>","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":"9 4","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149278398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Diagnostic Challenge in Linear Dermatoses: Differentiating Inflammatory Linear Verrucous Epidermal Nevus (ILVEN) Using Dermoscopy and Reflectance Confocal Microscopy-A Case Report.","authors":"Antonio Alma, Samantha Gherbassi, Alessandro Clementi, Silvana Ciardo, Francesca Farnetani","doi":"10.3390/reports9040357","DOIUrl":"https://doi.org/10.3390/reports9040357","url":null,"abstract":"<p><p><b>Background and Clinical Significance</b>: Inflammatory linear verrucous epidermal nevus (ILVEN) is a non-melanocytic skin lesion, typically present in early childhood, that is characterized by a linear verrucous appearance distributed along Blaschko's lines. However, cases with onset in adolescence can present a diagnostic challenge, requiring accurate distinction from other linear dermatoses. <b>Case Presentation</b>: We present the case of a 16-year-old boy with a linear verrucous lesion on his thigh showing atypical clinical features. The lesion was evaluated using dermoscopy and reflectance confocal microscopy (RCM), which revealed specific diagnostic patterns consistent with the final diagnosis. <b>Conclusions</b>: The combined use of dermoscopy and RCM provided valuable non-invasive diagnostic information, avoiding the need for an invasive biopsy, particularly in pediatric and adolescent patients.</p>","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":"9 4","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13692401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149278456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous Resolution of a Unilateral Epiretinal Membrane in Bilateral Peripheral Retinal Vasculopathy: A Case Report.","authors":"Alessandro Avitabile, Maria Ludovica Ruggeri, Alberto Quarta, Corina Valentina de Santis Ciacci, Vincenza Maria Elena Bonfiglio","doi":"10.3390/reports9040358","DOIUrl":"https://doi.org/10.3390/reports9040358","url":null,"abstract":"<p><p><b>Background and Clinical Significance</b>: Epiretinal membranes (ERMs) are uncommon in young patients, and spontaneous anatomical resolution is rare. We report spontaneous disappearance of a unilateral ERM after marked worsening in an 18-year-old woman with bilateral peripheral occlusive/telangiectatic retinal vasculopathy and vitritis of undetermined etiology. <b>Case Presentation</b>: She presented with right-eye (RE) metamorphopsia and uncorrected visual acuity of 20/25. Optical coherence tomography (OCT) showed a macular ERM; fluorescein angiography showed bilateral peripheral telangiectasia, leakage, vascular truncation, and capillary nonperfusion. Bilateral vitritis was present. Treatment comprised a single intravitreal ranibizumab injection in the RE and peripheral laser photocoagulation in both eyes for the vascular abnormalities; the ERM was managed conservatively. Before its disappearance, the ERM showed marked anatomical worsening accompanied by progressive visual decline. RE central macular thickness (CMT) peaked at 901 µm on Day 71; the lowest uncorrected visual acuity, 20/200, was recorded on Days 166 and 187. Posterior vitreous detachment was not clinically detectable throughout follow-up. On Day 243, the ERM was first documented as absent clinically and on OCT; visual acuity with correction was 20/30, CMT was 464 µm, and vitritis was no longer clinically detectable. At approximately 38 months, macular contour remained restored and recorded visual acuity was 20/20 in both eyes. When mapped to the MANE Select transcript, the retained VCAN variant notation corresponds to NM_004385.5:c.2234A>C (p.Lys745Thr); ClinVar reports conflicting classifications, and the finding was therefore considered non-diagnostic. <b>Conclusions</b>: This case documents spontaneous ERM disappearance without vitreoretinal surgery after marked anatomical and functional worsening. The separation mechanism and any causal contribution of ranibizumab or laser photocoagulation remain uncertain.</p>","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":"9 4","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13692474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149278503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parenteral Nutrition as a Strategic Therapeutic Option for Onco-Geriatric Rehabilitation After Total Gastrectomy and Anastomotic Stenosis Complicated by an Aorto-Esophageal Fistula: A Case Report.","authors":"Houssam Eddine Belaid, João Gabriel De Carvalho, Mariangela Gagliano","doi":"10.3390/reports9040356","DOIUrl":"https://doi.org/10.3390/reports9040356","url":null,"abstract":"<p><p><b>Background and Clinical Significance</b>: The nutritional management of onco-geriatric patients after a total gastrectomy remains a challenge, especially in the context of postoperative complications, such as stenosis of the esophagojejunal anastomosis, and in the presence of an aorto-esophageal fistula. Parenteral nutrition is a relevant therapeutic option to maintain nutritional support and enable rehabilitation when oral and enteral feeding are no longer feasible in this specific clinical context; <b>Case Presentation</b>: We report here the case of a 76-year-old patient who underwent a total gastrectomy for gastric adenocarcinoma with several dilated and stented esophagojejunal anastomoses. During the first postoperative year, the nutritional adaptation facilitated rehabilitation and helped him recover well. However, the occurrence of an aorto-esophageal fistula and its treatment with thoracic endovascular aortic repair (TEVAR) made oral and enteral feeding impossible. This was associated with persistent asthenia, physical deconditioning, sarcopenia, weight loss, exercise intolerance, and increased dependence for activities of daily living. Although parenteral nutrition allowed for nutritional stability and the beginning of rehabilitation, a suspected nosocomial infection involving the aortic endograft led to his death before his treatment was complete; <b>Conclusions</b>: This case highlights the relevance of parenteral nutrition as a therapeutic option to continue rehabilitation when enteral access is judged unacceptably risky. However, the risk of infectious complications in the context of malnutrition can compromise the prognosis, and any suspicion of infection involving prosthetic material should be documented microbiologically as completely as possible whenever compatible with the patient's care objectives. Onco-geriatric assessment to manage older patients with esophagogastric cancer is recommended.</p>","PeriodicalId":74664,"journal":{"name":"Reports (MDPI)","volume":"9 4","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13692501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149278371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}